Photo by Jessica Richter

Southeast Missouri Vacation Rentals

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Browse Select Southeast Missouri Vacation Homes

Fridge, microwave, oven, stovetop
Unique cabins in the woods<br>Not friendly for Street Bikes. Beautifulin FALL!
10.0 out of 10, Exceptional, (68)
"I love staying here. It is so clean and comfortable. I loved waking up in the morning and having my coffee on the front porch soaking in the beautiful natural world. It far enough away from town to enjoy the quiet but close enough to grab delicious food for meals. I’ll always stay here when visiting Eminence."
Unique cabins in the woods<br>Not friendly for Street Bikes. Beautifulin FALL!
Fridge, microwave, oven, stovetop
Cozy Three bedroom home in Central Farmington
9.6 out of 10, Exceptional, (7)
"Very nice little house and good stay"
The price is CA $164
CA $356 total
includes taxes & fees
Jun 3 - Jun 4
Cozy Three bedroom home in Central Farmington
Private kitchen
Quiet, Cozy Cabin!
8.6 out of 10, Excellent, (4)
"Cabin was exactly as pictured. Very comfortable for a short to medium stay, house was extremely clean when we got there. Owner was very quick to respond and was able to make arrangements for us. Will be coming back!"
The price is CA $133
CA $254 total
includes taxes & fees
Jun 2 - Jun 3
Quiet, Cozy Cabin!
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Fridge, microwave, oven, stovetop
Cozy town house - 3 Queen beds
10.0 out of 10, Exceptional, (2)
"We only used our stay to sleep and get ready. We gathered with our family so we only needed a place to stay. We would stay again if we were back in the area. The host were available when we called and they are very nice Hosts."
The price is CA $112
CA $223 total
includes taxes & fees
May 28 - May 29
Cozy town house - 3 Queen beds
Property grounds
RIVER FRONT HOUSE
9.8 out of 10, Exceptional, (24)
"My family group of five adults enjoyed our two nights here. The view and access to the Current was amazing. There are trees and vegetation between the house and river that allow for so many wonderful opportunities for bird watching right from the back screened in porch. We saw a bald eagle both mornings hunting just across the river. Other birds we saw were blue heron, green heron, cedar waxwings, hummingbirds, tons of warblers, red winged blackbirds, pileated woodpeckers, and a whippoorwill at...
RIVER FRONT HOUSE
Fridge, microwave, oven, stovetop
Serenity South -- Gardens, River-Views, and Refreshing Space
10.0 out of 10, Exceptional, (114)
"The place was perfect for our stay and was close to the farmers market and downtown shops. Highly recommend for location!"
The price is CA $205
CA $333 total
includes taxes & fees
May 28 - May 29
Serenity South -- Gardens, River-Views, and Refreshing Space
Exterior
Beautiful historical two story stone farmhouse
10.0 out of 10, Exceptional, (42)
"This place was absolutely gorgeous and so peaceful. Highly recommend it. It was so cool staying someplace with so much history."
The price is CA $369
CA $537 total
includes taxes & fees
Jun 9 - Jun 10
Beautiful historical two story stone farmhouse
Property grounds
Your home away from home in downtown, historic Farmington!
10.0 out of 10, Exceptional, (5)
"Have rented 2 prior locations and this was the best. Clean pleasant great location and was very surprised to see soap provided as well as coffee ...and so much more. I very much liked we had 2 separate bedrooms with doors! and 2 bathrooms. I was able to wash clothes and it was quiet! Great walking location. I would have loved to have stayed a week. Bed was very comfy."
The price is CA $149
CA $284 total
includes taxes & fees
Jun 3 - Jun 4
Your home away from home in downtown, historic Farmington!
Exterior
The 1801 House: A beautiful historic home in the Ste Genevieve Historic District
10.0 out of 10, Exceptional, (97)
"We needed an interesting place to visit that was not a big city. We wanted a nice relaxing environment. St Genevieve and the 1801 House met our expectations. The hosts thought of everything their guests would need. The kitchen was equipped with everything we needed to prepare meals. I will recommend this property to others."
The 1801 House: A beautiful historic home in the Ste Genevieve Historic District
Fridge, microwave, oven, stovetop
"Little Brick House on Main (1865)”
10.0 out of 10, Exceptional, (26)
"We took an impromptu overnight from St. Louis. Wonderful place in a nice area. Lots of places to see."
The price is CA $180
CA $235 total
includes taxes & fees
Jun 3 - Jun 4
"Little Brick House on Main (1865)”
Exterior
Guests enjoy their own one bedroom apartment in the Ozarks
10.0 out of 10, Exceptional, (54)
"Everything was great "
Guests enjoy their own one bedroom apartment in the Ozarks
Property grounds
Rustic Lodge for 14 near Current River on private 35 acres
10.0 out of 10, Exceptional, (12)
"Nine of us women cousins thoroughly enjoyed our three night stay. Lodge and grounds are beautiful. Everything we needed was right there. Only suggestion would be to include the pool fee in the daily rate and it be available all day. Thanks for a great time."
The price is CA $614
CA $1,050 total
includes taxes & fees
May 29 - May 30
Rustic Lodge for 14 near Current River on private 35 acres
Outdoor pool
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
10.0 out of 10, Exceptional, (51)
"We came with our whole family for a family vacation. We definitely enjoyed our time there even with three toddlers. The property is well cleaned and taken care of. My toddler’s favorite things to do during our stay was saying hi to the pony every morning, swimming, and playing with the neighbor dogs outside."
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
TV, fireplace, DVD player, books
40-Acre Poplar Bluff Nature Lovers Paradise!
9.4 out of 10, Exceptional, (23)
"Had everything we was wanting on our visit. And more. Very comfortable and accommodating. If we are back that way again will definitely try it again. Thanks."
40-Acre Poplar Bluff Nature Lovers Paradise!
Fridge, microwave, oven, stovetop
Newly renovated early 1900’s farmhouse
10.0 out of 10, Exceptional, (8)
"This house was a cozy, comfortable place to stay. Although it sits on a road that's busier than what I'm use to, I slept better than I had in a long time. I have nothing but good things to say about it."
The price is CA $217
CA $343 total
includes taxes & fees
May 28 - May 29
Newly renovated early 1900’s farmhouse
Exterior
Secluded Cabin with Heated Pool, hot tub, fireplace & so much more
10.0 out of 10, Exceptional, (62)
"We held our family Christmas here. 13 people, 7 adults and 6 children. We spent 6 days here. People played pool, ping pong, games, swam and we grilled outside. This house has everything you would in your own home! One day I hosted our huge family gathering of 40+people, plenty of room, it was nice outside and inside and once again everything is provided at the house. I would recommend this house to everyone. Beautiful home. I will rent this house again. Julie"
Secluded Cabin with Heated Pool, hot tub, fireplace & so much more
Property grounds
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
10.0 out of 10, Exceptional, (148)
"Would stay again."
Gabouri Place ~ Completely Renovated Victorian in Ste. Genevieve's Historic Dist
Smart TV, fireplace, stereo
Dexter Homestead. VERY Cozy & Clean 7 Bed home.
8.6 out of 10, Excellent, (15)
"The old house was charming. It could benefit from a really good, deep clean. The bathrooms and beds/linens were very clean and the kitchen was functional. We didn't use the outdoor area but it was nice and well suited to a comfortable place to hang out on a nice day. The town has food and necessity shopping available and easily accessible. Overall we were pleased with our overnight stay. "
The price is CA $122
CA $265 total
includes taxes & fees
Jun 3 - Jun 4
Dexter Homestead. VERY Cozy & Clean 7 Bed home.
Microwave, oven, stovetop, dishwasher
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
10.0 out of 10, Exceptional, (4)
"We cane for the total eclipse and couldn’t have picked a better place. The community is friendly, the parks are fun and the house was the oerfect balance of old and new. The beds are comfortable and the firepit makes for great storytelling and s’mores. Highly recommend."
The price is CA $410
CA $694 total
includes taxes & fees
May 29 - May 30
Gorgeous large rental home in Lesterville MO just minutes from Blackwater River.
Private kitchen
Private lake, beach & hot tub, romantic getaway or family vaca
10.0 out of 10, Exceptional, (14)
"The property was secluded enough to be private. We loved the deck that overlooked the small lake. Very clean, all the necessary kitchen equipment and comfortable beds and baths, and living room area. Myself and two friends were there to birdwatch for several days in the area (Mingo Wildlife Refuge and Otter Slough State Conservation Area)."
Private lake, beach & hot tub, romantic getaway or family vaca
Don't see what you're looking for?
See all available properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other property types in Southeast Missouri

Exterior
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
3.5 star property
9.4 out of 10, Exceptional, (126)
"When we walked in the lodge it was spotless. Very homey and clean. The staff was so kind. We will definitely be back."
The price is CA $245
CA $275 total
includes taxes & fees
Jun 9 - Jun 10
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Property grounds
Secluded Ozarks Tiny House cabin in Eminence, MO
10.0 out of 10, Exceptional, (78)
"My husband, young children (6 and 4), and I enjoyed our stay. The cabin was cute and clean. Great place to stay."
Secluded Ozarks Tiny House cabin in Eminence, MO
Property grounds
RIVER FRONT HOUSE
9.8 out of 10, Exceptional, (24)
"My family group of five adults enjoyed our two nights here. The view and access to the Current was amazing. There are trees and vegetation between the house and river that allow for so many wonderful opportunities for bird watching right from the back screened in porch. We saw a bald eagle both mornings hunting just across the river. Other birds we saw were blue heron, green heron, cedar waxwings, hummingbirds, tons of warblers, red winged blackbirds, pileated woodpeckers, and a whippoorwill at...
RIVER FRONT HOUSE
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Southeast Missouri Vacation Homes information

Number of reviews
734
Accommodation
149 Vacation Homes
Lowest Price
CA $112
Highest Price
CA $614

Recent Reviews in Southeast Missouri
Expedia verified reviews

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

5/5 Excellent
Fresh, reasonable w/ scrambled eggs & sausage
"We loved every thing about this place. Wyndham has brought its excellence to an old name in accommodations and made it VERY affordable."
A verified traveller stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Posted 7 hours ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau