Title: Book the Best Cape Girardeau CASINO Hotels & Resorts in 2025 | Expedia.ca [Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Skyy # Find Casino Hotels in Cape Girardeau, MO from CA $127 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Cape Girardeau Casino Hotels Tonight [Nov 1 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-11-01&endDate=2025-11-02&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Nov 2 - Nov 3](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-11-02&endDate=2025-11-03&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=CASINO&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Cape Girardeau Casino Hotels ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/363ef183.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/de11c650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview Cape Girardeau 9.4/10 Exceptional (443) "Location was perfect for family weekend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $127 CA $144 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/68c09770.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/20bc712d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Cape Girardeau Downtown Cape Girardeau 9.6/10 Exceptional (457) "Very clean and upscale hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mike CA $163 CA $184 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ![Standard Room, 1 Queen Bed, Non Smoking, Garden View](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/fc499141.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/000a3467.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/dbe031d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/a102ce70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rockwood Inn Cape Girardeau 10/10 Exceptional (16) "Very beautiful property and we loved the old school feel and hospitality" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $192 CA $217 total includes taxes & fees Nov 24 - Nov 25 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Rockwood-Inn.h105486893.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19260000/19252900/19252851/066095c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/20000000/19260000/19252900/19252851/35a75be2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/20000000/19260000/19252900/19252851/2dad0af1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/20000000/19260000/19252900/19252851/4af1938a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Loft Apartment Across From Semo University Houch Field House. Walk To Events Cape Girardeau 10/10 Exceptional (92) "Place is spacious and was great for a weekend in Cape. Walkable to nearby restaurants." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Myles O. CA $210 CA $258 total includes taxes & fees Nov 29 - Nov 30 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Loft-Apartment-Across-From-Semo-University-Houch-Field-House-Walk-To-Events.h19252851.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6b76cbc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Serenity South -- Gardens, River-Views, and Refreshing Space Cape Girardeau 10/10 Exceptional (144) "Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linden S. CA $210 CA $343 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars)](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (644) "Stayed on our way south for vacation. It was a clean nice place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joel CA $118 CA $127 total includes taxes & fees Nov 12 - Nov 13 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Smart TV, fireplace, DVD player](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ded6701c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/6b2b149b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/ea8173b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rest, Relax and Renew. Our log cabin experience awaits your arrival. Anna 10/10 Exceptional (400) "Serene, well appointed cabin, front porch rocker back deck" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christine CA $164 CA $283 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/05ba3853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, stovetop, coffee/tea maker](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/5d936793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/d3b8d0f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/95950b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Contemporary Glamping with Native American Appeal Anna 9.8/10 Exceptional (154) "Great stay! Perfect for our family and dog while we visited friends in Cobden. Cute and well appointed cabin!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kristin N. CA $280 CA $478 total includes taxes & fees Nov 22 - Nov 23 [](https://www.expedia.ca/Anna-Hotels-Contemporary-Glamping-With-Native-American-Appeal.h27145221.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89790000/89781400/89781354/83753556.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89790000/89781400/89781354/79befc74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, table tennis](https://images.trvl-media.com/lodging/90000000/89790000/89781400/89781354/9fd80641.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/90000000/89790000/89781400/89781354/f5019574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Luxury Log Cabin near SIU, Giant City, & Wineries Makanda 10/10 Exceptional (41) "Very clean, nice and plenty or space both indoor and outdoor. A lot of thing to do nearby! Would stay again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Monica K. CA $650 CA $812 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Makanda-Hotels-Luxury-Log-Cabin-Near-SIU.h89781354.Hotel-Information) ![TV, fireplace](https://images.trvl-media.com/lodging/55000000/54030000/54029400/54029336/86df2b72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/55000000/54030000/54029400/54029336/ba5471e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/55000000/54030000/54029400/54029336/39391c50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/55000000/54030000/54029400/54029336/abe79714.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Contemporary Glamping with Native American Appeal! Anna 10/10 Exceptional (102) "We loved our stay! The accommodations were clean and comfortable. The cabin atmosphere very was relaxing. We will be back. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beth C. CA $210 CA $415 total includes taxes & fees Nov 3 - Nov 4 [](https://www.expedia.ca/Anna-Hotels-Contemporary-Glamping-With-Native-American-Appeal.h54029336.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-15&endDate=2025-11-16®ionId=820&adults=2&amenities=CASINO&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Cape Girardeau ### Discover top Cape Girardeau attractions Cape Girardeau, Missouri, offers an exciting blend of activities for casino enthusiasts and their families. Adventure seekers can visit the nearby Isle Casino Cape Girardeau, where you can try your luck at the slots or enjoy lively table games, all while soaking up the vibrant atmosphere. After a day of gaming, take a leisurely stroll along the picturesque Riverfront, where you can enjoy stunning views of the Mississippi River and perhaps catch a live performance at the riverfront park. For history buffs, the Cape River Heritage Museum provides intriguing insights into the local culture, blending entertainment with education. Families can enjoy a fun outing at the Cape Splash Family Aquatic Center, perfect for a refreshing dip after a thrilling night at the casino. When it comes to accommodation, consider staying at a hotel near the casino area—these establishments often feature convenient amenities such as shuttle services to the casino, luxurious rooms, and top dining options, ensuring a pampered experience for the whole family. Exploring this vibrant area is sure to be a memorable getaway, where quality service meets thrilling entertainment. ## Top Cape Girardeau Hotel Reviews ![Drury Inn & Suites Cape Girardeau](//images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "Amazing…just finished a 90 mile bike ride into the wind and was looking forward to a little nicer hotel with a hot tub. Awesome room, free drinks, free dinner, great breakfast…and the hot tub. Employees were awesome too. No Drury inns where I live but I will always look for them when I travel" [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Pear Tree Inn Cape Girardeau Near the Medical Center](//images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg) ### Pear Tree Inn Cape Girardeau Near the Medical Center 10/10 Excellent "Simply the most friendly staff ever. There was a very minor computer glitch at check and they must have apologized three or four times. The hotel is in a great location, our rooms were very clean, and they were a good value. " [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Great stay" [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Candlewood Suites Cape Girardeau by IHG](//images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 10/10 Excellent "We have been coming to Cape for the past 4 years. We have a kid going to SEMO. Everytime we come this is our spot. This is our go to "PERFECT SPOT". Great location for everything and Great Staff." [](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](//images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 10/10 Excellent "We had a great overnight stay to see SEMO play TSU! The hotel was great! No issues whatsoever." [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Quality Inn](//images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg) ### Quality Inn 10/10 Excellent "Great place with great employees" [](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Town House Inn Cape Giradreau](//images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/7adb4452_y.jpg) ### Town House Inn Cape Giradreau 10/10 Excellent "The motel was in an odd location and I passed it twice. The bedding was fabulous but the room needs black out curtains. I could have slept till noon…" [](https://expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) ## Frequently asked questions ### Searching for casino hotels in Cape Girardeau? > Hoping to win big in Cape Girardeau? You're in luck, because you'll find Isle Casino Cape Girardeau here, not to mention lots more to see and do. Visitors enjoy the riverfront, shopping, and dining options. ### What's the best hotel for casino gaming in Cape Girardeau? > [The Riverview](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) is a top hotel featuring a casino and free WiFi. ### How many hotels that are good for gaming can I expect to find in Cape Girardeau? > Hit the casinos and have a good night's sleep at one of Expedia's 56 casino hotels in Cape Girardeau. ### When should I take my casino trip to Cape Girardeau? > You might spend a lot of your vacation inside, but if you're planning to venture beyond the casino, taking a look at local weather data can help you. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches. ### What is there to do in Cape Girardeau? > Cape Girardeau is known for its historic sites, offering you opportunities to enjoy the local culture. Some attractions to visit in the area are Cape Girardeau Conservation Nature Center and Lazy L Safari Park. For more to see and do, you can plan to visit Show Me Center and Cape Splash Family Aquatic Center. ### What are my transportation options for my casino getaway to Cape Girardeau? > Here are some transportation options in Cape Girardeau: You can arrange a flight to the closest airport, which is Cape Girardeau, MO (CGI-Cape Girardeau Municipal), situated 6 mi (9.7 km) from the city center. 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