Default HTG hotel image

Find hotels near Sikeston Depot Museum, Sikeston from CA $93

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Oct 6 - Oct 7
Tomorrow
Oct 7 - Oct 8
This weekend
Oct 9 - Oct 11
Next weekend
Oct 16 - Oct 18

Filter by

Star rating

Guest rating

Our top choices for Sikeston Depot Museum hotels

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.
An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

1. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.4 km from Sikeston Depot Museum
United States
Allen
CA $144
CA $163 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites by Marriott Sikeston
Property amenity
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

2. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
2.3 km from Sikeston Depot Museum
United States
Stacy
CA $150
CA $169 total
includes taxes & fees
Oct 18 - Oct 19
TownePlace Suites by Marriott Sikeston
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.
A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.
A conference room with a large rectangular table, six chairs with patterned upholstery, two modern ceiling lights, a bowl of fruit on the table, and large windows with curtains.

3. Hampton Inn Sikeston

Hampton Inn Sikeston
2.3 km from Sikeston Depot Museum
United States
Carolyn
CA $150
CA $171 total
includes taxes & fees
Oct 25 - Oct 26
Hampton Inn Sikeston
A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.
An indoor swimming pool with a tiled floor, a lifeguard chair, and a pool ladder.
A reception area with a reception desk, a large wall-mounted sign, and a potted plant.
A hotel room with a large bed, a nightstand with a lamp, a chair, and a desk with a lamp.

4. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.1 km from Sikeston Depot Museum
United States
Melissa
CA $144
CA $164 total
includes taxes & fees
Oct 25 - Oct 26
Holiday Inn Express & Suites Sikeston Southwest by IHG
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

5. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
5.1 km from Sikeston Depot Museum
United States
Scott
CA $134
CA $154 total
includes taxes & fees
Oct 11 - Oct 12
Drury Inn & Suites Sikeston, MO
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.
Room
A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.

6. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
5.4 km from Sikeston Depot Museum
United States
Shelley
CA $120
CA $137 total
includes taxes & fees
Oct 11 - Oct 12
Best Western Plus Sikeston I-55
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.
A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.
A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.
A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

7. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
5 km from Sikeston Depot Museum
United States
Craig
CA $88
CA $100 total
includes taxes & fees
Oct 26 - Oct 27
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.
A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.
A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.
A living room with two sofas, a coffee table, a TV, and a cabinet.

8. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
4.9 km from Sikeston Depot Museum
United States
Starlette
CA $119
CA $135 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn & Suites Sikeston I-55
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.
A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.
Lobby
A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

9. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
5.4 km from Sikeston Depot Museum
United States
David
CA $95
CA $108 total
includes taxes & fees
Oct 8 - Oct 9
Days Inn and Suites by Wyndham Sikeston
A bathroom with a shower, toilet, sink, and hand dryer.
A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.
A hotel kitchen with a long counter, various appliances, and a tiled backsplash.
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

10. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
4.7 km from Sikeston Depot Museum
United States
William
CA $81
CA $93 total
includes taxes & fees
Oct 14 - Oct 15
Super 8 by Wyndham Sikeston/Miner Area
A hotel room with two beds, a desk, a chair, a TV, and a mirror.
A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.
A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.
A bathroom with a bathtub, toilet, and shower curtain.

11. Country Yard Inn and Suite

Country Yard Inn and Suite
5.5 km from Sikeston Depot Museum
United States
William
CA $79
CA $95 total
includes taxes & fees
Oct 18 - Oct 19
Country Yard Inn and Suite
View all properties

Compare popular hotels close to Sikeston Depot Museum

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
Fairfield Inn & Suites by Marriott Sikeston
9.4
Exceptional
117 reviews
View
Property amenity
TownePlace Suites by Marriott Sikeston
9.4
Exceptional
26 reviews
View
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
Hampton Inn Sikeston
9.0
Wonderful
629 reviews
View
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
Holiday Inn Express & Suites Sikeston Southwest by IHG
8.8
Excellent
515 reviews
View
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
Drury Inn & Suites Sikeston, MO
9.6
Exceptional
1,005 reviews
View

Top Sikeston Depot Museum Hotel Reviews

Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"Clean, safe, quiet and a very good breakfast."
Carolyn 1-night trip
Posted 11 hours ago
Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

8/10 Good
"Overall it was a great stay. Kids loved the pool, breakfast was excellent, staff was very friendly and helpful, everything was very clean and nice.... Except the fold out couch bed. I don't know what happened there but the mattress was GROSS. Unfortunately when I went down to the front desk they didnt have a mattress to trade out and we were already settled in getting kids to bed, so the sweet lady gave me a nice very thick plush mattress pad to put over it and apologized over and over for not knowing it was like that. We would stay there again no problem."
Kim 1-night trip
Posted 2 days ago
Holiday Inn Express & Suites Sikeston Southwest by IHG
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"Great place"
BRANDY 1-night trip
Posted 3 days ago
Super 8 by Wyndham Sikeston/Miner Area
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good
"NA NA NA NA NA NA NA NA NA NA NA NA NA"
Kevin 1-night trip
Posted 8 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

10/10 Excellent
"This was a very good value. It has been the best hotel I've stayed at in awhile."
David 1-night trip
Posted 2 weeks ago
Days Inn and Suites by Wyndham Sikeston
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

8/10 Good
"Host is great. I've stayed here many times."
Susan R. 7-night trip
Posted 2 weeks ago
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston

10/10 Excellent
"My overall experience was amazing from the time I checked in until I left. The staff were super pleasant and incredible. My room was clean and spacious. I never been in an extended stay room before. I definitely will be booking a suite like this one again."
Stacy 2-night trip
Posted 3 weeks ago
TownePlace Suites by Marriott Sikeston
Eagle Inn Charleston

Eagle Inn Charleston

10/10 Excellent
"Great"
Jackson 1-night trip
Posted 6 months ago
Eagle Inn Charleston
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

10/10 Excellent
"The host was very quick to respond and so great to work with for on our stay. "
Jessica S. 3-night trip
Posted 1 year ago
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Other attractions near Sikeston Depot Museum

Central Park

7.2/10 (56 reviews)
Explore the great outdoors at Central Park, a lovely green space in Sikeston. While in this family-friendly area, you can savor the top-notch restaurants.
See properties

City of Miner Convention Center

Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants.
See properties

Front Street Studio & Art Gallery

8.6/10 (15 reviews)
You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savor the top-notch restaurants.
See properties

Hunter-Dawson State Historic Site

7.6/10 (13 reviews)
You can browse the exhibits at Hunter-Dawson State Historic Site, a museum with a story of its own, during your travels to New Madrid. Amble around the area's parks or experience its museums.
See properties

River Ridge Winery

8.4/10 (15 reviews)
You can enjoy a tasting or tour at River Ridge Winery during your travels to New Madrid. Amble around the area's parks or experience its museums.
See properties

New Madrid Historical Museum

8.2/10 (36 reviews)
You can study the exhibits at New Madrid Historical Museum, a museum with a storied past, during your travels to New Madrid. Amble around the area's parks or experience its museums.
See properties

Dexter Welcome Center Depot and Museum

7.6/10 (12 reviews)
You can study the exhibits at Dexter Welcome Center Depot and Museum, a museum with a story of its own, during your trip to Dexter. While in this family-friendly area, you can enjoy the restaurants.
See properties

The Heritage House

8.4/10 (7 reviews)
Learn about the local history of Dexter when you take a trip to The Heritage House. While in this family-friendly area, you can enjoy the restaurants.
See properties

Frequently asked questions

What's the area like around Sikeston Depot Museum?
Sikeston Depot Museum is located in a welcoming area of Sikeston known for its array of dining options. If you're looking for a convenient place to stay, check out the 5 hotels and other accommodations you'll find within a mile.
What's the best hotel to stay near Sikeston Depot Museum?
Drury Inn & Suites Sikeston, MO is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an outdoor pool. It's located 3.2 mi (5.1 km) from Sikeston Depot Museum. Other good choices within 5 miles include Hampton Inn Sikeston and Days Inn and Suites by Wyndham Sikeston.
How many hotels should I expect to find close to Sikeston Depot Museum?
Expedia has 5 hotels and other accommodations within a mile from Sikeston Depot Museum.
If I need to cancel the hotel reservation for my stay near Sikeston Depot Museum, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if cancelled prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before check in. If your reservation is non-refundable, you might still have the option to cancel and get a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to get the best deals near Sikeston Depot Museum.

Explore a world of travel with Expedia