Sikeston Vacation Packages

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Your Sikeston Vacation

There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to Sikeston Depot Museum, The Book Bug and Central Park, some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style.

Top Sikeston Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Marriott St. Louis Airport

Marriott St. Louis Airport

4 out of 5
Edmundson
Price was CA $1,130, price is now CA $1,012 per person
CA $1,012
per person
Jan 22 - Jan 25
found 17 hours ago
Roundtrip non-stop flight included
Edmonton (YEA) to St. Louis (STL)
8/10 Very good! (1,002 reviews)
It was a quick visit but everything ok

Reviewed on Nov 14, 2026

Moonrise Hotel

Moonrise Hotel

4 out of 5
Delmar Loop
Price was CA $1,231, price is now CA $1,056 per person
CA $1,056
per person
Jan 22 - Jan 25
found 17 hours ago
Roundtrip non-stop flight included
Edmonton (YEA) to St. Louis (STL)
9/10 Wonderful! (2,047 reviews)

Landing Furnished Apartments - Central West End

Landing Furnished Apartments - Central West End

3.5 out of 5
Central West End
Price was CA $1,317, price is now CA $1,160 per person
CA $1,160
per person
Jan 22 - Jan 26
found 17 hours ago
Roundtrip non-stop flight included
Edmonton (YEA) to St. Louis (STL)
7/10 Good! (7 reviews)

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

5 out of 5
Downtown St. Louis
Price was CA $1,724, price is now CA $1,520 per person
CA $1,520
per person
Jan 22 - Jan 26
found 17 hours ago
Roundtrip non-stop flight included
Edmonton (YEA) to St. Louis (STL)
9.4/10 Exceptional! (1,001 reviews)
Introducing my friends and family to Four Season St. Louis is probably my biggest flex as an adult who can treat the ones I love with an amazing experience. Never disappointed. Will be back.

Reviewed on Nov 11, 2026

Ready to book your vacation to Sikeston?

 

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Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $134 per night from Nov 22 to Nov 23
CA $134
CA $154 total
Nov 22 - Nov 23
includes taxes & fees
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $95 per night from Nov 17 to Nov 18
CA $95
CA $108 total
Nov 17 - Nov 18
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is CA $143 per night from Nov 22 to Nov 23
CA $143
CA $163 total
Nov 22 - Nov 23
includes taxes & fees
9/10 Wonderful! (661 reviews)
"Everything was great. Room was clean. Fitness center was nice"

Reviewed on Nov 15, 2026

Hampton Inn Sikeston
See all 314 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
You can spend time exploring the galleries in Sikeston Depot Museum in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices from CA $1,012 on Expedia for your Sikeston break. However, a range of factors like the season, choice of hotel and length of stay will influence how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you'd like to score a cheap Sikeston vacation package, consider travelling in January, February and September. You'll typically find better prices on hotels and flights during these months — ideal for a budget-friendly getaway.
How many days is enough for Sikeston?
For your Sikeston vacation, a few days will be enough to tour all the highlights. Be sure to check out Sikeston Depot Museum — it's one of the top attractions in this destination. If you're after more adventure, think about basing yourself here and heading off on some day trips from Sikeston.
Is it worth booking a vacation package to Sikeston?
Sikeston has everything you need for an unforgettable getaway. Get your Sikeston vacation off to a flying start by exploring top attractions like Central Park.
How to find the best Sikeston package deals?
Finding a cheap Sikeston package deal is easy with Expedia. After you've entered your travel dates and destination under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can customize your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Sikeston package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are usually lower.
Is it cheaper to book a Sikeston vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll usually score a better deal than booking each component separately. And you'll still get the freedom to create a tailored Sikeston vacation by choosing your favourite accommodation type, airline and car class.
When to book a vacation package to Sikeston?
If you've got your Sikeston travel dates finalized, book early to grab some terrific deals. With Expedia, you can typically reserve some flights up to one year in advance. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
How to plan a trip to Sikeston?

  1. Pick your travel dates: What you want to do in Sikeston and your preferred season can help you decide when to go.
  2. Figure out your budget: Ensure you have enough money to pay for everything from transportation and meals to flights and activities. Your accommodations will probably be the largest expense during your trip to Sikeston.
  3. Decide your trip length: Think about how much time you'd like to spend exploring Sikeston. Plan your itinerary so you can get to all the activities and attractions you're interested in without rushing.
  4. Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Sikeston vacation package.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.