Title: Book The Best Hotels in Southeast Missouri for 2026 from CA $78 - Fully Refundable Options - Expedia.ca

[Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Bill Dillard

![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in Southeast Missouri

Cabin

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&lodging=CABIN)

Hot tub

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=HOT_TUB)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=PETS)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=POOL)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&travelerType=family_friendly)

Farm

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&lodging=AGRITOURISM)

Cottage

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&lodging=COTTAGE)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&lodging=APARTMENT)

Waterpark

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-03-18&d1=2026-03-18&endDate=2026-03-20&d2=2026-03-20&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[Mar 4 - Mar 5](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-03-04&endDate=2026-03-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 5 - Mar 6](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-03-05&endDate=2026-03-06&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-03-06&endDate=2026-03-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Southeast Missouri hotels

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Jackson MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

Jackson

9.6/10

Exceptional

(1,007 reviews)

"Breakfast was great- staff was welcoming. Will stay there again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

CA $109

CA $116 total

includes taxes & fees

Mar 12 - Mar 13

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8447c54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/ccad2677.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

[](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

Jackson

9.0/10

Wonderful

(717 reviews)

"Conveniently located, clean, friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Philip

CA $115

CA $125 total

includes taxes & fees

Mar 12 - Mar 13

[](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

Sikeston

9.4/10

Exceptional

(60 reviews)

"Clean rooms great staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

IRA

CA $138

CA $156 total

includes taxes & fees

Mar 12 - Mar 13

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/182edc95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom (Feature)](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/40930878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(1,003 reviews)

"Breakfast was very good and staff was extremely friendly and rooms were very clean "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rex

CA $130

CA $147 total

includes taxes & fees

Mar 15 - Mar 16

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/589b05b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Farmstead Hotel

[](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

Caruthersville

8.6/10

Excellent

(502 reviews)

"Clean room, very nice staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mack

CA $94

CA $106 total

includes taxes & fees

Mar 5 - Mar 6

[](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/a3a28e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Accessible (Sofa Sleeper, Tub, 2 Rooms)](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/7611279e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/fa51e0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Poplar Bluff

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

Poplar Bluff

9.2/10

Wonderful

(998 reviews)

"Great location and room "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Curtis

CA $129

CA $145 total

includes taxes & fees

Mar 15 - Mar 16

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/274be6ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Poplar Bluff

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(875 reviews)

"Very clean and well maintained hotel. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael

CA $142

CA $161 total

includes taxes & fees

Mar 20 - Mar 21

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jackpot Suite | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverview

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(516 reviews)

"The room was clean and I was able to check in a bit early."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sara

CA $122

CA $138 total

includes taxes & fees

Mar 10 - Mar 11

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/db8c9491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(1,010 reviews)

"Great place "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly

CA $137

CA $154 total

includes taxes & fees

Mar 12 - Mar 13

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Desk, blackout drapes, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/c8c9ecf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/a26b8409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/72dcdb56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/13000000/12490000/12489600/12489555/2af66ba5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fort Davidson Hotel

[](https://www.expedia.ca/Farmington-Hotels-Fort-Davidson-Hotel.h12489555.Hotel-Information)

Ironton

9.2/10

Wonderful

(175 reviews)

"Fantastic local hotel that’s right next to a state historic site. A must stay if in the area"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Graham

CA $164

CA $179 total

includes taxes & fees

Mar 6 - Mar 7

[](https://www.expedia.ca/Farmington-Hotels-Fort-Davidson-Hotel.h12489555.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,008 reviews)

"As always it was a perfect visit"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

CA $129

CA $148 total

includes taxes & fees

Mar 12 - Mar 13

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2f374258.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/1ca0c293.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/5aa6a52b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/0aa802d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Tru By Hilton Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(113 reviews)

"It was a nice stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Douglas

CA $133

CA $152 total

includes taxes & fees

Mar 12 - Mar 13

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

![Lobby lounge](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(162 reviews)

"Great hotel - super clean, fast check-in, convenient, etc. We’ll definitely stay here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Richard

CA $138

CA $156 total

includes taxes & fees

Mar 19 - Mar 20

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/ab22ad5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/0c87c756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Perryville by IHG

[](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

Perryville

9.2/10

Wonderful

(562 reviews)

"lean, updated rooms, friendly staff and great breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Linda

CA $152

CA $174 total

includes taxes & fees

Mar 8 - Mar 9

[](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(493 reviews)

"Very Clean room, friendly staff, breakfast in the morning. Will be staying again! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Affinity

CA $129

CA $146 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/2025663e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor wedding area](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/d46ce6e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/16716658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Echo Bluff State Park

[](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

Eminence

9.4/10

Exceptional

(225 reviews)

"This entire trip was inspired by Tina, a staff member. I met Tina passing through the area and she provided me with a lot of information which gave me the idea to plan a weekend trip with my wife. The lodge room we had was clean and comfortable, My wife and I had a wonderful time exploring most of the areas Tina mentioned. Thank you Tina for a wonderful inspiration for a get away. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jared

CA $202

CA $214 total

includes taxes & fees

Mar 5 - Mar 6

[](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/b0632430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![39-inch LCD TV with cable channels, TV](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/51bc20b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/62b9e8ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/bc31acbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Poplar Bluff

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

Poplar Bluff

9.4/10

Exceptional

(804 reviews)

"Would stay again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

CA $128

CA $143 total

includes taxes & fees

Mar 15 - Mar 16

[](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/a2ea280c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shared kitchen](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/66a0aee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite, Patio](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/ccb6fd0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Suite, Patio | Bathroom](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/e25e1f83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Arcadia Academy

[](https://www.expedia.ca/Arcadia-Hotels-Arcadia-Academy.h112360980.Hotel-Information)

Arcadia

9.8/10

Exceptional

(11 reviews)

"Love the charm of the room with the hard wood floors, architecture, friendly staff and great food"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Joann

CA $186

CA $202 total

includes taxes & fees

Mar 5 - Mar 6

[](https://www.expedia.ca/Arcadia-Hotels-Arcadia-Academy.h112360980.Hotel-Information)

![Hiking](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/f1b1e4d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/79ff96cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Golf](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/4175ec90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Children's play area - outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Honeysuckle Inn - Mountain View

[](https://www.expedia.ca/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

Mountain View

8.6/10

Excellent

(340 reviews)

"It was a very nice hassle free stay. I will be staying here again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michael Grey

[](https://www.expedia.ca/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/c7d69739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/20bc712d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott Cape Girardeau Downtown

[](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(490 reviews)

"Very nice hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angie

CA $171

CA $194 total

includes taxes & fees

Mar 13 - Mar 14

[](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-18&endDate=2026-03-19&regionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## 

The Annual Vacation Sale 

Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 

[Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_6058763)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in

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## Stay near popular Central United States attractions

![A huge granite boulder located in Elephant Rocks State Park](https://images.trvl-media.com/place/6058764/b46f1ef8-a151-4a6d-a0ba-117f21235d8d.jpg)

Photo by Pat Long

### Elephant Rocks State Park

4.8/5 (52 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648464)

![Panorama of Academic Hall, Southeast Missouri State University ](https://images.trvl-media.com/place/553248621554122994/3bc9a5e0-c92b-4ca4-b94a-564376156913.jpg)

### Southeast Missouri State University

4.4/5 (137 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621554122994)

![Sunrise from the duck blind. ](https://images.trvl-media.com/place/183505/9493e565-66da-46c4-8222-30a8f5da22bb.jpg)

Photo by JG Morris

### Lake Wappapello

4.3/5 (40 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648460)

![Ozark Grist Mill](https://images.trvl-media.com/place/553248621532648450/5d510200-2188-41b5-a4e9-3dcff0b33b66.jpg)

### Current River State Park

4.6/5 (15 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648450)

### Isle Casino Cape Girardeau

4.2/5 (104 reviews)

Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655780)

### Century Casino Caruthersville

3.2/5 (31 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655201)

### Alley Spring & Mill

4.8/5 (9 reviews)

Learn about the local history of Eminence with a stop at Alley Spring & Mill. While you're in the area, stroll along the riverfront. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248622784732024)

## Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

[See all hotels in Southeast Missouri](https://www.expedia.ca/Hotel-Search?startDate=2026-03-18&endDate=2026-03-19&adults=2&regionId=6058763)

![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high)

Photo by Bill Dillard

## Top Southeast Missouri Hotel Reviews

## Recent Reviews in Southeast Missouri

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Plenty of good parking. Good food choices nearby. Very comfortable rooms"

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Enjoy our stay "

[](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

10/10 Excellent

"Run very well—check in great"

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"Great stop. Great facility and food. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81_y.jpg)

### The Farmstead Hotel

10/10 Excellent

"Clean"

[](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Great stay"

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Everything and Everyone was awesome "

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg)

### Candlewood Suites Cape Girardeau by IHG

10/10 Excellent

"Yes very nice and clean "

[](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"Friendly staff."

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

## More cheap stays in Southeast Missouri

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

CA $79

CA $90 total

Mar 12 - Mar 13

includes taxes & fees

8/10 Very Good! (1,006 reviews)

[](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/22960908_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Poplar Bluff, MO

4101 Highway 67 N Poplar Bluff MO

CA $89

CA $94 total

Mar 6 - Mar 7

includes taxes & fees

8/10 Very Good! (1,003 reviews)

[](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Farmstead Hotel

778 E 3rd St Caruthersville MO

CA $94

CA $106 total

Mar 5 - Mar 6

includes taxes & fees

8.6/10 Excellent! (502 reviews)

[](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $98

CA $111 total

Mar 8 - Mar 9

includes taxes & fees

9/10 Wonderful! (1,006 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Comfort Inn Festus - St Louis South](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/26be907b_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Comfort Inn Festus - St Louis South

1303 Veterans Blvd Festus MO

CA $97

CA $114 total

Mar 22 - Mar 23

includes taxes & fees

7.8/10 Good! (919 reviews)

[](https://expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

CA $129

CA $146 total

Mar 29 - Mar 30

includes taxes & fees

9/10 Wonderful! (493 reviews)

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

## Hotels in Southeast Missouri with star rating

![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg)

4 Star Hotels

2 properties

[](https://expedia.ca/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels)

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

53 properties

[](https://expedia.ca/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

142 properties

[](https://expedia.ca/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels)

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- [Book Hotels in Southeast Missouri on Expedia.com ](https://www.expedia.com/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)

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