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Compare 81 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Very clean, friendly staff, and reasonable rates. "
The price is CA $124
CA $142 total
includes taxes & fees
Aug 18 - Aug 19
Drury Inn & Suites Sikeston, MO

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1002)
"Great place to stay with kids "
The price is CA $110
CA $127 total
includes taxes & fees
Aug 18 - Aug 19
Pear Tree Inn Sikeston

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (737)
"I like the location of the property it was convenient to everything i was doing in Cape Girardeau "
The price is CA $151
CA $170 total
includes taxes & fees
Aug 22 - Aug 23
Hampton Inn Cape Girardeau I 55 East

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (579)
"Located very close to the expanse of corn fields, quiet, clean rooms, everything is neat, the bathroom is also very clean. Friendly receptionist."
The price is CA $81
CA $90 total
includes taxes & fees
Sep 8 - Sep 9
Super 8 by Wyndham Charleston/Sikeston East MO

Eagle Inn Charleston

2.0 star property
6.8 out of 10, (100)
"Comfortable bed, easy access to room"
The price is CA $88
CA $97 total
includes taxes & fees
Sep 1 - Sep 2
Eagle Inn Charleston

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (397)
"I consistently choose to stay there due to positive past encounters."
The price is CA $93
CA $103 total
includes taxes & fees
Sep 7 - Sep 8
Quality Inn Charleston - Sikeston

La Center Motel

2.0 star property
7.8 out of 10, Good, (14)
"Front desk staff was amazing. Room was comfy and quiet! Clean! Husband and I needed a place to crash on our long ride home and this motel did not disappoint!"
The price is CA $67
CA $79 total
includes taxes & fees
Aug 15 - Aug 16
La Center Motel

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very good, (1005)
"We enjoyed our stay and the breakfast was good!"
The price is CA $121
CA $138 total
includes taxes & fees
Aug 24 - Aug 25
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very good, (667)
"Property is always clean, rooms are nice."
The price is CA $77
CA $88 total
includes taxes & fees
Aug 17 - Aug 18
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
9.0 out of 10, Wonderful, (1005)
"Excellent place to stay "
The price is CA $96
CA $109 total
includes taxes & fees
Aug 17 - Aug 18
Pear Tree Inn Cape Girardeau Near the Medical Center

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
6.6 out of 10, (547)
"I enjoyed our stay"
The price is CA $87
CA $99 total
includes taxes & fees
Aug 17 - Aug 18
Super 8 by Wyndham Sikeston/Miner Area

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (384)
"A very cool destination!"
The price is CA $145
CA $164 total
includes taxes & fees
Aug 17 - Aug 18
The Riverview

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (264)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is CA $96
CA $106 total
includes taxes & fees
Sep 7 - Sep 8
Quality Inn Cairo I-57

Country Yard Inn and Suite

2.0 star property
7.0 out of 10, Good, (104)
"The property was well kept but lacked convenience of food and computer."
The price is CA $77
CA $92 total
includes taxes & fees
Aug 15 - Aug 16
Country Yard Inn and Suite

Drury Inn & Suites Cape Girardeau

3.0 star property
9.4 out of 10, Exceptional, (977)
"Easy access and parking"
The price is CA $124
CA $140 total
includes taxes & fees
Sep 1 - Sep 2
Drury Inn & Suites Cape Girardeau

Rockwood Inn

2.0 star property
10.0 out of 10, Exceptional, (16)
"The property was historic and renovations were perfect. Each room hads a bathroom, the beds were great. It was lovely and peaceful. "
The price is CA $192
CA $217 total
includes taxes & fees
Sep 14 - Sep 15
Rockwood Inn

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"The room was awesome and the building had a historical thing about it."
The price is CA $91
CA $104 total
includes taxes & fees
Aug 17 - Aug 18
Days Inn and Suites by Wyndham Sikeston

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (374)
"Great location and clean room. Plenty of food and shopping nearby."
The price is CA $146
CA $166 total
includes taxes & fees
Sep 7 - Sep 8
Hampton Inn Sikeston

Fairfield Inn & Suites by Marriott Cape Girardeau

2.5 star property
9.4 out of 10, Exceptional, (120)
"Hotel was very clean and the lady that checked us in was very friendly. "
The price is CA $128
CA $144 total
includes taxes & fees
Aug 24 - Aug 25
Fairfield Inn & Suites by Marriott Cape Girardeau

Pear Tree Inn Cape Girardeau West

2.5 star property
9.0 out of 10, Wonderful, (1000)
"We enjoyed the quick check in and how quiet the property was. "
The price is CA $96
CA $109 total
includes taxes & fees
Aug 17 - Aug 18
Pear Tree Inn Cape Girardeau West
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, cathedral, and more.

Frequently asked questions

Where is the best place for a stay in Charleston?

Quality Inn Charleston - Sikeston is a favorite with Expedia customers. This hotel offers free breakfast and free parking. Reviews from our site also recommend Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston as top options for your trip. See all available top hotels, or vacation rentals in Charleston.

What's the top vacation rental that Charleston has to offer?

Welcome campers, hikers, fishermen, girls' weekend wine getaways!!: Visitors like this Charleston vacation home rental. It is located in a rural location and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a garden and a selection of games. See all vacation rentals in Charleston.

If I need to cancel my hotel reservation in Charleston, will I receive a refund?

Yes! You'll find that most room reservations are fully refundable if cancelled before the hotel’s cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you might still have the option to cancel and get a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Charleston.

Where can I learn more about changing or cancelling my trip to Charleston?

To find more details about changing or cancelling your trip to Charleston, click here.

What's the best accommodation for a budget-friendly stay in Charleston?

Based on reviews, Quality Inn Charleston I-57 is a popular hotel for our travelers who want a more economical choice, and features free buffet breakfast and free WiFi. Another top option for your budget-friendly stay is Eagle Inn Charleston. View all budget hotels in Charleston.

What's the best pet-friendly hotel in Charleston?

Quality Inn Charleston - Sikeston is a top hotel for people traveling with their pets, and offers free WiFi for its human guests. Two other good options for you and your pet's trip include Super 8 by Wyndham Charleston/Sikeston East MO and Eagle Inn Charleston. See more pet-friendly hotel accommodations in Charleston.

What are some accommodations with pools in Charleston?

Best Western Plus Sikeston: Features free full breakfast, a pool, and free parking. Pear Tree Inn Sikeston and Drury Inn & Suites Sikeston, MO are a couple of other choices with an onsite pool. View all hotels with pools in Charleston.

What is the best spa hotel in Charleston?

Eagle Inn Charleston is a highly recommended spa hotel with a health club.

What's the best accommodation near Lambert-St. Louis International Airport (STL)?

Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.

How is it to stay in Charleston?

Visitors to Charleston are sure to enjoy the restaurants. Tourists can also enjoy the city's entertainment choices, theaters, and churches. In Charleston, there are 3 hotels and other accommodations to choose from. Find out more about Charleston.

What are the top places to visit in Charleston?

The picturesque setting of Mississippi River and Ohio River exemplify the area's natural beauty. You'll also find Columbus-Belmont State Park and Sikeston Depot Museum in the area. Check out what more to see and do in Expedia's Charleston guide.

What's the seasonal weather like in Charleston?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Charleston is 59 inches.