Southeast Missouri Vacation Packages

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

Top Southeast Missouri Vacation Deals

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
Price was CA $785, price is now CA $595 per person
CA $595
per person
Oct 28 - Oct 30
found 1 day ago
Roundtrip flight included
Halifax (YHZ) to St. Louis (STL)
9.2/10 Wonderful! (1,561 reviews)
Loved the room, pretty good breakfast in the morning lots of options.

Reviewed on Aug. 20, 2025

Hilton Garden Inn Chesterfield

Hilton Garden Inn Chesterfield

3 out of 5
Price was CA $959, price is now CA $761 per person
CA $761
per person
Sep 27 - Sep 30
found 1 hour ago
Roundtrip flight included
Halifax (YHZ) to St. Louis (STL)
8.2/10 Very Good! (760 reviews)
I booked online and paid via the app. When I arrived on site they explained they had overbooked and had no rooms available. The staff was amazing and went above and beyond and secured a room at another location. Thank you to the staff for taking care of us.

Reviewed on Jul. 26, 2025

The Cheshire

The Cheshire

4 out of 5
Price was CA $1,138, price is now CA $917 per person
CA $917
per person
Sep 27 - Sep 30
found 1 hour ago
Roundtrip flight included
Halifax (YHZ) to St. Louis (STL)
8.6/10 Excellent! (1,007 reviews)
Nice location, easy access and close to where I was going to be.

Reviewed on Aug. 17, 2025

Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
Price was CA $996, price is now CA $824 per person
CA $824
per person
Oct 10 - Oct 12
found 1 day ago
Roundtrip flight included
Toronto (YYZ) to St. Louis (STL)
8.4/10 Very Good! (1,002 reviews)
Loved my stay here will be back

Reviewed on Aug. 13, 2025

Courtyard by Marriott St. Louis Downtown/Convention Center

Courtyard by Marriott St. Louis Downtown/Convention Center

3 out of 5
Downtown St. Louis
Price was CA $1,011, price is now CA $838 per person
CA $838
per person
Sep 27 - Sep 30
found 1 hour ago
Roundtrip flight included
Halifax (YHZ) to St. Louis (STL)
9/10 Wonderful! (1,004 reviews)
I was very surprised at how empty the streets were but I asked a local policeman and he said it usually is. The streets were very clean. However like most big cities just be careful

Reviewed on Aug. 20, 2025

Ready to book your vacation to Southeast Missouri?

 

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Southeast Missouri Hotel Deals

Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO

2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is CA $75 per night from Sep 1 to Sep 2
CA $75
CA $86 total
Sep 1 - Sep 2
includes taxes & fees
8/10 Very Good! (1,000 reviews)
"I actually stay there a couple times a month. I do it for the pool most all their staff is very friendly jay is especially/. I would recommend it to anyone."

Reviewed on Aug. 17, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is CA $146 per night from Aug 24 to Aug 25
CA $146
CA $165 total
Aug 24 - Aug 25
includes taxes & fees
9.2/10 Wonderful! (392 reviews)
"I loved the rooms. They were spacious, clean and the bed was wonderful. However, the lobby smelled of smoke. The rooms did not, but the lobby definitely did."

Reviewed on Aug. 18, 2025

The Riverview
The Farmstead Hotel

The Farmstead Hotel

2.5 out of 5
778 E 3rd St, Caruthersville, MO
Fully refundableReserve now, pay when you stay
The price is CA $116 per night from Aug 22 to Aug 23
CA $116
CA $207 total
Aug 22 - Aug 23
includes taxes & fees
8.6/10 Excellent! (403 reviews)
"My wife and I are very pleased with Homestead Hotel. Very friendly and helpful staff at the front desk. For being 3 years old Homestead Hotel is very clean and welcoming. My wife and I highly recommend this hotel. Another plus with this motel is it’s right next to the casino."

Reviewed on Aug. 18, 2025

The Farmstead Hotel
See all 585 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Southeast Missouri

Rocky Falls

Rocky Falls

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Rocky Falls

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Southeast Missouri State University

Century Casino Caruthersville

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

Century Casino Caruthersville

What to do in Southeast Missouri

St Louis: City Museum General Admission Ticket

St Louis: City Museum General Admission Ticket

CA $31
per adult
96% of travellers recommend
St Louis: City Museum General Admission Ticket
St. Louis: Gateway Ghouls and Hauntings Walking Tour

St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour

CA $44
per adult
St Louis Ghost Tours: Sinister Sins & Shadows Ghost Tour
Best of St. Louis Small Group Tour w/ Arch & River Cruise

Best of St. Louis Small Group Tour w/ Arch & River Cruise

CA $233
per adult
84% of travellers recommend
Best of St. Louis Small Group Tour w/ Arch & River Cruise
See all activities in Southeast Missouri

Frequently asked questions

How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just CA $595. Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.