Title: Book The Best Hotels in Southeast Missouri, MO for 2026 from CA $84 - Fully Refundable Options - Expedia.ca [Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Bill Dillard # Find hotels in Southeast Missouri, MO from CA $84 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Southeast Missouri Cabin [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=CABIN) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=HOT_TUB) Pool [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=POOL) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=COTTAGE) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&travelerType=family_friendly) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=APARTMENT) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=PETS) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=WATER_PARK) Farm [](https://www.expedia.ca/Hotel-Search?destination=Southeast+Missouri%2C+Missouri%2C+United+States+of+America®ionId=6058763&latLong=37.223648%2C-90.426492&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=AGRITOURISM) ## Check prices for these dates Tonight [Dec 2 - Dec 3](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-02&endDate=2025-12-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 3 - Dec 4](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-03&endDate=2025-12-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 618 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Front of property](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/35f08a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/8003191a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/060976ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Farmstead Hotel Caruthersville 8.8/10 Excellent (460) "Clean rooms and really comfortable beds!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrea CA $108 CA $123 total includes taxes & fees Dec 10 - Dec 11 [](https://www.expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/c6e7fccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/668f3d2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds | Room amenity](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/d42a6e3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Perryville by IHG Perryville 9.2/10 Wonderful (536) "Clean room and pleasant staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $122 CA $140 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO Jackson 9.6/10 Exceptional (1013) "Breakfast was great- staff was welcoming. Will stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $116 CA $123 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/219ce8d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/540bf915.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/e3f5b676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/5600/5523/b5436bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Festus Festus 6.8/10 (918) "Room was clean and comfortable for an overnight stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack CA $107 CA $122 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Festus-Hotels-Baymont-By-Wyndham-Festus.h5523.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/032aa313.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/a085469e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/284f2de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West Cape Girardeau 9.0/10 Wonderful (1008) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather CA $98 CA $110 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d234bb55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/5d1ea140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/e565804d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator](https://images.trvl-media.com/lodging/1000000/860000/855800/855747/d7244881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Farmington Farmington 8.0/10 Very good (610) "Clean, friendly staff, quiet" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stacy CA $77 CA $88 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Farmington.h855747.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/ff3e4031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/f46408d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/a5281c8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42200/42109/b4e45ee9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Hayti Caruthersville Hayti 9.4/10 Exceptional (1006) "Great stay. Clean room, and Drury Inns always seem to have the most comfortable beds." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ted CA $132 CA $150 total includes taxes & fees Dec 13 - Dec 14 [](https://www.expedia.ca/Hayti-Hotels-Drury-Inn-Suites-Hayti-Caruthersville.h42109.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/720261dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/77434452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/w7137h4758x0y0-7ae60078.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/3000000/2700000/2699400/2699317/6d872386.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG Festus 9.4/10 Exceptional (698) "Great place to stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tracy CA $167 CA $191 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Farmington-Hotels-Holiday-Inn-Express-Hotel-Suites-FESTUS-SOUTH-ST-LOUIS.h2699317.Hotel-Information) ![Breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/e91b57a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/4ea0b11e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/0a692e3c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/2000000/1230000/1222200/1222183/874a4e6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Poplar Bluff by IHG Poplar Bluff 8.8/10 Excellent (695) "Amazing place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mladen CA $139 CA $157 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Poplar-Bluff-Hotels-Holiday-Inn-Poplar-Bluff.h1222183.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/7f26b79f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, 1 King Bed, Accessible, Non Smoking (Mobility Accessible)](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/4e8bbceb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/807f3a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Perryville Perryville 8.4/10 Very good (935) "The room was spotless, and the staff was extremely patient. Each one was very helpful. It was easy to get a good night's sleep - the building was very quiet." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia CA $88 CA $101 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/2cf60fb9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/05c7ee11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/79923507.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/160000/158800/158717/04ce172c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Potosi Potosi 7.0/10 Good (378) "The room was very good for the price." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benjamin CA $77 CA $84 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Farmington-Hotels-Super-8-By-Wyndham-Potosi.h158717.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Sikeston Sikeston 9.0/10 Wonderful (437) "Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Doncheial CA $133 CA $151 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/4071c448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/0c1d1e5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/136440e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Children's play area - outdoor](https://images.trvl-media.com/lodging/16000000/15490000/15487700/15487684/104061b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Echo Bluff State Park Eminence 9.6/10 Exceptional (216) "Beautiful location…excellent service and facilities / grounds were clean and well kept." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $209 CA $221 total includes taxes & fees Dec 3 - Dec 4 [](https://www.expedia.ca/Rolla-Hotels-Echo-Bluff-State-Park.h15487684.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (658) "Great place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) GUY CA $118 CA $127 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/ee6292b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/4ea3df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/da4fe5e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau Near the Medical Center Cape Girardeau 9.0/10 Wonderful (1007) "I liked how comfortable the beds and pillows were." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christine CA $98 CA $110 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/c41116cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/23ae42af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/7e9b49ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont Inn and Suites by Wyndham Farmington, MO Farmington 8.0/10 Very good (1008) "Room was clean and big. Breakfast was awesome!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ashley CA $76 CA $87 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/2d914387.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center Cape Girardeau 9.6/10 Exceptional (1006) "Great place and staff, very accommodating!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan CA $126 CA $142 total includes taxes & fees Dec 22 - Dec 23 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/05f90b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/356238c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Cape Girardeau Cape Girardeau 9.4/10 Exceptional (1007) "Rooms are nice and big. Breakfast was above average and staff was very nice and friendly. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandra CA $126 CA $142 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily to-go breakfast for a fee](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/de11c650.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview Cape Girardeau 9.4/10 Exceptional (464) "Place was nice and safe" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ryan CA $135 CA $152 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-16&endDate=2025-12-17®ionId=6058763&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Great weekend hotel deals in Southeast Missouri, MO Showing deals for:**Dec 12 - Dec 14** ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Fairfield Inn & Suites by Marriott Cape Girardeau Cape Girardeau **9.4/10**Exceptional (138 reviews) 15% off CA $148 CA $333 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=99972043&adults=2) ![Bar (on property)](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/0e9a77e3.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### TownePlace Suites by Marriott Sikeston Sikeston **9.0/10**Wonderful (8 reviews) 15% off CA $177 CA $402 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=111247452&adults=2) ![Lobby lounge](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Fairfield Inn & Suites by Marriott Poplar Bluff Poplar Bluff **9.4/10**Exceptional (845 reviews) 15% off CA $161 CA $363 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=28807257&adults=2) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9830000/9827800/9827793/2dc5e17d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Hampton Inn Poplar Bluff Poplar Bluff **9.4/10**Exceptional (794 reviews) 20% off CA $154 CA $345 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=9827793&adults=2) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Riverview Cape Girardeau **9.4/10**Exceptional (464 reviews) 10% off CA $223 CA $503 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=105081384&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76660000/76656600/76656560/b8f21647.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Ozark Oasis 3 B/ 3 B in Eminence with Spectacular View! Eminence **10/10**Exceptional (43 reviews) 10% off CA $208 CA $751 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=76656560&adults=2) ![Terrace/patio](https://images.trvl-media.com/lodging/84000000/83530000/83521000/83520985/c366c0a2.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Private scenic Ozark Mountain retreat near beautiful Current River; sleeps 1-10! Van Buren **10/10**Exceptional (22 reviews) 10% off CA $536 CA $1,544 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=83520985&adults=2) ![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Hampton Inn Sikeston Sikeston **9.0/10**Wonderful (437 reviews) 20% off CA $144 CA $327 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=25178175&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80810000/80805700/80805648/f332399a.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Private Hilltop Cabin Near Current River Van Buren **10/10**Exceptional (60 reviews) 10% off CA $226 CA $628 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=80805648&adults=2) ![Children's play area - outdoor](https://images.trvl-media.com/lodging/43000000/42100000/42093500/42093410/e8909449.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Honeysuckle Inn - Mountain View Mountain View **8.6/10**Excellent (330 reviews) 15% off CA $126 CA $273 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=42093410&adults=2) ![Interior](https://images.trvl-media.com/lodging/83000000/82930000/82926400/82926341/371f868e.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Lake Road Cabin B — Million Dollar Ozark View! Ironton **10/10**Exceptional (23 reviews) 10% off CA $202 CA $558 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=82926341&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/106000000/105790000/105790000/105789927/85b01dbf.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Mountain View at Pickle & Perk Ironton **10/10**Exceptional (15 reviews) 10% off CA $200 CA $527 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=105789927&adults=2) ![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/2cc8556c.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More Cape Girardeau **9.6/10**Exceptional (7 reviews) 10% off CA $422 CA $1,173 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=111971489&adults=2) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Tru By Hilton Cape Girardeau Cape Girardeau **9.6/10**Exceptional (97 reviews) 20% off CA $147 CA $335 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=111590879&adults=2) ![Exterior](https://images.trvl-media.com/lodging/4000000/3600000/3594600/3594547/3eea0c0d.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Hampton Inn Farmington Farmington **8.8/10**Excellent (517 reviews) 20% off CA $178 CA $406 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=3594547&adults=2) ![Standard Room, 1 Queen Bed, Non Smoking, Garden View](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/fc499141.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Rockwood Inn Cape Girardeau **10/10**Exceptional (18 reviews) 17% off CA $232 CA $525 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=105486893&adults=2) ![Private kitchen](https://images.trvl-media.com/lodging/71000000/70560000/70553000/70552948/0be52867.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Bluebird Meadows W/hot Tub and Pool Special Park Hills **10/10**Exceptional (2 reviews) 10% off CA $515 CA $1,274 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=70552948&adults=2) ![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/bcbc8581.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool Cape Girardeau **8.8/10**Excellent (34 reviews) 10% off CA $251 CA $673 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=71745619&adults=2) ![Exterior](https://images.trvl-media.com/lodging/72000000/71730000/71720200/71720165/14e44f48.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Deadwood Acres cabin #2 Eminence **9.8/10**Exceptional (38 reviews) 10% off CA $175 CA $449 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=71720165&adults=2) ![Property grounds](https://images.trvl-media.com/lodging/43000000/42540000/42533900/42533836/52e075c2.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Weber Farm - Enjoy a beautiful 100 acre farm! Frohna **10/10**Exceptional (32 reviews) 10% off CA $186 CA $513 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=42533836&adults=2) ![Shared kitchen](https://images.trvl-media.com/lodging/113000000/112370000/112361000/112360980/66a0aee5.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Arcadia Academy Arcadia **9.8/10**Exceptional (11 reviews) 12% off CA $168 CA $366 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=112360980&adults=2) ![Lobby](https://images.trvl-media.com/lodging/2000000/1430000/1429500/1429479/83119f36.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Crown Pointe Lodge, BW Signature Collection Farmington **9.0/10**Wonderful (572 reviews) 20% off CA $149 CA $339 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=1429479&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/54000000/53940000/53933900/53933898/3ce46935.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Secluded Eminence Ranch House Cabin in the Ozarks Eminence **9.8/10**Exceptional (105 reviews) 10% off CA $183 CA $519 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=53933898&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106060000/106052600/106052541/e186477c.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### ⚜️Rivertown Retreat⚜️ Lewis & Clark stayed here. King bed. Sleeps 4 Ste Genevieve **10/10**Exceptional (17 reviews) 10% off CA $183 CA $524 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-12&endDate=2025-12-14&selected=106052541&adults=2) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSoutheast-Missouri-Hotels.d6058763.Travel-Guide-Hotels) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=HTG_BF_PROMO_6058763) ## Learn more about Southeast Missouri Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to Walnut Hollow Lake. [See all hotels in Southeast Missouri](https://www.expedia.ca/Hotel-Search?startDate=2025-12-16&endDate=2025-12-17&adults=2®ionId=6058763) ![Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg: Moark Regional Railroad Museum HOURS: Saturdays 1 p.m. - 4 p.m. It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history. This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! #MTTS2014 #minitakesthestates #go11 #train](https://images.trvl-media.com/place/9449/f87e8b74-cb32-40ea-afa8-0f245bfdc84b.jpg?impolicy=fcrop&w=899&h=600&p=1&q=high) Photo by Bill Dillard ### Stay near popular Southeast Missouri attractions [](https://expedia.ca/Elephant-Rocks-State-Park-Hotels.0-l553248621532648464-0.Travel-Guide-Filter-Hotels) ![Elephant Rocks State Park](https://mediaim.expedia.com/destination/2/86e50eabc9d5592586815e7688be64ef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Elephant Rocks State Park You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648464) [](https://expedia.ca/Lake-Wappapello-Hotels.0-l553248621532648460-0.Travel-Guide-Filter-Hotels) ![Lake Wappapello](https://mediaim.expedia.com/destination/2/a6135d9f1717ada26d9944dd5bb40459.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Lake Wappapello Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532648460) [](https://expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels) #### Southeast Missouri State University Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621554122994) [](https://expedia.ca/Century-Casino-Caruthersville-Hotels.0-l553248621532655201-0.Travel-Guide-Filter-Hotels) #### Century Casino Caruthersville Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655201) [](https://expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels) #### Isle Casino Cape Girardeau Why not roll the dice with a visit to Isle Casino Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655780) [](https://expedia.ca/Alley-Spring-Mill-Hotels.0-l553248622784732024-0.Travel-Guide-Filter-Hotels) #### Alley Spring & Mill Learn about the local history of Eminence with a stop at Alley Spring & Mill. While you're in the area, stroll along the riverfront. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248622784732024) ## More cheap stays in Southeast Missouri ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO CA $76 CA $87 total Dec 8 - Dec 9 includes taxes & fees 8/10 Very Good! (1,005 reviews) [](https://expedia.ca/Farmington-Hotels-Baymont-Inn-And-Suites-By-Wyndham-Farmington.h16153.Hotel-Information) ![Motel 6 Poplar Bluff, MO](https://images.trvl-media.com/lodging/16000000/15690000/15689200/15689127/9e93b298_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Poplar Bluff, MO 4101 Highway 67 N Poplar Bluff MO CA $106 CA $112 total Dec 14 - Dec 15 includes taxes & fees 7.8/10 Good! (1,005 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Motel-6-Poplar-Bluff.h15689127.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn and Suites by Wyndham Sikeston 220 S Interstate Dr Sikeston MO CA $88 CA $100 total Dec 7 - Dec 8 includes taxes & fees 7.2/10 Good! (1,005 reviews) [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Pear Tree Inn Cape Girardeau West 103 Cape West Pkwy Cape Girardeau MO CA $98 CA $110 total Dec 8 - Dec 9 includes taxes & fees 9/10 Wonderful! (1,008 reviews) [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 3253 William Street Cape Girardeau MO CA $133 CA $150 total Dec 4 - Dec 5 includes taxes & fees 9.4/10 Exceptional! (1,004 reviews) [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Fairfield Inn & Suites by Marriott Poplar Bluff](https://images.trvl-media.com/lodging/29000000/28810000/28807300/28807257/76c46720_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Fairfield Inn & Suites by Marriott Poplar Bluff 3109 Oak Grove Poplar Bluff MO CA $145 CA $164 total Dec 7 - Dec 8 includes taxes & fees 9.4/10 Exceptional! (842 reviews) [](https://expedia.ca/Poplar-Bluff-Hotels-Fairfield-Inn-Suites-By-Marriott-Poplar-Bluff.h28807257.Hotel-Information) ## Hotels in Southeast Missouri with star-rating ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 2 properties [](https://expedia.ca/4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 53 properties [](https://expedia.ca/3Star-Southeast-Missouri-Hotels.s30-0-d6058763.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 142 properties [](https://expedia.ca/2Star-Southeast-Missouri-Hotels.s20-0-d6058763.Travel-Guide-Filter-Hotels) ## Recent reviews of Southeast Missouri hotels ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 5/5 Excellent "The room is very clean and there aren’t any little items that would cause me to feel frustrated. Also, the staff was very pleasant!" A verified traveller stayed at Pear Tree Inn Cape Girardeau West Posted 2 days ago [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 5/5 Excellent "It was great" A verified traveller stayed at Drury Inn & Suites Jackson MO Posted 3 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Pear Tree Inn Cape Girardeau Near the Medical Center](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031_y.jpg) ### Pear Tree Inn Cape Girardeau Near the Medical Center 5/5 Excellent "Very friendly people, clean rooms, comfortable bed, great breakfast," A verified traveller stayed at Pear Tree Inn Cape Girardeau Near the Medical Center Posted 5 days ago [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 5/5 Excellent "Clean room chuck was very helpful with checking in ect..." A verified traveller from Tatum stayed at Hampton Inn Sikeston Posted 5 days ago [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![The Farmstead Hotel](https://images.trvl-media.com/lodging/90000000/89310000/89303500/89303450/26d97631_y.jpg) ### The Farmstead Hotel 5/5 Excellent "The staff is super friendly and the property is very clean. I would stay there again but definitely would eat before get to the area because there are just literally 2 places to eat and they could be very pricey." A verified traveller stayed at The Farmstead Hotel Posted 5 days ago [](https://expedia.ca/Caruthersville-Hotels-The-Farmstead.h89303450.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 5/5 Excellent "Friendly staff, clean room, comfortable beds and great breakfast" A verified traveller stayed at Drury Inn & Suites Sikeston, MO Posted 6 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f_y.jpg) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG 5/5 Excellent "Room was prestine and the buffet was excellent!!" A verified traveller stayed at Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Posted 6 days ago [](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 5/5 Excellent "Helpful staff, clean room." A verified traveller stayed at The Riverview Posted 6 days ago [](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 5/5 Excellent "We had a wonderful stay at this hotel. The room and common areas were spotless and the food was wonderful. Our children had a glorious time swimming in the indoor pool." A verified traveller stayed at Drury Plaza Hotel Cape Girardeau Conference Center Posted 6 days ago [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ## Frequently asked questions ### Can I cancel my hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Southeast Missouri hotel for you. ### How can I save on a Southeast Missouri hotel booking with Expedia? > Members always get our best prices. Find our best Southeast Missouri hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings. ### How much is the nightly rate at a Southeast Missouri hotel? > Prices for hotels in Southeast Missouri often vary, but you can find a great deal from CA $84 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - More ways to book - [Advance Hotels](https://www.expedia.ca/Advance-Hotels.d553248634983475122.Travel-Guide-Hotels) - [B&B in Annapolis](https://www.expedia.ca/Annapolis-Bed-And-Breakfast.d6282465-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Hotels with Balconies in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Hotels-With-Balconies.0-0-d6282465-tHotelswithBalconies.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Luxury-Hotel.0-0-d6282465-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Annapolis](https://www.expedia.ca/Annapolis-Hotels-Spa-Hotel.0-0-d6282465-tSpaHotel.Travel-Guide-Filter-Hotels) - [Annapolis Hotels](https://www.expedia.ca/Annapolis-Hotels.d6282465.Travel-Guide-Hotels) - [Lodges in Annapolis](https://www.expedia.ca/Annapolis-Lodges.d6282465-aaLodges.Travel-Guide-Accommodation) - 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