Book The Best Hotels in Charleston, MO for 2026 from CA $88 - Fully Refundable Options

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Our top choices for Charleston hotels

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

1. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

CA $83

CA $93 total

includes taxes & fees

Oct 26 - Oct 27

A building with a fountain and flower beds in front.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

2. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

CA $93

CA $104 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

3. Eagle Inn Charleston

Charleston

Jackson

CA $92

CA $103 total

includes taxes & fees

Oct 24 - Oct 25

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

4. Drury Inn & Suites Sikeston, MO

Sikeston

Tim

CA $132

CA $151 total

includes taxes & fees

Nov 1 - Nov 2

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

5. Best Western Plus Sikeston I-55

Sikeston

Shelley

CA $112

CA $127 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

CA $91

CA $103 total

includes taxes & fees

Oct 26 - Oct 27

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

7. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Roslyn

CA $141

CA $161 total

includes taxes & fees

Oct 29 - Oct 30

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

8. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

CA $93

CA $106 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

9. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Laura

CA $81

CA $93 total

includes taxes & fees

Oct 29 - Oct 30

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A kitchenette with a coffee machine, a kettle, and storage shelves.

An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.

A breakfast buffet counter with a bakery section and a display for breakfast items.

10. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

CA $127

CA $145 total

includes taxes & fees

Nov 22 - Nov 23

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

11. Hampton Inn Sikeston

Sikeston

Deborah

CA $134

CA $152 total

includes taxes & fees

Nov 22 - Nov 23

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

12. Comfort Inn & Suites Sikeston I-55

Sikeston

Fred

CA $111

CA $126 total

includes taxes & fees

Nov 15 - Nov 16

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.

13. TownePlace Suites by Marriott Sikeston

Sikeston

Rubin

CA $153

CA $174 total

includes taxes & fees

Oct 29 - Oct 30

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

14. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Chris

CA $140

CA $158 total

includes taxes & fees

Oct 28 - Oct 29

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A hotel room with a desk, chair, television, and a lamp.

15. Quality Inn Cairo I-57

Cairo

Santiago

CA $95

CA $106 total

includes taxes & fees

Nov 13 - Nov 14

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A hotel room with two beds, a desk, a chair, and a view of the city.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

16. The Riverview

Cape Girardeau

Renee

CA $146

CA $164 total

includes taxes & fees

Oct 28 - Oct 29

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A bathroom with a bathtub, toilet, and shower curtain.

17. Country Yard Inn and Suite

Sikeston

William

CA $74

CA $88 total

includes taxes & fees

Oct 30 - Oct 31

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

18. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Troy

CA $101

CA $114 total

includes taxes & fees

Nov 8 - Nov 9

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

19. Drury Inn & Suites Cape Girardeau

Cape Girardeau

DENNIS

CA $126

CA $142 total

includes taxes & fees

Nov 5 - Nov 6

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

A bathroom with yellow walls, a wooden cabinet, a sink, a mirror, and a hanging towel rack.

A motel with a red roof and beige walls, a parking lot, and a signboard.

A reception desk with a computer, a framed picture on the wall, and a vase with flowers.

20. La Center Motel

La Center

Carrie

CA $68

CA $80 total

includes taxes & fees

Oct 24 - Oct 25

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Quaint Charleston is calling! Discover its opera, entertainment, cathedral, and more.

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Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Very clean. Food and drinks were excellent. Staff was very helpful."

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"I did not realize this was a Drury property until we got there, but I love Drury. Clean rooms, and very nice amenities. The staff was so friendly. We enjoyed our stay very much!"

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Nice clean room"

Hampton Inn Sikeston

10/10 Excellent

"Great hotel, clean spacious room, good breakfast choice"

The Riverview

8/10 Good

"The room was very spacious and beautiful"

Hampton Inn Cape Girardeau I 55 East

10/10 Excellent

"Stayed here overnight for a wedding. Room was clean and they allowed us to check in early with no fee. Location is ideal, being walking distance from a Cracker Barrel and a breakfast place. Stores like Target and Walmart are only about a 5 minute drive."

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent

"I was surprised how reasonable the cost was considering how clean & nice all of the finishers were."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"We have stayed here a number of times over 20 years. It’s always clean and well maintained. Breakfast is very good. Staff is always friendly and helpful."

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"good, clean, affordable :)"

More cheap stays in Charleston

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

CA $81

CA $93 total

Oct 29 - Oct 30

includes taxes & fees

7/10 Good! (688 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $93

CA $106 total

Nov 1 - Nov 2

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $101

CA $114 total

Nov 8 - Nov 9

includes taxes & fees

9.2/10 Wonderful! (1,001 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

CA $112

CA $127 total

Nov 8 - Nov 9

includes taxes & fees

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

CA $133

CA $151 total

Nov 22 - Nov 23

includes taxes & fees

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

CA $134

CA $152 total

Nov 22 - Nov 23

includes taxes & fees

9/10 Wonderful! (649 reviews)

Hotels in Charleston with star rating

Frequently asked questions

What is the best area to stay in Charleston?

The best area to stay in Charleston, Missouri, is near the intersection of Main Street and US-60, as this is the primary commercial hub.This area offers the most convenience for travellers, with several hotels, local eateries, and essential services clustered together. You'll find most of the town's amenities within a short drive or walk from here, making it an excellent base for exploring the surrounding region.For those travelling for business or looking for easy access to regional transport routes, this central location is ideal.

What are the best hotels in Charleston that travellers recommend?

Two of the best hotels in Charleston that receive consistently high recommendations from travellers are the Super 8 by Wyndham Charleston/Sikeston East MO and the Quality Inn Charleston - Sikeston.The Super 8 by Wyndham Charleston/Sikeston East MO provides air-conditioned rooms, with guests often commenting on how big the rooms are and how helpful the staff are. A free breakfast, including a to-go option, is available.Another highly recommended option is the Quality Inn Charleston - Sikeston. Guests often mention the good rooms, nice beds, and nice showers. This hotel offers a free buffet breakfast and free self-parking, including space for RVs, buses, and trucks. Fitness facilities are available at a nearby location at no extra charge.

What are the best family hotels in Charleston?

For family-friendly hotels in Charleston, consider the Super 8 by Wyndham Charleston/Sikeston East MO, the Quality Inn Charleston - Sikeston, or the Eagle Inn Charleston.The Super 8 by Wyndham Charleston/Sikeston East MO offers free breakfast and complimentary to-go breakfast options, which are very convenient for families on the go. Guests have noted that the staff are helpful and the rooms are big, providing ample space for families. Cribs are also available free of charge.The Quality Inn Charleston - Sikeston provides free buffet breakfast, free self-parking, and free WiFi, which are all excellent amenities for families. Many guests appreciate the comfortable beds, good rooms, and nice showers. Sofa beds are also available.Another good choice is the Eagle Inn Charleston. This hotel offers free WiFi and free parking for RVs, buses, and trucks, which can be useful for families traveling with larger vehicles. Rollaway and extra beds are available free of charge, adding flexibility for sleeping arrangements. Find more child-friendly accommodations in Charleston

What hotels in Charleston offer free breakfast?

For hotels in Charleston that offer a complimentary breakfast, consider the Quality Inn Charleston - Sikeston and the Super 8 by Wyndham Charleston/Sikeston East MO.The Quality Inn Charleston - Sikeston provides guests with a free buffet breakfast daily, and it also includes free self-parking and free WiFi. Guests have noted that the beds are nice and the rooms and showers are good.Another excellent option is the Super 8 by Wyndham Charleston/Sikeston East MO, which offers a free breakfast, including a convenient To Go breakfast option. This hotel also provides free self-parking and free WiFi. Guests frequently comment on the helpful and great staff, and the big rooms. Find more hotels with free breakfast in Charleston

What are the top pet-friendly hotels in Charleston?

For pet-friendly accommodation in Charleston, the Quality Inn Charleston - Sikeston, the Eagle Inn Charleston, and the Super 8 by Wyndham Charleston/Sikeston East MO are all excellent choices.The Quality Inn Charleston - Sikeston allows pets and provides complimentary buffet breakfast and free breakfast. Guests have frequently commented on the nice beds, good rooms, and nice showers.Another great option is the Eagle Inn Charleston, which also permits pets. This hotel offers free WiFi, along with complimentary RV, bus, and truck parking, as well as free self-parking.The Super 8 by Wyndham Charleston/Sikeston East MO welcomes pets and provides early check-in options, along with free breakfast and free to-go breakfast. Guests often praise the helpful and great staff, as well as the big rooms. See more pet-friendly hotels in Charleston

What are the best budget hotels in Charleston?

For budget hotels in Charleston, consider the Quality Inn Charleston - Sikeston, Super 8 by Wyndham Charleston/Sikeston East MO, or the Eagle Inn Charleston.The Quality Inn Charleston - Sikeston offers complimentary self-parking and free buffet breakfast, along with free WiFi. Guests have commented on the nice beds, good rooms, and nice shower facilities.Another good option is the Super 8 by Wyndham Charleston/Sikeston East MO. This hotel provides free to-go breakfast, free self-parking, and free WiFi. Guests often mention the helpful and great staff, as well as the big rooms.The Eagle Inn Charleston provides free WiFi, free RV, bus, or truck parking, and free self-parking. It also features a health club for guests. View all budget hotels in Charleston

When is the best time to go to Charleston?

The best time to visit Charleston, Missouri, is during the spring (April to May) and autumn (September to October) months.These periods offer pleasant weather, with moderate temperatures and less humidity, making it ideal for exploring the town and its surroundings comfortably. Spring brings blooming dogwood trees, while autumn showcases lovely fall foliage, particularly around the Mississippi River.For those interested in local events, the Dogwood-Azalea Festival in April is a highlight, featuring parades, home tours, and craft fairs. It's a popular time, so booking accommodation in advance is a good idea.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Charleston.

How much is the nightly rate at a Charleston hotel?

Prices for hotels in Charleston often vary, but you can find a great deal from CA $88 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Book Hotels in Charleston on Expedia.com

Find hotels in Charleston, MO from CA $88

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Charleston

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Charleston hotels

1. Super 8 by Wyndham Charleston/Sikeston East MO

2. The Riverstone Hotel Charleston-Sikeston

3. Eagle Inn Charleston

4. Drury Inn & Suites Sikeston, MO

5. Best Western Plus Sikeston I-55

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

7. Fairfield Inn & Suites by Marriott Sikeston

8. Days Inn and Suites by Wyndham Sikeston

9. Super 8 by Wyndham Sikeston/Miner Area

10. Holiday Inn Express & Suites Sikeston Southwest by IHG

11. Hampton Inn Sikeston

12. Comfort Inn & Suites Sikeston I-55

13. TownePlace Suites by Marriott Sikeston

14. Drury Plaza Hotel Cape Girardeau Conference Center

15. Quality Inn Cairo I-57

16. The Riverview

17. Country Yard Inn and Suite

18. Pear Tree Inn Cape Girardeau West

19. Drury Inn & Suites Cape Girardeau

20. La Center Motel

Learn more about Charleston

Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Pear Tree Inn Cape Girardeau West

Candlewood Suites Cape Girardeau by IHG

Hampton Inn Sikeston

The Riverview

Hampton Inn Cape Girardeau I 55 East

Courtyard by Marriott Cape Girardeau Downtown

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Super 8 by Wyndham Sikeston/Miner Area

More cheap stays in Charleston

Super 8 by Wyndham Sikeston/Miner Area

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Best Western Plus Sikeston I-55

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Sikeston

Hotels in Charleston with star rating

Frequently asked questions

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