Find hotels in Southeast Missouri, MO from CA $76

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Compare 585 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Southeast Missouri hotels

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Great location "
The price is CA $125
CA $144 total
includes taxes & fees
Aug 28 - Aug 29
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Jackson MO

3.0 star property
9.6 out of 10, Exceptional, (1002)
"We had a last minute reservation here. The staff was very pleasant, helpful and wonderful overall!!"
The price is CA $125
CA $132 total
includes taxes & fees
Aug 27 - Aug 28
Drury Inn & Suites Jackson MO

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (27)
"Sweet cabin"
The price is CA $124
CA $186 total
includes taxes & fees
Aug 25 - Aug 26
Postcard Cabins St. Francois

Microtel Inn & Suites by Wyndham Sainte Genevieve

2.5 star property
8.8 out of 10, Excellent, (588)
"It was a great stay. Only thimg maybe more variety or hot breakfast."
The price is CA $118
CA $131 total
includes taxes & fees
Sep 7 - Sep 8
Microtel Inn & Suites by Wyndham Sainte Genevieve

Drury Inn & Suites Hayti Caruthersville

3.0 star property
9.4 out of 10, Exceptional, (1001)
"We enjoyed our stay."
The price is CA $131
CA $149 total
includes taxes & fees
Aug 31 - Sep 1
Drury Inn & Suites Hayti Caruthersville

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1003)
"Very nice property Friendly helpful staff"
The price is CA $107
CA $123 total
includes taxes & fees
Sep 4 - Sep 5
Pear Tree Inn Sikeston

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
9.4 out of 10, Exceptional, (498)
"Have stayed here the past 3 years during the Laid Back on I-55 Truck Show! Great place to stay! The breakfast is fantastic!! The staff does not disappoint!! "
The price is CA $132
CA $151 total
includes taxes & fees
Aug 31 - Sep 1
Holiday Inn Express & Suites Perryville by IHG

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (794)
"Hotel was very clean and the staff was friendly! I would stay again. "
The price is CA $138
CA $156 total
includes taxes & fees
Sep 4 - Sep 5
Fairfield Inn & Suites by Marriott Poplar Bluff

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1004)
"Excellent place to stay "
The price is CA $97
CA $110 total
includes taxes & fees
Aug 25 - Aug 26
Pear Tree Inn Cape Girardeau Near the Medical Center

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (393)
"Nice place to stay! everything was fun and clean."
The price is CA $146
CA $165 total
includes taxes & fees
Aug 24 - Aug 25
The Riverview

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (125)
"The hotel was very clean and updated and the staff was super friendly and very informative!"
The price is CA $129
CA $146 total
includes taxes & fees
Aug 31 - Sep 1
Fairfield Inn & Suites by Marriott Cape Girardeau

Crown Pointe Lodge, BW Signature Collection

2.5 star property
9.0 out of 10, Wonderful, (545)
"We'd stay here again."
The price is CA $186
CA $212 total
includes taxes & fees
Sep 6 - Sep 7
Crown Pointe Lodge, BW Signature Collection

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (739)
"Nice and clean hotel friendly service"
The price is CA $152
CA $172 total
includes taxes & fees
Aug 31 - Sep 1
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Poplar Bluff

2.5 star property
9.4 out of 10, Exceptional, (751)
"Excellent property, great location. "
The price is CA $135
CA $151 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn Poplar Bluff

Shepherd Mountain Inn

2.5 star property
9.2 out of 10, Wonderful, (290)
"Wonderful small town motel in a beautiful & quiet location."
The price is CA $150
CA $164 total
includes taxes & fees
Aug 24 - Aug 25
Shepherd Mountain Inn

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (405)
"Great place. "
The price is CA $117
CA $208 total
includes taxes & fees
Aug 23 - Aug 24
The Farmstead Hotel

Pinemark Inn & Suites

2.0 star property
9.6 out of 10, Exceptional, (1001)
"Great place to stay. "
The price is CA $190
CA $209 total
includes taxes & fees
Aug 24 - Aug 25
Pinemark Inn & Suites

Super 8 by Wyndham Farmington

2.0 star property
8.0 out of 10, Very good, (577)
"Very friendly staff who make sure guests are taken care of! Clean, great location, and safe place to stay. "
The price is CA $81
CA $93 total
includes taxes & fees
Aug 23 - Aug 24
Super 8 by Wyndham Farmington

The Wildwood Hotel

3.5 star property
9.2 out of 10, Wonderful, (1557)
"Great place to stay."
The price is CA $123
CA $148 total
includes taxes & fees
Sep 1 - Sep 2
The Wildwood Hotel

Drury Plaza Hotel Cape Girardeau Conference Center

3.0 star property
9.6 out of 10, Exceptional, (1004)
"Enjoy my stay here. Very nice room and the breakfast was nice"
The price is CA $125
CA $141 total
includes taxes & fees
Aug 27 - Aug 28
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

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