Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from CA $80
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Our top choices for Southeast Missouri hotels

Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,009 reviews)
The price is CA $117
CA $123 total
includes taxes & fees
Jun 10 - Jun 11

Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (195 reviews)
The price is CA $128
CA $145 total
includes taxes & fees
Jun 28 - Jun 29

Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,001 reviews)
The price is CA $152
CA $172 total
includes taxes & fees
Jun 21 - Jun 22

Drury Inn & Suites Poplar Bluff
Drury Inn & Suites Poplar BluffPoplar Bluff
9.2 out of 10, Wonderful, (1,006 reviews)
The price is CA $152
CA $172 total
includes taxes & fees
Jun 21 - Jun 22

The Farmstead Hotel
The Farmstead HotelCaruthersville
8.6 out of 10, Excellent, (557 reviews)
The price is CA $119
CA $135 total
includes taxes & fees
Jun 17 - Jun 18

Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (132 reviews)
The price is CA $128
CA $146 total
includes taxes & fees
Jun 15 - Jun 16

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (75 reviews)
The price is CA $151
CA $222 total
includes taxes & fees
Jun 15 - Jun 16

Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (911 reviews)
The price is CA $153
CA $173 total
includes taxes & fees
Jul 5 - Jul 6

The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (587 reviews)
The price is CA $165
CA $186 total
includes taxes & fees
Jun 23 - Jun 24

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHGFestus
9.4 out of 10, Exceptional, (730 reviews)
The price is CA $168
CA $192 total
includes taxes & fees
Jun 14 - Jun 15

Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.6 out of 10, Exceptional, (1,005 reviews)
The price is CA $154
CA $177 total
includes taxes & fees
Jun 8 - Jun 9

Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (84 reviews)
The price is CA $152
CA $172 total
includes taxes & fees
Jun 25 - Jun 26

Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (862 reviews)
The price is CA $130
CA $145 total
includes taxes & fees
Jul 5 - Jul 6

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very good, (992 reviews)
The price is CA $116
CA $133 total
includes taxes & fees
Jun 15 - Jun 16

Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (1,001 reviews)
The price is CA $98
CA $112 total
includes taxes & fees
Jul 2 - Jul 3

Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (628 reviews)
The price is CA $164
CA $179 total
includes taxes & fees
Jun 10 - Jun 11

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MOFarmington
8.0 out of 10, Very good, (1,001 reviews)
The price is CA $80
CA $87 total
includes taxes & fees
Jun 21 - Jun 22

Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
9.6 out of 10, Exceptional, (514 reviews)
The price is CA $186
CA $210 total
includes taxes & fees
Jun 22 - Jun 23

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (776 reviews)
The price is CA $128
CA $139 total
includes taxes & fees
Jun 9 - Jun 10

Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (591 reviews)
The price is CA $140
CA $160 total
includes taxes & fees
Jun 11 - Jun 12
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
9.8 out of 10, Exceptional, (75 reviews)
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Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.

Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews

Pear Tree Inn Cape Girardeau West
10/10 Excellent
More cheap stays in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
The price is CA $80 per night from Jun 21 to Jun 22
CA $80
CA $87 total
Jun 21 - Jun 22
includes taxes & fees
8/10 Very Good! (1,001 reviews)
Hotels in Southeast Missouri with star rating

4 Star Hotels
2 properties
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