Title: Serenity South -- Gardens, River-Views, and Refreshing Space - Latest Reviews, Deals & Photos 2026 - Expedia.ca [See all properties](http://www.expedia.ca/Hotel-Search?regionId=&adults=2&children=&sort=RECOMMENDED&useRewards=false&semdtl=&userIntent=&vip=false) Entire home # Serenity South -- Gardens, River-Views, and Refreshing Space Riverfront vacation home with kitchen and balcony ## Photo gallery for Serenity South -- Gardens, River-Views, and Refreshing Space ![Dining - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=resizecrop&rw=598&ra=fit) ![Terrace/patio - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/564d6e43.jpg?impolicy=resizecrop&rw=297&ra=fit) ![Interior - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=resizecrop&rw=297&ra=fit) ![Fridge, microwave, oven, stovetop - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/0e13dd89.jpg?impolicy=resizecrop&rw=297&ra=fit) ![TV, fireplace, DVD player, books - Serenity South -- Gardens, River-Views, and Refreshing Space (Cape Girardeau)](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=resizecrop&rw=297&ra=fit) - Overview - Location - Amenities - Policies In the heart of Cape Girardeau Historic District, this beautifully renovated duplex offers a cozy living room and large dining room perfect for relaxation. Explore downtown's local restaurants, antique shops, and boutiques within walking distance or unwind on the balcony overlooking the shared yard. ## Reviews 10 Exceptional ### Entire home 3 bedrooms2 bathroomsSleeps 51600 sq ft ## Popular amenities - Kitchen - Outdoor Space - Parking available - Fireplace ## Add dates for prices Check-in Check-out Travellers ## About this property ### Entire place You'll have the entire home to yourself and will only share it with other guests in your party. ### Serenity South -- Gardens, River-Views, and Refreshing Space Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions. ## Property amenities ### Internet - Available in the house: WiFi ### Parking and transportation - Car not required - Parking on site ### Kitchen - Coffee grinder - Coffee/tea maker - Cookware, dishware, and utensils - Dishwasher - Ice maker - Microwave - Oven - Paper towels - Refrigerator - Spices - Stovetop - Toaster ### Bedrooms - 3 bedrooms - Bedsheets provided ### Bathroom - 1.5 bathrooms - Bathtub or shower - Hair dryer - Shampoo - Soap - Toilet paper - Towels provided ### Living spaces - Fireplace - Living room - Separate dining area ### Entertainment - Books - DVD player - Games - TV ### Outdoor areas - Balcony - Garden - Outdoor furniture ### Laundry - Laundromat nearby ### Comfort - Air conditioning - Heating ### Pets - No pets allowed ### Suitability/Accessibility - Smoking not allowed ### Services and conveniences - Iron/ironing board ### Location highlights - Near a health/beauty spa - Near a hospital - Near an outlet shopping mall - On a river ### Things to do - Water park - Basketball nearby - Casino nearby - Cycling nearby - Fishing nearby - Golfing nearby - Hiking/biking trails nearby - Horseback riding nearby - Motor boating nearby - Swimming nearby - Wildlife walks nearby - Winery tours nearby ### Safety features - Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property) - Smoke detector (host has indicated there is a smoke detector on the property) - Deadbolt lock ### General - Garden - Unit size: 1,600 square feet ## Similar properties ![Exterior detail](https://images.trvl-media.com/lodging/110000000/109930000/109929600/109929505/23d7d447.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Urban 2-bedroom Escape in Downtown Cape Girardeau Cape Girardeau - Kitchen - Washer - Dryer - Air conditioning 10 Exceptional 9 reviews [](https://www.expedia.ca/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03&selected=109929505&PinnedHotelID=109929505&HadPinnedHotel=true®ionId=-1&adults=2) ![Interior](https://images.trvl-media.com/lodging/95000000/95000000/94995100/94995011/33116e16.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Historic Victorian - Walkable to Downtown Cape Girardeau - King Bed - Fast Wifi Cape Girardeau - Kitchen - Washer - Dryer - Free WiFi 10 Exceptional 10 reviews [](https://www.expedia.ca/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03&selected=94995011&PinnedHotelID=94995011&HadPinnedHotel=true®ionId=-1&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19220000/19211900/19211821/adc03455.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Historical 'Kage House' Short Term Rental located in "Old Town Cape" Cape Girardeau - Kitchen - Washer - Dryer - Free WiFi 10 Exceptional 224 reviews [](https://www.expedia.ca/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03&selected=19211821&PinnedHotelID=19211821&HadPinnedHotel=true®ionId=-1&adults=2) ![Smart TV](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608350/64a218d1.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Downtown 4BR with 2 King Beds! 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Jackson - Kitchen - Washer - Dryer - Air conditioning 10 Exceptional 11 reviews [](https://www.expedia.ca/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03&selected=93056190&PinnedHotelID=93056190&HadPinnedHotel=true®ionId=-1&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/114000000/113880000/113876300/113876241/fab27fde.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### 2Bdrm Stay in Downtown Cape, Walkable, Laundry Cape Girardeau - Kitchen - Washer - Dryer - Free WiFi 10 Exceptional 1 review [](https://www.expedia.ca/Hotel-Search?startDate=2026-02-02&endDate=2026-02-03&selected=113876241&PinnedHotelID=113876241&HadPinnedHotel=true®ionId=-1&adults=2) ## Policies ### Check-in Check-in time starts at 4:00 PM Minimum check-in age: 18 ### Check-out Check-out before 11:00 AM ### Special check-in instructions You will receive an email from the host with check-in and check-out instructions Information provided by the property may be translated using automated translation tools ### Rules Back yard is shared with the other side of the duplex. Please respect their use of the common space. ### Pets Pets not allowed ### Children and extra beds Children are welcome Note from host: Excellent fenced back yard. ### Events Events allowed: family gatherings, birthday parties, weddings Parties or events must okayed before arrival. ### Smoking Smoking is not permitted ## Important information ### You need to know Extra-person charges may apply and vary depending on property policy Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed Parties and events (including family gatherings, birthday parties and weddings) are allowed on site; maximum attendees: 50 Note from host: Parties or events must okayed before arrival. Host has indicated there is a carbon monoxide detector on the property Host has indicated there is a smoke detector on the property Safety features at this property include a deadbolt lock This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation ### We should mention A car is not required for transportation to and from this property ## About the area Located in Cape Girardeau, this vacation home is on a river. The area's natural beauty can be seen at Shawnee National Forest and Mississippi River. Traveling with kids? Consider Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center. Discover the area's water adventures with motor boating and fishing nearby, or enjoy the great outdoors with hiking/biking trails and cycling. [Visit our Cape Girardeau travel guide](https://www.expedia.ca/Cape-Girardeau.dx820) [View more Vacation homes in Cape Girardeau](https://www.expedia.ca/Cape-Girardeau-Private-Vacation-Homes.d820-aaPrivateVacationHomes.Travel-Guide-Accommodation) ![Map](https://maps.googleapis.com/maps/api/staticmap?&size=660x330&map_id=3b266eb50d2997c6&zoom=13&markers=icon:https%3A%2F%2Fa.travel-assets.com%2Ftravel-assets-manager%2Feg-maps%2Fproperty.png%7C37.30075%2C-89.51995&channel=expedia-HotelInformation&maptype=roadmap&scale=1&key=AIzaSyCYjQus5kCufOpSj932jFoR_AJiL9yiwOw&signature=dshoScVVRLX4BbV52kd9Dl-8cK8=) Cape Girardeau, MO ### What's nearby - eDen Spa & Salon \- 2 min walk \- 0.2 km - Riverfront Park \- 2 min walk \- 0.2 km - Riverfront Bridge Park \- 5 min walk \- 0.4 km - Isle Casino Cape Girardeau \- 16 min walk \- 1.4 km - Southeast Missouri State University \- 2 min drive \- 1.8 km ### Getting around - Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 12 min drive ### Restaurants - ‪Sand's Pancake House - ‬11 min walk - ‪Katy O'Ferrell's Publick House - ‬9 min walk - ‪Hotshots Sports Bar & Grill - ‬5 min walk - ‪Minglewood Brewery - ‬7 min walk - ‪The Library - ‬3 min walk ## Frequently asked questions ### Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly? ### How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space? ### How much is parking? ### What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space? ### What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space? ### Where is Serenity South -- Gardens, River-Views, and Refreshing Space located? ## Have a question? Beta Get instant answers with AI powered search of property information and reviews. Ask a question ## Serenity South -- Gardens, River-Views, and Refreshing Space Reviews ## Reviews ### Exceptional All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative. [More information](https://www.expedia.ca/lp/b/content-guidelines) 10 - Excellent 145 8 - Good 5 6 - Okay 0 4 - Poor 0 2 - Terrible 0 ### 10 Cleanliness ### 9.8 Location ### 10 Property conditions & facilities ## Reviews ### 10/10 Excellent #### Michael R. Oct 14, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Nice property near downtown in the river. This was the perfect location for our 50th high school reunion. ##### Michael R. Stayed 2 nights in Oct 2025 ### 10/10 Excellent #### Penny F. Mar 28, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Beautiful getaway! The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area. ##### Penny F. Stayed 2 nights in Mar 2025 ### 10/10 Excellent #### Michelle K. Mar 28, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Perfect home for college visit When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay. ##### Michelle K. Stayed 1 night in Feb 2025 ### 10/10 Excellent #### Bradley T. Jul 1, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Peaceful place Very nice and beautiful place super nice people ##### Bradley T. Stayed 2 nights in Jun 2024 ### 10/10 Excellent #### Danita D. Sep 18, 2023 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Historic charm We loved staying at this house for SEMO family weekend! It was super clean and had everything we needed and more 😊 we will definitely try to stay here again! ##### Danita D. Stayed 1 night in Sep 2023 ### 10/10 Excellent #### Terry M. Apr 22, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Great family getaway Everything was perfect. From check in to check out. Great neighborhood and location. ##### Terry M. Stayed 1 night in Apr 2024 ### 10/10 Excellent #### Candice L. May 11, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Family Graduation The place was perfect for our stay and was close to the farmers market and downtown shops. Highly recommend for location! ##### Candice L. Stayed 1 night in May 2024 ### 10/10 Excellent #### Rhonda S. Feb 23, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Smith Women’s Weekend We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year! ##### Rhonda S. Stayed 2 nights in Feb 2025 ### 10/10 Excellent #### Scott R. Sep 11, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Family visit Nice property, real close to downtown and the river. Very relaxing ##### Scott R. Stayed 2 nights in Sep 2024 ### 10/10 Excellent #### Wendy M. Nov 6, 2023 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Excellent location This was a very cute home - well maintained! Perfect location. Had everything we needed. Very clean!! ##### Wendy M. Stayed 1 night in Oct 2023 ### 10/10 Excellent #### joe R. Oct 21, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Cape Girardeau Beautiful very clean house with a lot of character ##### joe R. Stayed 1 night in Oct 2024 ### 10/10 Excellent #### Debbie K. Sep 29, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Very charming house We stayed at Serenity South instead of a hotel for family weekend. We were able to have our daughter and her friends over for dinner which we could never do in a hotel! There are great views from upstairs. ##### Debbie K. Stayed 1 night in Sep 2024 ### 10/10 Excellent #### Michelle A B. Dec 16, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Great stay! This was the second year in a row that we have stayed here. This is a beautiful home to stay in. I love the charm and detail of the house. We stay here after a Christmas party and walk downtown so it’s definitely located in a convenient spot. I will be booking again for next year Great communication with Jo and if there’s any questions I need, Jo is very quick to respond. Thank you for making our stay good! ##### Michelle A B. Stayed 1 night in Dec 2024 ### 10/10 Excellent #### shirley g. Feb 18, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Outstanding Here for a volleyball tournament. Had 3 short days to enjoy this beautiful home. Just not long enough. Has everything u need and more. Jo is a lovely host. So quiet and peaceful.. most of all in a safe area. I plan to go back by summers end just so I can enjoy the home and walk to coffee shop and tour the old part of town. Just wonderful! ##### shirley g. Stayed 3 nights in Feb 2025 ### 10/10 Excellent #### Melissa M. Apr 28, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Charming, beautifully maintained home Lovely house, well maintained and stocked. Nice bed linens and towels. Lots of thoughtful features like a coffee and tea station upstairs with the bedrooms. The host even left fresh cookies for us in the kitchen. Beautiful gardens with cut flowers. Fantastic location just blocks from shopping, restaurants and bars. Highly recommend. ##### Melissa M. Stayed 2 nights in Apr 2024 ### 10/10 Excellent #### Mom 2. Aug 18, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Serenity South is out favorite place in Cape. I have stayed at Serenity South three times in the last 5 months. It is perfectly located near downtown restaurants and the Old St. Vincent's church, and it is literally a 2 minute drive to SEMO's River Campus. We will be returning to Cape next month, but sadly, this property was already booked. It will always be my first choice, though. ##### Mom 2. Stayed 2 nights in Aug 2024 ### 10/10 Excellent #### Alicia S. Mar 24, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Great house and amazing location! I stayed at Jo’s place with my sister and father. We absolutely loved it!! The location was truly amazing and close to so many restaurants and shops. The setup was perfect for us with the 3 bedrooms and full bath upstairs and it was great to have the 1/2 bath off the living space. We didn’t cook while we were there but the kitchen was huge and seemed well stocked with dishes. Communication with our host was easy and she was very helpful. The house was gorgeous and had tons of historical details. Would love to stay here again! ##### Alicia S. Stayed 1 night in Mar 2024 ### 10/10 Excellent #### Gary F. Nov 27, 2023 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Thanksgiving in Cape Girardeau This was our second Thanksgiving in Cape Girardeau at Serenity South. The property is very clean and has everything you need to prepare a Thanksgiving Day feast! Location is great! Had dinner at Ebb and Flow just down the street and won the trivia contest! Great restaurants and shopping very close to the property! The city issued a boil water alert due to a broken water main and Jo had bottled water to the property before we had time to get some ourselves! Thank you, Jo for another lovely trip to Cape! ##### Gary F. Stayed 4 nights in Nov 2023 ### 10/10 Excellent #### Ronald D. Apr 11, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Perfect stay, perfect day! We stayed at Serenity South as we visited the area for the total solar eclipse. The property was clean, comfortable, well maintained and furnished. When we booked it, we had no idea how convenient to downtown and the riverbank it actually was. We were within walking distance to the eclipse activities for the day. Jo was very attentive and responsive to any questions or needs we had. Check in and checkout instructions were very clear. Thank you for helping make our eclipse adventure absolutely perfect! ##### Ronald D. Stayed 3 nights in Apr 2024 ### 10/10 Excellent #### Monica R. Nov 6, 2023 Liked: Cleanliness, check-in, communication, listing accuracy #### House perfect.. This house is so clean and has everything you need for your stay! Probably the MOST well thought out place we've ever stayed for our traveling needs and convenience. Beds are comfortable! BUT, light sleepers beware.. the railroad tracks are nearby (the trains run in the middle of the night) and the traffic near riverfront on a Saturday night was loud til early morning. You can hear every hot rod motorcycle or sports car with loud exhaust that approaches / speeds off from the nearby stop sign. ##### Monica R. Stayed 1 night in Nov 2023 ### 10/10 Excellent #### Jennifer K. Dec 30, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### This property is excellent This is an older home (1920’s?) with so much charm. It’s exceptionally well cared for - the floors are clean and in excellent condition, the walls are clean, paint job is beautiful, etc. The air is clean (no smell of mold) bathroom fans work, etc! In short, one of the best maintained rentals we’ve stayed in. The beds are comfy. Oh - and the landscaping is also beautiful! It is winter - would love to see the gardens in the spring. Jo was easy to contact, check in was easy. The trains do run 1 or 2 times per night and are close and on Friday night there were some people having fun running their loud cars through town but otherwise it is quiet and peaceful. The walk to town is only a few blocks. We would definitely stay here again! ##### Jennifer K. Stayed 4 nights in Dec 2024 ### 10/10 Excellent #### Tracy H. Aug 1, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Such a great place and location ##### Tracy H. Stayed 2 nights in Jul 2025 ### 10/10 Excellent #### Sandy M. Sep 28, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy We were visiting our daughter who attends SEMO, so the location was perfect. ##### Sandy M. Stayed 3 nights in Sep 2025 ### 10/10 Excellent #### Shelley L. Sep 30, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Good stay. ##### Shelley L. Stayed 1 night in Sep 2025 ### 10/10 Excellent #### Vicki R. Jun 9, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Beautiful house. Great stay. Would definitely stay again! ##### Vicki R. 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