Title: Book The Best Hotels in Charleston, MO for 2026 from CA $92 - Fully Refundable Options - Expedia.ca

[Vacation Rentals in Charleston](https://expedia.ca/Charleston-Vacation-Rentals.d7182.Travel-Guide-VacationRentals)[Charleston Car Rentals](https://expedia.ca/Car-Rentals-In-Charleston.d7182.Car-Rental-Guide)[Charleston Vacation Packages](https://expedia.ca/Charleston.d7182.Destination-Travel-Guides)

![Cypress Trees on the Horizon.  A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.  ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)  
###  
Change your mind  
Book hotels with free cancellation
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)  
###  
Treat yourself  
Sign in to save 10% or more on thousands of hotels  
[Sign in](https://www.expedia.ca/login)
- ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)  
###  
Be picky  
Search almost a million properties worldwide

## Go beyond your typical stay in Charleston

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America&regionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-02-06&d1=2026-02-06&endDate=2026-02-08&d2=2026-02-08&amenities=POOL)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America&regionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-02-06&d1=2026-02-06&endDate=2026-02-08&d2=2026-02-08&amenities=PETS)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America&regionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-02-06&d1=2026-02-06&endDate=2026-02-08&d2=2026-02-08&travelerType=family_friendly)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America&regionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-02-06&d1=2026-02-06&endDate=2026-02-08&d2=2026-02-08&lodging=APARTMENT)

Waterpark

[](https://www.expedia.ca/Hotel-Search?destination=Charleston%2C+Missouri%2C+United+States+of+America&regionId=7182&latLong=36.923187%2C-89.349998&adults=2&startDate=2026-02-06&d1=2026-02-06&endDate=2026-02-08&d2=2026-02-08&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[Jan 23 - Jan 24](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-01-23&endDate=2026-01-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Jan 24 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-01-24&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=7182&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Charleston hotels

![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

Charleston

6.8/10

(622 reviews)

"Affordable for a quick one night stay. Restaurant and gas station next to hotel."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Annette

CA $86

CA $95 total

includes taxes & fees

Jan 24 - Jan 25

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/352edf3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eagle Inn Charleston

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

Charleston

6.6/10

(105 reviews)

"Middle of nowhere hotel was ok"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

CA $83

CA $93 total

includes taxes & fees

Jan 24 - Jan 25

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,002 reviews)

"As always it was a perfect visit"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

CA $124

CA $143 total

includes taxes & fees

Feb 3 - Feb 4

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(1,003 reviews)

"Great place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly

CA $138

CA $156 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/a2f06e13.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/945fac08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily breakfast](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/d0c3544f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,002 reviews)

"Rooms were very clean and comfortable "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lydia

CA $111

CA $127 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Basic Double Room | Living area](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/e95f9062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Double Room | Living area](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/dc7ca140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/f3adf3f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/bbe54b21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Center Motel

[](https://www.expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information)

La Center

7.8/10

Good

(17 reviews)

"Quiet and convenient."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Alma

[](https://www.expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/9b8cfc2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/2ea775b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Front of property](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/fe5a3b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/7ebce143.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quiet Country Stay: Modern Home Near Paducah

[](https://www.expedia.ca/Quiet-Country-Stay-Modern-Home-Near-Paducah.h122892138.Hotel-Information)

Cunningham

CA $167

CA $400 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/Quiet-Country-Stay-Modern-Home-Near-Paducah.h122892138.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

Sikeston

8.6/10

Excellent

(447 reviews)

"Stay was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kourtney

CA $128

CA $145 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/327b8d22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

Sikeston

8.4/10

Very good

(1,004 reviews)

"Great stay, everything was clean and comfortable. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Charles

CA $111

CA $127 total

includes taxes & fees

Jan 29 - Jan 30

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/59c49f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/a085469e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f29b08e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/05842f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Cape Girardeau West

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

Cape Girardeau

9.0/10

Wonderful

(1,001 reviews)

"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Colleen

CA $96

CA $109 total

includes taxes & fees

Jan 28 - Jan 29

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jackpot Suite | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverview

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(493 reviews)

"The room was clean and I was able to check in a bit early."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sara

CA $129

CA $146 total

includes taxes & fees

Jan 26 - Jan 27

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/74187a0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Cairo

6.6/10

(275 reviews)

"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6\. I was not satisfied at all."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

ReShena

CA $98

CA $109 total

includes taxes & fees

Jan 31 - Feb 1

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/ffb58563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/84598bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Cape Girardeau

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(1,006 reviews)

"Awesome stay!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Breckin

CA $124

CA $140 total

includes taxes & fees

Jan 27 - Jan 28

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

Sikeston

9.2/10

Wonderful

(52 reviews)

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

AHMAD

CA $139

CA $158 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/594efec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

Sikeston

8.4/10

Very good

(731 reviews)

"Clean room and easy access to room"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Anne

CA $81

CA $92 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(465 reviews)

"Very clean and super friendly staff!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Katherine

CA $131

CA $148 total

includes taxes & fees

Jan 30 - Jan 31

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/6afdbde2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/1fa29b5a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7a78d337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7657c6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Sikeston I-55

[](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

Sikeston

8.4/10

Very good

(285 reviews)

"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

aileen

CA $116

CA $132 total

includes taxes & fees

Jan 31 - Feb 1

[](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/c7d69739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/20bc712d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott Cape Girardeau Downtown

[](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(483 reviews)

"Very nice hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angie

CA $173

CA $196 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom (Feature)](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/40930878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/182edc95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(1,000 reviews)

"Breakfast was very good and staff was extremely friendly and rooms were very clean "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rex

CA $131

CA $148 total

includes taxes & fees

Feb 1 - Feb 2

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn and Suites by Wyndham Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

Sikeston

7.2/10

Good

(1,001 reviews)

"Everything was excellent"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

James

CA $87

CA $99 total

includes taxes & fees

Jan 25 - Jan 26

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-06&endDate=2026-02-07&regionId=7182&adults=2&sort=RECOMMENDED&openPlayBack=true)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCharleston-Hotels.d7182.Travel-Guide-Hotels)[

Sign up, it's free

](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCharleston-Hotels.d7182.Travel-Guide-Hotels)

## Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, food, and more. 

[See all hotels in Charleston](https://www.expedia.ca/Hotel-Search?startDate=2026-02-06&endDate=2026-02-07&adults=2&regionId=7182)

![Cypress Trees on the Horizon.  A sting of cypress trees of various sizes extend across the horizon as the sunken sun paints the multicolored sky.  ](https://images.trvl-media.com/place/7182/2c4b1a06-d3aa-4171-b8b6-0e4eaaa0e80e.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high)

## More cheap stays in Charleston

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $87

CA $99 total

Jan 25 - Jan 26

includes taxes & fees

7.2/10 Good! (1,003 reviews)

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $96

CA $109 total

Jan 28 - Jan 29

includes taxes & fees

9/10 Wonderful! (1,001 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

CA $111

CA $133 total

Feb 22 - Feb 23

includes taxes & fees

8/10 Very Good! (892 reviews)

[](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

CA $131

CA $148 total

Feb 1 - Feb 2

includes taxes & fees

9.4/10 Exceptional! (1,000 reviews)

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

CA $131

CA $148 total

Jan 30 - Jan 31

includes taxes & fees

8.8/10 Excellent! (463 reviews)

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Pear Tree Inn Cape Girardeau Near the Medical Center](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St Cape Girardeau MO

[Get rates](https://expedia.ca/Hotel-Search?startDate=06%2F02%2F2026&endDate=07%2F02%2F2026&selected=40113&PinnedHotelID=40113&HadPinnedHotel=true&regionId=7182)

8.8/10 Excellent! (1,002 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information)

## Hotels in Charleston with star-rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

6 properties

[](https://expedia.ca/3Star-Charleston-Hotels.s30-0-d7182.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

27 properties

[](https://expedia.ca/2Star-Charleston-Hotels.s20-0-d7182.Travel-Guide-Filter-Hotels)

## Recent reviews of Charleston hotels

![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg)

### Courtyard by Marriott Cape Girardeau Downtown

5/5 Excellent

"Room was spotless, comfy bed, friendly staff"

A verified traveller stayed at Courtyard by Marriott Cape Girardeau Downtown

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg)

### Candlewood Suites Cape Girardeau by IHG

5/5 Excellent

"Staff was friendly. Check-in was easy. The room was spotless. "

A verified traveller stayed at Candlewood Suites Cape Girardeau by IHG

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

5/5 Excellent

"Room was spacious and clean. Staff was nice and helpful. Good breakfast."

A verified traveller stayed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston

5/5 Excellent

"Clean and well-kept"

A verified traveller stayed at Best Western Plus Sikeston

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

5/5 Excellent

"The amenities were above and beyond. The staff were extremely helpful and courteous. "

A verified traveller stayed at Drury Inn & Suites Cape Girardeau

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

5/5 Excellent

"As always it was a perfect visit"

A verified traveller stayed at Drury Inn & Suites Sikeston, MO

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg)

### Pear Tree Inn Sikeston

5/5 Excellent

"Very welcoming staff. Nice room for the money plus 3 free drinks per guest and breakfast!"

A verified traveller stayed at Pear Tree Inn Sikeston

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

5/5 Excellent

"Everything was excellent"

A verified traveller stayed at Days Inn and Suites by Wyndham Sikeston

Posted 5 days ago

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

5/5 Excellent

"Great room! House keeping and breakfast was great Special shout out to Donya for the check in. "

A verified traveller stayed at Pear Tree Inn Cape Girardeau West

Posted 5 days ago

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

## Frequently asked questions

### What are the best budget hotels in Charleston?

> [Eagle Inn Charleston](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) is another excellent choice for budget-conscious travellers. This hotel not only provides free self-parking and high-speed internet but also features a health club for those who want to maintain their fitness routine. Additionally, the availability of rollaway extra beds at no additional cost makes it a great option for families needing a bit more space. View all [budget hotels in Charleston](https://www.expedia.ca/Charleston-Hotels-Cheap-Hotels.0-0-d7182-tCheapHotels.Travel-Guide-Filter-Hotels).

### When is the best time to go to Charleston?

> During the peak season, from March to May, Charleston experiences a delightful surge in tourist activity. The pleasant climate and stunning scenery create a superb backdrop for outdoor adventures, including exploring the picturesque waterfront or taking a scenic carriage ride through the historic district. Many visitors find this time particularly enchanting, as the city hosts various festivals and events that showcase its rich culture and history.
> 
>   
> For couples looking to enjoy a romantic getaway, April offers a fantastic opportunity to indulge in outdoor dining experiences. Many restaurants feature charming patio seating where you can savour the local cuisine, perhaps enjoying fresh seafood or traditional Lowcountry dishes while taking in the beautiful surroundings.
> 
>   
> If your travel preferences lean towards a more budget-friendly approach, consider visiting in September. This month often sees reduced accommodation rates and fewer crowds, allowing you to explore the city's attractions at a more leisurely pace. The weather remains warm, making it comfortable for outdoor activities and sightseeing.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Charleston hotel booking with Expedia?

### How much is the nightly rate at a Charleston hotel?

## Explore a world of travel with Expedia

- Lodging
- Flights
- Packages
- Cars
- More ways to book

- [Advance Hotels ](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels)
- [Apartments in Baker ](https://www.expedia.ca/Baker-Apartments.d553248634983252914-aaApartments.Travel-Guide-Accommodation)
- [Apartments in Bell City ](https://www.expedia.ca/Bell-City-Apartments.d553248634983588961-aaApartments.Travel-Guide-Accommodation)
- [Cheap Hotels in Benton ](https://www.expedia.ca/Benton-Hotels-Cheap-Hotels.0-0-d553248634983369680-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Benton ](https://www.expedia.ca/Benton-Hotels-Luxury-Hotel.0-0-d553248634983369680-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Benton Hotels ](https://www.expedia.ca/Benton-Hotels.d553248634983369680.Travel-Guide-Hotels)
- [Bernie Hotels ](https://www.expedia.ca/Bernie-Hotels.d3000349284.Travel-Guide-Hotels)
- [Cheap Hotels in Bertrand ](https://www.expedia.ca/Bertrand-Hotels-Cheap-Hotels.0-0-d3000349285-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in Bertrand ](https://www.expedia.ca/Bertrand-Hotels-Hotel-With-Pool.0-0-d3000349285-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Bertrand Hotels ](https://www.expedia.ca/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels)
- [Motels in Bertrand ](https://www.expedia.ca/Bertrand-Motels.d3000349285-aaMotels.Travel-Guide-Accommodation)
- [Blodgett Hotels ](https://www.expedia.ca/Blodgett-Hotels.d3000349291.Travel-Guide-Hotels)
- [Bloomfield Hotels ](https://www.expedia.ca/Bloomfield-Hotels.d6351829.Travel-Guide-Hotels)
- [Apartments in Canalou ](https://www.expedia.ca/Canalou-Apartments.d3000349311-aaApartments.Travel-Guide-Accommodation)
- [Canalou Hotels ](https://www.expedia.ca/Canalou-Hotels.d3000349311.Travel-Guide-Hotels)
- [Casino Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Casino-Hotel.0-0-d820-tCasinoHotel.Travel-Guide-Filter-Hotels)
- [Cheap Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Cheap-Hotels.0-0-d820-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotel-With-Pool.0-0-d820-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Hotels with Bar in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotels-With-Bar.0-0-d820-tHotelswithBar.Travel-Guide-Filter-Hotels)
- [Hotels with Free Airport Shuttle in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d820-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Pet-Friendly-Hotel.0-0-d820-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Spa Hotels in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Hotels-Spa-Hotel.0-0-d820-tSpaHotel.Travel-Guide-Filter-Hotels)
- [Cape Girardeau Hotels ](https://www.expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)
- [Inns in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-Inns.d820-aaInns.Travel-Guide-Accommodation)
- [Rv Parks in Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau-RV-Parks.d820-aaRVParks.Travel-Guide-Accommodation)
- [Hotels near Cape Rock Park ](https://www.expedia.ca/Cape-Rock-Park-Hotels.0-l553248621532655781-0.Travel-Guide-Filter-Hotels)
- [Catron Hotels ](https://www.expedia.ca/Catron-Hotels.d3000349317.Travel-Guide-Hotels)
- [Rv Parks in Chaffee ](https://www.expedia.ca/Chaffee-RV-Parks.d553248634983269107-aaRVParks.Travel-Guide-Accommodation)
- [Cabin Rentals in Commerce ](https://www.expedia.ca/Commerce-Cabins.d553248634983177483-aaCabins.Travel-Guide-Accommodation)
- [Mississippi County Hotels ](https://www.expedia.ca/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)
- [Dexter Hotels ](https://www.expedia.ca/Dexter-Hotels.d55097.Travel-Guide-Hotels)
- [Hotels near eDen Spa & Salon ](https://www.expedia.ca/EDen-Spa-Salon-Hotels.0-l553248621532655776-0.Travel-Guide-Filter-Hotels)
- [East Prairie Hotels ](https://www.expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)
- [Essex Hotels ](https://www.expedia.ca/Essex-Hotels.d553248634983169000.Travel-Guide-Hotels)
- [Howardville Hotels ](https://www.expedia.ca/Howardville-Hotels.d553248634983363505.Travel-Guide-Hotels)
- [Hotels near Isle Casino Cape Girardeau ](https://www.expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels)
- [Jackson Hotels ](https://www.expedia.ca/Jackson-Hotels.d55765.Travel-Guide-Hotels)
- [B&B in Kelso ](https://www.expedia.ca/Kelso-Bed-And-Breakfast.d553248634983171130-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Marston Hotels ](https://www.expedia.ca/Marston-Hotels.d55824.Travel-Guide-Hotels)
- [Matthews Hotels ](https://www.expedia.ca/Matthews-Hotels.d553248634983428760.Travel-Guide-Hotels)
- [Lodges in Matthews ](https://www.expedia.ca/Matthews-Lodges.d553248634983428760-aaLodges.Travel-Guide-Accommodation)
- [Hotels with smoking rooms in Miner ](https://www.expedia.ca/Miner-Hotels-Hotels-With-Smoking-Rooms.0-0-d553248634983441802-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Miner ](https://www.expedia.ca/Miner-Hotels-Luxury-Hotel.0-0-d553248634983441802-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Miner Hotels ](https://www.expedia.ca/Miner-Hotels.d553248634983441802.Travel-Guide-Hotels)
- [Lodges in Miner ](https://www.expedia.ca/Miner-Lodges.d553248634983441802-aaLodges.Travel-Guide-Accommodation)
- [Apartments in Morehouse ](https://www.expedia.ca/Morehouse-Apartments.d553248634983462037-aaApartments.Travel-Guide-Accommodation)
- [Morehouse Hotels ](https://www.expedia.ca/Morehouse-Hotels.d553248634983462037.Travel-Guide-Hotels)
- [Cheap Hotels in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Cheap-Hotels.0-0-d3000445315-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with a Pool in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Hotel-With-Pool.0-0-d3000445315-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in New Madrid ](https://www.expedia.ca/New-Madrid-Hotels-Luxury-Hotel.0-0-d3000445315-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [New Madrid Hotels ](https://www.expedia.ca/New-Madrid-Hotels.d3000445315.Travel-Guide-Hotels)
- [B&B in Oran ](https://www.expedia.ca/Oran-Bed-And-Breakfast.d3000445386-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Hotels with a Pool in Oran ](https://www.expedia.ca/Oran-Hotels-Hotel-With-Pool.0-0-d3000445386-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Luxury Hotels in Oran ](https://www.expedia.ca/Oran-Hotels-Luxury-Hotel.0-0-d3000445386-tLuxuryHotel.Travel-Guide-Filter-Hotels)
- [Oran Hotels ](https://www.expedia.ca/Oran-Hotels.d3000445386.Travel-Guide-Hotels)
- [Inns in Oran ](https://www.expedia.ca/Oran-Inns.d3000445386-aaInns.Travel-Guide-Accommodation)
- [Portageville Hotels ](https://www.expedia.ca/Portageville-Hotels.d183487.Travel-Guide-Hotels)
- [Risco Hotels ](https://www.expedia.ca/Risco-Hotels.d3000349516.Travel-Guide-Hotels)
- [Cheap Hotels in Scott City ](https://www.expedia.ca/Scott-City-Hotels-Cheap-Hotels.0-0-d553248634983544376-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Scott City Hotels ](https://www.expedia.ca/Scott-City-Hotels.d553248634983544376.Travel-Guide-Hotels)
- [Apartments in Sikeston ](https://www.expedia.ca/Sikeston-Apartments.d6058766-aaApartments.Travel-Guide-Accommodation)
- [Cheap Hotels in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Cheap-Hotels.0-0-d6058766-tCheapHotels.Travel-Guide-Filter-Hotels)
- [Hotels with Kitchenettes in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Hotels-With-Kitchenettes.0-0-d6058766-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels)
- [Pet-Friendly Hotels in Sikeston ](https://www.expedia.ca/Sikeston-Hotels-Pet-Friendly-Hotel.0-0-d6058766-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
- [Sikeston Hotels ](https://www.expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)
- [Hotels near Southeast Missouri State University ](https://www.expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels)
- [Wilson City Hotels ](https://www.expedia.ca/Wilson-City-Hotels.d553248634983391595.Travel-Guide-Hotels)

- [Flights to Cape Girardeau ](https://www.expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)
- [Flights from East Prairie ](https://www.expedia.ca/lp/flights/3000349349/flights-from-east-prairie)
- [Flights from Commerce ](https://www.expedia.ca/lp/flights/553248634983177483/flights-from-commerce)
- [Flights from Chaffee ](https://www.expedia.ca/lp/flights/553248634983269107/flights-from-chaffee)
- [Flights from Scott City ](https://www.expedia.ca/lp/flights/553248634983544376/flights-from-scott-city)
- [Flights from Cape Girardeau ](https://www.expedia.ca/lp/flights/820/flights-from-cape-girardeau)
- [Flights from Accra (ACC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/acc/cgi/accra-to-cape-girardeau)
- [Flights from Bloomington (BMI) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/bmi/cgi/bloomington-to-cape-girardeau)
- [Flights from Buffalo (BUF) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/buf/cgi/buffalo-to-cape-girardeau)
- [Flights from Colombo (CMB) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/cmb/cgi/colombo-to-cape-girardeau)
- [Flights from Dhaka (DAC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/dac/cgi/dhaka-to-cape-girardeau)
- [Flights from Detroit (DTW) to Sikeston (SIK) ](https://www.expedia.ca/lp/flights/dtw/sik/detroit-to-sikeston)
- [Flights from Grand Island (GRI) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/gri/cgi/grand-island-to-cape-girardeau)
- [Flights from New York (JFK) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/jfk/cgi/new-york-to-cape-girardeau)
- [Flights from Las Vegas (LAS) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/las/cgi/las-vegas-to-cape-girardeau)
- [Flights from Ocala (OCF) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/ocf/cgi/ocala-to-cape-girardeau)
- [Flights from Pierre (PIR) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/pir/cgi/pierre-to-cape-girardeau)
- [Flights from St. Louis (STL) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/stl/cgi/st-louis-to-cape-girardeau)
- [Flights from Edmonton (YEG) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yeg/cgi/edmonton-to-cape-girardeau)
- [Flights from Toronto (YTO) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yto/cgi/toronto-to-cape-girardeau)
- [Flights from Montreal (YUL) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yul/cgi/montreal-to-cape-girardeau)
- [Flights from Vancouver (YVR) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yvr/cgi/vancouver-to-cape-girardeau)
- [Flights from Winnipeg (YWG) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/ywg/cgi/winnipeg-to-cape-girardeau)
- [Flights from Calgary (YYC) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yyc/cgi/calgary-to-cape-girardeau)
- [Flights from Toronto (YYZ) to Cape Girardeau (CGI) ](https://www.expedia.ca/lp/flights/yyz/cgi/toronto-to-cape-girardeau)

- [Visit Cape Girardeau ](https://www.expedia.ca/Cape-Girardeau.dx820)
- [Eden Spa & Salon ](https://www.expedia.ca/EDen-Spa-Salon-Cape-Girardeau.d553248621532655776.Vacation-Attraction)

- [Avis Rental Cars in Sikeston ](https://www.expedia.ca/Avis-Car-Rentals-In-Sikeston.d6058766-c41.Car-Rental-Guide-Suppliers)
- [Rental cars Cape Girardeau Municipal airport ](https://www.expedia.ca/Car-Rentals-In-Cape-Girardeau-Municipal.d6026978.Car-Rental-Guide)
- [Car rental Cape Girardeau ](https://www.expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)
- [Car rental Sikeston ](https://www.expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)
- [Hertz Rental Cars in Sikeston ](https://www.expedia.ca/Hertz-Car-Rentals-In-Sikeston.d6058766-c40.Car-Rental-Guide-Suppliers)
- [National Car Rental Rental Cars in Sikeston ](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Sikeston.d6058766-c42.Car-Rental-Guide-Suppliers)

- [Book Hotels in Charleston on Expedia.com ](https://www.expedia.com/Charleston-Hotels.d7182.Travel-Guide-Hotels)

![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg)

## Go further with the Expedia app

Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go.

Scan the QR code with your device camera and download our app