Title: Book The Best Hotels in Southeast Missouri, MO for 2026 from CA $84 - Fully Refundable Options - Expedia.ca [Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard ![](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Southeast Missouri Cabin [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&lodging=CABIN) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&amenities=HOT_TUB) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&travelerType=family_friendly) Pool [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&amenities=POOL) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&lodging=COTTAGE) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&amenities=PETS) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&lodging=APARTMENT) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&amenities=WATER_PARK) Farm [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2026-01-31&d1=2026-01-31&endDate=2026-02-02&d2=2026-02-02&lodging=AGRITOURISM) ## Check prices for these dates Tonight [Jan 17 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-01-17&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 18 - Jan 19](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-01-18&endDate=2026-01-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 23 - Jan 25](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 30 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southeast Missouri hotels ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,007 reviews) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $125 CA $141 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/132cb18c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1,002 reviews) "Room was spotless, staff was SO kind. 5 day trip, stayed in 4 different hotels & this one was BY FAR the nicest. Breakfast was fabulous. 10 out of 10 recommend!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda CA $115 CA $122 total includes taxes & fees Jan 20 - Jan 21 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Sikeston [](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) Sikeston 9.2/10 Wonderful (49 reviews) "THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) AHMAD CA $140 CA $159 total includes taxes & fees Jan 24 - Jan 25 [](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/589b05b0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Farmstead Hotel [](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) Caruthersville 8.8/10 Excellent (472 reviews) "Clean room, very nice staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mack CA $106 CA $120 total includes taxes & fees Jan 30 - Jan 31 [](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/2025663e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/ca85d578.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/16716658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Echo Bluff State Park [](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) Eminence 9.4/10 Exceptional (219 reviews) "The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joanne CA $214 CA $227 total includes taxes & fees Jan 26 - Jan 27 [](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/b034b164.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/fa51e0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Refrigerator & Microwave (Sofabed, 2 Rooms, Tub)](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/7611279e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/41600/41515/239bd50a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) Poplar Bluff 9.2/10 Wonderful (979 reviews) "Great location and room " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Curtis CA $146 CA $165 total includes taxes & fees Feb 13 - Feb 14 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Drury-Inn-Suites-Poplar-Bluff.h41515.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (491 reviews) " Excellent stay. Will come again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) joydeep CA $131 CA $148 total includes taxes & fees Jan 19 - Jan 20 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2f374258.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/1ca0c293.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2e166a9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/0aa802d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau [](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (105 reviews) "It was a nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Douglas CA $124 CA $142 total includes taxes & fees Jan 27 - Jan 28 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/8f51ba4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/0a692e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/838b706d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/1e3aea9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Poplar Bluff by IHG [](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) Poplar Bluff 8.8/10 Excellent (714 reviews) "Amazing place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mladen CA $153 CA $173 total includes taxes & fees Jan 24 - Jan 25 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/59c49f31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f32a343b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f29b08e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/05842f9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) Cape Girardeau 9.0/10 Wonderful (1,000 reviews) "Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen CA $97 CA $111 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Blackout drapes, free WiFi, bed sheets](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/5b675ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/236a63e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchenette](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/a8a4b0a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/6388963b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Poplar Bluff, MO [](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) Poplar Bluff 7.8/10 Good (1,000 reviews) "Clean room/friendly staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sloan CA $79 CA $84 total includes taxes & fees Jan 20 - Jan 21 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f90ef358.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Sikeston, MO [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) Sikeston 9.4/10 Exceptional (1,003 reviews) "Breakfast was excellent, and fresh. Room was clean and spacious. We enjoyed our brief stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nicole CA $131 CA $150 total includes taxes & fees Jan 22 - Jan 23 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (151 reviews) "Great hotel - super clean, fast check-in, convenient, etc. We’ll definitely stay here again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richard CA $122 CA $138 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/2b5bb07a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/0c87c756.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/1d457549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG [](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) Perryville 9.2/10 Wonderful (551 reviews) "lean, updated rooms, friendly staff and great breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $127 CA $145 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Hiking](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/f1b1e4d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children's play area - outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/603f552a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/79ff96cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Honeysuckle Inn - Mountain View [](https://www.expedia.ca/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information) Mountain View 8.6/10 Excellent (336 reviews) "Staff was very friendly." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joyce CA $125 CA $136 total includes taxes & fees Jan 25 - Jan 26 [](https://www.expedia.ca/Mountain-View-Hotels-Honeysuckle-Inn-Mountain-View.h42093410.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) Sikeston 9.0/10 Wonderful (463 reviews) "Very clean and super friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Katherine CA $141 CA $159 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 By Wyndham Marston [](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) Marston 8.0/10 Very good (43 reviews) "Great hotel, great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dmitry CA $78 CA $89 total includes taxes & fees Jan 18 - Jan 19 [](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/bf46ac12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/cc7b340b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/8b122520.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (865 reviews) "The size of the room. The staff were great. The room was very clean. Will definitely stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brenda CA $144 CA $163 total includes taxes & fees Jan 31 - Feb 1 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/b0632430.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/bc31acbe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio, 1 King Bed, Non Smoking, Kitchenette](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/62b9e8ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![39-inch LCD TV with cable channels, TV](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/51bc20b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Poplar Bluff [](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) Poplar Bluff 9.4/10 Exceptional (798 reviews) "Staff was kind and provided a lot of information during check out." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shea CA $150 CA $168 total includes taxes & fees Feb 14 - Feb 15 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Hampton-Inn-Poplar-Bluff-Mo.h9827793.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/c7d69739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Cape Girardeau Downtown [](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (480 reviews) "Very nice hotel within walking distance to many good restaurants " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicky CA $174 CA $197 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-01-31&endDate=2026-02-01®ionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Great weekend hotel deals in Southeast Missouri, MO ### Showing deals for:**Jan 30 - Feb 1** ### Image gallery for Echo Bluff State Park ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/2025663e.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Echo Bluff State Park Eminence **9.4/10**Exceptional (219 reviews) 7% off CA $252 CA $534 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=15487684&adults=2) ### Image gallery for Fairfield Inn & Suites by Marriott Poplar Bluff ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Fairfield Inn & Suites by Marriott Poplar Bluff Poplar Bluff **9.4/10**Exceptional (865 reviews) 15% off CA $148 CA $335 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=28807257&adults=2) ### Image gallery for Honeysuckle Inn - Mountain View ![Hiking](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/f1b1e4d5.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Honeysuckle Inn - Mountain View Mountain View **8.6/10**Excellent (336 reviews) 15% off CA $131 CA $285 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=42093410&adults=2) ### Image gallery for Private scenic Ozark Mountain retreat near beautiful Current River; sleeps 1-10! ![Interior](https://images.trvl-media.com/lodging/84000000/83530000/83521000/83520985/6e7164bd.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Private scenic Ozark Mountain retreat near beautiful Current River; sleeps 1-10! Van Buren **10/10**Exceptional (22 reviews) 10% off CA $532 CA $1,567 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=83520985&adults=2) ### Image gallery for ⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4 ![Dining](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/1f2f3f97.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### ⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4 Ste. Genevieve **10/10**Exceptional (19 reviews) 10% off CA $160 CA $465 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=106052541&adults=2) ### Image gallery for Mountain View at Pickle & Perk ![1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/106000000/105790000/105790000/105789927/b5551dec.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Mountain View at Pickle & Perk Ironton **10/10**Exceptional (19 reviews) 10% off CA $187 CA $483 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=105789927&adults=2) ### Image gallery for The Weber Farm - Enjoy a beautiful 100 acre farm! ![Exterior](https://images.trvl-media.com/lodging/43000000/42540000/42533900/42533836/aa5618ca.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Weber Farm - Enjoy a beautiful 100 acre farm! Frohna **10/10**Exceptional (32 reviews) 10% off CA $188 CA $518 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=42533836&adults=2) ### Image gallery for Charming 3-bedroom house in delightful Advance with AC, WiFi ![Exterior detail](https://images.trvl-media.com/lodging/104000000/103370000/103362500/103362449/a162857d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Charming 3-bedroom house in delightful Advance with AC, WiFi Advance **10/10**Exceptional (5 reviews) 10% off CA $203 CA $596 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=103362449&adults=2) ### Image gallery for La Quinta Inn & Suites by Wyndham Festus - St. Louis South ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42120/6e70629c.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### La Quinta Inn & Suites by Wyndham Festus - St. Louis South Festus **8.0/10**Very good (905 reviews) Member Price available CA $161 CA $369 total Total includes taxes and fees [Sign in for Member Price ](https://www.expedia.ca/user/signin?uurl=e3id%3Dredr%26rurl%3D%2FHotel-Search%3FstartDate%3D2026-01-30%26endDate%3D2026-02-01%26selected%3D42120%26adults%3D2) [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=42120&adults=2) ### Image gallery for Cabin 1 queen bed with a separate bedroom with a double bed ![Interior](https://images.trvl-media.com/lodging/70000000/69810000/69804700/69804672/3d5d21be.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Cabin 1 queen bed with a separate bedroom with a double bed Piedmont **8.0/10**Very good (4 reviews) 10% off CA $188 CA $480 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=69804672&adults=2) ### Image gallery for Bluebird Meadows W/hot Tub and Pool Special ![Outdoor pool](https://images.trvl-media.com/lodging/71000000/70560000/70553000/70552948/5d7f6a2c.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Bluebird Meadows W/hot Tub and Pool Special Park Hills **10/10**Exceptional (2 reviews) 10% off CA $512 CA $1,259 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=70552948&adults=2) ### Image gallery for 16 Acres of beauty and relaxation ![Smart TV, fireplace, DVD player, foosball](https://images.trvl-media.com/lodging/93000000/92190000/92187000/92186937/6a213741.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### 16 Acres of beauty and relaxation Park Hills **9.8/10**Exceptional (19 reviews) 15% off CA $467 CA $1,414 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=92186937&adults=2) ### Image gallery for Deadwood Acres cabin #2 ![Outdoor dining](https://images.trvl-media.com/lodging/72000000/71730000/71720200/71720165/906677ad.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Deadwood Acres cabin #2 Eminence **9.8/10**Exceptional (38 reviews) 10% off CA $173 CA $437 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=71720165&adults=2) ### Image gallery for Private Hilltop Cabin Near Current River ![Exterior](https://images.trvl-media.com/lodging/81000000/80810000/80805700/80805648/575f1208.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Private Hilltop Cabin Near Current River Van Buren **10/10**Exceptional (60 reviews) 10% off CA $125 CA $390 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=80805648&adults=2) ### Image gallery for Spacious 4 bedroom cottage near Current River ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83400000/83395800/83395775/ac011d41.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Spacious 4 bedroom cottage near Current River Van Buren **9.8/10**Exceptional (23 reviews) 10% off CA $219 CA $609 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=83395775&adults=2) ### Image gallery for Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville. ![Outdoor dining](https://images.trvl-media.com/lodging/35000000/34330000/34325500/34325448/312837e2.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Gorgeous 5 Bedroom Log Home Less Than 5 Minutes From Chaumette And Charleville. Ste. Genevieve **10/10**Exceptional (58 reviews) 10% off CA $626 CA $1,504 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=34325448&adults=2) ### Image gallery for Secluded Eminence Ranch House Cabin in the Ozarks ![Interior](https://images.trvl-media.com/lodging/54000000/53940000/53933900/53933898/748264ca.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Secluded Eminence Ranch House Cabin in the Ozarks Eminence **9.8/10**Exceptional (105 reviews) 10% off CA $182 CA $511 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=53933898&adults=2) ### Image gallery for Charming Secluded Getaway Cabin within minutes of amenities ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Charming Secluded Getaway Cabin within minutes of amenities Cape girardeau **10/10**Exceptional (18 reviews) 5% off CA $205 CA $621 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=75891457&adults=2) ### Image gallery for Doves Nest Guest House
Tranquil & Relaxing ![Exterior](https://images.trvl-media.com/lodging/68000000/67140000/67135900/67135817/5aaf2aaa.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Doves Nest Guest House
Tranquil & Relaxing Ste. Genevieve **10/10**Exceptional (55 reviews) 10% off CA $225 CA $628 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=67135817&adults=2) ### Image gallery for Current River Inn ![Comfort Single Room](https://images.trvl-media.com/lodging/48000000/47040000/47039600/47039515/5e06e6ad.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Current River Inn Van Buren **8.2/10**Very good (165 reviews) 15% off CA $128 CA $278 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=47039515&adults=2) ### Image gallery for Deadwood acres cabin #3 ![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83730000/83722800/83722738/83f1ee91.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Deadwood acres cabin #3 Eminence **10/10**Exceptional (17 reviews) 10% off CA $209 CA $466 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=83722738&adults=2) ### Image gallery for Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy ![Cabin, 1 Queen Bed | Private kitchen](https://images.trvl-media.com/lodging/111000000/110560000/110550900/110550817/6dbce3c6.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy French Village **9.8/10**Exceptional (48 reviews) 15% off CA $147 CA $435 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=110550817&adults=2) ### Image gallery for Secluded Upper Ozarks Farmhouse in Ozarks Mountains ![Interior](https://images.trvl-media.com/lodging/104000000/103830000/103822500/103822424/b8e6b995.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Secluded Upper Ozarks Farmhouse in Ozarks Mountains SALEM **10/10**Exceptional (2 reviews) 10% off CA $250 CA $698 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=103822424&adults=2) ### Image gallery for The Farmstead Hotel ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/13275a81.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Farmstead Hotel Caruthersville **8.8/10**Excellent (472 reviews) 18% off CA $109 CA $248 total Total includes taxes and fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-01-30&endDate=2026-02-01&selected=89303450&adults=2) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels) ## Learn more about Southeast Missouri Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park. [See all hotels in Southeast Missouri](https://www.expedia.ca/Hotel-Search?startDate=2026-01-31&endDate=2026-02-01&adults=2®ionId=6058763) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high) Photo by Bill Dillard ### Stay near popular Southeast Missouri attractions [](https://expedia.ca/Elephant-Rocks-State-Park-Hotels.0-l553248621532648464-0.Travel-Guide-Filter-Hotels) ![Elephant Rocks State Park](https://mediaim.expedia.com/destination/2/86e50eabc9d5592586815e7688be64ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Elephant Rocks State Park You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648464) [](https://expedia.ca/Lake-Wappapello-Hotels.0-l553248621532648460-0.Travel-Guide-Filter-Hotels) ![Lake Wappapello](https://mediaim.expedia.com/destination/2/a6135d9f1717ada26d9944dd5bb40459.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lake Wappapello Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648460) [](https://expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels) #### Southeast Missouri State University Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621554122994) [](https://expedia.ca/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels) #### Century Casino Caruthersville Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655201) [](https://expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels) #### Isle Casino Cape Girardeau Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655780) [](https://expedia.ca/Bonne-Terre-Mine-Hotels.0-l553248621532648467-0.Travel-Guide-Filter-Hotels) #### Bonne Terre Mine Commune with nature and explore the great outdoors at Bonne Terre Mine during your travels in Bonne Terre. You can seek out the golf courses while in the area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648467) ## More cheap stays in Southeast Missouri ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO CA $73 CA $84 total Jan 25 - Jan 26 includes taxes & fees 7.8/10 Good! (1,000 reviews) [](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO CA $79 CA $84 total Jan 20 - Jan 21 includes taxes & fees 7.8/10 Good! (1,000 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn and Suites by Wyndham Sikeston 220 S Interstate Dr Sikeston MO CA $87 CA $100 total Feb 17 - Feb 18 includes taxes & fees 7.2/10 Good! (1,000 reviews) [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy Cape Girardeau MO CA $97 CA $111 total Jan 22 - Jan 23 includes taxes & fees 9/10 Wonderful! (1,001 reviews) [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 3253 William Street Cape Girardeau MO CA $127 CA $143 total Jan 25 - Jan 26 includes taxes & fees 9.4/10 Exceptional! (1,000 reviews) [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn & Suites by Marriott Poplar Bluff 3109 Oak Grove Poplar Bluff MO CA $144 CA $163 total Jan 31 - Feb 1 includes taxes & fees 9.2/10 Wonderful! (864 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ## Hotels in Southeast Missouri with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 2 properties [](https://expedia.ca/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 53 properties [](https://expedia.ca/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 142 properties [](https://expedia.ca/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels) ## Recent reviews of Southeast Missouri hotels ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 5/5 Excellent "Good" A verified traveller from Chicago stayed at Drury Inn & Suites Sikeston, MO Posted 3 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 5/5 Excellent "Loved the happy hour, and pet friendly & shower." A verified traveller stayed at Drury Inn & Suites Cape Girardeau Posted 4 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg) ### Motel 6 Poplar Bluff, MO 5/5 Excellent "Clean room/friendly staff " A verified traveller stayed at Motel 6 Poplar Bluff, MO Posted 4 days ago [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 5/5 Excellent "The breakfast menu was fresh except for some of the Half and Half creamer was curdled, spoiled. And the coffee was luke warm." A verified traveller stayed at Best Western Plus Sikeston Posted 5 days ago [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 5/5 Excellent "Everything was great" A verified traveller stayed at Drury Plaza Hotel Cape Girardeau Conference Center Posted 7 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg) ### Baymont Inn and Suites by Wyndham Farmington, MO 5/5 Excellent "The King Suite is huge!" A verified traveller stayed at Baymont Inn and Suites by Wyndham Farmington, MO Posted 7 days ago [](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 5/5 Excellent "The room was very clean and nicely appointed. The continental breakfast was good with hot food items and hard boiled eggs, oatmeal, fruit, etc. Price was reasonable. " A verified traveller stayed at Hampton Inn Sikeston Posted 7 days ago [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 5/5 Excellent "Coffee pot empty in breakfast area " A verified traveller stayed at La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Posted 7 days ago [](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 5/5 Excellent "Room was spotless. The whole hotel was clean and the staff were very kind. " A verified traveller stayed at The Riverview Posted 8 days ago [](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ## Frequently asked questions ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Southeast Missouri hotel booking with Expedia? ### How much is the nightly rate at a Southeast Missouri hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - More ways to book - [Advance Hotels ](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - [B&B in Annapolis ](https://www.expedia.ca/Annapolis-Bed-And-Breakfast.d6282465-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels with Balconies in Annapolis ](https://www.expedia.ca/Annapolis-Hotels-Hotels-With-Balconies.0-0-d6282465-tHotelswithBalconies.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Annapolis ](https://www.expedia.ca/Annapolis-Hotels-Luxury-Hotel.0-0-d6282465-tLuxuryHotel.Travel-Guide-Filter-Hotels) - 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