Cape Girardeau Vacation Rentals

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Check prices for these dates

In two weeks
Mar 13 - Mar 15
In two months
Apr 24 - Apr 26
In three months
May 22 - May 24
In four months
Jun 19 - Jun 21

Our top choices for Cape Girardeau vacation rentals

Exterior

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (39 reviews)
"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "
United States
Emily D.
The price is CA $185
CA $302 total
includes taxes & fees
Mar 1 - Mar 2
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Interior

Charming Secluded Getaway Cabin within minutes of amenities

Charming Secluded Getaway Cabin within minutes of amenities
Cape girardeau
10.0 out of 10, Exceptional, (18 reviews)
"We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others "
United States
Tammy M.
The price is CA $212
CA $417 total
includes taxes & fees
Mar 1 - Mar 2
Charming Secluded Getaway Cabin within minutes of amenities
Dining

Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space
Cape Girardeau
10.0 out of 10, Exceptional, (151 reviews)
"Such a great place and location"
United States
Tracy H.
The price is CA $205
CA $335 total
includes taxes & fees
Feb 28 - Mar 1
Serenity South -- Gardens, River-Views, and Refreshing Space
TV, fireplace

Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is CA $274
CA $428 total
includes taxes & fees
Mar 29 - Mar 30
Gorgeous 1856 Log Cabin, Completely Renovated
Interior

The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (31 reviews)
"This is the perfect private romantic getaway! We had such a blast here. Definitely recommend!"
United States
Eric S.
The price is CA $294
CA $434 total
includes taxes & fees
Mar 9 - Mar 10
The Twisted Sassafras Treehouse
Pool

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.6 out of 10, Exceptional, (8 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $368
CA $603 total
includes taxes & fees
Mar 1 - Mar 2
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
1 bedroom, desk, iron/ironing board, WiFi

The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (2 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $171
CA $269 total
includes taxes & fees
Mar 30 - Mar 31
The Cottage, Rusted Route Farms
Property grounds

Charming cottage overlooking Lake Acre

Charming cottage overlooking Lake Acre
Dongola
10.0 out of 10, Exceptional, (102 reviews)
"Great place so peaceful and relaxing "
United States
Paul D.
The price is CA $185
CA $388 total
includes taxes & fees
Feb 28 - Mar 1
Charming cottage overlooking Lake Acre
Smart TV, fireplace, table tennis

Luxury 4BR Log Cabin Near SIU & Wine Trail

Luxury 4BR Log Cabin Near SIU & Wine Trail
Makanda
10.0 out of 10, Exceptional, (44 reviews)
"The cabin was beautiful and just as described. Location was relaxing and really enjoyed the firepit. Will definitely consider staying again when in the area."
United States
Marjorie H.
The price is CA $587
CA $731 total
includes taxes & fees
Mar 1 - Mar 2
Luxury 4BR Log Cabin Near SIU & Wine Trail
Exterior

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Anna
10.0 out of 10, Exceptional, (405 reviews)
"Nice cabin and beautiful scenery! We enjoyed our stay."
United States
Hannah G.
The price is CA $160
CA $275 total
includes taxes & fees
Mar 29 - Mar 30
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Exterior

Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
10.0 out of 10, Exceptional, (5 reviews)
"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"
United States
Lori C.
The price is CA $322
CA $576 total
includes taxes & fees
Mar 8 - Mar 9
Magical Victorian near hiking / wine trail
Fridge, microwave, oven, stovetop

Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (33 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is CA $205
CA $244 total
includes taxes & fees
Feb 28 - Mar 1
Relax in the country at Countryside Villas! - Villa A
Exterior detail

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (61 reviews)
"Stephen very friendly and accomadations excellent!"
United States
Walter H.
The price is CA $129
CA $248 total
includes taxes & fees
Mar 30 - Mar 31
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Exterior

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Makanda
9.6 out of 10, Exceptional, (43 reviews)
"Everything was very nice. We enjoyed our stay! The cabin had everything we needed."
United States
Cheri U.
The price is CA $149
CA $287 total
includes taxes & fees
Mar 30 - Mar 31
Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!
Interior

Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (4 reviews)
"Kayla is an excellent host! Her home is stocked with everything you could need! Dog friendly, she has a crate. Have a baby, she has a highchair, playpen and other baby amenities. Need to do laundry, she has a full laundry room with soap etc. kitchen is stocked with all the appliances you need. Towels and sheets all there, no need to bring shampoo or conditioner she supplies that also. The home is comfy, cozy, clean and spacious! Excellent WiFi and smart tv! "
United States
claudia
The price is CA $108
CA $202 total
includes taxes & fees
Feb 28 - Mar 1
Cozy and Updated Farmhouse with King Suite
Outdoor dining

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Alto Pass
10.0 out of 10, Exceptional, (1 review)
"The house was very welcoming and clean. Very inviting for our short stay. "
United States
brian O.
The price is CA $239
CA $357 total
includes taxes & fees
Mar 30 - Mar 31
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Smart TV

Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
10.0 out of 10, Exceptional, (21 reviews)
"The cabin is perfect for a quiet getaway. Location is great close to Dollar General, gas station and restaurants"
United States
Marsha G.
The price is CA $171
CA $271 total
includes taxes & fees
Mar 1 - Mar 2
Peaceful secluded cabin located near Horseshoe Lake
Outdoor dining

Historic Farm Cottage on 800-Acre Orchard

Historic Farm Cottage on 800-Acre Orchard
Alto Pass
9.8 out of 10, Exceptional, (8 reviews)
"What an amazing spot! Perfect weekend getaway, close to several hikes in Shawnee and we enjoyed our time on the Rendleman Orchard. Came on a girls trip, but we agreed it would be a great spot for a weekend with our partners and kids. Will be back!"
United States
Julia S.
The price is CA $242
CA $303 total
includes taxes & fees
Mar 5 - Mar 6
Historic Farm Cottage on 800-Acre Orchard
Living area

Charming 2-bedroom apartment in fabulous Marble Hill with AC

Charming 2-bedroom apartment in fabulous Marble Hill with AC
Marble Hill
7.6 out of 10, Good, (5 reviews)
"Host was not properly notified of the booking, but made the accommodations made several trips to make sure we were checked in and comfortable. Also gave very good advice for local points of interest."
United States
Chrystine H.
The price is CA $105
CA $186 total
includes taxes & fees
Feb 28 - Mar 1
Charming 2-bedroom apartment in fabulous Marble Hill with AC
Outdoor dining

Beautiful location in the secluded woods

Beautiful location in the secluded woods
Pomona
10.0 out of 10, Exceptional, (64 reviews)
"It was very nice and clean. We really enjoyed staying there. We would love to rent this place again. "
United States
susan B.
The price is CA $128
CA $237 total
includes taxes & fees
Mar 2 - Mar 3
Beautiful location in the secluded woods
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Room was spotless and well appointed; very spacious. Staff was great. Wish there was more of them "
Walter 1-night trip
Posted 3 days ago
Drury Inn & Suites Cape Girardeau

Find out more about Cape Girardeau

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

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Frequently asked questions

Can I find vacation rentals in Cape Girardeau?

Yes, we offer vacation rentals in Cape Girardeau near Cape Splash Family Aquatic Center, or you can select a more remote option if you're looking for extra privacy while you relax. Visitors like the top-notch restaurants and shops in Cape Girardeau. Make sure you allow time to enjoy the riverfront during your vacation.

What are some of the best vacation home rentals in Cape Girardeau?

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau: This Cape Girardeau vacation home rental is located on a river and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Some other homes for rent in Cape Girardeau include Little Blue Cottage on Spanish and 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau.

How many vacation rentals will I find in Cape Girardeau?

Choose from 20 Expedia vacation rentals in Cape Girardeau for a memorable vacation.

What can I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. While here, Isle Casino Cape Girardeau and Show Me Center are other places worth a visit.

What are vacation rentals like in Cape Girardeau?

Vacation rentals are private properties you can book for a couple days or more in Cape Girardeau. Vacation rentals offer amenities such as hot tubs, fire pits, and patios so your stay will be comfortable. If you're concerned about cleanliness, vacation rentals can offer a sense of privacy away from public hotel elevators and lobbies bustling with people while still allowing you the excitement and enjoyment of travel. You'll also find more space in a vacation rental than in a standard hotel, which is another reason why a vacation rental is an attractive option for a small group gathering.