Title: Sikeston Vacation Packages & Trips 2026 from CA $1,374 | Expedia.ca [Hotels in Sikeston](https://expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.ca/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.ca/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Sikeston Car Rentals](https://expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide) ![](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Sikeston Vacation Packages ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place #### Your Sikeston Vacation There's tons to like about Sikeston, from its rich history to its rural countryside. When you're ready to say hi to this captivating city, our Sikeston vacation packages will be perfect for you. Fill your spare time with visits to [Sikeston Depot Museum](https://www.expedia.ca/Sikeston-Depot-Museum-Sikeston.d6305602.Vacation-Attraction), [The Book Bug](https://www.expedia.ca/The-Book-Bug-Sikeston.d553248621532655751.Vacation-Attraction) and [Central Park](https://www.expedia.ca/Central-Park-Sikeston.d6305608.Vacation-Attraction), some of the top attractions you just have to see during your trip to Sikeston. That dream Sikeston vacation is clicks away. Browse hotels, flights and more on Expedia for a getaway that's tailored to suit your travel style. ## Top Sikeston Vacation Deals Price found within the past 48 hours. Click for updated prices. ![Angad Arts Hotel St. Louis, Tapestry Collection by Hilton](https://images.trvl-media.com/lodging/28000000/27620000/27617000/27616925/25bc97a8_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Angad Arts Hotel St. Louis, Tapestry Collection by Hilton Grand Center CA $1,374 per person Jun 14 - Jun 21 found 1 day ago Roundtrip flight included Toronto (YYZ) to St. Louis (STL) 8.8/10 Excellent! (1,065 reviews) Cleaning needs help in the rooms and bathrooms. Room 511 hopefully is the smallest of all the rooms. You couldn’t use the chair fully with the desk and had to take turns in areas it was so tight. The staff was wrong about times for the Terrance bar and restaurant causing us to wait for that and then miss the downstairs restaurant being open so we waited a few more hours to find a place to eat. Simple mistake but that’s their job. Reviewed on Mar 22, 2026 ![The Wildwood Hotel](https://images.trvl-media.com/lodging/2000000/1770000/1768200/1768149/035dee6c_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Wildwood Hotel CA $1,556 per person May 18 - May 22 found 14 hours ago Roundtrip non-stop flight included Toronto (YYZ) to St. Louis (STL) 9.2/10 Wonderful! (1,620 reviews) The breakfaat was average, thou fresh. There was enough street parking nearby, safe. Reviewed on Mar 30, 2026 ![ The Royal Sonesta Chase Park Plaza St. Louis](https://images.trvl-media.com/lodging/1000000/470000/465800/465749/9bee4fd7_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Royal Sonesta Chase Park Plaza St. Louis Central West End CA $1,565 per person Jun 14 - Jun 21 found 1 day ago Roundtrip flight included Toronto (YYZ) to St. Louis (STL) 9/10 Wonderful! (1,005 reviews) Beautiful hotel, enjoyed the theater. Only problem was getting receipt for my boss. Reviewed on Mar 31, 2026 ![The Cheshire](https://images.trvl-media.com/lodging/1000000/30000/26100/26061/24983857_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### The Cheshire CA $1,389 per person Jun 14 - Jun 21 found 1 day ago Roundtrip flight included Toronto (YYZ) to St. Louis (STL) 8.6/10 Excellent! (1,009 reviews) The room was comfortable and we had the amenities we needed. It offered a generous breakfast every morning. Coffee and water were available at all times. The gym was clean and easily accessible. The pool was closed during our stay due to the season we traveled in. There was ample parking downstairs. The bar on site was really cute and the drinks were great. We were driving distance to a lot of things and it made it a great homebase. We would definitely stay here again. Reviewed on Mar 29, 2026 ![Spacious 3-Bedroom with King Bed](https://images.trvl-media.com/lodging/110000000/109680000/109680000/109679988/f2203ae1_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Spacious 3-Bedroom with King Bed Central West End CA $2,266 per person Jun 14 - Jun 21 found 1 day ago Roundtrip flight included Toronto (YYZ) to St. Louis (STL) 8.8/10 Excellent! (11 reviews) Clean room nice area Reviewed on Feb 1, 2026 ## Ready to book your vacation to Sikeston? Choose your dates ## Sikeston Hotel Deals ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO Fully refundableReserve now, pay when you stay CA $153 CA $176 total Apr 5 - Apr 6 includes taxes & fees 9.6/10 Exceptional! (1,007 reviews) Our first visit to a Drury Inn — what an amazing place. Not only was there an excellent breakfast with many choices, but there was also a light dinner served. This was all included for a very reasonable price. Our room was very clean and comfortable. We will definitely be looking for more Drury Inns ... Reviewed on Mar 30, 2026 [](https://expedia.ca/Hotel-Search?startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=6058766) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO Fully refundableReserve now, pay when you stay CA $147 CA $166 total Apr 19 - Apr 20 includes taxes & fees 9/10 Wonderful! (522 reviews) Yes Reviewed on Mar 30, 2026 [](https://expedia.ca/Hotel-Search?startDate=19%2F04%2F2026&endDate=20%2F04%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=6058766) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO Fully refundableReserve now, pay when you stay CA $122 CA $139 total Apr 4 - Apr 5 includes taxes & fees 8.4/10 Very Good! (1,002 reviews) The bed and chair was hard. Will not go back Reviewed on Mar 30, 2026 [](https://expedia.ca/Hotel-Search?startDate=04%2F04%2F2026&endDate=05%2F04%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=6058766) [See all 296 properties in Sikeston](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=01%2F04%2F2026&endDate=02%2F04%2F2026®ionId=6058766) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. 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Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app