Book The Best Hotels in Charleston, MO for 2026 from CA $79 - Fully Refundable Options

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Our top choices for Charleston hotels

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

1. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

France

CA $82

CA $91 total

includes taxes & fees

Sep 9 - Sep 10

A building with a fountain and flower beds in front.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

2. The Riverstone Hotel Charleston-Sikeston

Charleston

Jay

CA $92

CA $102 total

includes taxes & fees

Sep 12 - Sep 13

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A bathroom with a sink, mirror, towel rack, shower, and toilet.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

3. Eagle Inn Charleston

Charleston

Jackson

CA $106

CA $118 total

includes taxes & fees

Sep 9 - Sep 10

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

4. Drury Inn & Suites Sikeston, MO

Sikeston

Scott Andrew

CA $130

CA $150 total

includes taxes & fees

Sep 13 - Sep 14

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

5. Best Western Plus Sikeston I-55

Sikeston

Bernice

CA $120

CA $137 total

includes taxes & fees

Sep 20 - Sep 21

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A Travel Inn and Suites building with a prominent illuminated sign, a brick facade, and a parking lot.

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Sharika West

CA $78

CA $89 total

includes taxes & fees

Sep 10 - Sep 11

A hotel lobby with a reception desk, seating area, and a large window.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

7. Quality Inn Cairo I-57

Cairo

Susan

CA $97

CA $107 total

includes taxes & fees

Oct 2 - Oct 3

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A motel with a covered entrance, multiple rooms, and a parking lot.

8. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

Kevin

CA $79

CA $90 total

includes taxes & fees

Sep 15 - Sep 16

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

9. Days Inn and Suites by Wyndham Sikeston

Sikeston

Val

CA $92

CA $104 total

includes taxes & fees

Sep 10 - Sep 11

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

10. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

CA $140

CA $158 total

includes taxes & fees

Sep 17 - Sep 18

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

A motel with a red roof and beige walls, a parking lot, and a signboard.

A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.

A bathroom with yellow walls, a wooden cabinet, a sink, a mirror, and a hanging towel rack.

11. La Center Motel

La Center

Carrie

CA $67

CA $79 total

includes taxes & fees

Sep 22 - Sep 23

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A kitchenette with a coffee machine, a kettle, and storage shelves.

12. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

CA $146

CA $166 total

includes taxes & fees

Oct 9 - Oct 10

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

13. Comfort Inn & Suites Sikeston I-55

Sikeston

Lakeysha

CA $123

CA $140 total

includes taxes & fees

Oct 4 - Oct 5

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

14. Hampton Inn Sikeston

Sikeston

Jeffrey

CA $140

CA $159 total

includes taxes & fees

Sep 20 - Sep 21

A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.

A kitchen with white cabinets, a stainless steel refrigerator, a coffee maker, and a trash can.

A bedroom with a wooden bed, a bedside table with a lamp, a window with curtains, and a view of the outdoors.

A living room with a gray sofa, a patterned rug, wooden flooring, a ceiling fan, a wall-mounted lamp, and a framed picture.

15. Quiet Country Stay: Modern Home Near Paducah

Cunningham

CA $206

CA $401 total

includes taxes & fees

Sep 9 - Sep 10

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a counter, a coffee machine, and seating.

16. Country Yard Inn and Suite

Sikeston

William

CA $79

CA $94 total

includes taxes & fees

Oct 9 - Oct 10

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

17. TownePlace Suites by Marriott Sikeston

Sikeston

Lauren

CA $163

CA $185 total

includes taxes & fees

Sep 24 - Sep 25

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

18. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Raidas

CA $99

CA $112 total

includes taxes & fees

Sep 13 - Sep 14

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.

19. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

CA $138

CA $156 total

includes taxes & fees

Sep 13 - Sep 14

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern outdoor seating area with a glass-top table and a fire feature, overlooking a sunset view.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

20. The Riverview

Cape Girardeau

Alyssa

CA $141

CA $159 total

includes taxes & fees

Sep 13 - Sep 14

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Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, cathedral, and more.

See all hotels in Charleston

Top Charleston Hotel Reviews

Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Was overall great place to stay"

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"This place was awesome hands down! The staff was extremely accommodating and friendly. Thank you Madison for a great check in experience. Of all the hotels we stayed at over our road trip this weekend this was the best deal and the nicest establishment by far. The receptionist even gave my children little toys out the treasure chest as we were checking out. Thank y'all again! Will def be back if I am ever in the area."

The Riverview

8/10 Good

"Clean room"

The Riverstone Hotel Charleston-Sikeston

10/10 Excellent

"Everything was fine for a one night stay."

Best Western Plus Sikeston I-55

8/10 Good

"Great location, nice, clean and well maintained, Hotel employees were very helpful great customer service,"

Drury Inn & Suites Sikeston, MO

10/10 Excellent

"This was my second time staying at Drury hotel. I will most definitely book another stay."

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Nice place! Breakfast was amazing!"

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"This was a great place to stay. Everything about it was fantastic. We especially enjoyed the free breakfast and dinner!"

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"For a older hotel. It was pleasant. Very good staff"

More cheap stays in Charleston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

CA $78

CA $89 total

Sep 10 - Sep 11

includes taxes & fees

8.4/10 Very good! (820 reviews)

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

CA $79

CA $90 total

Sep 15 - Sep 16

includes taxes & fees

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $92

CA $104 total

Sep 10 - Sep 11

includes taxes & fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $99

CA $112 total

Sep 13 - Sep 14

includes taxes & fees

9.2/10 Wonderful! (1,007 reviews)

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

CA $120

CA $137 total

Sep 20 - Sep 21

includes taxes & fees

8.4/10 Very good! (1,009 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

CA $140

CA $159 total

Sep 13 - Sep 14

includes taxes & fees

9.4/10 Exceptional! (1,004 reviews)

Hotels in Charleston with star rating

Frequently asked questions

What is the best area to stay in Charleston?

The best area to stay in Charleston, Missouri, is near the intersection of Main Street and US-60, as this is the primary commercial hub.This area offers the most convenience for travellers, with several hotels, local eateries, and essential services clustered together. You'll find most of the town's amenities within a short drive or walk from here, making it an excellent base for exploring the surrounding region.For those travelling for business or looking for easy access to regional transport routes, this central location is ideal.

What are the best hotels in Charleston that travellers recommend?

Two of the best hotels in Charleston that receive consistently high recommendations from travellers are the Super 8 by Wyndham Charleston/Sikeston East MO and the Quality Inn Charleston - Sikeston.The Super 8 by Wyndham Charleston/Sikeston East MO provides air-conditioned rooms, with guests often commenting on how big the rooms are and how helpful the staff are. A free breakfast, including a to-go option, is available.Another highly recommended option is the Quality Inn Charleston - Sikeston. Guests often mention the good rooms, nice beds, and nice showers. This hotel offers a free buffet breakfast and free self-parking, including space for RVs, buses, and trucks. Fitness facilities are available at a nearby location at no extra charge.

What are the best family hotels in Charleston?

For family-friendly hotels in Charleston, consider the Super 8 by Wyndham Charleston/Sikeston East MO, the Quality Inn Charleston - Sikeston, or the Eagle Inn Charleston.The Super 8 by Wyndham Charleston/Sikeston East MO offers free breakfast and complimentary to-go breakfast options, which are very convenient for families on the go. Guests have noted that the staff are helpful and the rooms are big, providing ample space for families. Cribs are also available free of charge.The Quality Inn Charleston - Sikeston provides free buffet breakfast, free self-parking, and free WiFi, which are all excellent amenities for families. Many guests appreciate the comfortable beds, good rooms, and nice showers. Sofa beds are also available.Another good choice is the Eagle Inn Charleston. This hotel offers free WiFi and free parking for RVs, buses, and trucks, which can be useful for families traveling with larger vehicles. Rollaway and extra beds are available free of charge, adding flexibility for sleeping arrangements. Find more child-friendly accommodations in Charleston

What hotels in Charleston offer free breakfast?

For hotels in Charleston that offer a complimentary breakfast, consider the Quality Inn Charleston - Sikeston and the Super 8 by Wyndham Charleston/Sikeston East MO.The Quality Inn Charleston - Sikeston provides guests with a free buffet breakfast daily, and it also includes free self-parking and free WiFi. Guests have noted that the beds are nice and the rooms and showers are good.Another excellent option is the Super 8 by Wyndham Charleston/Sikeston East MO, which offers a free breakfast, including a convenient To Go breakfast option. This hotel also provides free self-parking and free WiFi. Guests frequently comment on the helpful and great staff, and the big rooms. Find more hotels with free breakfast in Charleston

What are the top pet-friendly hotels in Charleston?

For pet-friendly accommodation in Charleston, the Quality Inn Charleston - Sikeston, the Eagle Inn Charleston, and the Super 8 by Wyndham Charleston/Sikeston East MO are all excellent choices.The Quality Inn Charleston - Sikeston allows pets and provides complimentary buffet breakfast and free breakfast. Guests have frequently commented on the nice beds, good rooms, and nice showers.Another great option is the Eagle Inn Charleston, which also permits pets. This hotel offers free WiFi, along with complimentary RV, bus, and truck parking, as well as free self-parking.The Super 8 by Wyndham Charleston/Sikeston East MO welcomes pets and provides early check-in options, along with free breakfast and free to-go breakfast. Guests often praise the helpful and great staff, as well as the big rooms. See more pet-friendly hotels in Charleston

What are the best budget hotels in Charleston?

For budget hotels in Charleston, consider the Quality Inn Charleston - Sikeston, Super 8 by Wyndham Charleston/Sikeston East MO, or the Eagle Inn Charleston.The Quality Inn Charleston - Sikeston offers complimentary self-parking and free buffet breakfast, along with free WiFi. Guests have commented on the nice beds, good rooms, and nice shower facilities.Another good option is the Super 8 by Wyndham Charleston/Sikeston East MO. This hotel provides free to-go breakfast, free self-parking, and free WiFi. Guests often mention the helpful and great staff, as well as the big rooms.The Eagle Inn Charleston provides free WiFi, free RV, bus, or truck parking, and free self-parking. It also features a health club for guests. View all budget hotels in Charleston

When is the best time to go to Charleston?

The best time to visit Charleston, Missouri, is during the spring (April to May) and autumn (September to October) months.These periods offer pleasant weather, with moderate temperatures and less humidity, making it ideal for exploring the town and its surroundings comfortably. Spring brings blooming dogwood trees, while autumn showcases lovely fall foliage, particularly around the Mississippi River.For those interested in local events, the Dogwood-Azalea Festival in April is a highlight, featuring parades, home tours, and craft fairs. It's a popular time, so booking accommodation in advance is a good idea.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Charleston.

How much is the nightly rate at a Charleston hotel?

Prices for hotels in Charleston often vary, but you can find a great deal from CA $79 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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Book Hotels in Charleston on Expedia.com

Find hotels in Charleston, MO from CA $79

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Charleston

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Charleston hotels

1. Super 8 by Wyndham Charleston/Sikeston East MO

2. The Riverstone Hotel Charleston-Sikeston

3. Eagle Inn Charleston

4. Drury Inn & Suites Sikeston, MO

5. Best Western Plus Sikeston I-55

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

7. Quality Inn Cairo I-57

8. Super 8 by Wyndham Sikeston/Miner Area

9. Days Inn and Suites by Wyndham Sikeston

10. Fairfield Inn & Suites by Marriott Sikeston

11. La Center Motel

12. Holiday Inn Express & Suites Sikeston Southwest by IHG

13. Comfort Inn & Suites Sikeston I-55

14. Hampton Inn Sikeston

15. Quiet Country Stay: Modern Home Near Paducah

16. Country Yard Inn and Suite

17. TownePlace Suites by Marriott Sikeston

18. Pear Tree Inn Cape Girardeau West

19. Drury Plaza Hotel Cape Girardeau Conference Center

20. The Riverview

Learn more about Charleston

Top Charleston Hotel Reviews

Pear Tree Inn Cape Girardeau West

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

The Riverview

The Riverstone Hotel Charleston-Sikeston

Best Western Plus Sikeston I-55

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

More cheap stays in Charleston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Super 8 by Wyndham Sikeston/Miner Area

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Best Western Plus Sikeston I-55

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Charleston with star rating

Frequently asked questions

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