Title: Southeast Missouri Vacation Packages & Trips 2026 from CA $694 | Expedia.ca [Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide) ![](https://images.trvl-media.com/place/148078/1ef720df-0786-4e45-8a4f-890d982b757b.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Southeast Missouri Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings Photo by JG Morris - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Southeast Missouri Vacation Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in [Cape Girardeau](https://www.expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Centre. [Sikeston](https://www.expedia.ca/Sikeston.d6058766.Destination-Travel-Guides) is another city that lures travellers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today. ## Top Southeast Missouri Vacation Deals Price found within the past 48 hours. Click for updated prices. ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/800a6847_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel CA $694 per person Mar 5 - Mar 8 found 13 hours ago Roundtrip non-stop flight included Detroit (DTW) to St. Louis (STL) 9.2/10 Wonderful! (1,600 reviews) It’s a nice place, clean but dated. The reason I give it three stars is that I felt it was very overpriced. It is more or less your average hotel but it is priced like a five star resort. Reviewed on Jan 10, 2026 ![ White House at Grand Central](https://images.trvl-media.com/lodging/84000000/83130000/83121100/83121050/b3c8bf38_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### White House at Grand Central Grand Center CA $1,096 per person Feb 22 - Mar 1 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to St. Louis (STL) 8.6/10 Excellent! (123 reviews) Very clean and very friendly people Reviewed on Nov 11, 2025 ![Hotel Saint Louis, Autograph Collection](https://images.trvl-media.com/lodging/28000000/27480000/27478600/27478599/8a12cc18_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Hotel Saint Louis, Autograph Collection Downtown St. Louis CA $1,819 per person Feb 22 - Mar 1 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to St. Louis (STL) 8.8/10 Excellent! (458 reviews) Property and room was really nice. I will be staying here in the future Reviewed on Nov 25, 2025 ![The West End](https://images.trvl-media.com/lodging/107000000/106720000/106715700/106715696/ccf67b25_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The West End Central West End CA $1,121 per person Feb 22 - Mar 1 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to St. Louis (STL) 8.4/10 Very Good! (389 reviews) Great staff and management. Very helpful and fully responsive Reviewed on Dec 25, 2025 ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### 21C Museum Hotel St Louis Downtown West CA $1,313 per person Feb 22 - Mar 1 found 1 day ago Roundtrip non-stop flight included Edmonton (YEG) to St. Louis (STL) 9/10 Wonderful! (1,458 reviews) Our room wasn’t ready at 5pm, could not check in for about 1.5 hrs. Luckily they have a fantastic bar. Room was small but well appointed. The doors to some cabinets would not shut. The shower door would not shut. We did not have enough shampoo conditioner or body wash. The museum was nice. The restaurant is great. Probably wouldn’t stay again but would definitely eat at the restaurant or have drinks at the bar. Reviewed on Jan 5, 2026 ## Ready to book your vacation to Southeast Missouri? Choose your dates ## Southeast Missouri Hotel Deals ![Baymont Inn and Suites by Wyndham Farmington, MO](https://images.trvl-media.com/lodging/1000000/20000/16200/16153/02759b26_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont Inn and Suites by Wyndham Farmington, MO 1625 W Columbia St Farmington MO Fully refundableReserve now, pay when you stay CA $73 CA $84 total Jan 18 - Jan 19 includes taxes & fees 7.8/10 Good! (1,001 reviews) Great stay Reviewed on Jan 6, 2026 [](https://expedia.ca/Hotel-Search?startDate=18%2F01%2F2026&endDate=19%2F01%2F2026&selected=16153&PinnedHotelID=16153&HadPinnedHotel=true®ionId=6058763) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Plaza Hotel Cape Girardeau Conference Center 3351 Percy Drive Cape Girardeau MO Fully refundableReserve now, pay when you stay CA $125 CA $141 total Jan 19 - Jan 20 includes taxes & fees 9.4/10 Exceptional! (1,011 reviews) Breakfast buffet was very good. We ate at the restaurant onsite, and the food was very good. The room always spacious and nice. We were on the road side and you could hear a lot of noise from the trucks, loud cars, etc on the road. Reviewed on Jan 4, 2026 [](https://expedia.ca/Hotel-Search?startDate=19%2F01%2F2026&endDate=20%2F01%2F2026&selected=17269948&PinnedHotelID=17269948&HadPinnedHotel=true®ionId=6058763) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Riverview 777 Main St Cape Girardeau MO Fully refundableReserve now, pay when you stay CA $125 CA $142 total Feb 11 - Feb 12 includes taxes & fees 9.2/10 Wonderful! (484 reviews) Excellent stay. Will come again Reviewed on Dec 30, 2025 [](https://expedia.ca/Hotel-Search?startDate=11%2F02%2F2026&endDate=12%2F02%2F2026&selected=105081384&PinnedHotelID=105081384&HadPinnedHotel=true®ionId=6058763) [See all 622 properties in Southeast Missouri](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=12%2F01%2F2026&endDate=13%2F01%2F2026®ionId=6058763) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.ca/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.ca/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Family Vacations [](https://expedia.ca/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Family_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf Vacations [](https://expedia.ca/lp/theme-vacations/golf-vacations?rfrr=editorial.Golf_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/07/15/US_Luxury_VR_Miami.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Luxury Vacations [](https://expedia.ca/lp/theme-vacations/luxury-vacations?rfrr=editorial.Luxury_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/08/29/romantic.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Romantic Vacations [](https://expedia.ca/lp/theme-vacations/romantic-vacations?rfrr=editorial.Romantic_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/31952_v1_atfraraski22_insta_4.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Ski Vacations [](https://expedia.ca/lp/theme-vacations/ski-vacations?rfrr=editorial.Ski_Vacations.click) ### Discover the most popular places to visit in Southeast Missouri ![Rocky Falls](https://mediaim.expedia.com/destination/2/f2325d7f040c776e314b23ad9fbdb813.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Rocky Falls Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting. [](https://expedia.ca/Rocky-Falls-Winona.d553248621532648456.Vacation-Attraction) #### Southeast Missouri State University Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants. [](https://expedia.ca/Southeast-Missouri-State-University-Cape-Girardeau.d553248621554122994.Vacation-Attraction) #### Century Casino Caruthersville Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants. [](https://expedia.ca/Century-Casino-Caruthersville-Caruthersville.d553248621532655201.Vacation-Attraction) ### What to do in Southeast Missouri ![Ozark Craft Beverage - Brewery Tour](https://mediaim.expedia.com/localexpert/5026127/bb50ed0e-b72f-4359-9f79-f93dc0acc935.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Ozark Craft Beverage - Brewery Tour CA $212 per adult [](https://expedia.ca/things-to-do/ozark-craft-beverage-brewery-tour.a5026127.activity-details) [See all activities in Southeast Missouri](https://expedia.ca/things-to-do/search?rid=6058763) ## Frequently asked questions ### Can I cancel my flight booking to Southeast Missouri due to COVID-19? ### What's the best way to find cheap flights to Southeast Missouri that have flexible change policies? ### What are some of the general tips for travelers to Southeast Missouri during the COVID-19 outbreak? > - Find out what, if any, rules or restrictions apply to both your origin and destination. It may not be possible to travel depending on local circumstances, so be sure to check before you lock in your flight. > - When you pass through airport screening, keep your face mask on. You will be asked to lower it briefly for identification purposes. Those who refuse to wear a mask may be fined and denied entry. > - Instead of handing a TSA agent your boarding pass, position it straight on the reader yourself. Once that's done, hold it up for inspection. > - One container of liquid hand sanitizer is now permitted in your carry-on baggage. It must be no bigger than 12 oz (350 ml), and you'll need to take it out of your bag for scanning. > - Empty your personal items from your pockets, like your keys, phone and wallet, and put them in your carry-on instead of the bins. This will minimize handling during screening. > - Separate any food you have for screening. Food items often set off the alarm. Placing them in a clear plastic bag and into a bin reduces the need for a TSA officer to touch and inspect your belongings. ### Which airlines fly to Southeast Missouri? ### How can I find cheap tickets to Southeast Missouri? ### How much is a flight to Southeast Missouri? ### What are the most popular airports to fly into in Southeast Missouri? ### When is the cheapest time to fly to Southeast Missouri? ### How much is a plane ticket to Southeast Missouri? ### Which airlines with flights to Southeast Missouri employ COVID-19 cleanliness policies? > - Southwest Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - American Airlines - this airline is known for providing passenger masks and cleaning with disinfectant. > - Delta - this airline is known for electrostatic cleaning and cleaning with disinfectant. ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [B&B in Annapolis ](https://www.expedia.ca/Annapolis-Bed-And-Breakfast.d6282465-aaBedAndBreakfast.Travel-Guide-Accommodation) - 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