Title: Southeast Missouri Vacation Packages & Trips 2026 from CA $964 | Expedia.ca [Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide) ![](https://images.trvl-media.com/place/148078/1ef720df-0786-4e45-8a4f-890d982b757b.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeast Missouri Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings Photo by JG Morris - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Southeast Missouri Vacation Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in [Cape Girardeau](https://www.expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. [Sikeston](https://www.expedia.ca/Sikeston.d6058766.Destination-Travel-Guides) is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today. ## Top Southeast Missouri Vacation Deals Price found within the past 48 hours. Click for updated prices. ![ White House at Grand Central](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/b3c8bf38_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### White House at Grand Central Grand Center CA $964 per person Mar 28 - Apr 2 found 4 hours ago Roundtrip non-stop flight included Montreal (YUL) to St. Louis (STL) 8.6/10 Excellent! (123 reviews) Very clean and very friendly people Reviewed on Nov 11, 2025 ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel CA $1,067 per person Mar 28 - Apr 2 found 4 hours ago Roundtrip non-stop flight included Montreal (YUL) to St. Louis (STL) 9.2/10 Wonderful! (1,600 reviews) Breakfast great! Pool: hot tub being renovated. Reviewed on Jan 12, 2026 ![The Cheshire](https://images.trvl-media.com/lodging/1000000/30000/26100/26061/b6ec06de_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Cheshire CA $1,259 per person Mar 28 - Apr 2 found 4 hours ago Roundtrip non-stop flight included Montreal (YUL) to St. Louis (STL) 8.6/10 Excellent! (1,002 reviews) Loved the uniqueness of Cheshire inn and the themed rooms by authors. Had a great breakfast! Also the Fox and Hound Tavern inside and the Basso just a few steps away out the door. The one thing I did miss was having a mini fridge and microwave. Reviewed on Jan 4, 2026 ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center CA $1,166 per person Mar 28 - Apr 2 found 4 hours ago Roundtrip non-stop flight included Montreal (YUL) to St. Louis (STL) 8.8/10 Excellent! (1,022 reviews) I always love staying Angad art hotel! Reviewed on Jan 11, 2026 ![Hampton Inn By Hilton St Louis Airport](https://images.trvl-media.com/lodging/111000000/110650000/110648500/110648496/acc96ed2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hampton Inn By Hilton St Louis Airport Woodson Terrace CA $1,125 per person Mar 28 - Apr 2 found 4 hours ago Roundtrip non-stop flight included Montreal (YUL) to St. Louis (STL) 8.8/10 Excellent! (96 reviews) Front desk was excellent Reviewed on Jan 10, 2026 ## Ready to book your vacation to Southeast Missouri? Choose your dates ## Southeast Missouri Hotel Deals ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO Fully refundableReserve now, pay when you stay CA $73 CA $84 total Jan 18 - Jan 19 includes taxes & fees 7.8/10 Good! (1,001 reviews) Great stay Reviewed on Jan 6, 2026 [](https://expedia.ca/Hotel-Search?startDate=18%2F01%2F2026&endDate=19%2F01%2F2026&selected=16153&PinnedHotelID=16153&HadPinnedHotel=true®ionId=6058763) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay CA $125 CA $141 total Jan 19 - Jan 20 includes taxes & fees 9.4/10 Exceptional! (1,007 reviews) Everything was great Reviewed on Jan 10, 2026 [](https://expedia.ca/Hotel-Search?startDate=19%2F01%2F2026&endDate=20%2F01%2F2026&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true®ionId=6058763) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverview 777 Main St Cape Girardeau MO Fully refundableReserve now, pay when you stay CA $134 CA $151 total Jan 13 - Jan 14 includes taxes & fees 9.2/10 Wonderful! (484 reviews) Excellent stay. Will come again Reviewed on Dec 30, 2025 [](https://expedia.ca/Hotel-Search?startDate=13%2F01%2F2026&endDate=14%2F01%2F2026&selected=105081384&PinnedHotelID=105081384&HadPinnedHotel=true®ionId=6058763) [See all 622 properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=13%2F01%2F2026&endDate=14%2F01%2F2026®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Discover the most popular places to visit in Southeast Missouri ![Rocky Falls](https://mediaim.expedia.com/destination/2/f2325d7f040c776e314b23ad9fbdb813.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Rocky Falls Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting. [](https://expedia.ca/Rocky-Falls-Winona.d553248621532648456.Vacation-Attraction) #### Southeast Missouri State University Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.ca/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) #### Century Casino Caruthersville Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Century-Casino-Caruthersville-Caruthersville.d553248621532655201.Vacation-Attraction) ### What to do in Southeast Missouri ![Ozark Craft Beverage - Brewery Tour](https://mediaim.expedia.com/localexpert/5026127/bb50ed0e-b72f-4359-9f79-f93dc0acc935.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Ozark Craft Beverage - Brewery Tour CA $212 per adult [](https://expedia.ca/things-to-do/ozark-craft-beverage-brewery-tour.a5026127.activity-details) [See all activities in Southeast Missouri](https://expedia.ca/things-to-do/search?rid=6058763) ## Frequently asked questions ### Can I cancel my flight booking to Southeast Missouri due to COVID-19? ### What's the best way to find cheap flights to Southeast Missouri that have flexible change policies? ### What are some of the general tips for travelers to Southeast Missouri during the COVID-19 outbreak? > - Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight. > - When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry. > - Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection. > - One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning. > - Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening. > - Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings. ### Which airlines fly to Southeast Missouri? ### How can I find cheap tickets to Southeast Missouri? ### How much is a flight to Southeast Missouri? ### What are the most popular airports to fly into in Southeast Missouri? ### When is the cheapest time to fly to Southeast Missouri? ### How much is a plane ticket to Southeast Missouri? ### Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies? > - Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [B&B in Annapolis ](https://www.expedia.ca/Annapolis-Bed-And-Breakfast.d6282465-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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