Find hotels in Southeast Missouri, MO from CA $86
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Sep 3 - Sep 4Tomorrow
Sep 4 - Sep 5This weekend
Sep 4 - Sep 6Next weekend
Sep 11 - Sep 13Our top choices for Southeast Missouri hotels
1. Madison Inn Lodge
Madison Inn LodgeFredericktown
Bawan
CA $121
CA $132 total
includes taxes & fees
Sep 11 - Sep 12
2. Shepherd Mountain Inn
Shepherd Mountain InnIronton
Katie
CA $171
CA $186 total
includes taxes & fees
Sep 7 - Sep 8
3. Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
Jamie
CA $111
CA $117 total
includes taxes & fees
Sep 7 - Sep 8
4. Fort Davidson Hotel
Fort Davidson HotelIronton
richard
CA $166
CA $181 total
includes taxes & fees
Oct 4 - Oct 5
5. Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
David
CA $126
CA $144 total
includes taxes & fees
Oct 4 - Oct 5
6. Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
Sandra
CA $138
CA $156 total
includes taxes & fees
Sep 13 - Sep 14
7. Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
Allen
CA $140
CA $158 total
includes taxes & fees
Sep 27 - Sep 28
8. EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
JANEEN
CA $105
CA $114 total
includes taxes & fees
Sep 6 - Sep 7
9. Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
Sheila
CA $129
CA $145 total
includes taxes & fees
Oct 4 - Oct 5
10. Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
Arsenia
CA $140
CA $158 total
includes taxes & fees
Oct 4 - Oct 5
11. Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
ILUNGA
CA $79
CA $86 total
includes taxes & fees
Sep 13 - Sep 14
12. Super 8 by Wyndham Farmington
Super 8 by Wyndham FarmingtonFarmington
John
CA $81
CA $89 total
includes taxes & fees
Sep 13 - Sep 14
13. Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
Paul
CA $130
CA $147 total
includes taxes & fees
Sep 7 - Sep 8
14. Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
Susan
CA $152
CA $165 total
includes taxes & fees
Sep 13 - Sep 14
15. Holiday Inn Express & Suites Farmington by IHG
Holiday Inn Express & Suites Farmington by IHGFarmington
Shawn
CA $152
CA $166 total
includes taxes & fees
Sep 13 - Sep 14
16. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
Shawn
CA $128
CA $139 total
includes taxes & fees
Sep 7 - Sep 8
17. Holiday Inn Poplar Bluff by IHG
Holiday Inn Poplar Bluff by IHGPoplar Bluff
Stephanie
CA $118
CA $133 total
includes taxes & fees
Oct 4 - Oct 5
18. Black River Motel and Restaurant
Black River Motel and RestaurantLesterville
Douglas
CA $161
CA $170 total
includes taxes & fees
Sep 7 - Sep 8
19. The Riverview
The RiverviewCape Girardeau
Alyssa
CA $146
CA $164 total
includes taxes & fees
Sep 8 - Sep 9
20. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
Ronrecus
CA $140
CA $223 total
includes taxes & fees
Oct 4 - Oct 5
Vacation Rentals in Southeast Missouri
Cottage
'turtle Rock' - Ironton Cabin w/ Furnished Patio!
'turtle Rock' - Ironton Cabin w/ Furnished Patio!Ironton
"Stroller, pack n play and high chair. This was amazing "
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
"I really enjoyed my time at the stay !"
Vacation Home
Tiny Houses of French Village
Tiny Houses of French VillageFrench Village
"Very nice place very clean well kept inside an out it's a nice little romantic getaway they have it set up so great its a must see sunset very relaxing "
Cottage
Walk to Current River: Ozarks Adventure Home!
Walk to Current River: Ozarks Adventure Home!Van Buren
"Teresa & Chuck went out of their way to make the stay EXCELENT. Teresa is a great cook and shared some of her creations with me, again EXCELENT. The lodging was comfortable and easy to access. Next time in town that will be the place for me."
Cottage
Cozy Belgrade Cottage w/ Wood-burning Stove!
Cozy Belgrade Cottage w/ Wood-burning Stove!Belgrade
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Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Current River State Park
9.2/10 (20 reviews)
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.
See all hotels in Southeast Missouri
Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Comfort Inn Festus - St Louis South
8/10 Good
"room was clean and the front staff was nice. place served it's purpose (stayed for only 2 nights). Not much amenitites."
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
10/10 Excellent
"Room was clean. Bed was a very comfortable best pillows We’ve had the whole trip . close to several different places to eat."
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Quick check in, Friendly Staff. AC was cold. Breakfast was good, preparer was friendly."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"This location is a must stay any time I am traveling in the area. The staff are helpful. There are lots of dinning options near by. I can always count on a peaceful night sleep at this location."
The Riverview
10/10 Excellent
"My stay was wonderful and the food was good"
Silo Farm Haus- located in the heart of wine country!
10/10 Excellent
"Our stay at the Silo House was absolutely wonderful! The home and surrounding property are stunning, and the peaceful setting made it the perfect escape from the hustle and bustle of everyday life. If you’re looking for a place to truly relax and recharge, this is it.My favorite part of the entire stay was starting each morning on the porch swing, watching the sunrise while listening to the sounds of nature. It was such a calming and memorable experience.The house itself was immaculate and thoughtfully equipped with every amenity you could possibly need. It was clear that every detail had been considered to make guests feel comfortable and at home.We couldn’t have asked for a better getaway and would absolutely stay here again. Highly recommend the Silo House to anyone looking for a peaceful, beautiful retreat!"
More cheap stays in Southeast Missouri
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
CA $79
CA $86 total
Sep 13 - Sep 14
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
220 S Interstate Dr Sikeston MO
CA $91
CA $104 total
Sep 13 - Sep 14
includes taxes & fees
7.2/10 Good! (1,000 reviews)
Pear Tree Inn Cape Girardeau West
103 Cape West Pkwy Cape Girardeau MO
CA $100
CA $112 total
Sep 13 - Sep 14
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
Comfort Inn Festus - St Louis South
1303 Veterans Blvd Festus MO
CA $101
CA $118 total
Oct 4 - Oct 5
includes taxes & fees
7.8/10 Good! (999 reviews)
The Farmstead Hotel
778 E 3rd St Caruthersville MO
CA $117
CA $133 total
Sep 13 - Sep 14
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
3253 William Street Cape Girardeau MO
CA $140
CA $159 total
Sep 7 - Sep 8
includes taxes & fees
9.4/10 Exceptional! (1,001 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
3 Star Hotels
68 properties
2 Star Hotels
90 properties
Explore a world of travel with Expedia
- Crown Pointe Lodge
- Cabin Rentals in Centerville
- The Queen Bee Farm Stay/Hot tub
- Park Hills Hotels
- Hotels near Big River
- Cabin Rentals in Allenville
- French Village Hotels
- Dexter Inn
- Poplar Bluff Hotels
- Pine Perfect Cabin on the edge of town only 1/2 mile from Current River!
- Bonne Terre Hotels
- Cabin Rentals in Farmington
- Holiday Inn Poplar Bluff by IHG
- Resorts in Wayne County
- Secluded Cabin with Heated Pool
- Amazing lakeview Spring Lake Tree House #2 "LoveLight" w/ hot tub
- Pickleball Cafe & Micro Hotel
- Urban Loft #4 BLACK · Urban Loft above BrewCo & Restaurant
- Motels in Ellsinore
- Fredericktown Hotels
- Morehouse Hotels
- Rv Parks in Perryville
- Advance Hotels
- Quality Inn Perryville I
- Lazy River Cabin on the edge of town only 1/2 mile from Current River !
- Doniphan Hotels
- Bluebird Meadows W/hot Tub and Pool Special
- Silo Farm Haus
- Dexter Hotels
- B&B in Ste Genevieve
- Bullwinkles Rustic Lodge
- Pet-Friendly Hotels in Jackson
- Postcard Cabins St Francois
- Villas in Poplar Bluff
- Cheap Hotels in Viburnum
- Cottages in Pocahontas
- Cabin Rentals in Bonne Terre
- Oyo Hickory House Inn
- Condo Rentals in Fremont
- Scott City Hotels
- Rv Parks in Chaffee
- Hilton Hotels in Perryville
- Relax in the country at Countryside Villas!
- Apartments in Ozora
- Secluded Private Cabin with Pool
- Home Sweet Home
- Van Buren Hotels
- Farmstay in Oak Ridge
- Cozy Caledonia Cabin ~ 10 Mi to Elephant Rocks!
- Cabin Rentals in Southeast Missouri
- Cottages in Clearwater
- Cabin Rentals in Cadet
- Houseboats in Wappapello
- Spring Lake Ranch has a Private
- Alpaca Farm Stay
- Jackson Hotels
- Super 8 by Wyndham Perryville
- Motels in St Mary
- Winona Hotels
- Hilton Hotels in Ste Genevieve
- Triangle Inn Motel
- Hampton Inn Poplar Bluff
- Cheap Hotels in Bonne Terre
- Cabin Rentals in Leadwood
- Town House Inn
- Ozora Hotels
- Essex Hotels
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