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Serenity South -- Gardens, River-Views, and Refreshing Space

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Dining - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)
Terrace/patio - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)
TV, fireplace, DVD player, books - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)
Interior - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)
Fridge, microwave, oven, stovetop - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)
In the heart of Cape Girardeau Historic District, this beautifully renovated duplex offers a cozy living room and large dining room perfect for relaxation. Explore downtown's local restaurants, antique shops, and boutiques within walking distance or unwind on the balcony overlooking the shared yard.

Reviews

10 out of 10
Exceptional

Entire home

3 bedrooms2 bathroomsSleeps 51600 sq ft

Popular amenities

  • Kitchen
  • Outdoor Space
  • Parking available
  • Fireplace

Add dates for prices

About this property

Entire place

You'll have the entire home to yourself and will only share it with other guests in your party.

Serenity South -- Gardens, River-Views, and Refreshing Space

Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions.

Property amenities

Internet

  • Available in the house: WiFi

Parking and transportation

  • Car not required
  • Parking on site

Kitchen

  • Coffee grinder
  • Coffee/tea maker
  • Cookware, dishware, and utensils
  • Dishwasher
  • Ice maker
  • Microwave
  • Oven
  • Paper towels
  • Refrigerator
  • Spices
  • Stovetop
  • Toaster

Bedrooms

  • 3 bedrooms
  • Bedsheets provided

Bathroom

  • 1.5 bathrooms
  • Bathtub or shower
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Towels provided

Living spaces

  • Fireplace
  • Living room
  • Separate dining area

Entertainment

  • Books
  • DVD player
  • Games
  • TV

Outdoor areas

  • Balcony
  • Garden
  • Outdoor furniture

Laundry

  • Laundromat nearby

Comfort

  • Air conditioning
  • Heating

Pets

  • No pets allowed

Suitability/Accessibility

  • Smoking not allowed

Services and conveniences

  • Iron/ironing board

Location highlights

  • Near a health/beauty spa
  • Near a hospital
  • Near an outlet shopping mall
  • On a river

Things to do

  • Basketball nearby
  • Casino nearby
  • Cycling nearby
  • Fishing nearby
  • Golfing nearby
  • Hiking/biking trails nearby
  • Horseback riding nearby
  • Motor boating nearby
  • Swimming nearby
  • Wildlife walks nearby
  • Winery tours nearby

Safety features

  • Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
  • Smoke detector (host has indicated there is a smoke detector on the property)
  • Deadbolt lock

General

  • Garden
  • Unit size: 1,600 square feet

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The Riverview
  • Parking included
  • Free WiFi
  • Restaurant
  • Air conditioning
9.4 out of 10, Exceptional, 528 reviews
The price is CA $117
CA $133 total
includes taxes & fees
Mar 26 - Mar 27
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Policies

Check-in

Check-in time starts at 4:00 PM
Minimum check-in age: 18

Check-out

Check-out before 11:00 AM

Special check-in instructions

You will receive an email from the host with check-in and check-out instructions
Information provided by the property may be translated using automated translation tools

Rules

Back yard is shared with the other side of the duplex. Please respect their use of the common space.

Pets

Pets not allowed

Children and extra beds

Children are welcome
Note from host: Excellent fenced back yard.

Events

Events allowed: family gatherings, birthday parties, weddings
Parties or events must okayed before arrival.

Smoking

Smoking is not permitted

Important information

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Parties and events (including family gatherings, birthday parties and weddings) are allowed on site; maximum attendees: 50
Note from host: Parties or events must okayed before arrival.
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a deadbolt lock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation

We should mention

A car is not required for transportation to and from this property

About the area

Located in Cape Girardeau, this vacation home is near a water park and on a river. The area's natural beauty can be seen at Shawnee National Forest and Mississippi River. Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center are also worth visiting. Discover the area's water adventures with motor boating and fishing nearby, or enjoy the great outdoors with cycling and horse riding. Visit our Cape Girardeau travel guide
View more Vacation homes in Cape Girardeau
Map
Cape Girardeau, MO

What's nearby

  • View of the Christopher S. Bond Bridge over Missouri River in Kansas City, from the riverfront park
    Riverfront Bridge Park
    5 min walk - 0.4 km
  • Panorama of Academic Hall, Southeast Missouri State University
    Southeast Missouri State University
    2 min drive - 1.8 km
  • eDen Spa & Salon
    2 min walk - 0.2 km
  • Riverfront Park
    2 min walk - 0.2 km
  • Century Casino & Hotel Cape Girardeau
    19 min walk - 1.6 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    12 min drive

Restaurants

  • Sand's Pancake House
    11 min walk
  • Hamburger Express
    16 min walk
  • Roni’s Mac Bar
    16 min walk
  • Katy O'Ferrell's Publick House
    9 min walk
  • Minglewood Brewery
    7 min walk

Frequently asked questions

Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly?

No, pets are not allowed at this property.

How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space?

As of Mar 18, 2026, prices found for a 1-night stay for 2 adults at Serenity South -- Gardens, River-Views, and Refreshing Space on Mar 22, 2026 start from CA $205, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

How much is parking?

Onsite parking is available at the property.

What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space?

Check-in begins at 4:00 PM.

What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space?

Check-out is at 11:00 AM.

Where is Serenity South -- Gardens, River-Views, and Refreshing Space located?

Situated on a river, this vacation home is steps from eDen Spa & Salon, Shawnee National Forest, and Mississippi River. Riverfront Park and The Glenn House are also within 5 minutes.

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Serenity South -- Gardens, River-Views, and Refreshing Space Reviews

Reviews

Exceptional

All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.
More informationOpens in a new window
Rating 10 - Excellent. 146 out of 151 reviews
Rating 8 - Good. 5 out of 151 reviews
Rating 6 - Okay. 0 out of 151 reviews
Rating 4 - Poor. 0 out of 151 reviews
Rating 2 - Terrible. 0 out of 151 reviews

10

Cleanliness

9.8

Location

10

Property conditions & facilities

Reviews

Verified

10/10 Excellent

Alison C.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Wonderful location! WonderfulStay
Stayed 1 night in Nov 2025
Verified

10/10 Excellent

Michael R.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Nice property near downtown in the river. This was the perfect location for our 50th high school reunion.
Stayed 2 nights in Oct 2025
Verified

10/10 Excellent

Penny F.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Beautiful getaway!

The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area.
Stayed 2 nights in Mar 2025
Verified

10/10 Excellent

Bradley T.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Peaceful place

Very nice and beautiful place super nice people
Stayed 2 nights in Jun 2024
Verified

10/10 Excellent

Danita D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Historic charm

We loved staying at this house for SEMO family weekend! It was super clean and had everything we needed and more 😊 we will definitely try to stay here again!
Stayed 1 night in Sep 2023
Verified

10/10 Excellent

Terry M.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great family getaway

Everything was perfect. From check in to check out. Great neighborhood and location.
Stayed 1 night in Apr 2024
Verified

10/10 Excellent

Michelle K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect home for college visit

When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay.
Stayed 1 night in Feb 2025
Verified

10/10 Excellent

Candice L.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Family Graduation

The place was perfect for our stay and was close to the farmers market and downtown shops. Highly recommend for location!
Stayed 1 night in May 2024
Verified

10/10 Excellent

Rhonda S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Smith Women’s Weekend

We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year!
Stayed 2 nights in Feb 2025
Verified

10/10 Excellent

Scott R.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Family visit

Nice property, real close to downtown and the river. Very relaxing
Stayed 2 nights in Sep 2024
Verified

10/10 Excellent

Wendy M.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Excellent location

This was a very cute home - well maintained! Perfect location. Had everything we needed. Very clean!!
Stayed 1 night in Oct 2023
Verified

10/10 Excellent

joe R.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Cape Girardeau

Beautiful very clean house with a lot of character
Stayed 1 night in Oct 2024
Verified

10/10 Excellent

Debbie K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Very charming house

We stayed at Serenity South instead of a hotel for family weekend. We were able to have our daughter and her friends over for dinner which we could never do in a hotel! There are great views from upstairs.
Stayed 1 night in Sep 2024
Verified

10/10 Excellent

Michelle A B.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great stay!

This was the second year in a row that we have stayed here. This is a beautiful home to stay in. I love the charm and detail of the house. We stay here after a Christmas party and walk downtown so it’s definitely located in a convenient spot. I will be booking again for next year Great communication with Jo and if there’s any questions I need, Jo is very quick to respond. Thank you for making our stay good!
Stayed 1 night in Dec 2024
Verified

10/10 Excellent

Melissa M.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Charming, beautifully maintained home

Lovely house, well maintained and stocked. Nice bed linens and towels. Lots of thoughtful features like a coffee and tea station upstairs with the bedrooms. The host even left fresh cookies for us in the kitchen. Beautiful gardens with cut flowers. Fantastic location just blocks from shopping, restaurants and bars. Highly recommend.
Stayed 2 nights in Apr 2024
Verified

10/10 Excellent

shirley g.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Outstanding

Here for a volleyball tournament. Had 3 short days to enjoy this beautiful home. Just not long enough. Has everything u need and more. Jo is a lovely host. So quiet and peaceful.. most of all in a safe area. I plan to go back by summers end just so I can enjoy the home and walk to coffee shop and tour the old part of town. Just wonderful!
Stayed 3 nights in Feb 2025
Verified

10/10 Excellent

Mom 2.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Serenity South is out favorite place in Cape.

I have stayed at Serenity South three times in the last 5 months. It is perfectly located near downtown restaurants and the Old St. Vincent's church, and it is literally a 2 minute drive to SEMO's River Campus. We will be returning to Cape next month, but sadly, this property was already booked. It will always be my first choice, though.
Stayed 2 nights in Aug 2024
Verified

10/10 Excellent

Alicia S.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Great house and amazing location!

I stayed at Jo’s place with my sister and father. We absolutely loved it!! The location was truly amazing and close to so many restaurants and shops. The setup was perfect for us with the 3 bedrooms and full bath upstairs and it was great to have the 1/2 bath off the living space. We didn’t cook while we were there but the kitchen was huge and seemed well stocked with dishes. Communication with our host was easy and she was very helpful. The house was gorgeous and had tons of historical details. Would love to stay here again!
Stayed 1 night in Mar 2024
Verified

10/10 Excellent

Gary F.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Thanksgiving in Cape Girardeau

This was our second Thanksgiving in Cape Girardeau at Serenity South. The property is very clean and has everything you need to prepare a Thanksgiving Day feast! Location is great! Had dinner at Ebb and Flow just down the street and won the trivia contest! Great restaurants and shopping very close to the property! The city issued a boil water alert due to a broken water main and Jo had bottled water to the property before we had time to get some ourselves! Thank you, Jo for another lovely trip to Cape!
Stayed 4 nights in Nov 2023
Verified

10/10 Excellent

Ronald D.

Liked: Cleanliness, check-in, communication, location, listing accuracy

Perfect stay, perfect day!

We stayed at Serenity South as we visited the area for the total solar eclipse. The property was clean, comfortable, well maintained and furnished. When we booked it, we had no idea how convenient to downtown and the riverbank it actually was. We were within walking distance to the eclipse activities for the day. Jo was very attentive and responsive to any questions or needs we had. Check in and checkout instructions were very clear. Thank you for helping make our eclipse adventure absolutely perfect!
Stayed 3 nights in Apr 2024
Verified

10/10 Excellent

Monica R.

Liked: Cleanliness, check-in, communication, listing accuracy

House perfect..

This house is so clean and has everything you need for your stay! Probably the MOST well thought out place we've ever stayed for our traveling needs and convenience. Beds are comfortable! BUT, light sleepers beware.. the railroad tracks are nearby (the trains run in the middle of the night) and the traffic near riverfront on a Saturday night was loud til early morning. You can hear every hot rod motorcycle or sports car with loud exhaust that approaches / speeds off from the nearby stop sign.
Stayed 1 night in Nov 2023
Verified

10/10 Excellent

Jennifer K.

Liked: Cleanliness, check-in, communication, location, listing accuracy

This property is excellent

This is an older home (1920’s?) with so much charm. It’s exceptionally well cared for - the floors are clean and in excellent condition, the walls are clean, paint job is beautiful, etc. The air is clean (no smell of mold) bathroom fans work, etc! In short, one of the best maintained rentals we’ve stayed in. The beds are comfy. Oh - and the landscaping is also beautiful! It is winter - would love to see the gardens in the spring. Jo was easy to contact, check in was easy. The trains do run 1 or 2 times per night and are close and on Friday night there were some people having fun running their loud cars through town but otherwise it is quiet and peaceful. The walk to town is only a few blocks. We would definitely stay here again!
Stayed 4 nights in Dec 2024
Verified

10/10 Excellent

Tracy H.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Such a great place and location
Stayed 2 nights in Jul 2025
Verified

10/10 Excellent

Sandy M.

Liked: Cleanliness, check-in, communication, location, listing accuracy
We were visiting our daughter who attends SEMO, so the location was perfect.
Stayed 3 nights in Sep 2025
Verified

10/10 Excellent

Shelley L.

Liked: Cleanliness, check-in, communication, location, listing accuracy
Good stay.
Stayed 1 night in Sep 2025