Photo by Jessica Richter

Find hotels in Southeast Missouri, MO from CA $72

Most hotels are fully refundable. Because flexibility matters.

Save an average of 15% on thousands of hotels with Expedia Rewards

Search over 2.9 million properties and 550 airlines worldwide

Check Southeast Missouri hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Popular filters
Popular filters
Guest rating
Guest rating
Star rating
Payment type
Payment type
Property type
Property type
Area
Area
Popular locations
Popular locations
Meal plans available
Meal plans available
Amenities
Amenities
Accessibility
Accessibility
Traveller experience
Traveller experience

Top 10 Southeast Missouri hotels and places to stay

Courtyard
Hampton Inn Cape Girardeau I 55 East
2.5 star property
9.6 out of 10, Exceptional, (619)
"No deposit, which i like, was clean, pool aas nice, food was good at breakfast"
The price is CA $156
CA $176 total
includes taxes & fees
May 19 - May 20
Hampton Inn Cape Girardeau I 55 East
Lobby
Drury Inn & Suites Jackson MO
3.0 star property
9.6 out of 10, Exceptional, (955)
"Love this Drury Inn. It is my go to when in the area. Rooms are comfortable and clean. Staff are professional and friendly. Of course, the kickback happy hour and breakfast are excellent, too. Safe area with plenty of parking. Great stop on a trip!"
The price is CA $154
CA $163 total
includes taxes & fees
May 19 - May 20
Drury Inn & Suites Jackson MO
Lobby
Drury Inn & Suites Cape Girardeau
3.0 star property
9.4 out of 10, Exceptional, (777)
"Nice suite. Roomy and comfy. Bed was comfortable. Great amenities - good snacks, good breakfast. "
The price is CA $160
CA $180 total
includes taxes & fees
May 27 - May 28
Drury Inn & Suites Cape Girardeau
Save an average of 15% on thousands of hotels when you're signed in
Property amenity
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1002)
"Easy access of the highway in a very safe and convenient location. Newer hotel and staff was excellent. The included dinner and breakfast was an unexpected surprise and didn’t disappoint. "
The price is CA $135
CA $154 total
includes taxes & fees
May 19 - May 20
Drury Inn & Suites Sikeston, MO
Property amenity
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
2.5 star property
9.4 out of 10, Exceptional, (554)
"Great place to stay!"
The price is CA $164
CA $187 total
includes taxes & fees
May 28 - May 29
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS, an IHG Hotel
Exterior
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
3.5 star property
9.4 out of 10, Exceptional, (126)
"When we walked in the lodge it was spotless. Very homey and clean. The staff was so kind. We will definitely be back."
The price is CA $245
CA $275 total
includes taxes & fees
May 21 - May 22
Holiday Inn Club Vacations Timber Creek Resort at De Soto, an IHG Hotel
Lobby
Drury Inn & Suites Poplar Bluff
3.0 star property
9.2 out of 10, Wonderful, (705)
"The only thing that I was disappointed with is that I did not get my rewards as a Gold Key Member!"
The price is CA $141
CA $160 total
includes taxes & fees
May 19 - May 20
Drury Inn & Suites Poplar Bluff
Fridge, microwave, coffee/tea maker
Shepherd Mountain Inn
2.5 star property
9.2 out of 10, Wonderful, (211)
"Convenient "
The price is CA $157
CA $172 total
includes taxes & fees
May 14 - May 15
Shepherd Mountain Inn
Lobby
Pear Tree Inn Cape Girardeau West
2.5 star property
9.0 out of 10, Wonderful, (1007)
"when got inside room there was a VERY STRONG smell of smoking. Went down to desk and reported it. Desk clerk was very responsible and got us a different room immediately."
The price is CA $92
CA $104 total
includes taxes & fees
Jun 2 - Jun 3
Pear Tree Inn Cape Girardeau West
Reception
The Farmstead Hotel
2.5 star property
9.0 out of 10, Wonderful, (188)
"What we liked about it was it was convenient to the casino. What we didn't like was it's in a run down area that's a little sketchy, making you feel unsafe."
The price is CA $144
CA $163 total
includes taxes & fees
May 15 - May 16
The Farmstead Hotel
Exterior
Hampton Inn Farmington
2.5 star property
9.0 out of 10, Wonderful, (437)
"They were extremely busy at breakfast and was continually out of food and took a long time to get it refilled."
The price is CA $200
CA $228 total
includes taxes & fees
May 31 - Jun 1
Hampton Inn Farmington
BBQ/picnic area
Auburn Place Hotel And Suites
2.5 star property
8.8 out of 10, Excellent, (1011)
"The staff was sooo nice here, Thank you for a over the top breakfast thx"
The price is CA $98
CA $111 total
includes taxes & fees
May 26 - May 27
Auburn Place Hotel And Suites
Room, 2 Queen Beds, Non Smoking
Microtel Inn & Suites by Wyndham Sainte Genevieve
2.5 star property
8.8 out of 10, Excellent, (488)
"This Microtel was comfortable and clean. The local folks of Ste Genevieve make this motel a very good place to stay."
The price is CA $113
CA $126 total
includes taxes & fees
May 19 - May 20
Microtel Inn & Suites by Wyndham Sainte Genevieve
Fountain
Bullwinkles Rustic Lodge
2.5 star property
8.8 out of 10, Excellent, (152)
"everything was perfect"
The price is CA $115
CA $130 total
includes taxes & fees
May 20 - May 21
Bullwinkles Rustic Lodge
Lobby
Comfort Inn Sullivan
2.5 star property
8.8 out of 10, Excellent, (616)
"Very nice"
The price is CA $163
CA $177 total
includes taxes & fees
May 15 - May 16
Comfort Inn Sullivan
Exterior
Hampton Inn Sikeston
2.5 star property
8.8 out of 10, Excellent, (266)
"Great place and very clean and friendly staff!"
The price is CA $175
CA $198 total
includes taxes & fees
May 19 - May 20
Hampton Inn Sikeston
Front of property
Honeysuckle Inn - Mountain View
3.0 star property
8.6 out of 10, Excellent, (189)
"Everything was perfect! "
The price is CA $152
CA $165 total
includes taxes & fees
May 15 - May 16
Honeysuckle Inn - Mountain View
Hallway
Travel Inn & Suites
2.5 star property
8.4 out of 10, Very good, (521)
"Rooms a little small. "
The price is CA $100
CA $114 total
includes taxes & fees
May 14 - May 15
Travel Inn & Suites
Exterior
Comfort Inn & Suites Sikeston I-55
2.5 star property
8.4 out of 10, Very good, (194)
"The best value for money I have ever had. Exceptional service and cleanliness. My room was fantastic. Huge and spotless. Theres an elevator and they are pet friendly. I travel a great deal and this was the best. Good breakfast with lots of choices, including healthy choices. Safe area right next to a McDonalds and a Burger King, but not 24hr ones so it was quiet at night. "
The price is CA $126
CA $143 total
includes taxes & fees
May 19 - May 20
Comfort Inn & Suites Sikeston I-55
Blackout drapes, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO
2.0 star property
8.2 out of 10, Very good, (1011)
"Awsome facility would definitely recommend"
The price is CA $108
CA $114 total
includes taxes & fees
May 16 - May 17
Motel 6 Poplar Bluff, MO
Don't see what you're looking for?
See all available properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.