A calm body of water, a sandy beach, and a forested area in the distance.

Cape Girardeau Vacation Rentals

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Check prices for these dates

In two weeks
Jul 31 - Aug 2
In two months
Sep 11 - Sep 13
In three months
Oct 9 - Oct 11
In four months
Nov 6 - Nov 8

Our top choices for Cape Girardeau vacation rentals

Dining

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (159 reviews)
"Nice location to river front and downtown. Very lovely place."
United States
Marcie R.
Serenity South -- Gardens, River-Views, and Refreshing Space
Interior

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (34 reviews)
"Nice, quiet, close to shopping & restaurants"
United States
Jaime M.
The price is CA $302
CA $448 total
includes taxes & fees
Jul 27 - Jul 28
The Twisted Sassafras Treehouse
Property grounds

Vibrant Lofted Tiny Home

Vibrant Lofted Tiny Home
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"The tiny house was adorable, clean, and everything we expected. We can’t wait to stay in the others. We definitely recommend staying here. Lisa and Holly have done a wonderful job. Holly was great at getting back to me. Loved everything about our stay and the trip. Thank you so much"
United States
Kim K.
The price is CA $226
CA $329 total
includes taxes & fees
Jul 22 - Jul 23
Vibrant Lofted Tiny Home
TV, fireplace

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (4 reviews)
"This was the coolest place! Our family absolutely loved it. Plenty of space, bathrooms, sitting areas outside were plenty as well as fireplaces and fire pit. The bedrooms are spacious- the area where the two twin beds are is downstairs and the beds are smaller but just know that going in. Beautiful area. We’d love to stay again."
United States
Victoria
The price is CA $281
CA $443 total
includes taxes & fees
Jul 22 - Jul 23
Gorgeous 1856 Log Cabin, Completely Renovated
Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (41 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $280
CA $477 total
includes taxes & fees
Aug 5 - Aug 6
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Interior

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (23 reviews)
The price is CA $218
CA $428 total
includes taxes & fees
Jul 16 - Jul 17
Charming Secluded Getaway Cabin within minutes of amenities
Outdoor dining

Studio Apt | King Bed, Full Kitchen · By KeenStays

Studio Apt | King Bed, Full Kitchen · By KeenStays
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"I loved the location and the staff was wonderful. The bed was comfortable. I loved that King size bed!"
United States
Melvin
The price is CA $112
CA $235 total
includes taxes & fees
Jul 16 - Jul 17
Studio Apt | King Bed, Full Kitchen · By KeenStays
Living area

Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (57 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $114
CA $152 total
includes taxes & fees
Jul 27 - Jul 28
Little Blue Cottage on Spanish
Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (9 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $527
CA $840 total
includes taxes & fees
Aug 5 - Aug 6
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
1 bedroom, desk, iron/ironing board, WiFi

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $176
CA $280 total
includes taxes & fees
Jul 22 - Jul 23
The Cottage, Rusted Route Farms
Outdoor dining

A-Frame Cottage with Deck in Charming Inspiration Village

A-Frame Cottage with Deck in Charming Inspiration Village
Cape Girardeau
The price is CA $234
CA $341 total
includes taxes & fees
Jul 22 - Jul 23
A-Frame Cottage with Deck in Charming Inspiration Village
Terrace/patio

Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck

Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
Cape Girardeau
The price is CA $218
CA $319 total
includes taxes & fees
Jul 26 - Jul 27
Romantic Tea Cottage Retreat on Boulder Creek with Firepit and Deck
1 bedroom, free WiFi, bed sheets

Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
The price is CA $194
CA $288 total
includes taxes & fees
Jul 16 - Jul 17
Purple Tiny House with Fire pit & Nature
TV, offices

Fresh & Cozy Retreat w/ King Bed · By KeenStays

Fresh & Cozy Retreat w/ King Bed · By KeenStays
Cape Girardeau
The price is CA $112
CA $235 total
includes taxes & fees
Aug 10 - Aug 11
Fresh & Cozy Retreat w/ King Bed · By KeenStays
Property grounds

European Inspired Lofted Cottage in Tiny Home Village

European Inspired Lofted Cottage in Tiny Home Village
Cape Girardeau
The price is CA $218
CA $318 total
includes taxes & fees
Jul 16 - Jul 17
European Inspired Lofted Cottage in Tiny Home Village
Coffee/tea maker, fridge, microwave, oven

Modern Boho Getaway 1BR Apartment By KeenStays

Modern Boho Getaway 1BR Apartment By KeenStays
Cape Girardeau
The price is CA $112
CA $235 total
includes taxes & fees
Aug 2 - Aug 3
Modern Boho Getaway 1BR Apartment By KeenStays
Exterior

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (49 reviews)
"Easily the best cabin experience I’ve ever had! Wonderful amenities everything we needed for a nice weekend stay was there and ready when we got there. Very comfortable space with plenty of room perfect destination for a small family get away will be returning soon thanks Steve!"
United States
Justin
The price is CA $282
CA $461 total
includes taxes & fees
Jul 17 - Jul 18
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Exterior

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (422 reviews)
"Great location. Cozy cabin. Would stay there again. "
United States
jeffrey s
The price is CA $165
CA $283 total
includes taxes & fees
Jul 20 - Jul 21
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Property grounds

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (105 reviews)
"beautiful property. house was clean and comfortable."
United States
john m.
The price is CA $190
CA $399 total
includes taxes & fees
Jul 20 - Jul 21
Charming cottage overlooking Lake Acre
Interior

Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
10.0 out of 10, Exceptional, (12 reviews)
"It was great. "
United States
Benjamin Q.
The price is CA $211
CA $253 total
includes taxes & fees
Jul 22 - Jul 23
Villa B offers peace and quiet with beautiful views of the countryside.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"This room was very spacious and contained many more amenities than we even expected, like the couch, a little "kitchen" sink outside the bathroom, and a microwave. Our stay was very smooth and nice. The Jacuzzi tub was also a surprise, but tip for others: run a little bit of a flush first and drain it to make sure no gunk comes out in your bath with you in it."
Doyle 1-night trip
Posted 4 hours ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Find out more about Cape Girardeau

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia

Frequently asked questions

Can I find vacation rentals in Cape Girardeau?

Yes, we offer vacation rentals in Cape Girardeau near Cape Splash Family Aquatic Center, or you can select a more remote option if you're looking for extra privacy while you relax. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your vacation.

What are some of the best vacation home rentals in Cape Girardeau?

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau: This Cape Girardeau vacation home rental is located on a river and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Cape Girardeau include Little Blue Cottage on Spanish and 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau.

How many vacation rentals will I find in Cape Girardeau?

Choose from 24 Expedia vacation rentals in Cape Girardeau for a memorable vacation.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, eDen Spa & Salon and Century Casino & Hotel Cape Girardeau are other places worth a visit.

What are vacation rentals like in Cape Girardeau?

Vacation rentals are private properties you can book for a couple days or more in Cape Girardeau. Vacation rentals offer amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a small group gathering.