Title: Book The Best Hotels in Depew, NY for 2026 from CA $94 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Depew, NY from CA $94 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Depew Pool [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&amenities=POOL) Apart hotel [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&lodging=APART_HOTEL) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&amenities=HOT_TUB) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&amenities=PETS) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&travelerType=family_friendly) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&lodging=APARTMENT) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&amenities=WATER_PARK) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&lodging=COTTAGE) Condo [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-22&d1=2025-12-22&endDate=2025-12-24&d2=2025-12-24&lodging=CONDO) ## Check prices for these dates Tonight [Dec 8 - Dec 9](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-08&endDate=2025-12-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 9 - Dec 10](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-09&endDate=2025-12-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 871 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Down comforters, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009524/716b44ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009524/1606524c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009524/80b636a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/21000000/20010000/20009600/20009524/89989c3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Niagara Falls Blvd USA La Salle 8.8/10 Excellent (1400) "This was a safe quiet and easy access to shopping restaurants..Comfortable stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Lalji CA $101 CA $115 total includes taxes & fees Dec 12 - Dec 13 [](https://www.expedia.ca/Niagara-Falls-Hotels-Comfort-Inn-Suites-Niagara-Falls-Blvd-USA.h20009524.Hotel-Information) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/ae689eb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/ea0d463b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/f90ffba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Grand Island - Niagara Falls by IHG Grand Island 8.8/10 Excellent (1592) "Clean room, staff, amenities, and breakfast; everything is excellent and budget-worthy. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mohana Raju CA $102 CA $116 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Hypo-allergenic bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/970000/968200/968172/1a933b7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/968200/968172/aace4b93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/970000/968200/968172/82add878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/970000/968200/968172/804b264d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn East Aurora East Aurora 9.4/10 Exceptional (970) "Great place! easy parking , clean and quiet, nice breakfast and great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark CA $165 CA $187 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/East-Aurora-Hotels-Hampton-Inn-East-Aurora.h968172.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/65fc1711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/96e4ab82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Non Smoking (2 Double Beds & Sofa Bed)](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/278a83c6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Buffalo Airport Buffalo 8.0/10 Very good (1881) "Clean facility, friendly staff, convenient location, overall nice stay." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Kris CA $99 CA $112 total includes taxes & fees Dec 29 - Dec 30 [](https://www.expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/0164ef81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/26fdf830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/a3f43f95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/540000/532900/532803/518ec4b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Hamburg - Buffalo South Hamburg 7.2/10 Good (1004) "I was pleasantly surprised by this hotel. It was clean, quiet, and breakfast was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cindy CA $99 CA $112 total includes taxes & fees Dec 12 - Dec 13 [](https://www.expedia.ca/Buffalo-Hotels-Comfort-Inn-And-Suites-Hamburg.h532803.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/10000/900/816/f798ced4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/900/816/56cc9184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/10000/900/816/54ae3d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/900/816/bbb1c601.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Red Roof Inn Buffalo - Niagara Airport Bowmansville 7.2/10 Good (1004) "Good stay, Thank you. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Michele CA $75 CA $86 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Buffalo-Hotels-Red-Roof-Inn-Buffalo-Niagara-Airport.h816.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/17000000/16350000/16348700/16348639/fce3e5f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/17000000/16350000/16348700/16348639/b9a48adb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave](https://images.trvl-media.com/lodging/17000000/16350000/16348700/16348639/a4d7cf88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/17000000/16350000/16348700/16348639/c9e2a1ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Microtel Inn & Suites by Wyndham Niagara Falls Niagara Falls 8.2/10 Very good (1005) "Great hotel & great area! Very centric to stores & the falls. Beds were so comfortable & staff was great. Would stay here again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Melissa CA $106 CA $121 total includes taxes & fees Dec 10 - Dec 11 [](https://www.expedia.ca/Niagara-Falls-Hotels-Microtel-Inn-Suites-By-Wyndham-Niagara-Falls.h16348639.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing, Tub w/Grab Bars)](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/b02c3e71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/c16c966d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/f96730ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Buffalo Amherst Buffalo 8.6/10 Excellent (1963) "The building was so nice and clean and so was the room. The staff was so nice. We really enjoyed the stay and will stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $106 CA $120 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/df50dbea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/828a364a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/9e549435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/68195744.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Amherst, NY - Buffalo Buffalo 6.4/10 (1002) "It was very safe staying there for the night. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lateefah CA $69 CA $78 total includes taxes & fees Dec 10 - Dec 11 [](https://www.expedia.ca/Buffalo-Hotels-Motel-6-Amherst.h42198.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/890400/890385/023ac782.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/900000/890400/890385/2ac00d85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/900000/890400/890385/96595615.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/900000/890400/890385/62f91443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge At The Falls North La Salle 7.8/10 Good (1121) "Staff were very friendly,helpful," ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) john CA $77 CA $88 total includes taxes & fees Jan 4 - Jan 5, 2026 [](https://www.expedia.ca/Niagara-Falls-Hotels-Econo-Lodge-At-The-Falls-North.h890385.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/76400/76371/66013c67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/80000/76400/76371/4fbfceee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Comfort Single Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/80000/76400/76371/61fe4005.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/80000/76400/76371/73118da5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### CenterWay Hotel Tonawanda Tonawanda 7.8/10 Good (1004) " THIS is a good hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chia Hung CA $83 CA $94 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Buffalo-Hotels-CenterWay-Hotel-Tonawanda.h76371.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/1edd14d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/04a86351.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/cbcb3a80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/328c49a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG Buffalo 8.2/10 Very good (1002) "The staff was awesome, our room was clean and all around it made our vacation for the location and friendly people. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Brenda CA $115 CA $130 total includes taxes & fees Dec 15 - Dec 16 [](https://www.expedia.ca/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Buffalo-Airport.h973773.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/8000000/7540000/7532300/7532268/614cb509.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/8000000/7540000/7532300/7532268/e037c33d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/8000000/7540000/7532300/7532268/0b734ca4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/8000000/7540000/7532300/7532268/15198ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Niagara Falls/Blvd La Salle 8.4/10 Very good (1000) "Breakfast options were great, easy access to Niagara Falls blvd attractions." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vivienne CA $98 CA $117 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Niagara-Falls-Hotels-Hampton-Inn-Niagara-FallsBlvd.h7532268.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/a429a676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/95db0ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/08466402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/e8fdcb22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Amherst - Buffalo North near University Buffalo 8.8/10 Excellent (1141) "Staff is friendly, stores close.by, and hot tub was bubbly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina CA $114 CA $129 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Buffalo-Hotels-Sleep-Inn.h126836.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/5207dfe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/a196e14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/0e406b64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/6fe2d7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Near Walden Galleria Mall Buffalo 8.0/10 Very good (1010) "Staff were great,room was clean and the location of the hotel was convenient. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sean CA $105 CA $119 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Buffalo-Hotels-Quality-Inn-Near-Walden-Galleria-Mall.h558591.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/c135a4a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/098077ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/23031bfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/10000/5200/5183/5febfbbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Summit Inn Niagara Falls 8.6/10 Excellent (1408) "Great hotel for a short stay. Front staff upon check in was super friendly and helpful! Breakfast items had a big variety and was perfect before our drive back home." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Crystal CA $111 CA $126 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Niagara-Falls-Hotels-Best-Western-Summit-Inn.h5183.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/2db1a2f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/bd6d68a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/a57eee4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/fe3bf14f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn University Buffalo 8.0/10 Very good (1199) "Good place to stay and rest " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $127 CA $145 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Buffalo-Hotels-Comfort-Inn-University.h66581.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/4969c4dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/a4c49971.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/3f2fe391.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/f7f089be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Buffalo Airport Buffalo 8.0/10 Very good (1344) "Clean room and very nice and helpful staff! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $100 CA $114 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-By-Wyndham-Buffalo-Airport.h27531.Hotel-Information) ![Blackout drapes, soundproofing, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15100/15046/w5755h3840x5y0-539c4305.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/1000000/20000/15100/15046/8a313254.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/15100/15046/50c55c40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15100/15046/w5760h3835x0y5-983b4ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Spark by Hilton Lockport Lockport 7.2/10 Good (67) "Very good hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Evin CA $87 CA $99 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Lockport-Hotels-Lockport-Hotel.h15046.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/2100/2071/19db4ac2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/2100/2071/7e0692a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/2100/2071/b86bb874.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/1000000/10000/2100/2071/34d618d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Econo Lodge Darien Lakes Corfu 7.8/10 Good (803) "Staff was really friendly!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen CA $99 CA $110 total includes taxes & fees Jan 8 - Jan 9, 2026 [](https://www.expedia.ca/Corfu-Hotels-Econo-Lodge-Darien-Lakes.h2071.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-22&endDate=2025-12-23®ionId=6338362&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels.d6338362.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels.d6338362.Travel-Guide-Hotels) ### Stay near popular Depew attractions [](https://expedia.ca/Highmark-Stadium-Hotels.0-l6058007-0.Travel-Guide-Filter-Hotels) ![Highmark Stadium](https://mediaim.expedia.com/destination/2/e08a99743003db29cf79493d56d265ad.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Highmark Stadium 4/5(363 reviews) Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6058007) [](https://expedia.ca/University-At-Buffalo-North-Campus-Hotels.0-l6175369-0.Travel-Guide-Filter-Hotels) ![University At Buffalo - North Campus](https://mediaim.expedia.com/destination/2/8ea6db0a07e2e52246c5856b45ff9cec.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### University At Buffalo - North Campus 4/5(16 reviews) Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's entertainment choices and acclaimed theater scene. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6175369) [](https://expedia.ca/Buffalo-Zoo-Hotels.0-l6064383-0.Travel-Guide-Filter-Hotels) ![Buffalo Zoo](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/187000/187150-Buffalo-Zoological-Gardens.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Buffalo Zoo 3.5/5(286 reviews) See more than 1,200 animals at this small zoo in Buffalo’s Delaware Park. Explore the rainforest building or see the big cats of the African plains. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6064383) [](https://expedia.ca/Buffalo-And-Erie-County-Naval-And-Military-Park-Hotels.0-l6064397-0.Travel-Guide-Filter-Hotels) ![Buffalo and Erie County Naval and Military Park](https://mediaim.expedia.com/destination/2/9e65743a11306011027ff94241242e39.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Buffalo and Erie County Naval and Military Park 4/5(39 reviews) After visiting Buffalo and Erie County Naval and Military Park, make a plan to see the other sights and activities in Buffalo. Experience the area's great live music or attend a hockey game. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6064397) [](https://expedia.ca/Canisius-College-Hotels.0-l6181324-0.Travel-Guide-Filter-Hotels) ![Canisius College](https://mediaim.expedia.com/destination/2/fa0f166e5a5e0ebec8bb0cd2701f1416.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Canisius College 3/5(1 review) Explore the campus of Canisius College, during your trip to Buffalo. Experience the area's entertainment choices and acclaimed theater scene. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6181324) [](https://expedia.ca/Peace-Bridge-Hotels.0-l6171624-0.Travel-Guide-Filter-Hotels) ![Peace Bridge](https://mediaim.expedia.com/destination/2/4e6bc263b4e5e916f9ef48f3b41972d5.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Peace Bridge 3.5/5(6 reviews) You can find out about the history of Buffalo with a stop at Peace Bridge. Stroll along the area's riverfront or experience its great live music. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6171624) ## More cheap stays in Depew ![Sleep Inn & Suites Buffalo Airport](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sleep Inn & Suites Buffalo Airport 100 Holtz Dr Buffalo NY CA $99 CA $112 total Dec 29 - Dec 30 includes taxes & fees 7.8/10 Good! (1,878 reviews) [](https://expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Hampton Inn Buffalo - Amherst, NY](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Buffalo - Amherst, NY 1601 Amherst Manor Drive Buffalo NY CA $143 CA $162 total Dec 15 - Dec 16 includes taxes & fees 9.2/10 Wonderful! (1,984 reviews) [](https://expedia.ca/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![CenterWay Hotel Tonawanda](https://images.trvl-media.com/lodging/1000000/80000/76400/76371/66013c67_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### CenterWay Hotel Tonawanda 225 Crestmount Avenue Tonawanda NY CA $83 CA $94 total Dec 9 - Dec 10 includes taxes & fees 7.8/10 Good! (1,003 reviews) [](https://expedia.ca/Buffalo-Hotels-CenterWay-Hotel-Tonawanda.h76371.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 2761 Long Road Grand Island NY CA $102 CA $116 total Jan 4 - Jan 5, 2026 includes taxes & fees 8.8/10 Excellent! (1,585 reviews) [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG](https://images.trvl-media.com/lodging/1000000/10000/6300/6258/73c0de62_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG 601 Main St Buffalo NY CA $155 CA $181 total Dec 23 - Dec 24 includes taxes & fees 8.6/10 Excellent! (1,009 reviews) [](https://expedia.ca/Buffalo-Hotels-Holiday-Inn-Express-Suites-Buffalo-Downtown-Medical-CTR.h6258.Hotel-Information) ![Quality Inn Near Walden Galleria Mall](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/5207dfe7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Near Walden Galleria Mall 475 Dingens St Buffalo NY CA $105 CA $119 total Dec 18 - Dec 19 includes taxes & fees 8/10 Very Good! (1,040 reviews) [](https://expedia.ca/Buffalo-Hotels-Quality-Inn-Near-Walden-Galleria-Mall.h558591.Hotel-Information) ## Hotels in Depew with star-rating ![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg) 5 Star Hotels 1 properties [](https://expedia.ca/5Star-Depew-Hotels.s50-0-d6338362.Travel-Guide-Filter-Hotels) ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 9 properties [](https://expedia.ca/4Star-Depew-Hotels.s40-0-d6338362.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 98 properties [](https://expedia.ca/3Star-Depew-Hotels.s30-0-d6338362.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 188 properties [](https://expedia.ca/2Star-Depew-Hotels.s20-0-d6338362.Travel-Guide-Filter-Hotels) ## Find out more about Depew ### Top reasons to visit Depew - **Family-Friendly Activities:** Depew offers a variety of enjoyable activities suitable for families, including local amusement parks and shopping centres. - **Cultural Experiences:** Explore nearby Buffalo for its vibrant culture, dining options, and artistic attractions. - **Convenient Location:** Depew is an ideal base for day trips to various destinations in Western New York. - **Diverse Accommodations:** A range of hotels cater to different needs, from pet-friendly to business amenities. - **Friendly Atmosphere:** Experience the warm hospitality of the local community during your visit. ### Find great hotels near Depew Explore a variety of hotel accommodations in Depew, New York, catering to diverse needs from business travellers to pet-friendly options. Whether you seek a welcoming environment for LGBTQIA guests or enjoy bar service, there’s something for everyone. Discover local favourites such as the Delavan Hotel and enjoy nearby attractions like Maple Leaf and Allentown Homes for a memorable stay. - **[M Hotel Buffalo: ](https://www.expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information)** This 3.5-star hotel offers a vibrant and inclusive atmosphere, making it an ideal choice for LGBTQIA travellers seeking a business-themed vacation. Situated 4.8km from Depew, M Hotel Buffalo is affiliated with LGBTQI travel guides, ensuring a welcoming experience. Business amenities include a 24-hour business centre, accessible meeting rooms, and a dedicated business district site location. Guests appreciate the stylish decor and modern facilities, which cater to both leisure and work needs, creating a balanced and enjoyable stay. - **Country Inn & Suites by Radisson, Buffalo South I-90, NY:** Located 9.7km from Depew, this hotel is perfect for those looking for a pet-friendly environment combined with business amenities. The Country Inn & Suites offers a warm and inviting atmosphere, featuring a business centre, meeting rooms, and conference space. With a pet policy that permits dogs and cats, guests can enjoy their stay with their furry companions. The property’s homely feel, combined with its professional services, ensures a comfortable and productive experience for all visitors. - **Motel 6 Buffalo, NY - Airport - Williamsville:** A budget-friendly option located 4.8km from Depew, Motel 6 Buffalo is an excellent choice for pet owners. This motel allows pets on-site, making it a convenient stop for travellers with furry friends. With a straightforward and no-frills approach, it offers essential amenities to ensure a pleasant stay. The pet-friendly policy includes service animals, dogs, and cats, creating a welcoming environment for all guests. Ideal for those prioritizing affordability without sacrificing comfort. ### Where to stay in Depew Depew, New York, offers a delightful blend of family-friendly activities and business amenities, making it the perfect vacation spot for all types of travellers. Explore the nearby downtown Buffalo for vibrant culture and dining, while enjoying the warm atmosphere of friendly locals. With convenient locations and budget-friendly excursions, Depew serves as an ideal base to experience the best of Western New York. - **[Buffalo: ](https://www.expedia.ca/Buffalo-Hotels.d602674.Travel-Guide-Hotels)** Buffalo is a vibrant metropolis and acts as the heart of the region, with Depew nestled within its boundaries. The city experiences moderately seasonal travel, with a peak in visitors from June to August, making it a lively summer destination. Buffalo attracts families, business travellers, and city explorers alike. Key highlights include shopping centres, educational institutions, and renowned local landmarks such as the stadium and national state park. Visitors can immerse themselves in the rich culture, enjoy sports events, and take advantage of the diverse shopping options available. - **[Cheektowaga: ](https://www.expedia.ca/Cheektowaga-Hotels.d7197.Travel-Guide-Hotels)** Located a mere 4.8km from Depew, Cheektowaga is a welcoming village that maintains a steady influx of visitors year-round, with peak periods occurring in March to April and July. This charming area is ideal for families, business-oriented travellers, and those seeking a city-themed experience. Cheektowaga boasts an array of shopping centres and educational facilities, along with notable landmarks like modern colleges and sports facilities. The village offers a relaxed atmosphere while still being close to urban amenities, making it a perfect spot for exploration. - **[Bowmansville: ](https://www.expedia.ca/Bowmansville-Hotels.d7978.Travel-Guide-Hotels)** Situated just 4.8km from Depew, Bowmansville is a lively city that draws visitors primarily during the summer months from June to August. It’s an excellent destination for families and business travellers alike. With easy access to shopping centres, a thrilling amusement park, and a theme park for endless entertainment, Bowmansville combines the charm of a small city with the excitement of larger attractions. Local sports facilities and stadiums enhance the experience, providing ample opportunities for fun and leisure. ### Things to do near Depew Depew, New York, is an excellent destination for families and business travellers alike, offering a variety of enjoyable activities. Visitors can explore local shopping centres and malls, or have fun at the nearby amusement park. Ideal for day trips, Depew provides a mix of entertainment and leisure options that cater to diverse interests, making it a perfect spot for a memorable vacation. **Shopping** In Depew, you can enjoy shopping at [Walden Galleria Mall](https://www.expedia.ca/Walden-Galleria-Mall-Hotels.0-l6129205-0.Travel-Guide-Filter-Hotels), just 4.8km away, with its vibrant atmosphere and diverse shops. [Eastern Hills Mall](https://www.expedia.ca/Eastern-Hills-Mall-Hotels.0-l6129207-0.Travel-Guide-Filter-Hotels) is also nearby at 8.0km, offering family-friendly entertainment. If you're up for a drive, visit [Broadway Market](https://www.expedia.ca/Broadway-Market-Hotels.0-l6178575-0.Travel-Guide-Filter-Hotels), located 11.3km away, for local flavours. **Recreation** [Diamond Hawk Golf Course](https://www.expedia.ca/Diamond-Hawk-Golf-Course-Hotels.0-l6276883-0.Travel-Guide-Filter-Hotels) offers a beautiful outdoor setting for golf enthusiasts, just 3.2km from Depew, where you can enjoy fresh air and stunning views. For a fun-filled experience, visit [Holiday Twin Rinks](https://www.expedia.ca/Holiday-Twin-Rinks-Hotels.0-l6207411-0.Travel-Guide-Filter-Hotels), only 3.2km away, for ice skating and lively entertainment. [Northtown Center at Amherst](https://www.expedia.ca/Northtown-Center-At-Amherst-Hotels.0-l6205612-0.Travel-Guide-Filter-Hotels), located 12.9km from Depew, is an excellent venue for sports lovers, featuring various facilities for active recreation and events. **Adventure** Experience the thrill of karting at [Pole Position Raceway](https://www.expedia.ca/Pole-Position-Raceway-Hotels.0-l553248621561872721-0.Travel-Guide-Filter-Hotels), located 4.8km from Depew, where you can race against friends and family. For outdoor enthusiasts, explore the scenic [Amherst Canalway Trail](https://www.expedia.ca/Amherst-Canalway-Trail-Hotels.0-l553248621532664870-0.Travel-Guide-Filter-Hotels), 19.3km away, perfect for hiking and cycling. If you enjoy winter sports, head to [Buffalo Ski Club](https://www.expedia.ca/Buffalo-Ski-Club-Hotels.0-l553248635981428400-0.Travel-Guide-Filter-Hotels), 24.1km from Depew, for an exciting day on the slopes. **Nightlife** Experience the charm of the [Lancaster Opera House](https://www.expedia.ca/Lancaster-Opera-House-Hotels.0-l553248621532664862-0.Travel-Guide-Filter-Hotels), just 3.2km away, offering a romantic theatre atmosphere. For some excitement, venture to [Lasertron](https://www.expedia.ca/Lasertron-Hotels.0-l6187846-0.Travel-Guide-Filter-Hotels), 12.9km out, where adventure awaits. Don't miss the [University At Buffalo Center for the Arts](https://www.expedia.ca/University-At-Buffalo-Center-For-The-Arts-Hotels.0-l6175362-0.Travel-Guide-Filter-Hotels), also 12.9km away, for a cultural evening. \*Distances are measured in a straight line; actual driving distances may vary depending on the route. ### Booking tips and Expedia advantages for Depew To save money on your trip to Depew, New York, consider visiting between January and March when accommodation prices are lower. Tuesdays are the most affordable days to stay, while Saturdays are the priciest. Use Expedia to find good hotel deals by filtering for eco-certified options and arranging flights and activities in a package for added savings. Public transport can be an economical way to explore the area, and look for free local activities to enjoy without spending much. Plan ahead to make the most of your budget while visiting Depew. - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Depew are January to March, where the prices are slightly lower. This is in comparison to July to September, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Depew is Tuesday. The most expensive day to stay in Depew is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia’s search tool to refine your preferences, such as your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified option will showcase sustainable and environmentally friendly accommodations currently available. To discover the best prices and deals, simply arrange the price filter from lowest to highest. - **Consider bundling your trip:** You can save money by combining your hotel stay in Depew with your flights and activities through an Expedia package deal. ### Find the best attractions near Depew Depew, New York, is a great destination for families and business travellers alike, offering a blend of modern attractions. Visitors can explore local points of interest such as colleges and universities, urban parks, and arts centres. This vibrant area caters to those seeking cultural experiences and city adventures, making it an ideal spot for a memorable vacation. - **[University At Buffalo - North Campus: ](https://www.expedia.ca/University-At-Buffalo-North-Campus-Hotels.0-l6175369-0.Travel-Guide-Filter-Hotels)** Experience the vibrant atmosphere of this modern university, located 12.9km from Depew. The campus features stunning architecture and beautiful green spaces, making it a perfect spot for a leisurely stroll or a picnic. - **[Shea's Performing Arts Center: ](https://www.expedia.ca/Sheas-Performing-Arts-Center-Hotels.0-l6064405-0.Travel-Guide-Filter-Hotels)** Immerse yourself in the cultural scene at this historic venue, located 14.5km away. Shea's hosts a variety of performances, from Broadway shows to concerts, showcasing the rich artistic heritage of the region. - **[Roswell Park Cancer Institute: ](https://www.expedia.ca/Roswell-Park-Cancer-Institute-Hotels.0-l6175413-0.Travel-Guide-Filter-Hotels)** Explore the unique blend of recreation and history at this renowned research facility, situated 12.9km from Depew. The institute offers informative tours that highlight its groundbreaking contributions to cancer research and care. ### Best time to go to Depew The best time to visit Depew can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Depew falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature in Depew falls in January, visitor numbers are average and weather is very cloudy with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | ---------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------- | ---------------------------------------------------------------------------------------------------------------------------- | -------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------- | | January | 25.0°F (-3.9°C) | Light Rain | Very Cloudy | Average | Slightly Low | | February | 25.9°F (-3.4°C) | Light Rain | Mostly Cloudy | Average | Slightly Low | | March | 34.2°F (1.2°C) | Light Rain | Mostly Cloudy | Average | Slightly Low | | April | 45.0°F (7.2°C) | Light Rain | Mostly Cloudy | Slightly High | Average | | May | 57.6°F (14.2°C) | Light Rain | Mostly Sunny | Average | Average | | June | 65.5°F (18.6°C) | Light Rain | Mostly Sunny | Average | Average | | July | 71.1°F (21.7°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | August | 69.8°F (21.0°C) | Light Rain | Mostly Sunny | Average | Slightly High | | September | 63.5°F (17.5°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | October | 52.3°F (11.3°C) | Light Rain | Mostly Cloudy | Slightly Low | Average | | November | 40.5°F (4.7°C) | Light Rain | Mostly Cloudy | Slightly Low | Average | | December | 32.4°F (0.2°C) | Light Rain | Mostly Cloudy | Slightly Low | Average | ### The nearest major airports for your trip to Depew When visiting Depew, New York, the closest major airport is Buffalo Niagara International Airport ([BUF](https://www.expedia.ca/Buffalo-Niagara-Intl-Airport-Hotels.0-aBUF-0.Travel-Guide-Filter-Hotels)), located 4.8km away. Excellent hotel options nearby include the 4-star Delavan Hotel & Spa and Mosey Buffalo Williamsville, both just 3.2km from the airport, offering convenient access. For those considering other airports, Greater Rochester International Airport ([ROC](https://www.expedia.ca/Greater-Rochester-Intl-Airport-Hotels.0-aROC-0.Travel-Guide-Filter-Hotels)) is 88.5km away, with quality accommodations like the [DoubleTree by Hilton Rochester](https://www.expedia.ca/Rochester-Hotels-DoubleTree-By-Hilton-Rochester.h18137.Hotel-Information), situated 6.4km from the airport. Niagara Falls International Airport ([IAG](https://www.expedia.ca/Niagara-Falls-Intl-Airport-Hotels.0-aIAG-0.Travel-Guide-Filter-Hotels)) is 29.0km from Depew, featuring hotels such as the [Seneca Niagara Resort & Casino](https://www.expedia.ca/Niagara-Falls-Hotels-Seneca-Niagara-Resort-Casino.h2238838.Hotel-Information), located 9.7km away, ensuring a comfortable stay during your travels. ## Recent reviews of Depew hotels ![Comfort Inn University](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/2db1a2f1_y.jpg) ### Comfort Inn University 5/5 Excellent "Friendly staff!" A verified traveller from Peterborough stayed at Comfort Inn University Posted 1 day ago [](https://expedia.ca/Buffalo-Hotels-Comfort-Inn-University.h66581.Hotel-Information) ![The Richardson Hotel](https://images.trvl-media.com/lodging/19000000/18140000/18136300/18136290/16863301_y.jpg) ### The Richardson Hotel 5/5 Excellent "My new favorite stay in Buffalo! The hotel is a beautiful tribute to its own heritage. The room was so comfortable and quiet, the common areas are beautifully preserved and restored. I walked the 4 floors in awe. This is a must-see property. I will be staying there again." A verified traveller stayed at The Richardson Hotel Posted 2 days ago [](https://expedia.ca/Buffalo-Hotels-Hotel-Henry-Urban-Resort.h18136290.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 5/5 Excellent "The room was very nice and clean. Parking was slim, but we did come on a holiday. Breakfast was great in the morning. I would stay here again." A verified traveller stayed at Holiday Inn Express Grand Island - Niagara Falls by IHG Posted 3 days ago [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Hyatt Regency Buffalo / Hotel and Conference Center](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234_y.jpg) ### Hyatt Regency Buffalo / Hotel and Conference Center 5/5 Excellent "Could use some updates and hvac system cleaned. Some black mold type and dust" A verified traveller stayed at Hyatt Regency Buffalo / Hotel and Conference Center Posted 4 days ago [](https://expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Buffalo Amherst](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072_y.jpg) ### La Quinta Inn & Suites by Wyndham Buffalo Amherst 5/5 Excellent "The building was so nice and clean and so was the room. The staff was so nice. We really enjoyed the stay and will stay there again. " A verified traveller stayed at La Quinta Inn & Suites by Wyndham Buffalo Amherst Posted 4 days ago [](https://expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) ![Garden Place Hotel](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg) ### Garden Place Hotel 5/5 Excellent "The pictures of the hotel posted here on Expedia and the reasonable price is what intrigued me to book. The Tuscan themed architecture was so nice imho. Having my morning coffee and breakfast sandwich from the hotel kitchen. Enjoying it while sitting in the beautiful indoor piazza in the middle of the hotel was so cool! Loved it! Friendly courtious staff. Rooms were a little dated, but very clean. My only issue was the super soft matress. Trying to get out of the plush super soft bed was almost comical. Most hotels have either firm or medium mattresses. Nevertheless I would stay there again. " A verified traveller stayed at Garden Place Hotel Posted 5 days ago [](https://expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) ![M Hotel Buffalo](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593_y.jpg) ### M Hotel Buffalo 5/5 Excellent "Everything was great. " A verified traveller stayed at M Hotel Buffalo Posted 6 days ago [](https://expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![La Quinta Inn by Wyndham Buffalo Airport](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/4969c4dc_y.jpg) ### La Quinta Inn by Wyndham Buffalo Airport 5/5 Excellent "The front desk staff was amazing I had a small issue and they made sure I was great throughout the ordeal I take my hat off to the front desk crew and the entire staff overall thanks for your help Antoine " A verified traveller stayed at La Quinta Inn by Wyndham Buffalo Airport Posted 6 days ago [](https://expedia.ca/Buffalo-Hotels-La-Quinta-Inn-By-Wyndham-Buffalo-Airport.h27531.Hotel-Information) ![Buffalo Airport Hotel](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d_y.jpg) ### Buffalo Airport Hotel 5/5 Excellent "It was a good value and a clean comfortable room" A verified traveller stayed at Buffalo Airport Hotel Posted 6 days ago [](https://expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ## Frequently asked questions ### When is the best time to go to Depew? > As the peak season runs from February to April, you'll find that Depew becomes a vibrant hub of activity, particularly in the lead-up to spring. This is a fantastic time to engage in sightseeing, with local parks and gardens coming to life. Families and couples alike can enjoy leisurely walks while soaking in the fresh air and natural beauty. > > > April is especially appealing for those who appreciate outdoor dining and community events. Many local eateries begin to open their terraces, allowing you to savour delicious local cuisine while basking in the mild weather. Additionally, this month often features various festivals that celebrate the arrival of spring, providing an excellent opportunity to connect with the local culture. > > > If you're looking for a more budget-friendly option, visiting in December can also be rewarding. It's cooler, the festive atmosphere and holiday lights create a unique charm, superb for those who enjoy seasonal celebrations. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Depew hotel booking with Expedia? ### How much is the nightly rate at a Depew hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rentals - Other - More ways to book - [4 Star Hotels in Cheektowaga ](https://www.expedia.ca/4Star-Cheektowaga-Hotels.s40-0-d7197.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Cheektowaga ](https://www.expedia.ca/5Star-Cheektowaga-Hotels.s50-0-d7197.Travel-Guide-Filter-Hotels) - [Amherst Hotels ](https://www.expedia.ca/Amherst-Hotels.d9323.Travel-Guide-Hotels) - [Bowmansville Hotels ](https://www.expedia.ca/Bowmansville-Hotels.d7978.Travel-Guide-Hotels) - [Hotels near Broadway Market ](https://www.expedia.ca/Broadway-Market-Hotels.0-l6178575-0.Travel-Guide-Filter-Hotels) - [Hotels near Buffalo Central Terminal ](https://www.expedia.ca/Buffalo-Central-Terminal-Hotels.0-l6064429-0.Travel-Guide-Filter-Hotels) - 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