Find Spa Hotels in Southeast Missouri, MO from CA $159
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Spa Hotels
Tonight
Oct 19 - Oct 20Tomorrow
Oct 20 - Oct 21This weekend
Oct 23 - Oct 25Next weekend
Oct 30 - Nov 1Our top choices for Southeast Missouri hotels with a spa
1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
- Luxurious spa sanctuary awaits with full-service treatments and indoor pool in this centrally located hotel.
CA $140
CA $159 total
includes taxes & fees
Nov 19 - Nov 20
Top Southeast Missouri Hotel Reviews
Drury Inn & Suites Hayti Caruthersville
8/10 Good
"Group of patrons were extremely loud at both dinner and breakfast was nnoi enjoyable n"
Explore a world of travel with Expedia
- Cheap Hotels in Cape Girardeau
- Cabin Rentals in Allenville
- Hilton Hotels in Ste Genevieve
- Silo Farm Haus
- Cabin Rentals in Farmington
- Pet-Friendly Hotels in Jackson
- Houseboats in Wappapello
- Dexter Inn
- Cabin Rentals in Cadet
- Rv Parks in Perryville
- Bonne Terre Hotels
- Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
- Postcard Cabins St Francois
- Rv Parks in Chaffee
- Holiday Inn Poplar Bluff by IHG
- Cabin Rentals in Centerville
- Lazy River Cabin on the edge of town only 1/2 mile from Current River !
- Cabin Rentals in Leadwood
- Quality Inn Perryville I
- Bullwinkles Rustic Lodge
- Hilton Hotels in Perryville
- Van Buren Hotels
- French Village Hotels
- Alpaca Farm Stay
- B&B in Ste Genevieve
- Farmstay in Oak Ridge
- Spring Lake Ranch has a Private
- Super 8 by Wyndham Perryville
- The Queen Bee Farm Stay/Hot tub
- Hampton Inn Poplar Bluff
- Villas in Poplar Bluff
- Town House Inn
- Pickleball Cafe & Micro Hotel
- Adults Only Resorts & in Cape Girardeau
- Casino Hotels in Cape Girardeau
- Poplar Bluff Hotels
- Spa Hotels in Cape Girardeau
- Park Hills Hotels
- Motels in St Mary
- Dexter Hotels
- Hotels with Free Airport Shuttle in Cape Girardeau
- Cottages in Pocahontas
- Condo Rentals in Fremont
- Oyo Hickory House Inn
- Cheap Hotels in Viburnum
- Cabin Rentals in Southeast Missouri
- Motels in Ellsinore
- Cheap Hotels in Bonne Terre
- Triangle Inn Motel
- Apartments in Ozora
- Secluded Cabin with Heated Pool
- Fredericktown Hotels
- Urban Loft #4 BLACK · Urban Loft above BrewCo & Restaurant
- Resorts in Wayne County
- Home Sweet Home
- Advance Hotels
- Jackson Hotels
- Essex Hotels
- Crown Pointe Lodge
- Amazing lakeview Spring Lake Tree House #2 "LoveLight" w/ hot tub
- Hotels near Big River
- Secluded Private Cabin with Pool
- Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
- Ozora Hotels
- Relax in the country at Countryside Villas!
- Cabin Rentals in Bonne Terre
- Cheap Hotels in Benton
- Bluebird Meadows W/hot Tub and Pool Special
- Cottages in Clearwater
- Flights from New York (JFK) to Cape Girardeau (CGI)
- Flights from Colombo (CMB) to Cape Girardeau (CGI)
- Flights from Calgary (YYC) to Cape Girardeau (CGI)
- Flights from Arcadia
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Ocala (OCF) to Cape Girardeau (CGI)
- Flights to Butler County
- Flights from St. Louis (STL) to Poplar Bluff (POF)
- Flights to Bonne Terre
- Flights from Belleview
- Flights from Toronto (YYZ) to Cape Girardeau (CGI)
- Flights from Toronto (YTO) to Cape Girardeau (CGI)
- Flights to Farmington
- Flights from Montreal (YUL) to Cape Girardeau (CGI)
- Flights to Poplar Bluff
- Flights from Chaffee
- Flights from Bloomington (BMI) to Cape Girardeau (CGI)
- Flights from Bonne Terre
- Flights from Edmonton (YEG) to Cape Girardeau (CGI)
- Flights to Dexter