Southeast Missouri Vacation Packages
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Your Southeast Missouri Vacation
Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. Sikeston is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.
Top Southeast Missouri Vacation Deals
Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel
CA $772
per person
Nov 13 - Nov 15
found 7 hours ago
Roundtrip non-stop flight included
Vancouver (YVR) to St. Louis (STL)
9.2/10 Wonderful! (1,679 reviews)
Room was clean, yet picures and description are a bit deceiving.
Overall, stay was good and would come back again.
Reviewed on Oct 4, 2026
Ready to book your vacation to Southeast Missouri?
Southeast Missouri Hotel Deals
Drury Plaza Hotel Cape Girardeau Conference Center
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
CA $143
CA $161 total
Oct 11 - Oct 12
includes taxes & fees
9.6/10 Exceptional! (1,004 reviews)
"Needs some more luxurious bedding. My sheets were worn and scratchy."
Reviewed on Oct 4, 2026
Drury Inn & Suites Sikeston, MO
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
CA $134
CA $154 total
Oct 11 - Oct 12
includes taxes & fees
Baymont Inn and Suites by Wyndham Farmington, MO
1625 W Columbia St Farmington MO
Fully refundableReserve now, pay when you stay
CA $78
CA $89 total
Nov 1 - Nov 2
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southeast Missouri attractions
Photo by Pat Long
Elephant Rocks State Park
9.6/10 (98 reviews)
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Southeast Missouri State University
8.8/10 (248 reviews)
Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.
Photo by JG Morris
Lake Wappapello
8.8/10 (54 reviews)
Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.
Century Casino Caruthersville
7.0/10 (57 reviews)
Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.
What to do in Southeast Missouri
Night Ghost Tour of Pythian Castle in Springfield Missouri
CA $28
per adult
96% of travellers recommend
Tour The Ozarks Private Springfield Brewery Tour
CA $299
per adult
Frequently asked questions
How much does a Southeast Missouri vacation package cost?
Cross off another part of the world with our Southeast Missouri vacation packages, which start from just CA $763. Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri vacation packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center and Pear Tree Inn Cape Girardeau West are a couple of favorites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri vacation?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Vacationing for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia vacation package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri vacation package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri vacation package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.
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- Park Hills Hotels
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- Flights from New York (JFK) to Cape Girardeau (CGI)
- Flights from Colombo (CMB) to Cape Girardeau (CGI)
- Flights from St. Louis (STL) to Poplar Bluff (POF)
- Flights to Poplar Bluff
- Flights from Vancouver (YVR) to Cape Girardeau (CGI)
- Flights to Farmington
- Flights from Bloomington (BMI) to Cape Girardeau (CGI)
- Flights from Toronto (YTO) to Cape Girardeau (CGI)
- Flights from Grand Island (GRI) to Cape Girardeau (CGI)
- Flights to Bonne Terre
- Flights from Bonne Terre
- Flights from Stuart (SUA) to Cape Girardeau (CGI)
- Flights from Arcadia
- Flights from Chaffee
- Flights from Belleview
- Flights from Calgary (YYC) to Cape Girardeau (CGI)
- Flights to Butler County
- Flights from Toronto (YYZ) to Cape Girardeau (CGI)
- Flights from Edmonton (YEG) to Cape Girardeau (CGI)
- Flights from Montreal (YUL) to Cape Girardeau (CGI)
- Flights to Dexter
- Flights from Eugene (EUG) to Cape Girardeau (CGI)
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Ocala (OCF) to Cape Girardeau (CGI)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
