Title: Cape Girardeau Vacation Rentals from CA $139: Short-Term Rentals for 2026 | Expedia.ca

[Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides)

![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Alice Burghart

# Cape Girardeau Vacation Rentals

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## Check prices for these dates

Tonight

[Jan 5 - Jan 6](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-01-05&endDate=2026-01-06&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Jan 6 - Jan 7](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-01-06&endDate=2026-01-07&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-01-09&endDate=2026-01-11&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-01-16&endDate=2026-01-18&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Cape Girardeau vacation rentals

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/17fd79b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/d8535e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/89b52c31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/e90509fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(47)

"This place is AWESOME! It's clean, artsy, fun, and if we ever have a chance, we will certainly return!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jordan S.

CA $112

CA $190 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Artistic-Indoor-Swing-2-Blocks-To-Downtown.h71736900.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6b76cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/ec557893.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(149)

"Such a great place and location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy H.

CA $206

CA $336 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/403251a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/02b08ccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/599e7a95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/a7405e78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy upstairs unit in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Cozy-Upstairs-Unit-In-Cape-Girardeau.h112624271.Hotel-Information)

Cape Girardeau

CA $165

CA $192 total

includes taxes & fees

Jan 31 - Feb 1

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Cozy-Upstairs-Unit-In-Cape-Girardeau.h112624271.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/bcbc8581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/81932f13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/1136aaf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/7298889d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

Cape Girardeau

8.6/10

Excellent

(37)

"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily D.

CA $185

CA $298 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/1e8bea93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

Cape Girardeau

8.6/10

Excellent

(48)

"I would definitely stay here again!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Bonita

CA $111

CA $139 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/55527a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/725f800a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/ed5a3737.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Twisted Sassafras Treehouse 

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(30)

"The place was awesome very clean the host was very accommodating. Nice a quiet for a relaxing stay highly recommend "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gary C.

CA $295

CA $428 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/c37e5dfd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/5663734f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/8b525f5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Gorgeous 1856 Log Cabin, Completely Renovated

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

Jackson

10/10

Exceptional

(3)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

CA $275

CA $426 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/6463ef7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/9544d239.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cottage, Rusted Route Farms

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

Jackson

10/10

Exceptional

(2)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

CA $172

CA $272 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/2cc8556c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/77eb14c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Game room](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/07e510a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

[](https://www.expedia.ca/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(7)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

CA $370

CA $598 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/8a8ad86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/26d9355a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/e0cd2cb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

[](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

Makanda

9.6/10

Exceptional

(40)

"The cabin was perfect for our 5 nights in the area. There was plenty of room and everything we needed. The pictures online were nice but in real life, it was a real gem. Can't wait to visit again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Victoria H.

CA $150

CA $290 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/4a0f272b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rest, Relax and Renew. Our log cabin experience awaits your arrival. 

[](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information)

Anna

10/10

Exceptional

(405)

"Very clean, courteus staff. Beautiful area and quiet. Very relaxing."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tommy

CA $161

CA $278 total

includes taxes & fees

Jan 8 - Jan 9

[](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/b6736ddb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, bed sheets](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/e29b8d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/d47379a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/235ba001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Peaceful secluded cabin located near Horseshoe Lake 

[](https://www.expedia.ca/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

Miller City

9.8/10

Exceptional

(20)

"cute A frame in a secluded spot. Couldn’t ask for a more relaxing situation. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jason M.

CA $192

CA $293 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/c221a56c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/3f7db1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming cottage overlooking Lake Acre

[](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Dongola

10/10

Exceptional

(101)

"Location was great, everything was great for what we were there for. Already booked again for November. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

carlton h.

CA $185

CA $390 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/52fdc4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/df1f8854.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/23c71fcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy cabins on beautiful Horseshoe Lake

[](https://www.expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

Olive Branch

9.8/10

Exceptional

(35)

"Beautiful place, host was kind and and quick to respond to messages "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa W.

CA $155

CA $193 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/db83638f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/853dbdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/ddef3125.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker, toaster](https://images.trvl-media.com/lodging/89000000/88870000/88869200/88869111/8845b0fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

[](https://www.expedia.ca/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

Makanda

9.8/10

Exceptional

(60)

"The property was extremely clean and well cared for.would definitely stay again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Dan H.

CA $129

CA $249 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Makanda-Hotels-3-Minutes-To-Giant-City-6-Minutes-To-SIU-4-Minutes-To-Shawnee-Winetrail.h88869111.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/05ba3853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/5d936793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/95950b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/d3b8d0f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Contemporary Glamping with Native American Appeal

[](https://www.expedia.ca/Anna-Hotels-Contemporary-Glamping-With-Native-American-Appeal.h27145221.Hotel-Information)

Anna

9.8/10

Exceptional

(155)

"Every Th I was perfect close to the shopping we wanted to and such quiet area "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christina S.

CA $206

CA $390 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Anna-Hotels-Contemporary-Glamping-With-Native-American-Appeal.h27145221.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/73a1d2fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, bed sheets](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/b3100701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, towels, soap, shampoo](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/1959f5ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Rested Duck Mallard Room

[](https://www.expedia.ca/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information)

Olive Branch

9.2/10

Wonderful

(25)

"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

mike b.

CA $155

CA $193 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information)

![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/193ecf29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/36b0a800.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/df1ce01d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/104000000/103090000/103080200/103080140/9b2c1789.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Beautiful location in the secluded woods 

[](https://www.expedia.ca/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information)

Pomona

10/10

Exceptional

(61)

"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

susan B.

CA $93

CA $201 total

includes taxes & fees

Jan 8 - Jan 9

[](https://www.expedia.ca/Pomona-Hotels-Beautiful-Location-In-The-Secluded-Woods.h103080140.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/b3197e50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/w1320h1474x0y0-c28d188d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/1dd8c683.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, travel crib, free WiFi, bed sheets](https://images.trvl-media.com/lodging/119000000/118740000/118735000/118734902/3044be54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 2-bedroom with AC, WiFi in lovely Jonesboro

[](https://www.expedia.ca/Jonesboro-Hotels-Charming-2-Bedroom-With-AC.h118734902.Hotel-Information)

Jonesboro

10/10

Exceptional

(4)

"great place. wonderful host."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Carla m.

CA $152

CA $346 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Jonesboro-Hotels-Charming-2-Bedroom-With-AC.h118734902.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/d46d2628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/c90e4e30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/249a50ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/124000000/123430000/123422100/123422053/9f8f9a52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy and Updated Farmhouse with King Suite

[](https://www.expedia.ca/Anna-Hotels-Cozy-And-Updated-Farmhouse-With-King-Suite.h123422053.Hotel-Information)

Anna

CA $109

CA $203 total

includes taxes & fees

Jan 6 - Jan 7

[](https://www.expedia.ca/Anna-Hotels-Cozy-And-Updated-Farmhouse-With-King-Suite.h123422053.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-19&endDate=2026-01-20&regionId=820&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

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Private vacation homes

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Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau%2C+Missouri%2C+United+States+of+America&regionId=820&latLong=37.305884%2C-89.518148&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-08&d2=2026-04-08&lodging=APARTMENT)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau%2C+Missouri%2C+United+States+of+America&regionId=820&latLong=37.305884%2C-89.518148&adults=2&startDate=2026-04-05&d1=2026-04-05&endDate=2026-04-08&d2=2026-04-08&lodging=COTTAGE)

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## Top Cape Girardeau Hotel Reviews

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Clean one night stay"

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

10/10 Excellent

"The room was clean and staff friendly and helpful. Very nice for the price. No complaints. And appreciated the hot breakfast and sweet hostess."

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg)

### Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"Fantastic staff"

[](https://expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

" Excellent stay. Will come again"

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Fairfield Inn & Suites by Marriott Cape Girardeau](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98_y.jpg)

### Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent

"Lovely staff clean hotel comfortable beds "

[](https://expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"This Drury is our preferred place to stay when visiting family in Cape Girardeau. The hotel Staff is always warm and small town friendly! The hotel is nice and the breakfast buffet is outstanding!! "

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Quality Inn](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg)

### Quality Inn

10/10 Excellent

"The room was clean and nice. The breakfast was really good."

[](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information)

![3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/7d35641a_y.jpg)

### 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

10/10 Excellent

"Stay was clean and comfortable"

[](https://expedia.ca/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information)

![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg)

### Tru By Hilton Cape Girardeau

10/10 Excellent

"They were great "

[](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

## Find out more about Cape Girardeau

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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- [Vacation Homes in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Private-Vacation-Homes.d820-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Cabins.d820-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Apartments.d820-aaApartments.Travel-Guide-Accommodation)
- [Farmstay in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Agritourism.d820-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Bed-And-Breakfast.d820-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Lodges in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Lodges.d820-aaLodges.Travel-Guide-Accommodation)
- [Cottages in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Cottages.d820-aaCottages.Travel-Guide-Accommodation)
- [Motels in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-Motels.d820-aaMotels.Travel-Guide-Accommodation)
- [RV Parks in Cape Girardeau ](https://expedia.ca/Cape-Girardeau-RV-Parks.d820-aaRVParks.Travel-Guide-Accommodation)

## Frequently asked questions

### Can I find vacation rentals in Cape Girardeau?

### What are some of the best vacation home rentals in Cape Girardeau?

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### What are vacation rentals like in Cape Girardeau?

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