Find hotels in Southeast Missouri, MO from CA $80

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,009 reviews)
"The breakfast and nightly gathering makes this location a fantastic value and will be our choice of stops when heading south again!"
United States
William
The price is CA $117
CA $123 total
includes taxes & fees
Jun 10 - Jun 11
Drury Inn & Suites Jackson MO

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (195 reviews)
"The hotel was super clean, very friendly, the beds were very comfortable."
United States
Candia
The price is CA $128
CA $145 total
includes taxes & fees
Jun 28 - Jun 29
Fairfield Inn & Suites by Marriott Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,001 reviews)
"Very clean, helpful staff"
United States
Cathy
The price is CA $152
CA $172 total
includes taxes & fees
Jun 21 - Jun 22
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (1,006 reviews)
"Great place to stay. Clean, great staff and the food is good. Would stay again."
United States
Stephanie
The price is CA $152
CA $172 total
includes taxes & fees
Jun 21 - Jun 22
Drury Inn & Suites Poplar Bluff

The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (557 reviews)
"felt safe stayed only in hotel was clean and quiet and felt safe."
United States
Michael
The price is CA $119
CA $135 total
includes taxes & fees
Jun 17 - Jun 18
The Farmstead Hotel

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (132 reviews)
"This is a clean, quiet, well designed hotel."
United States
Kendra
The price is CA $128
CA $146 total
includes taxes & fees
Jun 15 - Jun 16
Tru By Hilton Cape Girardeau

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
9.8 out of 10, Exceptional, (75 reviews)
"Here is good accommodation! Next time, I hope I will stay here."
United States
YOSHIRO
The price is CA $151
CA $222 total
includes taxes & fees
Jun 15 - Jun 16
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (911 reviews)
"Hotel Staff was very friendly!"
United States
Alice
The price is CA $153
CA $173 total
includes taxes & fees
Jul 5 - Jul 6
Fairfield Inn & Suites by Marriott Poplar Bluff

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (587 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
United States
John
The price is CA $165
CA $186 total
includes taxes & fees
Jun 23 - Jun 24
The Riverview

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
Festus
9.4 out of 10, Exceptional, (730 reviews)
"Great stay."
United States
Delos
The price is CA $168
CA $192 total
includes taxes & fees
Jun 14 - Jun 15
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,005 reviews)
"Breakfast was good,pool hot tub excellent "
United States
Janica
The price is CA $154
CA $177 total
includes taxes & fees
Jun 8 - Jun 9
Drury Inn & Suites Sikeston, MO

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (84 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is CA $152
CA $172 total
includes taxes & fees
Jun 25 - Jun 26
Fairfield Inn & Suites by Marriott Sikeston

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (862 reviews)
"Nice quiet overnight stay."
United States
Tammy
The price is CA $130
CA $145 total
includes taxes & fees
Jul 5 - Jul 6
Hampton Inn Poplar Bluff

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
8.0 out of 10, Very good, (992 reviews)
"Was just ok, good price."
United States
Duane
The price is CA $116
CA $133 total
includes taxes & fees
Jun 15 - Jun 16
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.4 out of 10, Very good, (1,001 reviews)
"Enjoyed our stay "
United States
Cynthia
The price is CA $98
CA $112 total
includes taxes & fees
Jul 2 - Jul 3
Super 8 by Wyndham Perryville

Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
9.0 out of 10, Wonderful, (628 reviews)
"Excellent staff and location was nice and quiet "
United States
Colleen
The price is CA $164
CA $179 total
includes taxes & fees
Jun 10 - Jun 11
Crown Pointe Lodge, BW Signature Collection

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,001 reviews)
"Very nice, clean, friendly staff"
United States
Patty
The price is CA $80
CA $87 total
includes taxes & fees
Jun 21 - Jun 22
Baymont Inn and Suites by Wyndham Farmington, MO

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (514 reviews)
"Great stay!!"
United States
Taylor
The price is CA $186
CA $210 total
includes taxes & fees
Jun 22 - Jun 23
Courtyard by Marriott Cape Girardeau Downtown

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (776 reviews)
"Nice hotel"
United States
Jeff
The price is CA $128
CA $139 total
includes taxes & fees
Jun 9 - Jun 10
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (591 reviews)
"Breakfast was great. Fresh coffee, pancake maker so good. "
United States
Kristin
The price is CA $140
CA $160 total
includes taxes & fees
Jun 11 - Jun 12
Holiday Inn Express & Suites Perryville by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in Southeast Missouri

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeast Missouri attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star rating

Explore a world of travel with Expedia