Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from CA $78
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Southeast Missouri
Cabin
Family friendly
Check prices for these dates
Our top choices for Southeast Missouri hotels

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,009 reviews)
The price is CA $151
CA $170 total
includes taxes & fees
Apr 19 - Apr 20

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,001 reviews)
The price is CA $151
CA $173 total
includes taxes & fees
Apr 19 - Apr 20

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (173 reviews)
The price is CA $121
CA $137 total
includes taxes & fees
Apr 26 - Apr 27

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
The price is CA $144
CA $162 total
includes taxes & fees
Apr 26 - Apr 27

Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (538 reviews)
The price is CA $150
CA $170 total
includes taxes & fees
May 10 - May 11

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (548 reviews)
The price is CA $165
CA $186 total
includes taxes & fees
May 3 - May 4

Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (346 reviews)
The price is CA $131
CA $142 total
includes taxes & fees
Apr 20 - Apr 21

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (888 reviews)
The price is CA $151
CA $170 total
includes taxes & fees
Apr 23 - Apr 24

Echo Bluff State Park
Echo Bluff State ParkEminence
9.6 out of 10, Exceptional, (239 reviews)
The price is CA $227
CA $240 total
includes taxes & fees
Apr 29 - Apr 30

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (819 reviews)
The price is CA $128
CA $143 total
includes taxes & fees
May 10 - May 11

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,000 reviews)
The price is CA $129
CA $145 total
includes taxes & fees
Apr 26 - Apr 27

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,001 reviews)
The price is CA $116
CA $123 total
includes taxes & fees
May 10 - May 11

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (72 reviews)
The price is CA $151
CA $171 total
includes taxes & fees
May 7 - May 8

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (579 reviews)
The price is CA $138
CA $158 total
includes taxes & fees
May 3 - May 4

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (607 reviews)
The price is CA $138
CA $151 total
includes taxes & fees
Apr 26 - Apr 27

Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (981 reviews)
The price is CA $90
CA $103 total
includes taxes & fees
Apr 30 - May 1

Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.2 out of 10, Wonderful, (310 reviews)
The price is CA $148
CA $162 total
includes taxes & fees
Apr 19 - Apr 20

Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (1,003 reviews)
The price is CA $144
CA $162 total
includes taxes & fees
May 3 - May 4

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (747 reviews)
The price is CA $122
CA $132 total
includes taxes & fees
Apr 27 - Apr 28

Hampton Inn Farmington
Hampton Inn FarmingtonFarmington
8.8 out of 10, Excellent, (546 reviews)
The price is CA $181
CA $197 total
includes taxes & fees
May 10 - May 11
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (60 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Central United States attractions
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Recent Reviews in Southeast Missouri

Motel 6 Poplar Bluff, MO
10/10 Excellent
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is CA $82 per night from May 7 to May 8
CA $82
CA $89 total
May 7 - May 8
includes taxes & fees
8/10 Very Good! (1,005 reviews)
Hotels in Southeast Missouri with star rating

4 Star Hotels
2 properties
Explore a world of travel with Expedia
- Advance Hotels
- B&B in Annapolis
- Hotels with Balconies in Annapolis
- Luxury Hotels in Annapolis
- Spa Hotels in Annapolis
- Annapolis Hotels
- Lodges in Annapolis
- Farmstay in Arcadia
- B&B in Arcadia
- Cheap Hotels in Arcadia
- Luxury Hotels in Arcadia
- Arcadia Hotels
- Lodges in Arcadia
- B&B in Belleview
- Cabin Rentals in Belleview
- Belleview Hotels
- Motels in Belleview
- B&B in Bismarck
- Hotels with a Pool in Bismarck
- Luxury Hotels in Bismarck
- Bismarck Hotels
- Cheap Hotels in Black
- Luxury Hotels in Black
- Black Hotels
- Lodges in Black
- Caledonia Hotels
- Apartments in Centerville
- Centerville Hotels
- Motels in Centerville
- Cottages in Clearwater
- Lodges in Clearwater
- Cobalt Hotels
- Cheap Hotels in Des Arc
- Des Arc Hotels
- Wayne County Hotels
- Cheap Hotels in Doe Run
- Doe Run Hotels
- Lodges in Doe Run
- Hotels near Elephant Rocks State Park
- Ellington Hotels
- Rv Parks in Ellington
- B&B in Farmington
- Cabin Rentals in Farmington
- Cheap Hotels in Farmington
- Hotels with Hot Tubs in Farmington
- Pet-Friendly Hotels in Farmington
- Farmington Hotels
- Motels in Farmington
- Cheap Hotels in Fredericktown
- Pet-Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Glen Allen Hotels
- Vacation Homes in Glen Allen
- Greenville Hotels
- Lodges in Greenville
- Resorts in Greenville
- Farmstay in Iron Mountain Lake
- Ironton Hotels
- Hotels near Johnson's Shut-ins State Park
- Lodges in Knob Lick
- Leadington Hotels
- Cheap Hotels in Lesterville
- Lesterville Hotels
- Cheap Hotels in Marble Hill
- Marble Hill Hotels
- B&B in Middle Brook
- Middle Brook Hotels
- Lodges in Middle Brook
- Mill Spring Hotels
- Park Hills Hotels
- Patterson Hotels
- Lodges in Patterson
- Resorts in Patterson
- Cheap Hotels in Piedmont
- Luxury Hotels in Piedmont
- Piedmont Hotels
- Motels in Piedmont
- Hotels with Wifi in Pilot Knob
- Pilot Knob Hotels
- Lodges in Pilot Knob
- Puxico Hotels
- Cottages in St. Francois County
- Cheap Hotels in Wappapello
- Luxury Hotels in Wappapello
- Resorts in Wayne County
- Hotels with a Pool in Williamsville






















































































































