Title: Book The Best Hotels in Southeast Missouri for 2025 from CA $85 - Fully Refundable Options - Expedia.ca

  

[Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides)

![The Current River flows through the Ozark National Scenic Riverway through the mountains of Missouri](https://images.trvl-media.com/place/553248635976196024/558eb86b-b1ac-4ef2-8a0c-6bebbb1e2aae.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find hotels in Southeast Missouri, MO from CA $85

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## Go beyond your typical stay in Southeast Missouri

Cabin

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&lodging=CABIN)

Hot tub

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&amenities=HOT_TUB)

Farm

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&lodging=AGRITOURISM)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&amenities=PETS)

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&travelerType=family_friendly)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&amenities=POOL)

Cottage

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&lodging=COTTAGE)

Apart­ment

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&lodging=APARTMENT)

Waterpark

[](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America&regionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-10-12&d1=2025-10-12&endDate=2025-10-14&d2=2025-10-14&amenities=WATER_PARK)

## Check prices for these dates

Tonight

[Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-09-28&endDate=2025-09-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-09-29&endDate=2025-09-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Compare 603 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

![Exterior](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/3b6f469d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/d9c54765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/3ec0c384.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Cabin, 2 Queen Beds | Private kitchen](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/aa026ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Postcard Cabins St. Francois

French Village

9.8/10

Exceptional

(36)

"Peaceful, beautiful stay. "

CA $124

CA $186 total

includes taxes & fees

Sep 29 - Sep 30

[](https://www.expedia.ca/French-Village-Hotels-Postcard-Cabins-St-Francois.h110550817.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Jackson MO

Jackson

9.6/10

Exceptional

(1018)

"Was a clean room, nice staff, good parking "

CA $125

CA $133 total

includes taxes & fees

Oct 2 - Oct 3

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/d42a6e3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Perryville by IHG

Perryville

9.4/10

Exceptional

(512)

"The property was well maintained. Checkin was fast and efficient. Room was clean and comfortable and pillows were great. Breakfast was good. "

CA $118

CA $136 total

includes taxes & fees

Oct 19 - Oct 20

[](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Farmstead Hotel

Caruthersville

8.8/10

Excellent

(421)

"Great place. "

CA $104

CA $119 total

includes taxes & fees

Oct 1 - Oct 2

[](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d234bb55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/3a2c35d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking, Refrigerator](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d7244881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/5d1ea140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Farmington

Farmington

8.0/10

Very good

(588)

"Location "

CA $83

CA $94 total

includes taxes & fees

Oct 5 - Oct 6

[](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/284f2de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/a085469e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f32a343b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Cape Girardeau West

Cape Girardeau

9.0/10

Wonderful

(1012)

"My room was clean and I was very close to shopping and restaurants. I really enjoyed my stay there."

CA $98

CA $110 total

includes taxes & fees

Oct 2 - Oct 3

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/7e9b49ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/23ae42af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/c41116cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Baymont Inn and Suites by Wyndham Farmington, MO

Farmington

8.0/10

Very good

(1022)

"Great location"

CA $75

CA $85 total

includes taxes & fees

Oct 24 - Oct 25

[](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars)](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

8.8/10

Excellent

(626)

"Friendly staff, very clean and pleasant environment."

CA $117

CA $127 total

includes taxes & fees

Sep 30 - Oct 1

[](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/3ea7ebcc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/4d9ecdd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/fc42ec39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40138/705e1bff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn Festus - St Louis South

Festus

8.0/10

Very good

(884)

"The stay and food "

CA $110

CA $129 total

includes taxes & fees

Sep 30 - Oct 1

[](https://www.expedia.ca/Farmington-Hotels-Comfort-Inn-Festus-St-Louis-South.h40138.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/7f26b79f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible)](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/4e8bbceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/504b77a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Perryville

Perryville

8.4/10

Very good

(913)

" Love the stay and staff was great "

CA $101

CA $115 total

includes taxes & fees

Oct 5 - Oct 6

[](https://www.expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information)

![Business centre](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/05f90b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/356238c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/c56432e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Cape Girardeau

Cape Girardeau

9.4/10

Exceptional

(1004)

"Excellent place. Really friendly staff"

CA $125

CA $141 total

includes taxes & fees

Oct 2 - Oct 3

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

9.6/10

Exceptional

(1023)

"Very nice hotel and nice staff "

CA $125

CA $141 total

includes taxes & fees

Oct 2 - Oct 3

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/a5281c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/b4e45ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/f46408d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Hayti Caruthersville

Hayti

9.4/10

Exceptional

(1008)

"Nice place for a over night stay would recamend."

CA $131

CA $149 total

includes taxes & fees

Oct 5 - Oct 6

[](https://www.expedia.ca/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/e66aa4eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/e9e97147.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/6e70629c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Festus

8.0/10

Very good

(859)

"Great easy place to stay. Good location."

CA $154

CA $176 total

includes taxes & fees

Oct 5 - Oct 6

[](https://www.expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/db5aadc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Children's play area - outdoor](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/104061b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Echo Bluff State Park

Eminence

9.4/10

Exceptional

(209)

"Beautiful location…excellent service and facilities / grounds were clean and well kept."

CA $197

CA $209 total

includes taxes & fees

Oct 28 - Oct 29

[](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub)](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

Sikeston

9.4/10

Exceptional

(1014)

"Everything was extremely nice"

CA $125

CA $144 total

includes taxes & fees

Oct 5 - Oct 6

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/da4fe5e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/2df4267b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/ee6292b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Cape Girardeau Near the Medical Center

Cape Girardeau

9.0/10

Wonderful

(1010)

"Staff was friendly, room was clean, good location, good rate."

CA $98

CA $110 total

includes taxes & fees

Oct 2 - Oct 3

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information)

![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/2cf60fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/05c7ee11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laundry room](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/b3da6b1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/79923507.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Potosi

Potosi

7.0/10

Good

(367)

"The room was very good for the price."

CA $73

CA $80 total

includes taxes & fees

Oct 26 - Oct 27

[](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Potosi.h158717.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/de11c650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverview

Cape Girardeau

9.4/10

Exceptional

(426)

"Location was perfect for family weekend!"

CA $172

CA $194 total

includes taxes & fees

Sep 29 - Sep 30

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/720261dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/6d872386.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/2d71c942.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/w7137h4758x0y0-7ae60078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Festus

9.4/10

Exceptional

(685)

"Great place to stay!"

CA $203

CA $233 total

includes taxes & fees

Oct 5 - Oct 6

[](https://www.expedia.ca/Farmington-Hotels-Holiday-Inn-Express-Hotel-Suites-FESTUS-SOUTH-ST-LOUIS.h2699317.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13&regionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Great weekend hotel deals in Southeast Missouri, MO

Showing deals for:Oct 10 - Oct 12

![Mini-golf](https://images.trvl-media.com/lodging/49000000/48820000/48818100/48818085/e6890a76.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Wilderness Lodge

Lesterville

9.4/10Exceptional (34 reviews)

10% off

CA $288

CA $610 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=48818085&adults=2)

![Standard Room, 1 Queen Bed, Non Smoking, Garden View](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/fc499141.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Rockwood Inn

Cape Girardeau

10/10Exceptional (16 reviews)

13% off

CA $268

CA $606 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=105486893&adults=2)

![Standard Double Room, 2 Queen Beds, Transfer Shower](https://images.trvl-media.com/lodging/112000000/111410000/111402100/111402094/690c1aa2.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Century Casino & Hotel Caruthersville

Caruthersville

8.4/10Very good (67 reviews)

14% off

CA $161

CA $367 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=111402094&adults=2)

![BBQ/picnic area](https://images.trvl-media.com/lodging/48000000/47040000/47039600/47039515/708e4b63.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Current River Inn

Van Buren

8.2/10Very good (156 reviews)

13% off

CA $124

CA $269 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=47039515&adults=2)

![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Hampton Inn Poplar Bluff

Poplar Bluff

9.4/10Exceptional (764 reviews)

15% off

CA $156

CA $349 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=9827793&adults=2)

![Children's play area - outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Honeysuckle Inn - Mountain View

Mountain View

8.6/10Excellent (312 reviews)

15% off

CA $149

CA $324 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=42093410&adults=2)

![Exterior](https://images.trvl-media.com/lodging/4000000/3600000/3594600/3594547/3eea0c0d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Hampton Inn Farmington

Farmington

8.8/10Excellent (504 reviews)

15% off

CA $228

CA $519 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=3594547&adults=2)

![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/13000000/12590000/12582100/12582009/57db158c.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Shepherd Mountain Inn

Ironton

9.4/10Exceptional (300 reviews)

10% off

CA $186

CA $405 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=12582009&adults=2)

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### The Riverview

Cape Girardeau

9.4/10Exceptional (426 reviews)

10% off

CA $209

CA $473 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=105081384&adults=2)

![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### The Farmstead Hotel

Caruthersville

8.8/10Excellent (421 reviews)

14% off

CA $114

CA $260 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=89303450&adults=2)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Hampton Inn Sikeston

Sikeston

8.8/10Excellent (400 reviews)

15% off

CA $140

CA $316 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=25178175&adults=2)

![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Jackson

8.8/10Excellent (626 reviews)

15% off

CA $144

CA $313 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=53348099&adults=2)

![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### Tru By Hilton Cape Girardeau

Cape Girardeau

9.6/10Exceptional (70 reviews)

15% off

CA $171

CA $388 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=111590879&adults=2)

![Premier Room, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high)

### New Orleans Inn Portageville

Portageville

8.0/10Very good (699 reviews)

13% off

CA $88

CA $191 total

includes taxes & fees

[](https://www.expedia.ca/Hotel-Search?startDate=2025-10-10&endDate=2025-10-12&selected=38979739&adults=2)

![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg)

Save an average of 15% on thousands of hotels when you're signed in

[Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)

## Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

[See all hotels in Southeast Missouri](https://www.expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13&adults=2&regionId=6058763)

![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=899&h=541&p=1&q=high)

### Stay near popular Southeast Missouri attractions

[](https://expedia.ca/Elephant-Rocks-State-Park-Hotels.0-l553248621532648464-0.Travel-Guide-Filter-Hotels)

![Elephant Rocks State Park](https://mediaim.expedia.com/destination/2/86e50eabc9d5592586815e7688be64ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648464)

[](https://expedia.ca/Rocky-Falls-Hotels.0-l553248621532648456-0.Travel-Guide-Filter-Hotels)

![Rocky Falls](https://mediaim.expedia.com/destination/2/f2325d7f040c776e314b23ad9fbdb813.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648456)

[](https://expedia.ca/Lake-Wappapello-Hotels.0-l553248621532648460-0.Travel-Guide-Filter-Hotels)

![Lake Wappapello](https://mediaim.expedia.com/destination/2/a6135d9f1717ada26d9944dd5bb40459.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh)

#### Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648460)

[](https://expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels)

#### Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621554122994)

[](https://expedia.ca/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels)

#### Century Casino Caruthersville

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655201)

[](https://expedia.ca/Current-River-State-Park-Hotels.0-l553248621532648450-0.Travel-Guide-Filter-Hotels)

#### Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

[See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532648450)

## More cheap stays in Southeast Missouri

![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

CA $75

CA $85 total

Oct 24 - Oct 25

includes taxes & fees

8/10 Very Good! (1,020 reviews)

[](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information)

![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Riverview

777 Main St, Cape Girardeau, MO

CA $172

CA $194 total

Sep 29 - Sep 30

includes taxes & fees

9.2/10 Wonderful! (426 reviews)

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Farmstead Hotel

778 E 3rd St, Caruthersville, MO

CA $104

CA $119 total

Oct 1 - Oct 2

includes taxes & fees

8.6/10 Excellent! (421 reviews)

[](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![Pear Tree Inn Cape Girardeau Near the Medical Center](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau Near the Medical Center

3248 William St, Cape Girardeau, MO

CA $98

CA $110 total

Oct 2 - Oct 3

includes taxes & fees

8.8/10 Excellent! (1,008 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information)

![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Motel 6 Poplar Bluff, MO

4101 Highway 67 N, Poplar Bluff, MO

CA $110

CA $116 total

Sep 29 - Sep 30

includes taxes & fees

7.8/10 Good! (1,016 reviews)

[](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy, Cape Girardeau, MO

CA $98

CA $110 total

Oct 2 - Oct 3

includes taxes & fees

9/10 Wonderful! (1,012 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

## Recent reviews of Southeast Missouri hotels

![The Riverview](//images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg)

### The Riverview

5/5 Excellent

"Great view."

A verified traveller stayed at The Riverview

Posted 11 hours ago

[](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Courtyard by Marriott Cape Girardeau Downtown](//images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg)

### Courtyard by Marriott Cape Girardeau Downtown

5/5 Excellent

"Well lit parking lot "

A verified traveller stayed at Courtyard by Marriott Cape Girardeau Downtown

Posted 23 hours ago

[](https://expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![Best Western Plus Sikeston](//images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston

5/5 Excellent

"Very convenient and great breakfast "

A verified traveller stayed at Best Western Plus Sikeston

Posted 1 day ago

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

5/5 Excellent

"Don’t even bother staying anywhere else. Hands down the best in Sikeston."

A verified traveller stayed at Drury Inn & Suites Sikeston, MO

Posted 1 day ago

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Holiday Inn Express & Suites Perryville by IHG](//images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg)

### Holiday Inn Express & Suites Perryville by IHG

5/5 Excellent

"The property was well maintained. Checkin was fast and efficient. Room was clean and comfortable and pillows were great. Breakfast was good. "

A verified traveller stayed at Holiday Inn Express & Suites Perryville by IHG

Posted 1 day ago

[](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information)

![The Farmstead Hotel](//images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg)

### The Farmstead Hotel

5/5 Excellent

"Very good overall "

A verified traveller stayed at The Farmstead Hotel

Posted 1 day ago

[](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Festus - St. Louis South](//images.trvl-media.com/lodging/1000000/50000/42200/42120/1887aa70_y.jpg)

### La Quinta Inn & Suites by Wyndham Festus - St. Louis South

5/5 Excellent

"Great stay! Friendly staff"

A verified traveller stayed at La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Posted 2 days ago

[](https://expedia.ca/Farmington-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Festus-St-Louis-South.h42120.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](//images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

5/5 Excellent

"Everything was clean and looked newly renovated. Staff was friendly. Parking was convenient and the area seemed safe. "

A verified traveller stayed at Pear Tree Inn Cape Girardeau West

Posted 2 days ago

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](//images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

5/5 Excellent

"My partner and I were in town for a family wedding and stayed for 3 nights. The staff at this hotel were amazing! They were, over the top, friendly and helpful with anything we needed. They allowed us to gather with family outside on the patio and checked on us several times. The room was clean, the bed was super comfortable, breakfast was great and we loved the patio area. Overall, it was a wonderful experience!"

A verified traveller stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Posted 3 days ago

[](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

## Frequently asked questions

### Can I cancel my hotel reservation on Expedia?

> Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Southeast Missouri hotel for you.

### How can I save on a Southeast Missouri hotel booking with Expedia?

> Members always get our best prices. Find our best Southeast Missouri hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.

### How much is the nightly rate at a Southeast Missouri hotel?

> Prices for hotels in Southeast Missouri often vary, but you can find a great deal from CA $85 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

## Explore a world of travel with Expedia

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-   [Advance Hotels](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels)
-   [B&B in Annapolis](https://www.expedia.ca/Annapolis-Bed-And-Breakfast.d6282465-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Hotels with Balconies in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Hotels-With-Balconies.0-0-d6282465-tHotelswithBalconies.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Luxury-Hotel.0-0-d6282465-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Spa-Hotel.0-0-d6282465-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Annapolis Hotels](https://www.expedia.ca/Annapolis-Hotels.d6282465.Travel-Guide-Hotels)
-   [Lodges in Annapolis](https://www.expedia.ca/Annapolis-Lodges.d6282465-aaLodges.Travel-Guide-Accommodation)
-   [Farmstay in Arcadia](https://www.expedia.ca/Arcadia-Agritourism.d6346857-aaAgritourism.Travel-Guide-Accommodation)
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-   [Arcadia Hotels](https://www.expedia.ca/Arcadia-Hotels.d6346857.Travel-Guide-Hotels)
-   [Lodges in Arcadia](https://www.expedia.ca/Arcadia-Lodges.d6346857-aaLodges.Travel-Guide-Accommodation)
-   [B&B in Belleview](https://www.expedia.ca/Belleview-Bed-And-Breakfast.d3000444413-aaBedAndBreakfast.Travel-Guide-Accommodation)
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-   [Motels in Belleview](https://www.expedia.ca/Belleview-Motels.d3000444413-aaMotels.Travel-Guide-Accommodation)
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-   [Hotels with a Pool in Bismarck](https://www.expedia.ca/Bismarck-Hotels-Hotel-With-Pool.0-0-d553248634983538264-tHotelwithPool.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Bismarck](https://www.expedia.ca/Bismarck-Hotels-Luxury-Hotel.0-0-d553248634983538264-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Bismarck Hotels](https://www.expedia.ca/Bismarck-Hotels.d553248634983538264.Travel-Guide-Hotels)
-   [Cheap Hotels in Black](https://www.expedia.ca/Black-Hotels-Cheap-Hotels.0-0-d3000444470-tCheapHotels.Travel-Guide-Filter-Hotels)
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-   [Black Hotels](https://www.expedia.ca/Black-Hotels.d3000444470.Travel-Guide-Hotels)
-   [Lodges in Black](https://www.expedia.ca/Black-Lodges.d3000444470-aaLodges.Travel-Guide-Accommodation)
-   [Caledonia Hotels](https://www.expedia.ca/Caledonia-Hotels.d6359344.Travel-Guide-Hotels)
-   [Apartments in Centerville](https://www.expedia.ca/Centerville-Apartments.d553248634983078632-aaApartments.Travel-Guide-Accommodation)
-   [Centerville Hotels](https://www.expedia.ca/Centerville-Hotels.d553248634983078632.Travel-Guide-Hotels)
-   [Motels in Centerville](https://www.expedia.ca/Centerville-Motels.d553248634983078632-aaMotels.Travel-Guide-Accommodation)
-   [Cottages in Clearwater](https://www.expedia.ca/Clearwater-Cottages.d553248635975868303-aaCottages.Travel-Guide-Accommodation)
-   [Lodges in Clearwater](https://www.expedia.ca/Clearwater-Lodges.d553248635975868303-aaLodges.Travel-Guide-Accommodation)
-   [Cobalt Hotels](https://www.expedia.ca/Cobalt-Hotels.d553248634983153223.Travel-Guide-Hotels)
-   [Cheap Hotels in Des Arc](https://www.expedia.ca/Des-Arc-Hotels-Cheap-Hotels.0-0-d553248634983251690-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Des Arc Hotels](https://www.expedia.ca/Des-Arc-Hotels.d553248634983251690.Travel-Guide-Hotels)
-   [Wayne County Hotels](https://www.expedia.ca/Destinations-In-Wayne-County.d553248635976433836.Hotel-Destinations)
-   [Cheap Hotels in Doe Run](https://www.expedia.ca/Doe-Run-Hotels-Cheap-Hotels.0-0-d3000349343-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Doe Run Hotels](https://www.expedia.ca/Doe-Run-Hotels.d3000349343.Travel-Guide-Hotels)
-   [Lodges in Doe Run](https://www.expedia.ca/Doe-Run-Lodges.d3000349343-aaLodges.Travel-Guide-Accommodation)
-   [Hotels near Elephant Rocks State Park](https://www.expedia.ca/Elephant-Rocks-State-Park-Hotels.0-l553248621532648464-0.Travel-Guide-Filter-Hotels)
-   [Ellington Hotels](https://www.expedia.ca/Ellington-Hotels.d3000444859.Travel-Guide-Hotels)
-   [Rv Parks in Ellington](https://www.expedia.ca/Ellington-RV-Parks.d3000444859-aaRVParks.Travel-Guide-Accommodation)
-   [B&B in Farmington](https://www.expedia.ca/Farmington-Bed-And-Breakfast.d6058764-aaBedAndBreakfast.Travel-Guide-Accommodation)
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-   [Cheap Hotels in Farmington](https://www.expedia.ca/Farmington-Hotels-Cheap-Hotels.0-0-d6058764-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Farmington](https://www.expedia.ca/Farmington-Hotels-Hotels-With-Hot-Tubs.0-0-d6058764-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
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-   [Farmington Hotels](https://www.expedia.ca/Farmington-Hotels.d6058764.Travel-Guide-Hotels)
-   [Motels in Farmington](https://www.expedia.ca/Farmington-Motels.d6058764-aaMotels.Travel-Guide-Accommodation)
-   [Cheap Hotels in Fredericktown](https://www.expedia.ca/Fredericktown-Hotels-Cheap-Hotels.0-0-d55114-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Fredericktown](https://www.expedia.ca/Fredericktown-Hotels-Pet-Friendly-Hotel.0-0-d55114-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Fredericktown Hotels](https://www.expedia.ca/Fredericktown-Hotels.d55114.Travel-Guide-Hotels)
-   [Glen Allen Hotels](https://www.expedia.ca/Glen-Allen-Hotels.d553248634983455025.Travel-Guide-Hotels)
-   [Vacation Homes in Glen Allen](https://www.expedia.ca/Glen-Allen-Private-Vacation-Homes.d553248634983455025-aaPrivateVacationHomes.Travel-Guide-Accommodation)
-   [Greenville Hotels](https://www.expedia.ca/Greenville-Hotels.d553248634983564794.Travel-Guide-Hotels)
-   [Lodges in Greenville](https://www.expedia.ca/Greenville-Lodges.d553248634983564794-aaLodges.Travel-Guide-Accommodation)
-   [Resorts in Greenville](https://www.expedia.ca/Greenville-Resort-Hotels.d553248634983564794-aaResortHotels.Travel-Guide-Accommodation)
-   [Farmstay in Iron Mountain Lake](https://www.expedia.ca/Iron-Mountain-Lake-Agritourism.d553248634983534888-aaAgritourism.Travel-Guide-Accommodation)
-   [Ironton Hotels](https://www.expedia.ca/Ironton-Hotels.d6053585.Travel-Guide-Hotels)
-   [Hotels near Johnson's Shut-ins State Park](https://www.expedia.ca/Johnsons-Shut-Ins-State-Park-Hotels.0-l553248621555612544-0.Travel-Guide-Filter-Hotels)
-   [Lodges in Knob Lick](https://www.expedia.ca/Knob-Lick-Lodges.d553248635975872774-aaLodges.Travel-Guide-Accommodation)
-   [Leadington Hotels](https://www.expedia.ca/Leadington-Hotels.d553248634983521787.Travel-Guide-Hotels)
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-   [Cheap Hotels in Marble Hill](https://www.expedia.ca/Marble-Hill-Hotels-Cheap-Hotels.0-0-d3000445212-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Marble Hill Hotels](https://www.expedia.ca/Marble-Hill-Hotels.d3000445212.Travel-Guide-Hotels)
-   [B&B in Middle Brook](https://www.expedia.ca/Middle-Brook-Bed-And-Breakfast.d3000445241-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Middle Brook Hotels](https://www.expedia.ca/Middle-Brook-Hotels.d3000445241.Travel-Guide-Hotels)
-   [Lodges in Middle Brook](https://www.expedia.ca/Middle-Brook-Lodges.d3000445241-aaLodges.Travel-Guide-Accommodation)
-   [Mill Spring Hotels](https://www.expedia.ca/Mill-Spring-Hotels.d553248634983294338.Travel-Guide-Hotels)
-   [Park Hills Hotels](https://www.expedia.ca/Park-Hills-Hotels.d183485.Travel-Guide-Hotels)
-   [Patterson Hotels](https://www.expedia.ca/Patterson-Hotels.d553248635975853657.Travel-Guide-Hotels)
-   [Lodges in Patterson](https://www.expedia.ca/Patterson-Lodges.d553248635975853657-aaLodges.Travel-Guide-Accommodation)
-   [Resorts in Patterson](https://www.expedia.ca/Patterson-Resort-Hotels.d553248635975853657-aaResortHotels.Travel-Guide-Accommodation)
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-   [Luxury Hotels in Piedmont](https://www.expedia.ca/Piedmont-Hotels-Luxury-Hotel.0-0-d3000445413-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Piedmont Hotels](https://www.expedia.ca/Piedmont-Hotels.d3000445413.Travel-Guide-Hotels)
-   [Motels in Piedmont](https://www.expedia.ca/Piedmont-Motels.d3000445413-aaMotels.Travel-Guide-Accommodation)
-   [Hotels with Wifi in Pilot Knob](https://www.expedia.ca/Pilot-Knob-Hotels-Hotel-With-Wifi.0-0-d3000008143-tHotelwithwifi.Travel-Guide-Filter-Hotels)
-   [Pilot Knob Hotels](https://www.expedia.ca/Pilot-Knob-Hotels.d3000008143.Travel-Guide-Hotels)
-   [Lodges in Pilot Knob](https://www.expedia.ca/Pilot-Knob-Lodges.d3000008143-aaLodges.Travel-Guide-Accommodation)
-   [Puxico Hotels](https://www.expedia.ca/Puxico-Hotels.d553248634983343452.Travel-Guide-Hotels)
-   [Cottages in St. Francois County](https://www.expedia.ca/St-Francois-County-Cottages.d553248635083907787-aaCottages.Travel-Guide-Accommodation)
-   [Cheap Hotels in Wappapello](https://www.expedia.ca/Wappapello-Hotels-Cheap-Hotels.0-0-d183505-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Wappapello](https://www.expedia.ca/Wappapello-Hotels-Luxury-Hotel.0-0-d183505-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Resorts in Wayne County](https://www.expedia.ca/Wayne-County-Resort-Hotels.d553248635976433836-aaResortHotels.Travel-Guide-Accommodation)
-   [Hotels with a Pool in Williamsville](https://www.expedia.ca/Williamsville-Hotels-Hotel-With-Pool.0-0-d553248634983506457-tHotelwithPool.Travel-Guide-Filter-Hotels)

-   [Flights to Farmington](https://www.expedia.ca/Cheap-Flights-To-Farmington.d6058764.Travel-Guide-Flights)
-   [Flights to Fredericktown](https://www.expedia.ca/Cheap-Flights-To-Fredericktown.d55114.Travel-Guide-Flights)
-   [Flights to Ironton](https://www.expedia.ca/Cheap-Flights-To-Ironton.d6053585.Travel-Guide-Flights)
-   [Flights from Belleview](https://www.expedia.ca/lp/flights/3000444413/flights-from-belleview)
-   [Flights from Black](https://www.expedia.ca/lp/flights/3000444470/flights-from-black)
-   [Flights from Ellington](https://www.expedia.ca/lp/flights/3000444859/flights-from-ellington)
-   [Flights from Centerville](https://www.expedia.ca/lp/flights/553248634983078632/flights-from-centerville)

-   [Visit Fredericktown](https://www.expedia.ca/Fredericktown.dx55114)
-   [K Bridge Recreation Area](https://www.expedia.ca/K-Bridge-Recreation-Area-Annapolis.d6282501.Vacation-Attraction)
-   [Wappapello Vacations](https://www.expedia.ca/Wappapello.d183505.Destination-Travel-Guides)

-   [Avis Rental Cars in Farmington](https://www.expedia.ca/Avis-Car-Rentals-In-Farmington.d6058764-c41.Car-Rental-Guide-Suppliers)
-   [Hertz Rental Cars in Marble Hill](https://www.expedia.ca/Hertz-Car-Rentals-In-Marble-Hill.d3000445212-c40.Car-Rental-Guide-Suppliers)
-   [National Car Rental Rental Cars in Fredericktown](https://www.expedia.ca/National-Car-Rental-Car-Rentals-In-Fredericktown.d55114-c42.Car-Rental-Guide-Suppliers)

-   [Marble Hill Vacation Rentals](https://www.expedia.ca/Marble-Hill-Vacation-Rentals.d3000445212.Travel-Guide-VacationRentals)

-   [Book Hotels in Southeast Missouri on Expedia.com](https://www.expedia.com/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)

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