
Cape Girardeau Vacation Packages
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to CA $4,200 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Your Cape Girardeau Vacation
Food, history, entertainment and more … There's so much to immerse yourself in with a Cape Girardeau vacation package. And with the ability to easily customize your city break, it's guaranteed to be one that's memorable. If sightseeing is on the agenda during your trip to Cape Girardeau, swing by major attractions like Isle Casino Cape Girardeau, Cape Rock Park and Cape Girardeau Conservation Nature Center. Expedia will help you escape your routine. Tailor your vacation to Cape Girardeau to suit your travel style, whatever that may be.
Cape Girardeau Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $139 per night from Nov 15 to Nov 16
CA $139
CA $157 total
Nov 15 - Nov 16
includes taxes & fees

Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $101 per night from Nov 15 to Nov 16
CA $101
CA $114 total
Nov 15 - Nov 16
includes taxes & fees
9.2/10 Wonderful! (1,000 reviews)
"Will stay again"
Reviewed on Nov 2, 2026

The Riverview
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is CA $152 per night from Nov 11 to Nov 12
CA $152
CA $172 total
Nov 11 - Nov 12
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Cape Girardeau attractions
Frequently asked questions
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.









