Title: Book The Best Hotels in Depew, NY for 2026 from CA $95 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Depew, NY from CA $95 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Depew Pool [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=POOL) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=APARTMENT) Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&travelerType=family_friendly) Condo [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=CONDO) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&amenities=WATER_PARK) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Depew%2C+New+York%2C+United+States+of+America®ionId=6338362&latLong=42.900423%2C-78.70494&adults=2&startDate=2025-12-16&d1=2025-12-16&endDate=2025-12-18&d2=2025-12-18&lodging=COTTAGE) ## Check prices for these dates Tonight [Dec 2 - Dec 3](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-02&endDate=2025-12-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 3 - Dec 4](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-03&endDate=2025-12-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Compare 868 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable. ![Lobby](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, Non Smoking (2 Double Beds & Sofa Bed)](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/f29ef300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/96e4ab82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/65fc1711.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn & Suites Buffalo Airport Buffalo 8.0/10 Very good (1878) "Our 4th stay here at Sleep Inn, it's always a great experience. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Lalchand CA $95 CA $108 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/e72e8dfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/462b3003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/5394387a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Garden Place Hotel Buffalo 7.8/10 Good (2110) "Great location the staff worked so hard keeeping the hotel clean thanks for everything " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Shannon CA $107 CA $121 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) ![Reception hall](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/f9c7d85f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/ad6c6de2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/db76cf58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### M Hotel Buffalo Buffalo 7.4/10 Good (2502) "Clean rooms, good breakfast, check in process was quick." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $97 CA $110 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/79b2bbdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/f2d28773.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/fe2b6be7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Buffalo / Hotel and Conference Center Downtown Buffalo 8.2/10 Very good (1652) "Clean room, pleasant staff at the check in and check out." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sinia CA $146 CA $170 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/2db1a2f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/20e00197.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/fe3bf14f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/70000/66600/66581/bd6d68a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn University Buffalo 8.0/10 Very good (1200) "Good place to stay and rest " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis CA $142 CA $162 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Buffalo-Hotels-Comfort-Inn-University.h66581.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/e05cc583.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/655c2793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/115eb7cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Buffalo - Amherst, NY Buffalo 9.4/10 Exceptional (1984) "The rooms were clean, the breakfast set up was great, and everything at the hotel was wonderful" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John CA $144 CA $164 total includes taxes & fees Dec 9 - Dec 10 [](https://www.expedia.ca/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/4969c4dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/a4c49971.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/f7f089be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/27600/27531/9614d0d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Buffalo Airport Buffalo 8.0/10 Very good (1358) "Clean room and very nice and helpful staff! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $102 CA $116 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-By-Wyndham-Buffalo-Airport.h27531.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/10000000/9460000/9456500/9456445/523e54f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9460000/9456500/9456445/da79c609.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free self parking](https://images.trvl-media.com/lodging/10000000/9460000/9456500/9456445/5bccc2ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9460000/9456500/9456445/8f886a54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Buffalo/Amherst Buffalo 9.0/10 Wonderful (1100) "Great hotel and in close proximity to Himark Stadium for game day; Gallaria Mall for shopping and other fun areas to visit. Will definitely stay again!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Suzanna CA $207 CA $236 total includes taxes & fees Dec 11 - Dec 12 [](https://www.expedia.ca/Buffalo-Hotels-Hyatt-Place-BuffaloAmherst.h9456445.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/a429a676.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/e8fdcb22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/08466402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/130000/126900/126836/05264f1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sleep Inn Amherst - Buffalo North near University Buffalo 8.8/10 Excellent (1138) "Staff is friendly, stores close.by, and hot tub was bubbly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tina CA $122 CA $139 total includes taxes & fees Dec 30 - Dec 31 [](https://www.expedia.ca/Buffalo-Hotels-Sleep-Inn.h126836.Hotel-Information) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/f90ffba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop terrace](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/3274a349.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/ea0d463b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Grand Island - Niagara Falls by IHG Grand Island 8.8/10 Excellent (1580) "Clean room, staff, amenities, and breakfast; everything is excellent and budget-worthy. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mohana Raju CA $89 CA $101 total includes taxes & fees Dec 8 - Dec 9 [](https://www.expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Courtyard view](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/19bd0f50.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/e6ba9cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/7585a4c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Buffalo Airport Hotel Buffalo 8.0/10 Very good (2778) "Nice place to stay in " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dey CA $102 CA $116 total includes taxes & fees Dec 4 - Dec 5 [](https://www.expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ![2 restaurants, dinner served](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/c468db44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Queen Beds](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/bde63631.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/7ae798f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/2d8aa914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Delavan Hotel & Spa Bowmansville 8.8/10 Excellent (1000) "The food & bar are top notch. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew CA $175 CA $199 total includes taxes & fees Dec 16 - Dec 17 [](https://www.expedia.ca/Buffalo-Hotels-The-Delavan-Hotel-Spa.h15031117.Hotel-Information) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/5207dfe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/6fe2d7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/0e406b64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/a196e14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Near Walden Galleria Mall Buffalo 8.0/10 Very good (1040) "Staff were great,room was clean and the location of the hotel was convenient. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sean CA $106 CA $121 total includes taxes & fees Dec 18 - Dec 19 [](https://www.expedia.ca/Buffalo-Hotels-Quality-Inn-Near-Walden-Galleria-Mall.h558591.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/6000000/5060000/5058700/5058670/ce7e42e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/6000000/5060000/5058700/5058670/0f576097.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Studio, 1 Queen Bed, Non Smoking | Private kitchen](https://images.trvl-media.com/lodging/6000000/5060000/5058700/5058670/4690f91d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/6000000/5060000/5058700/5058670/6aa8ebc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel at the Lafayette Trademark Collection by Wyndham Downtown Buffalo 8.6/10 Excellent (1009) "Nice place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Glen CA $141 CA $165 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Buffalo-Hotels-Hotel-At-The-Lafayette-Trademark-Collection-By-Wyndham.h5058670.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/456d3072.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/c16c966d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Accessible, Non Smoking (Mobility/Hearing, Tub w/Grab Bars)](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/b02c3e71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/25000000/24730000/24723600/24723591/f96730ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Buffalo Amherst Buffalo 8.6/10 Excellent (1954) "Very clean facility, beds were comfortable, good shower pressure and hot water" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $109 CA $125 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Buffalo-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Buffalo-Amherst.h24723591.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/159000/158959/2e0799e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/160000/159000/158959/801e8ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/160000/159000/158959/dfd9177e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/160000/159000/158959/80e2350d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Garden Buffalo Downtown Downtown Buffalo 9.0/10 Wonderful (1709) "Staff was great Nice breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathleen CA $173 CA $202 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Buffalo-Hotels-Wyndham-Garden-Buffalo-Downtown.h158959.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/1edd14d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/a15d989c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/04a86351.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/980000/973800/973773/328c49a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Buffalo-Airport by IHG Buffalo 8.2/10 Very good (1017) "The staff was awesome, our room was clean and all around it made our vacation for the location and friendly people. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Brenda CA $111 CA $126 total includes taxes & fees Dec 23 - Dec 24 [](https://www.expedia.ca/Buffalo-Hotels-Holiday-Inn-Express-Hotel-Suites-Buffalo-Airport.h973773.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/900000/892600/892571/3b4ec85c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Bedroom | Private kitchen](https://images.trvl-media.com/lodging/1000000/900000/892600/892571/e8fe22a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/900000/892600/892571/a6db64ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/900000/892600/892571/8865f22a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Buffalo Downtown Downtown Buffalo 8.8/10 Excellent (1014) "Great location. Parking available. Good breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carmen CA $178 CA $207 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Buffalo-Hotels-Hampton-Inn-Suites-Buffalo-Downtown.h892571.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/28726905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/d148ff08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/f914a3ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Kitchenette (with Sofabed) | Private kitchen](https://images.trvl-media.com/lodging/1000000/30000/23200/23120/dad06591.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Galleria Inn & Suites Buffalo 6.6/10 (1000) "Check-in was great. This place is clean. That is awesome. Food is delicious. I would recommend it if anyone’s passing through or staying in Buffalo New York." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $119 CA $135 total includes taxes & fees Jan 1 - Jan 2, 2026 [](https://www.expedia.ca/Buffalo-Hotels-Best-Western-Plus-Galleria-Inn-Suites.h23120.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/d64d0a69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/8f1a74c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/327eb062.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/9000000/8140000/8130600/8130557/1a008e5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Cheektowaga North East by IHG Buffalo 8.4/10 Very good (1209) "The lady at the desk (check-in and check-out) was so nice and friendly." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Maryam CA $116 CA $132 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Buffalo-Hotels-Holiday-Inn-Express-Cheektowaga-North-East.h8130557.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-17&endDate=2025-12-18®ionId=6338362&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels.d6338362.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDepew-Hotels.d6338362.Travel-Guide-Hotels) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Limited-time deals: save up to 50% on select hotels [Book now](https://expedia.ca/deals?rfrr=HTG_BF_PROMO_6338362) ### Stay near popular Depew attractions [](https://expedia.ca/Highmark-Stadium-Hotels.0-l6058007-0.Travel-Guide-Filter-Hotels) ![Highmark Stadium](https://mediaim.expedia.com/destination/2/e08a99743003db29cf79493d56d265ad.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Highmark Stadium Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6058007) [](https://expedia.ca/University-At-Buffalo-North-Campus-Hotels.0-l6175369-0.Travel-Guide-Filter-Hotels) ![University At Buffalo - North Campus](https://mediaim.expedia.com/destination/2/8ea6db0a07e2e52246c5856b45ff9cec.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### University At Buffalo - North Campus Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's great live music and entertainment choices. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6175369) [](https://expedia.ca/Buffalo-Zoo-Hotels.0-l6064383-0.Travel-Guide-Filter-Hotels) ![Buffalo Zoo](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/187000/187150-Buffalo-Zoological-Gardens.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Buffalo Zoo See more than 1,200 animals at this small zoo in Buffalo’s Delaware Park. Explore the rainforest building or see the big cats of the African plains. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6064383) [](https://expedia.ca/Buffalo-And-Erie-County-Naval-And-Military-Park-Hotels.0-l6064397-0.Travel-Guide-Filter-Hotels) ![Buffalo and Erie County Naval and Military Park](https://mediaim.expedia.com/destination/2/9e65743a11306011027ff94241242e39.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Buffalo and Erie County Naval and Military Park After visiting Buffalo and Erie County Naval and Military Park, make a plan to see the other sights and activities in Buffalo. Experience the area's acclaimed theater scene or attend a hockey game. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6064397) [](https://expedia.ca/Canisius-College-Hotels.0-l6181324-0.Travel-Guide-Filter-Hotels) ![Canisius College](https://mediaim.expedia.com/destination/2/fa0f166e5a5e0ebec8bb0cd2701f1416.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Canisius College Explore the campus of Canisius College, during your trip to Buffalo. Experience the area's acclaimed theater scene and entertainment choices. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6181324) [](https://expedia.ca/Peace-Bridge-Hotels.0-l6171624-0.Travel-Guide-Filter-Hotels) ![Peace Bridge](https://mediaim.expedia.com/destination/2/4e6bc263b4e5e916f9ef48f3b41972d5.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Peace Bridge You can find out about the history of Buffalo with a stop at Peace Bridge. Stroll along the area's riverfront or experience its acclaimed theater scene. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6171624) ## More cheap stays in Depew ![Sleep Inn & Suites Buffalo Airport](https://images.trvl-media.com/lodging/1000000/90000/85100/85007/ae021a7d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Sleep Inn & Suites Buffalo Airport 100 Holtz Dr Buffalo NY CA $95 CA $108 total Dec 9 - Dec 10 includes taxes & fees 7.8/10 Good! (1,855 reviews) [](https://expedia.ca/Buffalo-Hotels-Sleep-Inn-Suites-Buffalo-Airport.h85007.Hotel-Information) ![Hampton Inn Buffalo - Amherst, NY](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn Buffalo - Amherst, NY 1601 Amherst Manor Drive Buffalo NY CA $144 CA $164 total Dec 9 - Dec 10 includes taxes & fees 9.2/10 Wonderful! (1,968 reviews) [](https://expedia.ca/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![CenterWay Hotel Tonawanda](https://images.trvl-media.com/lodging/1000000/80000/76400/76371/66013c67_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### CenterWay Hotel Tonawanda 225 Crestmount Avenue Tonawanda NY CA $84 CA $95 total Dec 4 - Dec 5 includes taxes & fees 7.8/10 Good! (1,014 reviews) [](https://expedia.ca/Buffalo-Hotels-CenterWay-Hotel-Tonawanda.h76371.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 2761 Long Road Grand Island NY CA $89 CA $101 total Dec 8 - Dec 9 includes taxes & fees 8.8/10 Excellent! (1,566 reviews) [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ![Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG](https://images.trvl-media.com/lodging/1000000/10000/6300/6258/73c0de62_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG 601 Main St Buffalo NY CA $139 CA $162 total Dec 9 - Dec 10 includes taxes & fees 8.6/10 Excellent! (1,007 reviews) [](https://expedia.ca/Buffalo-Hotels-Holiday-Inn-Express-Suites-Buffalo-Downtown-Medical-CTR.h6258.Hotel-Information) ![Quality Inn Near Walden Galleria Mall](https://images.trvl-media.com/lodging/1000000/560000/558600/558591/5207dfe7_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Near Walden Galleria Mall 475 Dingens St Buffalo NY CA $106 CA $121 total Dec 18 - Dec 19 includes taxes & fees 8/10 Very Good! (1,033 reviews) [](https://expedia.ca/Buffalo-Hotels-Quality-Inn-Near-Walden-Galleria-Mall.h558591.Hotel-Information) ## Hotels in Depew with star-rating ![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg) 5 Star Hotels 1 properties [](https://expedia.ca/5Star-Depew-Hotels.s50-0-d6338362.Travel-Guide-Filter-Hotels) ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 9 properties [](https://expedia.ca/4Star-Depew-Hotels.s40-0-d6338362.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 98 properties [](https://expedia.ca/3Star-Depew-Hotels.s30-0-d6338362.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 188 properties [](https://expedia.ca/2Star-Depew-Hotels.s20-0-d6338362.Travel-Guide-Filter-Hotels) ## Find out more about Depew ### Top reasons to visit Depew - **Family-Friendly Activities:** Depew offers a variety of enjoyable activities suitable for families, including local amusement parks and shopping centres. - **Cultural Experiences:** Explore nearby Buffalo for its vibrant culture, dining options, and artistic attractions. - **Convenient Location:** Depew is an ideal base for day trips to various destinations in Western New York. - **Diverse Accommodations:** A range of hotels cater to different needs, from pet-friendly to business amenities. - **Friendly Atmosphere:** Experience the warm hospitality of the local community during your visit. ### Find great hotels near Depew Explore a variety of hotel accommodations in Depew, New York, catering to diverse needs from business travellers to pet-friendly options. Whether you seek a welcoming environment for LGBTQIA guests or enjoy bar service, there’s something for everyone. Discover local favourites such as the Delavan Hotel and enjoy nearby attractions like Maple Leaf and Allentown Homes for a memorable stay. - **[M Hotel Buffalo:](https://www.expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information)** This 3.5-star hotel offers a vibrant and inclusive atmosphere, making it an ideal choice for LGBTQIA travellers seeking a business-themed vacation. Situated 4.8km from Depew, M Hotel Buffalo is affiliated with LGBTQI travel guides, ensuring a welcoming experience. Business amenities include a 24-hour business centre, accessible meeting rooms, and a dedicated business district site location. Guests appreciate the stylish decor and modern facilities, which cater to both leisure and work needs, creating a balanced and enjoyable stay. - **Country Inn & Suites by Radisson, Buffalo South I-90, NY:** Located 9.7km from Depew, this hotel is perfect for those looking for a pet-friendly environment combined with business amenities. The Country Inn & Suites offers a warm and inviting atmosphere, featuring a business centre, meeting rooms, and conference space. With a pet policy that permits dogs and cats, guests can enjoy their stay with their furry companions. The property’s homely feel, combined with its professional services, ensures a comfortable and productive experience for all visitors. - **Motel 6 Buffalo, NY - Airport - Williamsville:** A budget-friendly option located 4.8km from Depew, Motel 6 Buffalo is an excellent choice for pet owners. This motel allows pets on-site, making it a convenient stop for travellers with furry friends. With a straightforward and no-frills approach, it offers essential amenities to ensure a pleasant stay. The pet-friendly policy includes service animals, dogs, and cats, creating a welcoming environment for all guests. Ideal for those prioritizing affordability without sacrificing comfort. ### Where to stay in Depew Depew, New York, offers a delightful blend of family-friendly activities and business amenities, making it the perfect vacation spot for all types of travellers. Explore the nearby downtown Buffalo for vibrant culture and dining, while enjoying the warm atmosphere of friendly locals. With convenient locations and budget-friendly excursions, Depew serves as an ideal base to experience the best of Western New York. - **[Buffalo:](https://www.expedia.ca/Buffalo-Hotels.d602674.Travel-Guide-Hotels)** Buffalo is a vibrant metropolis and acts as the heart of the region, with Depew nestled within its boundaries. The city experiences moderately seasonal travel, with a peak in visitors from June to August, making it a lively summer destination. Buffalo attracts families, business travellers, and city explorers alike. Key highlights include shopping centres, educational institutions, and renowned local landmarks such as the stadium and national state park. Visitors can immerse themselves in the rich culture, enjoy sports events, and take advantage of the diverse shopping options available. - **[Cheektowaga:](https://www.expedia.ca/Cheektowaga-Hotels.d7197.Travel-Guide-Hotels)** Located a mere 4.8km from Depew, Cheektowaga is a welcoming village that maintains a steady influx of visitors year-round, with peak periods occurring in March to April and July. This charming area is ideal for families, business-oriented travellers, and those seeking a city-themed experience. Cheektowaga boasts an array of shopping centres and educational facilities, along with notable landmarks like modern colleges and sports facilities. The village offers a relaxed atmosphere while still being close to urban amenities, making it a perfect spot for exploration. - **[Bowmansville:](https://www.expedia.ca/Bowmansville-Hotels.d7978.Travel-Guide-Hotels)** Situated just 4.8km from Depew, Bowmansville is a lively city that draws visitors primarily during the summer months from June to August. It’s an excellent destination for families and business travellers alike. With easy access to shopping centres, a thrilling amusement park, and a theme park for endless entertainment, Bowmansville combines the charm of a small city with the excitement of larger attractions. Local sports facilities and stadiums enhance the experience, providing ample opportunities for fun and leisure. ### Things to do near Depew Depew, New York, is an excellent destination for families and business travellers alike, offering a variety of enjoyable activities. Visitors can explore local shopping centres and malls, or have fun at the nearby amusement park. Ideal for day trips, Depew provides a mix of entertainment and leisure options that cater to diverse interests, making it a perfect spot for a memorable vacation. **Shopping** In Depew, you can enjoy shopping at [Walden Galleria Mall](https://www.expedia.ca/Walden-Galleria-Mall-Hotels.0-l6129205-0.Travel-Guide-Filter-Hotels), just 4.8km away, with its vibrant atmosphere and diverse shops. [Eastern Hills Mall](https://www.expedia.ca/Eastern-Hills-Mall-Hotels.0-l6129207-0.Travel-Guide-Filter-Hotels) is also nearby at 8.0km, offering family-friendly entertainment. If you're up for a drive, visit [Broadway Market](https://www.expedia.ca/Broadway-Market-Hotels.0-l6178575-0.Travel-Guide-Filter-Hotels), located 11.3km away, for local flavours. **Recreation** [Diamond Hawk Golf Course](https://www.expedia.ca/Diamond-Hawk-Golf-Course-Hotels.0-l6276883-0.Travel-Guide-Filter-Hotels) offers a beautiful outdoor setting for golf enthusiasts, just 3.2km from Depew, where you can enjoy fresh air and stunning views. For a fun-filled experience, visit [Holiday Twin Rinks](https://www.expedia.ca/Holiday-Twin-Rinks-Hotels.0-l6207411-0.Travel-Guide-Filter-Hotels), only 3.2km away, for ice skating and lively entertainment. [Northtown Center at Amherst](https://www.expedia.ca/Northtown-Center-At-Amherst-Hotels.0-l6205612-0.Travel-Guide-Filter-Hotels), located 12.9km from Depew, is an excellent venue for sports lovers, featuring various facilities for active recreation and events. **Adventure** Experience the thrill of karting at [Pole Position Raceway](https://www.expedia.ca/Pole-Position-Raceway-Hotels.0-l553248621561872721-0.Travel-Guide-Filter-Hotels), located 4.8km from Depew, where you can race against friends and family. For outdoor enthusiasts, explore the scenic [Amherst Canalway Trail](https://www.expedia.ca/Amherst-Canalway-Trail-Hotels.0-l553248621532664870-0.Travel-Guide-Filter-Hotels), 19.3km away, perfect for hiking and cycling. If you enjoy winter sports, head to [Buffalo Ski Club](https://www.expedia.ca/Buffalo-Ski-Club-Hotels.0-l553248635981428400-0.Travel-Guide-Filter-Hotels), 24.1km from Depew, for an exciting day on the slopes. **Nightlife** Experience the charm of the [Lancaster Opera House](https://www.expedia.ca/Lancaster-Opera-House-Hotels.0-l553248621532664862-0.Travel-Guide-Filter-Hotels), just 3.2km away, offering a romantic theatre atmosphere. For some excitement, venture to [Lasertron](https://www.expedia.ca/Lasertron-Hotels.0-l6187846-0.Travel-Guide-Filter-Hotels), 12.9km out, where adventure awaits. Don't miss the [University At Buffalo Center for the Arts](https://www.expedia.ca/University-At-Buffalo-Center-For-The-Arts-Hotels.0-l6175362-0.Travel-Guide-Filter-Hotels), also 12.9km away, for a cultural evening. *\*Distances are measured in a straight line; actual driving distances may vary depending on the route.* ### Booking tips and Expedia advantages for Depew To save money on your trip to Depew, New York, consider visiting between January and March when accommodation prices are lower. Tuesdays are the most affordable days to stay, while Saturdays are the priciest. Use Expedia to find good hotel deals by filtering for eco-certified options and arranging flights and activities in a package for added savings. Public transport can be an economical way to explore the area, and look for free local activities to enjoy without spending much. Plan ahead to make the most of your budget while visiting Depew. - **The most and least expensive months on average to stay in a hotel:** The cheapest months to stay in Depew are January to March, where the prices are slightly lower. This is in comparison to July to September, where prices are slightly higher. - **The most and least expensive days on average to stay in a hotel:** The least expensive day to stay in Depew is Tuesday. The most expensive day to stay in Depew is Saturday. - **Find cheap hotels on Expedia:** Utilize Expedia’s search tool to refine your preferences, such as your budget, desired location, and preferred hotel type. For instance, selecting the Eco-certified option will showcase sustainable and environmentally friendly accommodations currently available. To discover the best prices and deals, simply arrange the price filter from lowest to highest. - **Consider bundling your trip:** You can save money by combining your hotel stay in Depew with your flights and activities through an Expedia package deal. ### Find the best attractions near Depew Depew, New York, is a great destination for families and business travellers alike, offering a blend of modern attractions. Visitors can explore local points of interest such as colleges and universities, urban parks, and arts centres. This vibrant area caters to those seeking cultural experiences and city adventures, making it an ideal spot for a memorable vacation. - **[University At Buffalo - North Campus:](https://www.expedia.ca/University-At-Buffalo-North-Campus-Hotels.0-l6175369-0.Travel-Guide-Filter-Hotels)** Experience the vibrant atmosphere of this modern university, located 12.9km from Depew. The campus features stunning architecture and beautiful green spaces, making it a perfect spot for a leisurely stroll or a picnic. - **[Shea's Performing Arts Center:](https://www.expedia.ca/Sheas-Performing-Arts-Center-Hotels.0-l6064405-0.Travel-Guide-Filter-Hotels)** Immerse yourself in the cultural scene at this historic venue, located 14.5km away. Shea's hosts a variety of performances, from Broadway shows to concerts, showcasing the rich artistic heritage of the region. - **[Roswell Park Cancer Institute:](https://www.expedia.ca/Roswell-Park-Cancer-Institute-Hotels.0-l6175413-0.Travel-Guide-Filter-Hotels)** Explore the unique blend of recreation and history at this renowned research facility, situated 12.9km from Depew. The institute offers informative tours that highlight its groundbreaking contributions to cancer research and care. ### Best time to go to Depew The best time to visit Depew can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Depew falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature in Depew falls in January, visitor numbers are average and weather is very cloudy with light rain. | **![calendar](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/calendar.png)Calendar Month** | **![temperature](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__hot.png)Temperature** | **![rain](https://forever.travel-assets.com/flex/flexmanager/images/2024/03/04/weather__rain.png)Precipitation** | **![mostly](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/21/weather__day_mostly_cloudy.png)Cloudiness** | **![occupation](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/peoplebex.png)Occupancy** | **![price](https://forever.travel-assets.com/flex/flexmanager/images/2024/10/29/currency_dollar.png)Pricing** | | --- | --- | --- | --- | --- | --- | | January | 25.0°F (-3.9°C) | Light Rain | Very Cloudy | Average | Slightly Low | | February | 25.9°F (-3.4°C) | Light Rain | Mostly Cloudy | Average | Slightly Low | | March | 34.2°F (1.2°C) | Light Rain | Mostly Cloudy | Average | Slightly Low | | April | 45.0°F (7.2°C) | Light Rain | Mostly Cloudy | Slightly High | Average | | May | 57.6°F (14.2°C) | Light Rain | Mostly Sunny | Average | Average | | June | 65.5°F (18.6°C) | Light Rain | Mostly Sunny | Average | Average | | July | 71.1°F (21.7°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | August | 69.8°F (21.0°C) | Light Rain | Mostly Sunny | Average | Slightly High | | September | 63.5°F (17.5°C) | Light Rain | Mostly Sunny | Slightly High | Slightly High | | October | 52.3°F (11.3°C) | Light Rain | Mostly Cloudy | Slightly Low | Average | | November | 40.5°F (4.7°C) | Light Rain | Mostly Cloudy | Slightly Low | Average | | December | 32.4°F (0.2°C) | Light Rain | Mostly Cloudy | Slightly Low | Average | ### The nearest major airports for your trip to Depew When visiting Depew, New York, the closest major airport is Buffalo Niagara International Airport ([BUF](https://www.expedia.ca/Buffalo-Niagara-Intl-Airport-Hotels.0-aBUF-0.Travel-Guide-Filter-Hotels)), located 4.8km away. Excellent hotel options nearby include the 4-star Delavan Hotel & Spa and Mosey Buffalo Williamsville, both just 3.2km from the airport, offering convenient access. For those considering other airports, Greater Rochester International Airport ([ROC](https://www.expedia.ca/Greater-Rochester-Intl-Airport-Hotels.0-aROC-0.Travel-Guide-Filter-Hotels)) is 88.5km away, with quality accommodations like the [DoubleTree by Hilton Rochester](https://www.expedia.ca/Rochester-Hotels-DoubleTree-By-Hilton-Rochester.h18137.Hotel-Information), situated 6.4km from the airport. Niagara Falls International Airport ([IAG](https://www.expedia.ca/Niagara-Falls-Intl-Airport-Hotels.0-aIAG-0.Travel-Guide-Filter-Hotels)) is 29.0km from Depew, featuring hotels such as the [Seneca Niagara Resort & Casino](https://www.expedia.ca/Niagara-Falls-Hotels-Seneca-Niagara-Resort-Casino.h2238838.Hotel-Information), located 9.7km away, ensuring a comfortable stay during your travels. ## Recent reviews of Depew hotels ![Hyatt Regency Buffalo / Hotel and Conference Center](https://images.trvl-media.com/lodging/1000000/30000/23200/23101/00561234_y.jpg) ### Hyatt Regency Buffalo / Hotel and Conference Center 5/5 Excellent "I didn’t see the free breakfast offer when we were there. Not sure why it’s mentioned in the review question " A verified traveller stayed at Hyatt Regency Buffalo / Hotel and Conference Center Posted 2 days ago [](https://expedia.ca/Buffalo-Hotels-Hyatt-Regency-Buffalo-Hotel-And-Conference-Center.h23101.Hotel-Information) ![The Richardson Hotel](https://images.trvl-media.com/lodging/19000000/18140000/18136300/18136290/16863301_y.jpg) ### The Richardson Hotel 5/5 Excellent "Everything was wonderful, the staff were great!" A verified traveller stayed at The Richardson Hotel Posted 4 days ago [](https://expedia.ca/Buffalo-Hotels-Hotel-Henry-Urban-Resort.h18136290.Hotel-Information) ![Buffalo Airport Hotel](https://images.trvl-media.com/lodging/1000000/30000/26100/26001/90223c0d_y.jpg) ### Buffalo Airport Hotel 5/5 Excellent "Great location for the price. Helpful staff. Very accommodating ." A verified traveller stayed at Buffalo Airport Hotel Posted 5 days ago [](https://expedia.ca/Buffalo-Hotels-Buffalo-Airport-Hotel.h26001.Hotel-Information) ![M Hotel Buffalo](https://images.trvl-media.com/lodging/1000000/20000/11300/11231/2c4d5593_y.jpg) ### M Hotel Buffalo 5/5 Excellent "This hotel was amazing in every aspect! My husband and I frequent Buffalo often, and have had some other hotels that have been less than acceptable. We will continue to stay at this hotel everytime! The staff was amazing, the jacuzzi was perfect and everything was perfect!" A verified traveller stayed at M Hotel Buffalo Posted 5 days ago [](https://expedia.ca/Buffalo-Hotels-Millennium-Buffalo.h11231.Hotel-Information) ![Hilton Garden Inn Buffalo Airport](https://images.trvl-media.com/lodging/2000000/1350000/1348600/1348597/47d81773_y.jpg) ### Hilton Garden Inn Buffalo Airport 5/5 Excellent "friendly staff, friendly manager, top-notch" A verified traveller stayed at Hilton Garden Inn Buffalo Airport Posted 6 days ago [](https://expedia.ca/Buffalo-Hotels-Hilton-Garden-Inn-Buffalo-Airport.h1348597.Hotel-Information) ![Hampton Inn Buffalo - Amherst, NY](https://images.trvl-media.com/lodging/51000000/50710000/50706500/50706489/63fc013f_y.jpg) ### Hampton Inn Buffalo - Amherst, NY 5/5 Excellent "I stayed here for 1 night. Very clean and quiet. Comfortable room. Friendly staff." A verified traveller stayed at Hampton Inn Buffalo - Amherst, NY Posted 6 days ago [](https://expedia.ca/Buffalo-Hotels-Hampton-Inn-Buffalo-Amherst.h50706489.Hotel-Information) ![Garden Place Hotel](https://images.trvl-media.com/lodging/2000000/1070000/1060800/1060721/40afc3e4_y.jpg) ### Garden Place Hotel 5/5 Excellent "The staff was professional and very courteous The room was cery clean. I had an amazing stay" A verified traveller stayed at Garden Place Hotel Posted 6 days ago [](https://expedia.ca/Buffalo-Hotels-Garden-Place-Hotel.h1060721.Hotel-Information) ![Motel 6 Amherst, NY - Buffalo](https://images.trvl-media.com/lodging/1000000/50000/42200/42198/df50dbea_y.jpg) ### Motel 6 Amherst, NY - Buffalo 5/5 Excellent "Yes everything was easy " A verified traveller stayed at Motel 6 Amherst, NY - Buffalo Posted 7 days ago [](https://expedia.ca/Buffalo-Hotels-Motel-6-Amherst.h42198.Hotel-Information) ![Holiday Inn Express Grand Island - Niagara Falls by IHG](https://images.trvl-media.com/lodging/19000000/18570000/18567300/18567279/50c6a12d_y.jpg) ### Holiday Inn Express Grand Island - Niagara Falls by IHG 5/5 Excellent "Wow! This place was amazing. Great customer service, attentive. Facility was clean and upscale. Breakfast was wonderful. Big room with comfortable bed, beautiful bathroom. Luxurious especially for off season. " A verified traveller stayed at Holiday Inn Express Grand Island - Niagara Falls by IHG Posted 7 days ago [](https://expedia.ca/Niagara-Falls-Hotels-Holiday-Inn-Express-Grand-Island-Niagara-Falls.h18567279.Hotel-Information) ## Frequently asked questions ### When is the best time to go to Depew? > The most popular time to visit Depew is April, when the weather begins to warm up and the arrival of spring brings beautiful blooms to the area. During this month, temperatures typically range from 10 to 17°C, creating a pleasant backdrop for outdoor activities and exploration. > > > > As the peak season runs from February to April, you'll find that Depew becomes a vibrant hub of activity, particularly in the lead-up to spring. This is a fantastic time to engage in sightseeing, with local parks and gardens coming to life. Families and couples alike can enjoy leisurely walks while soaking in the fresh air and natural beauty. > > > > April is especially appealing for those who appreciate outdoor dining and community events. Many local eateries begin to open their terraces, allowing you to savour delicious local cuisine while basking in the mild weather. Additionally, this month often features various festivals that celebrate the arrival of spring, providing an excellent opportunity to connect with the local culture. > > > > If you're looking for a more budget-friendly option, visiting in December can also be rewarding. It's cooler, the festive atmosphere and holiday lights create a unique charm, superb for those who enjoy seasonal celebrations. ### Can I cancel my hotel reservation on Expedia? > Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Depew hotel for you. ### How can I save on a Depew hotel booking with Expedia? > With Expedia, you'll unlock our lowest prices by becoming a member. It's free and easy to join, and you can even access member perks too. Just remember to sign in to get our best prices on Depew hotels. Another way to save is by booking your hotel and flights together on Expedia, where bundling can lead to significant savings. ### How much is the nightly rate at a Depew hotel? > Prices for hotels in Depew often vary, but you can find a great deal from CA $95 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. 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