Cape Girardeau Vacation Rentals

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Check prices for these dates

In two weeks
Jun 12 - Jun 14
In two months
Jul 24 - Jul 26
In three months
Aug 21 - Aug 23
In four months
Sep 18 - Sep 20

Our top choices for Cape Girardeau vacation rentals

1 bedroom, desk, iron/ironing board, WiFi

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $172
CA $273 total
includes taxes & fees
Jun 1 - Jun 2
The Cottage, Rusted Route Farms
Living area

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (57 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $112
CA $149 total
includes taxes & fees
Jun 7 - Jun 8
Little Blue Cottage on Spanish
Interior

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (20 reviews)
"Nice little Cabin in a beautiful area. Blair and her family were wonderful!"
United States
Keegan C.
The price is CA $214
CA $420 total
includes taxes & fees
Jun 1 - Jun 2
Charming Secluded Getaway Cabin within minutes of amenities
Interior

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (34 reviews)
"Great location , great view, awesome place"
United States
Derek E.
The price is CA $297
CA $438 total
includes taxes & fees
Jun 3 - Jun 4
The Twisted Sassafras Treehouse
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (40 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $247
CA $436 total
includes taxes & fees
Jun 4 - Jun 5
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Dining

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (156 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
The price is CA $207
CA $340 total
includes taxes & fees
Jun 1 - Jun 2
Serenity South -- Gardens, River-Views, and Refreshing Space
TV, offices

Modern Boho Getaway · 1BR Apartment · By KeenStays

Modern Boho Getaway · 1BR Apartment · By KeenStays
Cape Girardeau
The price is CA $110
CA $231 total
includes taxes & fees
Jun 1 - Jun 2
Modern Boho Getaway · 1BR Apartment · By KeenStays
Desk, iron/ironing board, WiFi, bed sheets

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
The price is CA $110
CA $231 total
includes taxes & fees
Jun 14 - Jun 15
Studio Apt | King Bed, Full Kitchen · By KeenStays
TV, fireplace

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is CA $276
CA $432 total
includes taxes & fees
Jun 1 - Jun 2
Gorgeous 1856 Log Cabin, Completely Renovated
Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $466
CA $763 total
includes taxes & fees
Jun 4 - Jun 5
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Exterior

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.8 out of 10, Exceptional, (48 reviews)
"Easily the best cabin experience I’ve ever had! Wonderful amenities everything we needed for a nice weekend stay was there and ready when we got there. Very comfortable space with plenty of room perfect destination for a small family get away will be returning soon thanks Steve!"
United States
Justin
The price is CA $166
CA $314 total
includes taxes & fees
Jun 1 - Jun 2
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Exterior detail

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (66 reviews)
"A nice quiet stay in the Shawnee Forest. Host was easy to communicate with and the cabin had everything we needed for a nice get away. Close to nature or close to shopping and dinner. It was the perfect little spot "
United States
Ruth O.
The price is CA $142
CA $265 total
includes taxes & fees
Jun 8 - Jun 9
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Exterior

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (411 reviews)
"Great location. Cozy cabin. Would stay there again. "
United States
jeffrey s
The price is CA $161
CA $279 total
includes taxes & fees
Jun 1 - Jun 2
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Smart TV

Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
9.8 out of 10, Exceptional, (27 reviews)
"The place was quiet, clean and secluded. Exactly what my wife and I were looking for. Thanks for having us!"
United States
Andy I.
The price is CA $172
CA $272 total
includes taxes & fees
Jun 8 - Jun 9
Peaceful secluded cabin located near Horseshoe Lake
Property grounds

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (103 reviews)
"Enjoyed our stay great hospitality, everything we needed was addressed. We would highly recommend staying there. Great location "
United States
carlton h.
The price is CA $186
CA $392 total
includes taxes & fees
Jun 1 - Jun 2
Charming cottage overlooking Lake Acre
TV

Fantastic 1-bedroom Cabin in peaceful Makanda, Pet-Friendly!

Fantastic 1-bedroom Cabin in peaceful Makanda, Pet-Friendly!
Makanda
10.0 out of 10, Exceptional, (13 reviews)
"Great host, amenities, and location!"
United States
Kevin W.
The price is CA $170
CA $209 total
includes taxes & fees
Jun 28 - Jun 29
Fantastic 1-bedroom Cabin in peaceful Makanda, Pet-Friendly!
Interior

Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (15 reviews)
"Nice little house that was perfect for our family of five plus our dog. We would stay here again if we found ourselves out this way again."
United States
Kyle
The price is CA $123
CA $218 total
includes taxes & fees
Jun 2 - Jun 3
Cozy and Updated Farmhouse with King Suite
Terrace/patio

Contemporary Glamping with Native American Appeal

Contemporary Glamping with Native American Appeal
Anna
9.8 out of 10, Exceptional, (158 reviews)
"Everything was just as advertised. Perfect stay. "
United States
Jonathan P.
The price is CA $253
CA $461 total
includes taxes & fees
Jun 15 - Jun 16
Contemporary Glamping with Native American Appeal
Dining

Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (41 reviews)
"Peaceful and suited our needs perfectly."
United States
Matthew
The price is CA $155
CA $194 total
includes taxes & fees
Jun 2 - Jun 3
Cozy cabins on beautiful Horseshoe Lake
Exterior

The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (31 reviews)
"It’s very nice and comfortable "
United States
John S.
The price is CA $155
CA $194 total
includes taxes & fees
Jun 2 - Jun 3
The Rested Duck Mallard Room
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Great staff with tips on what to do in town."
Mark 1-night trip
Posted 7 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Find out more about Cape Girardeau

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Cape Girardeau?

Yes, we offer vacation rentals in Cape Girardeau near Cape Splash Family Aquatic Center, or you can select a more remote option if you're looking for extra privacy while you relax. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your vacation.

What are some of the best vacation home rentals in Cape Girardeau?

Serenity South -- Gardens, River-Views, and Refreshing Space: This Cape Girardeau vacation home rental is located on a river and has a fireplace, a balcony, and air-conditioning to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. Some other homes for rent in Cape Girardeau include 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau and “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau.

How many vacation rentals will I find in Cape Girardeau?

Choose from 23 Expedia vacation rentals in Cape Girardeau for a memorable vacation.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Century Casino & Hotel Cape Girardeau and Hunter Valley Winery are other places worth a visit.

What are vacation rentals like in Cape Girardeau?

Vacation rentals are private properties you can book for a couple days or more in Cape Girardeau. Vacation rentals offer amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a small group gathering.