Title: 4 Stars Hotels in Southeast Missouri, Missouri - Find Cheap Southeast Missouri Hotels With 4 Stars | Expedia.ca [Southeast Missouri Travel Guide](https://expedia.ca/Southeast-Missouri.dx6058763)[Hotels in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Hotels.d6058763.Travel-Guide-Hotels)[Vacation Rentals in Southeast Missouri](https://expedia.ca/Southeast-Missouri-Vacation-Rentals.d6058763.Travel-Guide-VacationRentals)[Flights to Southeast Missouri](https://expedia.ca/Cheap-Flights-To-Southeast-Missouri.d6058763.Travel-Guide-Flights)[Things to do in Southeast Missouri](https://expedia.ca/Things-To-Do-In-Southeast-Missouri.d6058763.Travel-Guide-Activities)[Southeast Missouri Car Rentals](https://expedia.ca/Car-Rentals-In-Southeast-Missouri.d6058763.Car-Rental-Guide)[Southeast Missouri Vacation Packages](https://expedia.ca/Southeast-Missouri.d6058763.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Stars Hotels in Southeast Missouri, Missouri ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southeast Missouri 4 Star Hotels Tonight [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-09-28&endDate=2025-09-29&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-09-29&endDate=2025-09-30&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058763&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southeast Missouri 4 Star Hotels ![Street view](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/1b66adae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Urban Loft #3 | Living area](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/8f7a623b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Urban Loft #2 | Private kitchen](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/ab222ad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Urban Loft #3](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/c739acc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Urban Lofts Perryville [](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h39926011.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Southeast-Missouri-Hotels.s40-0-d6058763.Travel-Guide-Filter-Hotels) ## Learn more about Southeast Missouri Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area. [See all hotels in Southeast Missouri](https://www.expedia.ca/Hotel-Search?startDate=2025-10-12&endDate=2025-10-13&adults=2®ionId=6058763) ![](https://mediaim.expedia.com/destination/9/6538ce9b088c58039b33a5fe701e7a1f.jpg?impolicy=fcrop&w=899&h=541&p=1&q=high) ## Top Southeast Missouri Hotel Reviews ## Find out more about Southeast Missouri If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Southeast Missouri are calling your name. Known for providing first-rate service in amazing locations, each of the Southeast Missouri 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Southeast Missouri. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Southeast Missouri, Missouri, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Southeast Missouri hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Southeast Missouri? > To lock in a 4-star hotel in Southeast Missouri that fits your budget, take advantage of Expedia's search and sort filters. Take a look at the available options during your chosen dates and use our pricing filter to set your maximum rate. You can also sort your results by the most economical option first. > > > > - Search for the lowest price ### What's the difference between 5-star and 4-star hotels in Southeast Missouri? > Offering an inviting guest experience and upmarket décor, 4-star hotels are a wonderful option for your Southeast Missouri escape. These types of stays generally feature loads of useful amenities that make it easy to kick back and relax — think 24-hour room service, gyms and restaurants. Or enjoy even more lavishness at a 5-star hotel designed to indulge you in luxury perks and amenities. Concierge assistance, premium toiletries and fine dining are typically included at these swanky retreats. ### Does Southeast Missouri have any 4-star all-inclusive resorts? > Enjoy a stress-free vacation experience where just about everything is included in the one upfront price by using our "All inclusive" filter. Sticking to your budget is a piece of cake when your room, food and many activities are already taken care of. Eager for more ideas? 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