Resorts in Wayne County
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A frozen lake with clear ice and a forested shoreline.

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Top cities in Wayne County

Large boulders on a rocky landscape with a cloudy sky.

Piedmont

A sunset over a calm lake with a rocky shoreline and trees in the background.

Wappapello

Williamsville

A gravel path leading to a stone structure with a triangular roof, surrounded by trees and a road.

Patterson

Greenville

Des Arc

Mill Spring

Lowndes

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Top reviews in Wayne County

A spacious lobby with a reception desk, seating area, and large windows.

A spacious lobby with a high ceiling, a mezzanine level, and a seating area with a sofa and chairs.

An indoor swimming pool with a clear view of the outside through large windows.

A hotel room with a bed, a desk, a chair, a sofa, and a TV.

Drury Inn & Suites Poplar Bluff

Poplar Bluff

10/10 Excellent

We enjoyed our stay.

Esther

Reviewed March 25, 2025Reviewed March 25, 2025

Drury Inn & Suites Poplar Bluff

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

A Hampton Inn hotel with a brick facade, multiple windows, and a well-lit entrance.

Hampton Inn Poplar Bluff

Poplar Bluff

10/10 Excellent

Great spot close to the college. Clean, quiet and staff were great

Sheila

Reviewed August 30, 2026Reviewed August 30, 2026

Hampton Inn Poplar Bluff

A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

A reception area with a wooden counter, a coffee machine, and a display of pastries.

An outdoor patio with a table and chairs, a large umbrella, and a glass door leading to an interior space.

A reception desk with a bicycle light, potted plants, and a 'Connect & Print' sign.

Fairfield Inn & Suites by Marriott Poplar Bluff

Poplar Bluff

10/10 Excellent

Excellent staff, always ready and willing to help with anything we asked. Very friendly. Breakfast was great. The best chilli sauce ever!!!! Can’t wait till our next stay.

Wendy

Reviewed April 1, 2022Reviewed April 1, 2022

Fairfield Inn & Suites by Marriott Poplar Bluff

A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

A hotel room with two beds, a desk, a chair, a TV mounted on the wall, and a mirror.

A hotel reception area with a modern design, featuring a reception desk, a glass door, and a wall with framed pictures and a large number '6' sign.

A motel with a prominent '66' sign, large windows, and a flat roof.

Motel 6 Poplar Bluff, MO

Poplar Bluff

10/10 Excellent

Great value for the price

John

Reviewed April 23, 2025Reviewed April 23, 2025

Motel 6 Poplar Bluff, MO

A diner with booth seating, a checkered floor, and a counter with a cash register.

A reception area with a marble counter, potted plants, a clock, and a TV on the wall.

A hotel room with a bed, a desk, a chair, a large mirror, a sink, and a trash bin.

A gym with multiple exercise machines, a clock on the wall, and a window with blinds.

Travelodge by Wyndham Dexter

Dexter

8/10 Good

Needed a place for 10 days - first room lock didn't work so they moved me - Nice comfy beds, clean rooms. Surprisingly quiet even though close to the highway. Blockout drapes were great! Staff, especially cleaning staff, were very nice, pleasant and helpful in finding locations to eat. Diner onsite kinda dirty inside but food was good. Mexican restaurant was fantastic - food, price, service I would definitely stay again - i stayed in the new rooms, not the old part and I would...

susan

Reviewed June 2, 2016Reviewed June 2, 2016

Travelodge by Wyndham Dexter

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Eagle's Landing River Resort
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Quality Inn Perryville I
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Super 8 by Wyndham Perryville
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Morehouse Hotels
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Country Yard Inn and Suite
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Rv Parks in Chaffee
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Cottages in Clearwater
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Advance Hotels
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Poplar Bluff Hotels
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Park Hills Hotels
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Travel Inn & Suites
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Houseboats in Wappapello
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Apartments in Ozora
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Farmstay in Oak Ridge
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Hogan's Hideout Cottage #8
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Jackson Hotels
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Vacation Homes in Couch
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Alpaca Farm Stay
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Bluebird Meadows W/hot Tub and Pool Special
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Rv Parks in Haywood City
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Home Sweet Home
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Motels in Ellsinore
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Lazy River Cabin on the edge of town only 1/2 mile from Current River !
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Cabin Rentals in Leadwood
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Rv Parks in Cape Girardeau
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Villas in Poplar Bluff
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"Firefly on the Current" Gorgeous Riverfront Modern Cabin on Current River
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Town House Inn
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Cheap Hotels in Benton
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Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
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Deadwood Acres cabin #2
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Dexter Hotels
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Hampton Inn Poplar Bluff
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Comfort Inn & Suites Sikeston I
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Cottages in Pocahontas
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Winona Hotels
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Cabin Rentals in Farmington
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Hotels near Big River
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Holiday Inn Express & Suites Sikeston Southwest by IHG
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Essex Hotels
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Condo Rentals in Fremont
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Van Buren Hotels
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Oyo Hickory House Inn
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Pickleball Cafe & Micro Hotel
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Cabin Rentals in Southeast Missouri
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Crown Pointe Lodge
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Cheap Hotels in Parma
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Dexter Inn
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Cabin Rentals in Bonne Terre
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Holiday Inn Poplar Bluff by IHG
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The Queen Bee Farm Stay/Hot tub
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Cabin Rentals in Allenville
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Lodges in Campbell
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Fredericktown Hotels
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Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
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Deadwood Acres cabin #1
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Relax in the country at Countryside Villas!
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Bullwinkles Rustic Lodge
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Scott City Hotels
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Cabin Rentals in Centerville
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Doniphan Hotels
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Echo Bluff State Park
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Pet-Friendly Hotels in Jackson
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Rv Parks in Perryville
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Flights from Kelso
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Flights from Eugene (EUG) to Cape Girardeau (CGI)
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Flights from Toronto (YYZ) to Cape Girardeau (CGI)
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Flights from Montreal (YUL) to Cape Girardeau (CGI)
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Flights from Chaffee
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Flights to Poplar Bluff
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Flights from Scott City
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Flights from St. Louis (STL) to Poplar Bluff (POF)
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Flights to Dexter
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Flights to Sikeston
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Flights from Grand Island (GRI) to Cape Girardeau (CGI)
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Flights from Los Angeles (LAX) to Poplar Bluff (POF)
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Flights from Bloomington (BMI) to Cape Girardeau (CGI)
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Flights from Toronto (YTO) to Cape Girardeau (CGI)
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Flights from Vancouver (YVR) to Cape Girardeau (CGI)
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Flights to Farmington
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Flights from Calgary (YYC) to Cape Girardeau (CGI)
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Flights from Stuart (SUA) to Cape Girardeau (CGI)
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Flights from Edmonton (YEG) to Cape Girardeau (CGI)
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Flights to Butler County
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Flights from Colombo (CMB) to Cape Girardeau (CGI)
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Flights from Arcadia
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Flights from New York (JFK) to Cape Girardeau (CGI)
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Flights from Belleview
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Flights from Ocala (OCF) to Cape Girardeau (CGI)
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Wappapello Vacations
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All inclusive Vacation Packages Southeast Missouri
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Visit Fredericktown
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Rocky Falls
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Visit Poplar Bluff
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Cicar Rental Cars in Morley
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Hertz Rental Cars in Park Hills
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Enterprise Rental Cars in Southeast Missouri
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National Car Rental Rental Cars in Sikeston
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Hertz Rental Cars in Marble Hill
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Search Resort Hotels in Wayne County from CA $87

Change your mind

Treat yourself

Be picky

Top cities in Wayne County

Piedmont

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Top reviews in Wayne County

Drury Inn & Suites Poplar Bluff

10/10 Excellent

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