Find hotels in Southeast Missouri, MO from CA $70
- Plan, book, travel with confidence
- Better togetherSave up to CA $1,096 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Go beyond your typical stay in Southeast Missouri
Pet friendly
Cabin
Check prices for these dates
Our top choices for Southeast Missouri hotels
Hampton Inn Sikeston
Hampton Inn SikestonSikeston
9.0 out of 10, Wonderful, (483 reviews)
"Very Clean room, friendly staff, breakfast in the morning. Will be staying again! "
Affinity
The price is CA $130
CA $147 total
includes taxes & fees
Feb 28 - Mar 1
Fairfield Inn & Suites by Marriott Poplar Bluff
Fairfield Inn & Suites by Marriott Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (873 reviews)
"Very clean and well maintained hotel. "
Michael
The price is CA $142
CA $161 total
includes taxes & fees
Mar 20 - Mar 21
Drury Inn & Suites Sikeston, MO
Drury Inn & Suites Sikeston, MOSikeston
9.4 out of 10, Exceptional, (1,002 reviews)
"As always it was a perfect visit"
John
The price is CA $129
CA $148 total
includes taxes & fees
Feb 24 - Feb 25
Holiday Inn Express & Suites Perryville by IHG
Holiday Inn Express & Suites Perryville by IHGPerryville
9.2 out of 10, Wonderful, (559 reviews)
"Staff was friendly and the place is clean. Our stay was in late January and the air was so very dry and the static electricity from blankets & sheets was off the charts."
Roger
The price is CA $125
CA $143 total
includes taxes & fees
Feb 22 - Feb 23
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (708 reviews)
"Yes everything was great"
jerry
The price is CA $115
CA $125 total
includes taxes & fees
Feb 22 - Feb 23
Fairfield Inn & Suites by Marriott Sikeston
Fairfield Inn & Suites by Marriott SikestonSikeston
9.4 out of 10, Exceptional, (58 reviews)
"Clean rooms great staff"
IRA
The price is CA $138
CA $157 total
includes taxes & fees
Feb 26 - Feb 27
Hampton Inn Poplar Bluff
Hampton Inn Poplar BluffPoplar Bluff
9.4 out of 10, Exceptional, (801 reviews)
"Would stay again"
David
The price is CA $128
CA $143 total
includes taxes & fees
Mar 1 - Mar 2
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,005 reviews)
"Great place "
Kelly
The price is CA $137
CA $154 total
includes taxes & fees
Feb 24 - Feb 25
Echo Bluff State Park
Echo Bluff State ParkEminence
9.4 out of 10, Exceptional, (222 reviews)
"This entire trip was inspired by Tina, a staff member. I met Tina passing through the area and she provided me with a lot of information which gave me the idea to plan a weekend trip with my wife. The lodge room we had was clean and comfortable, My wife and I had a wonderful time exploring most of the areas Tina mentioned. Thank you Tina for a wonderful inspiration for a get away. "
Jared
The price is CA $211
CA $224 total
includes taxes & fees
Mar 1 - Mar 2
Honeysuckle Inn - Mountain View
Honeysuckle Inn - Mountain ViewMountain View
8.6 out of 10, Excellent, (338 reviews)
"It was a very nice hassle free stay. I will be staying here again."
Michael Grey
The price is CA $123
CA $134 total
includes taxes & fees
Mar 15 - Mar 16
Crown Pointe Lodge, BW Signature Collection
Crown Pointe Lodge, BW Signature CollectionFarmington
9.0 out of 10, Wonderful, (585 reviews)
"Very nice stay. The front desk lady named Tracy was terrific!"
Kevin
The price is CA $127
CA $144 total
includes taxes & fees
Mar 1 - Mar 2
The Riverview
The RiverviewCape Girardeau
9.4 out of 10, Exceptional, (507 reviews)
"The room was clean and I was able to check in a bit early."
Sara
The price is CA $121
CA $137 total
includes taxes & fees
Mar 1 - Mar 2
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
9.6 out of 10, Exceptional, (1,006 reviews)
"Suited our purpose for overnight on a road trip "
Angela
The price is CA $109
CA $116 total
includes taxes & fees
Feb 25 - Feb 26
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Breakfast was very good and staff was extremely friendly and rooms were very clean "
Rex
The price is CA $125
CA $141 total
includes taxes & fees
Mar 15 - Mar 16
Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
9.6 out of 10, Exceptional, (109 reviews)
"It was a nice stay"
Douglas
The price is CA $122
CA $139 total
includes taxes & fees
Feb 26 - Feb 27
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (158 reviews)
"Great hotel - super clean, fast check-in, convenient, etc.
We’ll definitely stay here again. "
Richard
The price is CA $127
CA $144 total
includes taxes & fees
Mar 5 - Mar 6
Hampton Inn Farmington
Hampton Inn FarmingtonFarmington
8.8 out of 10, Excellent, (531 reviews)
"Hot tub still listed for property/on photos but not actual available (cemented in) but pool was nice, hotel was quiet, pet friendly with areas to walk pets and bags available for pet potty pick ups. Friendly staff, good housekeeping, and pretty decent breakfast spread "
Tirzah
The price is CA $154
CA $175 total
includes taxes & fees
Feb 27 - Feb 28
Shepherd Mountain Inn
Shepherd Mountain InnIronton
9.2 out of 10, Wonderful, (306 reviews)
"Everything was wonderful- the family that owns this is very kind, and it’s in a beautiful location!"
Nathan
The Farmstead Hotel
The Farmstead HotelCaruthersville
8.8 out of 10, Excellent, (490 reviews)
"Clean room, very nice staff"
Mack
The price is CA $94
CA $106 total
includes taxes & fees
Feb 23 - Feb 24
Super 8 by Wyndham Perryville
Super 8 by Wyndham PerryvillePerryville
8.4 out of 10, Very good, (957 reviews)
"If you're looking for a great deal, this is it. Unlike many less expensive hotels, this one has been refreshed with new carpeting and paint. Staff was courteous and friendly. "
Judith
The price is CA $95
CA $109 total
includes taxes & fees
Mar 8 - Mar 9
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Vacation Rentals in Southeast Missouri
Cabin
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
Postcard Cabins St Francois, Outdoor Collection by Marriott BonvoyFrench Village
10.0 out of 10, Exceptional, (52 reviews)
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Central United States attractions
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Clearwater Lake.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Recent Reviews in Southeast Missouri
Drury Inn & Suites Sikeston, MO
10/10 Excellent
More cheap stays in Southeast Missouri
Motel 6 Poplar Bluff, MO
4101 Highway 67 N Poplar Bluff MO
The price is CA $67 per night from Feb 22 to Feb 23
CA $67
CA $70 total
Feb 22 - Feb 23
includes taxes & fees
8/10 Very Good! (1,004 reviews)
Hotels in Southeast Missouri with star rating
4 Star Hotels
2 properties
Explore a world of travel with Expedia
- B&B in Annapolis
- Hotels with Balconies in Annapolis
- Luxury Hotels in Annapolis
- Spa Hotels in Annapolis
- Annapolis Hotels
- Lodges in Annapolis
- Farmstay in Arcadia
- B&B in Arcadia
- Cheap Hotels in Arcadia
- Luxury Hotels in Arcadia
- Arcadia Hotels
- Lodges in Arcadia
- B&B in Belleview
- Cabin Rentals in Belleview
- Belleview Hotels
- Motels in Belleview
- Black Hotels
- Lodges in Black
- Apartments in Centerville
- Centerville Hotels
- Motels in Centerville
- Cobalt Hotels
- Cheap Hotels in Des Arc
- Des Arc Hotels
- Wayne County Hotels
- Cheap Hotels in Doe Run
- Doe Run Hotels
- Lodges in Doe Run
- Hotels near Elephant Rocks State Park
- Cheap Hotels in Fredericktown
- Pet-Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Glen Allen Hotels
- Vacation Homes in Glen Allen
- Greenville Hotels
- Lodges in Greenville
- Resorts in Greenville
- Farmstay in Iron Mountain Lake
- Ironton Hotels
- Hotels near Johnson's Shut-ins State Park
- Lodges in Knob Lick
- Cheap Hotels in Lesterville
- Lesterville Hotels
- Cheap Hotels in Marble Hill
- Marble Hill Hotels
- B&B in Middle Brook
- Middle Brook Hotels
- Lodges in Middle Brook
- Mill Spring Hotels
- Patterson Hotels
- Lodges in Patterson
- Resorts in Patterson
- Cheap Hotels in Piedmont
- Luxury Hotels in Piedmont
- Piedmont Hotels
- Motels in Piedmont
- Hotels with Wifi in Pilot Knob
- Pilot Knob Hotels
- Lodges in Pilot Knob
- Resorts in Wayne County
- Hotels with a Pool in Williamsville
- Busch Stadium
- Eden Spa & Salon
- Enterprise Center
- Visit Fredericktown
- Gateway Arch
- Gateway Arch National Park
- Grant's Farm
- Houston Vacations
- K Bridge Recreation Area
- Kirkwood Vacations
- Labadie Vacations
- Laumeier Sculpture Park
- Magic House - St. Louis Children's Museum
- Missouri Botanical Gardens and Arboretum
- Missouri National Guard Armory
- Missouri University of Science and Technology
- Old Courthouse
- Qulin Vacations
- Rocky Falls
- Senath Vacations
- Six Flags St. Louis
- Southeast Missouri State University
- St. James Vacations
- St. Louis Science Center
- St. Louis Zoo
- St. Louis Vacations
- Tiff Vacations
- Union Vacations
- Wappapello Vacations
- Wesco Vacations
- Wildwood Vacations
