Title: Book the Best Cape Girardeau SPA Resorts from CA $150 - Spa Hotels in Cape Girardeau, MO | Expedia.ca [Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Skyy # Find Spa Hotels in Cape Girardeau, MO from CA $150 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cape Girardeau Spa Hotels Tonight [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-10-11&endDate=2025-10-12&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-10-12&endDate=2025-10-13&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-10-17&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cape Girardeau Spa Hotels ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/eb2507f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Cape Girardeau 9.4/10 Exceptional (1004) "It was right off the interstate with lots of restaurant options " CA $133 CA $150 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=820&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Cape Girardeau ### Top Cape Girardeau attractions for a relaxing vacation In Cape Girardeau, Missouri, travellers seeking spa hotel experiences can indulge in both relaxation and adventure. Begin your exploration at the tranquil Cape Riverfront Park, where scenic walking trails wind along the Mississippi River, providing a serene backdrop perfect for unwinding after a day of pampering. For those who appreciate local culture, the Cape Girardeau Conservation Nature Center offers engaging exhibits and trails that immerse you in the area's natural beauty, ideal for a leisurely stroll or a more vigorous hike. Families can enjoy a fun day at the Cape Splash Family Aquatic Center, which boasts thrilling water slides and a lazy river, ensuring a mix of relaxation and excitement. Don't miss the historic downtown area, where charming boutiques and art galleries await, perfect for a leisurely afternoon of shopping and exploring. After a day of activities, you can retreat to one of the hotels near the riverfront, where luxurious spa services and attentive guest care promise a rejuvenating stay. With the perfect blend of relaxation and local charm, Cape Girardeau offers a unique opportunity to recharge while enjoying its vibrant community. ### Find the best hotels & resorts with spas in Cape Girardeau For those seeking relaxation and rejuvenation during their stay in Cape Girardeau, these hotels offer exceptional spa amenities that will enhance your experience. [Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) - **Why it's great for tailored spa getaway:** The Holiday Inn Express Hotel & Suites Cape Girardeau is an excellent choice for travelers looking to unwind in a serene environment, featuring a full-service spa that promises a refreshing escape from daily stress. With a remarkable guest review rating of 9.4, this hotel ensures that relaxation is at the forefront of your stay. The spa facilities allow guests to indulge in soothing treatments, making it an ideal retreat after a day of exploring the area. - **Other amenities:** In addition to the spa, guests can enjoy a range of conveniences including a complimentary breakfast to kickstart your day, an inviting indoor pool perfect for a refreshing dip, and fitness facilities for those looking to stay active. Each room is equipped with premium bedding, a microwave, and daily housekeeping to enhance comfort. Free self-parking is available, ensuring a straightforward arrival and departure, while the hotel also offers pool sun loungers for leisurely afternoons. - **Nearby attractions:** Saint Francis Healthcare System - 3.9 km, Cape Splash Family Aquatic Center - 3.8 km ## Top Cape Girardeau Hotel Reviews ![Drury Inn & Suites Cape Girardeau](//images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Very tasty buffet-style food every morning and evening, the suites were large & clean. All of the staff members were friendly & helpful: From the people at the front desk, to the folks preparing the food, to the housekeeping staff keeping the rooms and public areas all nice & tidy. 5 Stars!" [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](//images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "The lady that checked me in was amazing!" [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ## Frequently asked questions ### Looking for a spa hotel in Cape Girardeau? > Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in Cape Girardeau. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your routine and add a layer of luxury to your weekend away. ### What is the best spa hotel in Cape Girardeau? > [Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) is a top spa hotel featuring a pool and a fitness center. ### How many spa hotels will I find in Cape Girardeau? > Among Expedia's 57 accommodation options in Cape Girardeau, there is 1 spa hotel. ### What's there to see and do in Cape Girardeau? > Experience all that Cape Girardeau has to offer when you visit Isle Casino Cape Girardeau, Show Me Center, and Hunter Valley Winery. If you have a bit of extra time while you're in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest. ### What is a Cape Girardeau spa hotel? > Spa hotels in Cape Girardeau have full on-site spas offering services such as massages and a choice of body treatments. Some also provide a selection of in-room treatments for the ultimate luxury. 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