Beginning of main content

Search over 1,000,000 properties worldwide and 550 airlines worldwide.

Search over a million flights, hotels, packages, and more

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Vacation Rentals in Cape Girardeau

Estimated price for 1 night/2 adults

Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau Downtown
3.0 out of 5.0 400 Broadway St., Cape Girardeau, MO
C$111
4.7/5 (23 reviews)

Loved the retro feel. Great location. Easy parking. Friendly staff.

Reviewed on 27 May 2019
Situated in Cape Girardeau, this condo building is within a 15-minute walk of Shawnee National Forest and Isle Casino Cape Girardeau. Southeast Missouri State ...
Laidback...disconnect...recharge With a Weekend Spent at Shawneetown Log Cabins
Laidback...disconnect...recharge With a Weekend Spent at Shawneetown Log Cabins
Jackson, Missouri
5.0/5 (3 reviews)
Situated in a rural location, this romantic cabin is 8.7 mi (14.1 km) from Shawnee National Forest and 12.4 mi (19.9 km) from Steele Crest Winery. Litz Park ...
Feels Like Your in a Tree House! On the Creek! Fire Pit! 2min to the Winery!
Feels Like Your in a Tree House! On the Creek! Fire Pit! 2min to the Winery!
Cobden, Illinois
4.8/5 (40 reviews)

Our family was looking for a remote little cabin and this fit right in with what we wanted! Brian was great and contacted us during our stay to make sure we had everything we needed. Our daughter loved the creek our back. Very peaceful! Would highly recommend staying here!

Reviewed on 28 Mar. 2019
Situated in Cobden, this romantic cabin is 0.1 mi (0.1 km) from Shawnee National Forest and 11.4 mi (18.3 km) from Giant City State Park. Southern Illinois University ...
Historic Downtown Getaway
Historic Downtown Getaway
Cape Girardeau, Missouri
Located in the heart of Cape Girardeau, this apartment building is within a 15-minute walk of Shawnee National Forest and Isle Casino Cape Girardeau. Southeast ...
Rest, Relax and Renew. Serving our Guests Since 1989. Union Counties First
Rest, Relax and Renew. Serving our Guests Since 1989. Union Counties First
Anna, Illinois
4.9/5 (56 reviews)

Perfect getaway and better than a hotel while traveling to Nashville. Owners were great, scenery was breathtaking which made it perfect for an evening walk after a long drive. Extra amenities gave us the comfort of feeling at home, thanks again for the accommodations

Reviewed on 25 Jun. 2019
Situated in a rural location, this historic cabin is within 9 mi (15 km) of Shawnee National Forest, Shawnee Community College, and Anna City Park. Ferne Clyffe ...
The Dunklin House...we Recently Renovated This Comfortable 2 Bedroom Cottage
The Dunklin House...we Recently Renovated This Comfortable 2 Bedroom Cottage
Cape Girardeau, Missouri
5.0/5 (2 reviews)

Pros: Responsive and helpful landlords, very clean (virtually spotless), well stocked kitchen, very nice assortment of snacks and beverages were left for us (may have been an eclipse special). Enjoyed a walk down to the town park, and stroll around lake with multiple playgrounds for the little ones. ...

Reviewed on 31 Aug. 2017
Located in the heart of Cape Girardeau, this vacation home is within 2 mi (3 km) of Southeast Missouri State University, Isle Casino Cape Girardeau, and Shawnee ...
Loft Apartment Across From Semo University Houch Field House. Walk To Events
Loft Apartment Across From Semo University Houch Field House. Walk To Events
Cape Girardeau, Missouri
4.7/5 (12 reviews)

The apartment is great and the location perfect! You can walk to the game, the Playdium, Pagliaia's and a great Mexican restaurant, just to mention a few places. All of the hotels are across town from campus and this is so much more convenient and the price is about the same. The apartment was super ...

Reviewed on 30 Oct. 2018
Situated in Cape Girardeau, this apartment building is within 1 mi (2 km) of Southeast Missouri State University, Shawnee National Forest, and Isle Casino Cape ...
Adamsrock Cabins mix Native American Charm With Luxury and Contemporary Comfort!
Adamsrock Cabins mix Native American Charm With Luxury and Contemporary Comfort!
Anna, Illinois
4.9/5 (15 reviews)

We really enjoyed staying in this cabin. Everything was clean and hot tub is nice. The location is great it is close to several wineries. We will definitely stay here again!

Reviewed on 13 Feb. 2019
Situated in a rural location, this historic cabin is within 9 mi (15 km) of Shawnee Community College, Shawnee National Forest, and Anna City Park. Ferne Clyffe ...
The Cottage at Eden
The Cottage at Eden
Cape Girardeau, Missouri
5.0/5 (1 reviews)
Situated in Cape Girardeau, this vacation home is 0.1 mi (0.2 km) from Shawnee National Forest and 1 mi (1.7 km) from Isle Casino Cape Girardeau. Southeast Missouri ...
Map

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Cape Girardeau. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Other types of properties in Cape Girardeau you may be interested in

Estimated price for 1 night/2 adults

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau, MO
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Pear Tree Inn Cape Girardeau WestC$85

22 Jul - 23 Jul

Pear Tree Inn Cape Girardeau WestC$85
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO
  • Free Cancellation
  • Reserve now, pay when you stay
2.5 out of 5.0
 
 

Pear Tree Inn Cape Girardeau Near the Medical CenterC$85

24 Jul - 25 Jul

Pear Tree Inn Cape Girardeau Near the Medical CenterC$85