Depew Vacation Packages

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

Top Depew Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Price was CA $872, price is now CA $689 per person
CA $689
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Buffalo (BUF)
8/10 Very Good! (3,005 reviews)
Really nice hotel for the price. Comfortable beds. Close to the airport. Close to restaurants.

Reviewed on May 21, 2026

Niagara Crossing Hotel & Spa

Niagara Crossing Hotel & Spa

3.5 out of 5
Price was CA $1,032, price is now CA $821 per person
CA $821
per person
Jul 1 - Jul 4
found 1 day ago
Roundtrip non-stop flight included
Vancouver (YVR) to Buffalo (BUF)
9/10 Wonderful! (1,667 reviews)
Beautiful and quaint little town. The hotel was amazing. Friendly staff and close to great restaurants

Reviewed on May 22, 2026

Lenox Hotel and Suites

Lenox Hotel and Suites

2.5 out of 5
Downtown Buffalo
Price was CA $949, price is now CA $770 per person
CA $770
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Buffalo (BUF)
9.4/10 Exceptional! (9 reviews)
Nice clean room, friendly staff and free parking. Bed and room were comfortable and nice. I would definitely stay again

Reviewed on May 22, 2026

M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
Price was CA $835, price is now CA $696 per person
CA $696
per person
Jul 31 - Aug 3
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Buffalo (BUF)
7.4/10 Good! (2,745 reviews)
Overall a nice hotel with beautiful pool. My only complaint is the bath tubs are peeling…with new tubs would be perfect.

Reviewed on May 21, 2026

Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
Price was CA $1,077, price is now CA $902 per person
CA $902
per person
Jul 1 - Jul 4
found 1 day ago
Roundtrip non-stop flight included
Vancouver (YVR) to Buffalo (BUF)
9/10 Wonderful! (1,805 reviews)
I liked the bed sheets soft and silk like. I loved the fresh brewed coffee machine.The rooftop restaurant could use some managerial monitoring. Food was served with sandwich hot and sweet potato fries cold. My pizza served 10 minutes after and we had to find waitress to ask where it was. Parking free that’s a plus!

Reviewed on May 20, 2026

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Depew Hotel Deals

M Hotel Buffalo

M Hotel Buffalo

3.5 out of 5
2040 Walden Ave Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $118 per night from Jun 9 to Jun 10
CA $118
CA $135 total
Jun 9 - Jun 10
includes taxes & fees
7.4/10 Good! (2,755 reviews)
"Overall a nice hotel with beautiful pool. My only complaint is the bath tubs are peeling…with new tubs would be perfect."

Reviewed on May 21, 2026

M Hotel Buffalo
Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $104 per night from May 24 to May 25
CA $104
CA $119 total
May 24 - May 25
includes taxes & fees
8/10 Very Good! (3,031 reviews)
"All good"

Reviewed on May 21, 2026

Buffalo Airport Hotel
Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
2761 Long Road Grand Island NY
Fully refundable
The price is CA $223 per night from May 26 to May 27
CA $223
CA $254 total
May 26 - May 27
includes taxes & fees
9/10 Wonderful! (1,829 reviews)
"Good not the best"

Reviewed on May 22, 2026

Holiday Inn Express Grand Island - Niagara Falls by IHG
See all 890 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Discover the most popular places to visit in Depew

University At Buffalo - North Campus

University At Buffalo - North Campus

Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's great live music and entertainment choices.

University At Buffalo - North Campus
Highmark Stadium

Highmark Stadium

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's great live music and entertainment choices.

Highmark Stadium
Downtown Buffalo NY

KeyBank Center

Catch an event at KeyBank Center during your trip to Buffalo. Experience the area's great live music and acclaimed theater scene.

KeyBank Center

What to do in Depew

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

CA $18
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Niagara Falls Day Tour from Toronto

Niagara Falls Day Tour from Toronto

CA $99
per adult
96% of travellers recommend
Niagara Falls Day Tour from Toronto
Niagara Falls, USA Side: Maid of the Mist Boat Ride, Walking Tour

Niagara Falls, USA Side: Maid of the Mist Boat Ride, Walking Tour

CA $81
per adult
Niagara Falls, USA Side: Maid of the Mist Boat Ride, Walking Tour
See all activities in Depew

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.