Photo by Bill Dillard

Search Apartment Rentals in Southeast Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Find vacation rentals that suit your style

cabin image
Cabins
Cabins
Cottage image
Cottages
Cottages

Check prices for these dates

Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29
In one month
Dec 11 - Dec 13
In two months
Jan 8 - Jan 10

Our top choices for Southeast Missouri apartments

A modern kitchen with dark cabinets, a built-in microwave, a flat-screen TV, and a large window with a view of the street.

1. Ironton Hub: Near Elephant Rocks & Shut-ins

Ironton Hub: Near Elephant Rocks & Shut-ins
3.0 star property
Ironton
The price is CA $144
CA $280 total
includes taxes & fees
Nov 10 - Nov 11
Ironton Hub: Near Elephant Rocks & Shut-ins
A modern living room with a sofa, a coffee table, and a TV mounted on the wall.

2. Mountain View at Pickle & Perk

Mountain View at Pickle & Perk
Ironton
10.0 out of 10, Exceptional, (32 reviews)
"Could not have asked for better hosts or accommodations."
United States
David
The price is CA $202
CA $278 total
includes taxes & fees
Nov 11 - Nov 12
Mountain View at Pickle & Perk
A table with two chairs under a large tree with a potted plant on it.

3. Pickleball Cafe & Micro Hotel

Pickleball Cafe & Micro Hotel
Ironton
10.0 out of 10, Exceptional, (33 reviews)
"Great place to get away. Loved the coffee . "
United States
Craig C.
The price is CA $240
CA $315 total
includes taxes & fees
Nov 10 - Nov 11
Pickleball Cafe & Micro Hotel
A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

4. Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!
Ste. Genevieve
10.0 out of 10, Exceptional, (296 reviews)
"Absolutely beautiful place to stay!! Very clean!"
United States
Jimmy B.
The price is CA $209
CA $273 total
includes taxes & fees
Nov 17 - Nov 18
Beautiful Modern Loft In Wine Country!
A dining area with a dark wooden table, four chairs, and a central decorative item. A white refrigerator and a kitchen area with a stove and cabinets are visible in the background.

5. Upstairs 2 bedroom Private Apt Off I- 55 in Pevely

Upstairs 2 bedroom Private Apt Off I- 55 in Pevely
Pevely
9.6 out of 10, Exceptional, (12 reviews)
"We had a peaceful, quiet stay while visiting family in the area."
United States
Caren L.
The price is CA $295
CA $321 total
includes taxes & fees
Nov 10 - Nov 11
Upstairs 2 bedroom Private Apt Off I- 55 in Pevely
A tent with a clear view of a forested area outside.

6. Wandering Willow – Private Stargazing Glamping Tent with Fire Pit & Open Skies

Wandering Willow – Private Stargazing Glamping Tent with Fire Pit & Open Skies
Bunker
10.0 out of 10, Exceptional, (6 reviews)
"Beautiful location, very clean and quiet. "
United States
Rachal
The price is CA $193
CA $226 total
includes taxes & fees
Nov 10 - Nov 11
Wandering Willow – Private Stargazing Glamping Tent with Fire Pit & Open Skies
A tented accommodation with a bed, a sofa, and a small table with a lamp.

7. Private Stargazing Tent Dogwood Den – Peaceful Glamping with Fire Pit & Open Skies

Private Stargazing Tent Dogwood Den – Peaceful Glamping with Fire Pit & Open Skies
Bunker
10.0 out of 10, Exceptional, (1 review)
"Amazing location amazing staff. Just absolutely amazing incredible people. "
United States
cory
The price is CA $193
CA $216 total
includes taxes & fees
Nov 10 - Nov 11
Private Stargazing Tent Dogwood Den – Peaceful Glamping with Fire Pit & Open Skies
A compact kitchen with wooden cabinets and a dining area with a table and chairs.

8. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
9.8 out of 10, Exceptional, (16 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
The price is CA $212
CA $241 total
includes taxes & fees
Nov 10 - Nov 11
Villa B offers peace and quiet with beautiful views of the countryside.
A wooden deck with a bed and a table, overlooking a forested area.

9. Tiny Houses of French Village Tranquil & Relaxing

Tiny Houses of French Village Tranquil & Relaxing
French Village
9.0 out of 10, Wonderful, (4 reviews)
"Great place to stay to get away from the rat race of busy life"
United States
Shannon S.
The price is CA $304
CA $485 total
includes taxes & fees
Nov 11 - Nov 12
Tiny Houses of French Village Tranquil & Relaxing
A cabin with a deck, a staircase, and a fire pit.

10. Easy Street Apartment

Easy Street Apartment
Van Buren
10.0 out of 10, Exceptional, (4 reviews)
"Great place. Would definitely go again."
United States
Jeramy T.
The price is CA $211
CA $309 total
includes taxes & fees
Nov 11 - Nov 12
Easy Street Apartment
Room

11. Cozy Corner

Cozy Corner
Van Buren
9.8 out of 10, Exceptional, (10 reviews)
"Great property! Very clean and close to town."
United States
Mindy R.
The price is CA $211
CA $321 total
includes taxes & fees
Nov 10 - Nov 11
Cozy Corner
A modern kitchen with dark wood cabinets, a central island, and a brick wall.

12. Downtown Urban Loft #9

Downtown Urban Loft #9
Perryville
10.0 out of 10, Exceptional, (8 reviews)
"The Zen atmosphere made it really relaxing and the spa bathroom was incredible"
United States
Hunter
The price is CA $276
CA $415 total
includes taxes & fees
Nov 10 - Nov 11
Downtown Urban Loft #9
Exterior

13. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
The price is CA $195
CA $268 total
includes taxes & fees
Nov 10 - Nov 11
Purple Tiny House with Fire pit & Nature
A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

14. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (39 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is CA $212
CA $241 total
includes taxes & fees
Nov 10 - Nov 11
Relax in the country at Countryside Villas! - Villa A
A spacious loft with exposed brick walls, large windows, a kitchen with bar seating, and a ceiling fan.

15. Downtown Urban Loft #1

Downtown Urban Loft #1
Perryville
The price is CA $276
CA $432 total
includes taxes & fees
Nov 11 - Nov 12
Downtown Urban Loft #1
A living room with a fireplace, a sofa, a dining table with chairs, and a lamp.

16. Stay On Festus Main 2 bedroom 1.5 bath Near Mercy

Stay On Festus Main 2 bedroom 1.5 bath Near Mercy
Festus
10.0 out of 10, Exceptional, (1 review)
"Great property and location. Property was clean. Very convenient to local attractions. Communications with the host was fast and efficient. Will rent this property again in the future."
United States
Jennifer B.
The price is CA $325
CA $353 total
includes taxes & fees
Nov 10 - Nov 11
Stay On Festus Main 2 bedroom 1.5 bath Near Mercy
A campsite with a tent, wooden deck, and seating area, surrounded by trees and string lights.

17. Private Stargazing Tent Hickory Hideaway – Peaceful Glamping with Fire Pit & Open Skies

Private Stargazing Tent Hickory Hideaway – Peaceful Glamping with Fire Pit & Open Skies
Bunker
9.0 out of 10, Wonderful, (2 reviews)
"Super clean property,friendly hosts and horses! A great escape "off grid"! Would definitely go back."
United States
Chelsea L.
The price is CA $193
CA $216 total
includes taxes & fees
Nov 10 - Nov 11
Private Stargazing Tent Hickory Hideaway – Peaceful Glamping with Fire Pit & Open Skies
A tent with two beds, a table with a mug, a chair, and a small plant.

18. Private Stargazing Tent Maple Haven – Peaceful Glamping with Fire Pit & Open Skies

Private Stargazing Tent Maple Haven – Peaceful Glamping with Fire Pit & Open Skies
Bunker
The price is CA $209
CA $235 total
includes taxes & fees
Nov 10 - Nov 11
Private Stargazing Tent Maple Haven – Peaceful Glamping with Fire Pit & Open Skies
A modern kitchen with stainless steel appliances, a large window, and a breakfast setup on the counter.

19. Gorgeous, downtown house!

Gorgeous, downtown house!
Perryville
10.0 out of 10, Exceptional, (1 review)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
The price is CA $721
CA $1,135 total
includes taxes & fees
Nov 10 - Nov 11
Gorgeous, downtown house!
A greenhouse structure with a transparent roof, surrounded by a metal fence, and various plants inside.

20. Peaceful Farm Stay in Alton w/ Private Patio

Peaceful Farm Stay in Alton w/ Private Patio
3.0 star property
Alton
The price is CA $100
CA $209 total
includes taxes & fees
Nov 10 - Nov 11
Peaceful Farm Stay in Alton w/ Private Patio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

See all hotels in Southeast Missouri
A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top reviews in Southeast Missouri

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson

10/10 Excellent

Fantastic property! The staff and service were top notch! Definitely our go too place in the area,
Canada
Rodney
Reviewed October 21, 2025
Drury Inn & Suites Jackson MO

Explore a world of travel with Expedia