Photo by Bill Dillard
Find Historic Hotels in Southeast Missouri, MO from CA $208
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Historic Hotels
Our top choices for Southeast Missouri historic hotels
Beautiful Modern Loft In Wine Country!
Beautiful Modern Loft In Wine Country!Ste. Genevieve
10.0 out of 10, Exceptional, (273 reviews)
"It was the perfect spot for a weekend getaway!"
Brittany P.
The price is CA $202
CA $245 total
includes taxes & fees
Mar 4 - Mar 5
Serenity South -- Gardens, River-Views, and Refreshing Space
Serenity South -- Gardens, River-Views, and Refreshing SpaceCape Girardeau
10.0 out of 10, Exceptional, (151 reviews)
"Such a great place and location"
Tracy H.
The price is CA $205
CA $335 total
includes taxes & fees
Feb 28 - Mar 1
The Weber Farm - Enjoy a beautiful 100 acre farm!
The Weber Farm - Enjoy a beautiful 100 acre farm!Frohna
10.0 out of 10, Exceptional, (32 reviews)
"We enjoyed the beautiful countryside. "
Jaymie T.
The price is CA $123
CA $224 total
includes taxes & fees
Mar 4 - Mar 5
Rest, Relax and Renew. Our log cabin experience awaits your arrival.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.Anna
10.0 out of 10, Exceptional, (405 reviews)
"Nice cabin and beautiful scenery! We enjoyed our stay."
Hannah G.
The price is CA $160
CA $277 total
includes taxes & fees
Mar 26 - Mar 27
Charming cottage overlooking Lake Acre
Charming cottage overlooking Lake AcreDongola
10.0 out of 10, Exceptional, (102 reviews)
"Great place so peaceful and relaxing "
Paul D.
The price is CA $185
CA $388 total
includes taxes & fees
Feb 28 - Mar 1
Chic Minimalist Gem w/ Fenced Backyard + W/D
Chic Minimalist Gem w/ Fenced Backyard + W/DPrinceton Heights
9.6 out of 10, Exceptional, (9 reviews)
"Clean, very comfortable apartment in a great location: easy walk to restaurants, coffee shops, Francis Park. Attractive, quiet, tree-lined neighborhood. Would definitely stay here again!"
Jack S.
The price is CA $77
CA $243 total
includes taxes & fees
Mar 2 - Mar 3
Peter Ray House
Peter Ray HouseMaeystown
10.0 out of 10, Exceptional, (72 reviews)
"The house was wonderful, the town was delightful, and the people were very friendly! We can’t wait for our next trip!"
Deborah
The price is CA $185
CA $304 total
includes taxes & fees
Mar 5 - Mar 6
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!
Cozy Studio Cottage on "The Hill," walkably close to everything! The Zoo, Park!!The Hill
9.8 out of 10, Exceptional, (167 reviews)
"Easy access and great location. Place was kept very clean. "
Andrew P.
The price is CA $117
CA $208 total
includes taxes & fees
Mar 3 - Mar 4
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Baymont Inn and Suites by Wyndham Farmington, MO
10/10 Excellent
Explore a world of travel with Expedia
- Cheap Hotels in Advance
- B&B in Annapolis
- Hotels with Balconies in Annapolis
- Luxury Hotels in Annapolis
- Spa Hotels in Annapolis
- Annapolis Hotels
- Lodges in Annapolis
- Farmstay in Arcadia
- B&B in Arcadia
- Cheap Hotels in Arcadia
- Luxury Hotels in Arcadia
- Arcadia Hotels
- Lodges in Arcadia
- B&B in Belleview
- Cabin Rentals in Belleview
- Belleview Hotels
- Motels in Belleview
- Hotels with a Pool in Bismarck
- Luxury Hotels in Bismarck
- Cheap Hotels in Black
- Luxury Hotels in Black
- Black Hotels
- Lodges in Black
- Cheap Hotels in Caledonia
- Golf Hotels in Caledonia
- Historic Hotels in Caledonia
- Hotel Wedding Venues Hotels in Caledonia
- Apartments in Centerville
- Centerville Hotels
- Motels in Centerville
- Cobalt Hotels
- Cheap Hotels in Des Arc
- Des Arc Hotels
- Wayne County Hotels
- Cheap Hotels in Doe Run
- Doe Run Hotels
- Lodges in Doe Run
- Hotels near Elephant Rocks State Park
- Ellington Hotels
- Rv Parks in Ellington
- Cabin Rentals in Farmington
- Cheap Hotels in Farmington
- Hotels with Hot Tubs in Farmington
- Pet-Friendly Hotels in Farmington
- Farmington Hotels
- Motels in Farmington
- Cheap Hotels in Fredericktown
- Pet-Friendly Hotels in Fredericktown
- Fredericktown Hotels
- Glen Allen Hotels
- Vacation Homes in Glen Allen
- Greenville Hotels
- Lodges in Greenville
- Resorts in Greenville
- Farmstay in Iron Mountain Lake
- Ironton Hotels
- Hotels near Johnson's Shut-ins State Park
- Lodges in Knob Lick
- Cheap Hotels in Lesterville
- Lesterville Hotels
- Cheap Hotels in Marble Hill
- Marble Hill Hotels
- B&B in Middle Brook
- Middle Brook Hotels
- Lodges in Middle Brook
- Mill Spring Hotels
- Luxury Hotels in Park Hills
- Patterson Hotels
- Lodges in Patterson
- Resorts in Patterson
- Cheap Hotels in Piedmont
- Luxury Hotels in Piedmont
- Piedmont Hotels
- Motels in Piedmont
- Hotels with Wifi in Pilot Knob
- Pilot Knob Hotels
- Lodges in Pilot Knob
- Cottages in St. Francois County
- Honeymoon Resorts and in St. Louis
- Hotels with Childcare in St. Louis
- Hotels with smoking rooms in St. Louis
- Oceanfront Hotels in St. Louis
- Winery Hotels in St. Louis
- Cheap Hotels in Wappapello
- Luxury Hotels in Wappapello
- Resorts in Wayne County
- Hotels with a Pool in Williamsville