Title: Book the Best Cape Girardeau SPA Resorts from CA $146 - Spa Hotels in Cape Girardeau, MO | Expedia.ca [Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) ![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Alice Burghart ![](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cape Girardeau Spa Hotels Tonight [Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-02&endDate=2026-02-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-03&endDate=2026-02-04&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-06&endDate=2026-02-08&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-13&endDate=2026-02-15&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Cape Girardeau hotels with a spa ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Feature)](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/40930878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (1,004 reviews) "Breakfast was very good and staff was extremely friendly and rooms were very clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rex CA $129 CA $146 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-16&endDate=2026-02-17®ionId=820&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Choose what matters most at spa hotels in Cape Girardeau 4 stars 5 stars Resort ![](https://forever.travel-assets.com/flex/flexmanager/mediaasset/1342516-0_2-icon__massages.svg) Massage Ocean view ## Find out more about Cape Girardeau ### Top Cape Girardeau attractions for a relaxing vacation In Cape Girardeau, Missouri, travellers seeking spa hotel experiences can indulge in both relaxation and adventure. Begin your exploration at the tranquil Cape Riverfront Park, where scenic walking trails wind along the Mississippi River, providing a serene backdrop perfect for unwinding after a day of pampering. For those who appreciate local culture, the Cape Girardeau Conservation Nature Center offers engaging exhibits and trails that immerse you in the area's natural beauty, ideal for a leisurely stroll or a more vigorous hike. Families can enjoy a fun day at the Cape Splash Family Aquatic Center, which boasts thrilling water slides and a lazy river, ensuring a mix of relaxation and excitement. Don't miss the historic downtown area, where charming boutiques and art galleries await, perfect for a leisurely afternoon of shopping and exploring. After a day of activities, you can retreat to one of the hotels near the riverfront, where luxurious spa services and attentive guest care promise a rejuvenating stay. With the perfect blend of relaxation and local charm, Cape Girardeau offers a unique opportunity to recharge while enjoying its vibrant community. ### Find the best hotels & resorts with spas in Cape Girardeau For those seeking relaxation and rejuvenation during their stay in Cape Girardeau, these hotels offer exceptional spa amenities that will enhance your experience. [**Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG**](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) - **Why it's great for tailored spa getaway:** The Holiday Inn Express Hotel & Suites Cape Girardeau is an excellent choice for travelers looking to unwind in a serene environment, featuring a full-service spa that promises a refreshing escape from daily stress. With a remarkable guest review rating of 9.4, this hotel ensures that relaxation is at the forefront of your stay. The spa facilities allow guests to indulge in soothing treatments, making it an ideal retreat after a day of exploring the area. - **Other amenities:** In addition to the spa, guests can enjoy a range of conveniences including a complimentary breakfast to kickstart your day, an inviting indoor pool perfect for a refreshing dip, and fitness facilities for those looking to stay active. Each room is equipped with premium bedding, a microwave, and daily housekeeping to enhance comfort. Free self-parking is available, ensuring a straightforward arrival and departure, while the hotel also offers pool sun loungers for leisurely afternoons. - **Nearby attractions:** Saint Francis Healthcare System - 3.9 km, Cape Splash Family Aquatic Center - 3.8 km ## Top Cape Girardeau Hotel Reviews ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "The room was lage and clean. We really enjoyed the free food and drinks provided." [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "This place feels like customer service from 1950\. The service was outstanding " [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ## Frequently asked questions ### Which hotels in Cape Girardeau offer the best spa experiences? > This hotel has a 9.4 rating, and its spa provides a range of treatments for relaxation and rejuvenation. Guests can expect a dedicated space for wellness therapies. ### How much does a spa hotel in Cape Girardeau cost? ### Is it cheaper to book a spa hotel in Cape Girardeau with flights as part of a package deal? ### Are there any unique spa experiences available in Cape Girardeau? > Dawn of Life Aesthetics & Wellness Med Spa provides an extensive approach, including medical spa treatments such as microneedling, laser hair removal, facials, and IV therapy. They also offer unique functional medicine services like blood testing, gut testing, food sensitivity testing, lymphatic therapy, and hormone testing, blending aesthetics, weight management, and functional medicine. > > > eDen Spa & Salon is highly rated for its personalised services, including aromatic hot stone massages, facials, pedicures, and couples massages, and is known for its excellent customer care and attention to detail. > > > West Em Medical Spa offers upscale medical spa services with a focus on customised skin health plans, advanced treatments like BBL and Halo laser procedures, all within an inviting space. > > > Roots Spa & Salon focuses on health-conscious beauty and wellness, utilising organic and natural products for chemical-free treatments in a peaceful environment. > > > Aurora Medical Spa offers non-surgical body contouring, long-lasting injectable treatments for wrinkle reduction, and personalised aesthetic plans, focusing on cosmetic outcomes with zero downtime. ### How can I save on a spa hotel in Cape Girardeau with Expedia? ### Can I cancel my spa hotel reservation on Expedia? ## Explore a world of travel with Expedia - 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