Title: Cape Girardeau Vacation Rentals from CA $139: Short-Term Rentals for 2026 | Expedia.ca

[Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides)

![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Alice Burghart

# Cape Girardeau Vacation Rentals

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## Check prices for these dates

In two weeks

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-01-09&endDate=2026-01-11&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-20&endDate=2026-02-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-03-20&endDate=2026-03-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[Apr 17 - Apr 19](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-04-17&endDate=2026-04-19&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Cape Girardeau vacation rentals

![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/725f800a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/ed5a3737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

10/10

Exceptional

(28)

"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gary C.

CA $296

CA $429 total

includes taxes & fees

Dec 28 - Dec 29

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/1e8bea93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

8.6/10

Excellent

(48)

"I would definitely stay here again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bonita

CA $111

CA $139 total

includes taxes & fees

Dec 26 - Dec 27

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/ec557893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6b76cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Cape Girardeau

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

10/10

Exceptional

(149)

"Such a great place and location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy H.

CA $206

CA $337 total

includes taxes & fees

Dec 25 - Dec 26

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/17fd79b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/d8535e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/941f57c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/89b52c31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information)

9.4/10

Exceptional

(45)

"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jordan S.

CA $113

CA $190 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/bcbc8581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/1136aaf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/7298889d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/81932f13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

8.6/10

Excellent

(37)

"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily D.

CA $186

CA $298 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8932b23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/5663734f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8b525f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Jackson

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

10/10

Exceptional

(3)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

CA $275

CA $426 total

includes taxes & fees

Jan 5 - Jan 6, 2026

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/2cc8556c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/07e510a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/77eb14c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

9.6/10

Exceptional

(7)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

CA $370

CA $602 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/94d9c4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/9544d239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Mobile Home in Jackson

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

10/10

Exceptional

(2)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

CA $172

CA $268 total

includes taxes & fees

Jan 4 - Jan 5, 2026

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/83a275c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/26d9355a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/e0cd2cb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Makanda

[](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

9.6/10

Exceptional

(40)

"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Victoria H.

CA $150

CA $293 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/3f7db1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Dongola

[](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

10/10

Exceptional

(101)

"Location was great, everything was great for what we were there for. Already booked again for November. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

carlton h.

CA $186

CA $386 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/23c71fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/3bc4c831.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/df1f8854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Olive Branch

[](https://www.expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

9.8/10

Exceptional

(35)

"Beautiful place, host was kind and and quick to respond to messages "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa W.

CA $155

CA $193 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/6b2b149b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Anna

[](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information)

10/10

Exceptional

(404)

"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tommy

CA $161

CA $278 total

includes taxes & fees

Dec 28 - Dec 29

[](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/81921ef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/0eaa42e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/66621448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, free WiFi, bed sheets](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/5281fd34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Cobden

[](https://www.expedia.ca/Cobden-Hotels-Exquisite-Views-Of-Shawnee-National-Forest-Seen-From-A-Private.h89641032.Hotel-Information)

9.8/10

Exceptional

(41)

"great cabin with breathtaking views! clean and well appointed. truly enjoyed the stay and will plan to revisit soon. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Amiee T.

CA $188

CA $351 total

includes taxes & fees

Jan 19 - Jan 20, 2026

[](https://www.expedia.ca/Cobden-Hotels-Exquisite-Views-Of-Shawnee-National-Forest-Seen-From-A-Private.h89641032.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/db83638f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/ddef3125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/853dbdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/8845b0fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Makanda

[](https://www.expedia.ca/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

9.8/10

Exceptional

(60)

"The property was extremely clean and well cared for.would definitely stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dan H.

CA $129

CA $250 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/fcf2830c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/c31730ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/04f26ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/94000000/93060000/93056200/93056190/91a8cbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Apartment in Jackson

[](https://www.expedia.ca/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

10/10

Exceptional

(11)

"It was great. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Benjamin Q.

CA $206

CA $251 total

includes taxes & fees

Jan 2 - Jan 3, 2026

[](https://www.expedia.ca/Jackson-Hotels-Villa-B-Offers-Peace-And-Quiet-With-Beautiful-Views-Of-The-Countryside.h93056190.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/73a1d2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/b3100701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/1959f5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cabin in Olive Branch

[](https://www.expedia.ca/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information)

9.2/10

Wonderful

(25)

"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

mike b.

CA $155

CA $193 total

includes taxes & fees

Dec 24 - Dec 25

[](https://www.expedia.ca/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/193ecf29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/36b0a800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/9b2c1789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/df1ce01d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Pomona

[](https://www.expedia.ca/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information)

10/10

Exceptional

(61)

"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

susan B.

CA $116

CA $225 total

includes taxes & fees

Dec 25 - Dec 26

[](https://www.expedia.ca/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/118000000/117040000/117036800/117036792/6c5412ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/118000000/117040000/117036800/117036792/bb0c0319.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/118000000/117040000/117036800/117036792/4d2e92b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/118000000/117040000/117036800/117036792/789c5de5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Alto Pass

[](https://www.expedia.ca/Alto-Pass-Hotels-Farm-Immersion-Experience-At-Rendleman-Orchards.h117036792.Hotel-Information)

9.8/10

Exceptional

(8)

"Awesome"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luke K.

CA $244

CA $300 total

includes taxes & fees

Jan 11 - Jan 12, 2026

[](https://www.expedia.ca/Alto-Pass-Hotels-Farm-Immersion-Experience-At-Rendleman-Orchards.h117036792.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/67134b8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/24e6e51c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/39bdfc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/14363a53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Anna

[](https://www.expedia.ca/Anna-Hotels-Magical-Victorian-Near-Hiking-Wine-Trail.h116288506.Hotel-Information)

10/10

Exceptional

(4)

"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lori C.

CA $286

CA $545 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Anna-Hotels-Magical-Victorian-Near-Hiking-Wine-Trail.h116288506.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/d46d2628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/9f8f9a52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/d050ba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/c90e4e30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Vacation Home in Anna

[](https://www.expedia.ca/Anna-Hotels-Cozy-And-Updated-Farmhouse-With-King-Suite.h123422053.Hotel-Information)

CA $109

CA $203 total

includes taxes & fees

Dec 27 - Dec 28

[](https://www.expedia.ca/Anna-Hotels-Cozy-And-Updated-Farmhouse-With-King-Suite.h123422053.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Cape Girardeau Hotel Reviews

![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg)

### Tru By Hilton Cape Girardeau

10/10 Excellent

"Hotel was very clean, quiet and has a great location! "

[](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

![The Twisted Sassafras Treehouse ](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20_y.jpg)

### The Twisted Sassafras Treehouse 

10/10 Excellent

"Beautiful space indoors and out, can’t wait to come back when the weather allows more time for the outdoor amenities! "

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Breakfast great hot and big variety "

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/7d35641a_y.jpg)

### 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

10/10 Excellent

"Look. It’s not fancy. It’s an older home. But….it was perfect for what we needed. We will use it again next year. If you want affordable and close to campus look no further. "

[](https://expedia.ca/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Didn’t eat the breakfast but I’m sure it is wonderful. Everything from the Check in process to the condition of the rooms to the comfort of the stay was worth the money "

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Quality Inn](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg)

### Quality Inn

10/10 Excellent

"Comfortable bed"

[](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg)

### Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Room was clean and spacious."

[](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Hampton Inn Cape Girardeau I 55 East](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d_y.jpg)

### Hampton Inn Cape Girardeau I 55 East

10/10 Excellent

"Cleanliest hotel I’ve ever stayed at! Staff was friendly. Room was spacious. Bed was comfortable. I would 100% recommend! Close to the university. Across the street from Starbucks and many other places to eat."

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"The room was clean and the mattress was extremely comfortable "

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

## Find out more about Cape Girardeau

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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- [Vacation Homes in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Private-Vacation-Homes.d820-aaPrivateVacationHomes.Travel-Guide-Accommodation)
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- [Apartments in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Apartments.d820-aaApartments.Travel-Guide-Accommodation)
- [Farmstay in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Agritourism.d820-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Bed-And-Breakfast.d820-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Lodges in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Lodges.d820-aaLodges.Travel-Guide-Accommodation)
- [Cottages in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Cottages.d820-aaCottages.Travel-Guide-Accommodation)
- [Motels in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Motels.d820-aaMotels.Travel-Guide-Accommodation)
- [RV Parks in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-RV-Parks.d820-aaRVParks.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Cape Girardeau?

### What are some of the best vacation home rentals in Cape Girardeau?

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