Title: Serenity South -- Gardens, River-Views, and Refreshing Space - Latest Reviews, Deals & Photos 2025 - Expedia.ca [See all properties](http://www.expedia.ca/Hotel-Search?regionId=&adults=2&children=&sort=RECOMMENDED&useRewards=false&semdtl=&userIntent=&vip=false) Entire home # Serenity South -- Gardens, River-Views, and Refreshing Space Riverfront vacation home with kitchen and balcony ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/29617056.jpg?impolicy=resizecrop&rw=598&ra=fit) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/ec557893.jpg?impolicy=resizecrop&rw=297&ra=fit) ![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=resizecrop&rw=297&ra=fit) ![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/c59bcf0b.jpg?impolicy=resizecrop&rw=297&ra=fit) ![Outdoor dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6b76cbc5.jpg?impolicy=resizecrop&rw=297&ra=fit) - Overview - Location - Amenities - Policies In the heart of Cape Girardeau Historic District, this beautifully renovated duplex offers a cozy living room and large dining room perfect for relaxation. Explore downtown's local restaurants, antique shops, and boutiques within walking distance or unwind on the balcony overlooking the shared yard. 10 Exceptional ### Entire home 3 bedrooms2 bathroomsSleeps 51600 sq ft ## Popular amenities - - Kitchen - Parking available - Fireplace - Outdoor space ## Add dates for prices Check-in Check-out Travellers ## About this property ### Entire place You'll have the entire home to yourself and will only share it with other guests in your party. ### Serenity South -- Gardens, River-Views, and Refreshing Space Beautifully renovated duplex with large shared yard in Cape Girardeau Historic District. Cozy living room, large dining room, fully stocked kitchen, 3 second-story bedrooms with balcony at the end of the hall, and 1 1/2 bathes. Perfect for getting away for rejuvenation or exploring downtown. Within walking distance to local downtown restaurants, antique shops, and boutiques. Two blocks from the Mississippi River and many other attractions. ## Property amenities ### Internet - Available in the house: WiFi ### Parking and transportation - Car not required - Parking on site ### Kitchen - Coffee grinder - Coffee/tea maker - Cookware, dishware, and utensils - Dishwasher - Ice maker - Microwave - Oven - Paper towels - Refrigerator - Spices - Stovetop - Toaster ### Bedrooms - 3 bedrooms - Bedsheets provided ### Bathroom - 1.5 bathrooms - Bathtub or shower - Hair dryer - Shampoo - Soap - Toilet paper - Towels provided ### Living spaces - Fireplace - Living room - Separate dining area ### Entertainment - Books - DVD player - Games - TV ### Outdoor areas - Balcony - Garden - Outdoor furniture ### Laundry - Laundromat nearby ### Comfort - Air conditioning - Heating ### Pets - No pets allowed ### Suitability/Accessibility - Smoking not allowed ### Services and conveniences - Iron/ironing board ### Location highlights - Near a health/beauty spa - Near a hospital - Near an outlet shopping mall - On a river ### Things to do - Water park - Basketball nearby - Casino nearby - Cycling nearby - Fishing nearby - Golfing nearby - Hiking/biking trails nearby - Horseback riding nearby - Motor boating nearby - Swimming nearby - Wildlife walks nearby - Winery tours nearby ### Safety features - Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property) - Smoke detector (host has indicated there is a smoke detector on the property) - Deadbolt lock ### General - Garden - Unit size: 1,600 square feet ## Similar properties ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71740000/71736900/71736900/17fd79b9.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Artistic and Creative Vibe with Indoor Swing 2 Blocks to Downtown & near SEMO Cape Girardeau - Kitchen - Free WiFi - Air conditioning - Outdoor space 9.6 Exceptional 44 reviews CA $116 CA $195 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-07&endDate=2025-12-08&selected=71736900&PinnedHotelID=71736900&HadPinnedHotel=true®ionId=-1&adults=2) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76550000/76544100/76544096/b002a425.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau Cape Girardeau - Kitchen - Washer - Dryer - Free WiFi 10 Exceptional 27 reviews [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-10&endDate=2025-12-11&selected=76544096&PinnedHotelID=76544096&HadPinnedHotel=true®ionId=-1&adults=2) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/7d35641a.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau Cape Girardeau - Washer - Dryer - Pet-friendly - Air conditioning 10 Exceptional 3 reviews [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-10&endDate=2025-12-11&selected=120661701&PinnedHotelID=120661701&HadPinnedHotel=true®ionId=-1&adults=2) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Little Blue Cottage on Spanish Cape Girardeau 8.6 Excellent 48 reviews CA $114 CA $142 total includes taxes & fees Dec 7 - Dec 8 [](https://www.expedia.ca/Hotel-Search?startDate=2025-12-07&endDate=2025-12-08&selected=45712431&PinnedHotelID=45712431&HadPinnedHotel=true®ionId=-1&adults=2) ![Exterior](https://images.trvl-media.com/lodging/101000000/100610000/100608400/100608350/aa158a60.jpg?impolicy=fcrop&w=469&h=201&p=1&q=medium) ### Downtown 4BR with 2 King Beds! 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Please respect their use of the common space. ### Pets Pets not allowed ### Children and extra beds Children are welcome Note from host: Excellent fenced back yard. ### Events Events allowed: family gatherings, birthday parties, weddings Parties or events must okayed before arrival. ### Smoking Smoking is not permitted ## Important information ### You need to know Extra-person charges may apply and vary depending on property policy Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed Parties and events (including family gatherings, birthday parties and weddings) are allowed on site; maximum attendees: 50 Note from host: Parties or events must okayed before arrival. Host has indicated there is a carbon monoxide detector on the property Host has indicated there is a smoke detector on the property Safety features at this property include a deadbolt lock This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation ### We should mention A car is not required for transportation to and from this property ## About the area ![Map](https://maps.googleapis.com/maps/api/staticmap?&size=660x330&map_id=3b266eb50d2997c6&zoom=13&markers=icon:https%3A%2F%2Fa.travel-assets.com%2Ftravel-assets-manager%2Feg-maps%2Fproperty.png%7C37.30075%2C-89.51995&channel=expedia-HotelInformation&maptype=roadmap&scale=1&key=AIzaSyCYjQus5kCufOpSj932jFoR_AJiL9yiwOw&signature=dshoScVVRLX4BbV52kd9Dl-8cK8=) Cape Girardeau, MO #### What's nearby - eDen Spa & Salon - 2 min walk - 0.2 km - Riverfront Park - 2 min walk - 0.2 km - Riverfront Bridge Park - 5 min walk - 0.4 km - Isle Casino Cape Girardeau - 16 min walk - 1.4 km - Southeast Missouri State University - 2 min drive - 1.8 km #### Getting around - Cape Girardeau, MO (CGI-Cape Girardeau Municipal) - 12 min drive #### Restaurants - ‪Sand's Pancake House - ‬11 min walk - ‪Katy O'Ferrell's Publick House - ‬9 min walk - ‪Hotshots Sports Bar & Grill - ‬5 min walk - ‪Minglewood Brewery - ‬7 min walk - ‪The Library - ‬3 min walk ## Frequently asked questions ### Is Serenity South -- Gardens, River-Views, and Refreshing Space pet-friendly? > No, pets are not allowed at this property. ### How much does it cost to stay at Serenity South -- Gardens, River-Views, and Refreshing Space? > As of Nov 26, 2025, prices found for a 1-night stay for 2 adults at Serenity South -- Gardens, River-Views, and Refreshing Space on Dec 7, 2025 start from CA $211.55, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. [Choose your dates](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information?rfrr=HOT.HIS.question.link.click) for more accurate prices. ### How much is parking? > Onsite parking is available at the property. ### What time is check-in at Serenity South -- Gardens, River-Views, and Refreshing Space? > Check-in begins at 4:00 PM. ### What time is check-out at Serenity South -- Gardens, River-Views, and Refreshing Space? > Check-out is at 11:00 AM. ### Where is Serenity South -- Gardens, River-Views, and Refreshing Space located? > This family-friendly Cape Girardeau vacation home is located on a river, steps from eDen Spa & Salon, Shawnee National Forest, and Mississippi River. Riverfront Park and Riverfront Bridge Park are also within 5 minutes. ## Have a question? Beta Get instant answers with AI powered search of property information and reviews. Ask a question ## Serenity South -- Gardens, River-Views, and Refreshing Space Reviews 10 ### Exceptional All reviews shown are from real guest experiences. Only travellers who have booked a stay with us can submit a review. We verify reviews according to our guidelines and publish all reviews, positive or negative.[More information](https://www.expedia.ca/lp/b/content-guidelines) 10 - Excellent 144 8 - Good 4 6 - Okay 0 4 - Poor 0 2 - Terrible 0 ### 10/10 Cleanliness ### 10/10 Property conditions & facilities ### 10/10 Excellent #### Tracy H. Aug 1, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Such a great place and location ##### Tracy H. Stayed 2 nights in Jul 2025 ### 10/10 Excellent #### Jodie F. Jul 26, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Enjoyed everything! Great location! ##### Jodie F. Stayed 4 nights in Jul 2025 ### 10/10 Excellent #### Vicki R. Jun 9, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Beautiful house. Great stay. Would definitely stay again! ##### Vicki R. Stayed 1 night in Jun 2025 ### 10/10 Excellent #### Donna D. Aug 11, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Lovely as always Moving our daughter in to the dorm at SEMO for yr 2. Been coming to this location since our trip here during her senior year of HS when she visited SEMO to audition for the musical theatre program. It is a great place to stay when you have more than 2 people. ##### Donna D. Stayed 1 night in Aug 2025 ### 10/10 Excellent #### Penny F. Mar 28, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Beautiful getaway! The property was exactly as listed with so many little touches that made it special. Communication was great and we were close to downtown shops and the casino. We will definitely stay again when we are in the area. ##### Penny F. Stayed 2 nights in Mar 2025 ### 10/10 Excellent #### John Dec 10, 2023 Liked: Cleanliness, property conditions & facilities, communication Great place. ##### John Stayed 1 night in Dec 2023 ### 10/10 Excellent #### Sam E. Apr 19, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Downtown home with great character My son and two brothers stayed a night in this lovely home. I travel to Cape frequently to visit my son and will definitely stay here again. ##### Sam E. Stayed 1 night in Apr 2025 ### 10/10 Excellent #### Linden S. Jun 1, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### A Beautiful Retreat for Three Generations Three generations found rest,beauty,& joy at Serenity South. Thoughtful touches,beautiful gardens and Cape charm made this more than a stay-it became a treasured memory. We were so appreciative of the details, the fresh flowers, homemade cookies, the coffeemaker upstairs and the books and games. The beds were all comfortable. We enjoyed this historical home and our stay. ##### Linden S. Stayed 2 nights in May 2025 ### 10/10 Excellent #### Bryan P. Jul 1, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Comfortable & Clean Great Location short walking distance to the Downtown Area with lots do do, Restaurants, Water Park, Shopping. This is the 2nd time I have stayed and it is a true delight. Very spacious and comfortable. Easy to communicate with the Owner/Manager. I will be staying there again in the future. I recommend it with 5 Stars! ##### Bryan P. Stayed 1 night in Jun 2025 ### 10/10 Excellent #### Tim B. Oct 28, 2022 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Great stay Beautiful home, great location, well equipped kitchen. ##### Tim B. Stayed 5 nights in Oct 2022 ### 10/10 Excellent #### Michelle K. Mar 28, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Perfect home for college visit When looking for a VRBO for our daughter's college visit, we knew the perfect place to stay! This is our second stay at Serenity South and it was just as incredible as the first visit. Clean, inviting and cozy. Thanks Jo for another beautiful stay. ##### Michelle K. Stayed 1 night in Feb 2025 ### 10/10 Excellent #### Nichole C. Jul 25, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy Serenity south was welcoming comfortable and very clean. Impeccably maintained historic home. Comfortable beds, great water pressure and shower head, easy to maintain consistent temperature. Good vibes throughout. Not haunted. Beautiful outdoor space but it was too hot to use it much while we were there. Recommend stopping by the olive oil store William and Water across the street. ##### Nichole C. Stayed 3 nights in Jul 2025 ### 10/10 Excellent #### STEPHANIE L. May 19, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### In town for one day Its was different, but over all it was on point.I will rebook this summer ##### STEPHANIE L. Stayed 1 night in May 2025 ### 10/10 Excellent #### Rhonda S. Feb 23, 2025 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Smith Women’s Weekend We had a wonderful time at Serenity South! The house is quiet and very clean, in walking distance of fantastic shops and fun places to eat. We look forward to returning next year! ##### Rhonda S. Stayed 2 nights in Feb 2025 ### 10/10 Excellent #### Bradley T. Jul 1, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Peaceful place Very nice and beautiful place super nice people ##### Bradley T. Stayed 2 nights in Jun 2024 ### 10/10 Excellent #### Terry M. Apr 22, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Great family getaway Everything was perfect. From check in to check out. Great neighborhood and location. ##### Terry M. Stayed 1 night in Apr 2024 ### 10/10 Excellent #### Danita D. Sep 18, 2023 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Historic charm We loved staying at this house for SEMO family weekend! It was super clean and had everything we needed and more 😊 we will definitely try to stay here again! ##### Danita D. Stayed 1 night in Sep 2023 ### 10/10 Excellent #### Candice L. May 11, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Family Graduation The place was perfect for our stay and was close to the farmers market and downtown shops. Highly recommend for location! ##### Candice L. Stayed 1 night in May 2024 ### 10/10 Excellent #### Scott R. Sep 11, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Family visit Nice property, real close to downtown and the river. Very relaxing ##### Scott R. Stayed 2 nights in Sep 2024 ### 10/10 Excellent #### Steve B. Nov 4, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Excellent choice Very nice property. Highly recommend. ##### Steve B. Stayed 2 nights in Oct 2024 ### 10/10 Excellent #### Nolan R., Tacoma, WA Oct 28, 2019 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Wonderful all around! Great location and property! Stayed with several friends and it’s offered lots of space for everyone. Very close to many downtown attractions! Would definitely stay again! ##### Nolan R. Stayed 2 nights in Oct 2019 ### 10/10 Excellent #### Tim B. Oct 15, 2023 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Homecoming As always, a fantastic place to stay. ##### Tim B. Stayed 2 nights in Oct 2023 ### 10/10 Excellent #### Cheryl R. Aug 14, 2023 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Repeat guest Great home away from home for our visits to Cape. ##### Cheryl R. Stayed 3 nights in Aug 2023 ### 10/10 Excellent #### Nicholas H. Mar 31, 2021 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Cool vintage place in a great town Loved it! ##### Nicholas H. Stayed 1 night in Mar 2021 ### 10/10 Excellent #### joe R. Oct 21, 2024 Liked: Cleanliness, check-in, communication, location, listing accuracy #### Cape Girardeau Beautiful very clean house with a lot of character ##### joe R. 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