Title: 5 Stars Hotels in Depew, Buffalo from CA $168 - Find Cheap Depew Hotels With 5 Stars | Expedia.ca [Depew Travel Guide](https://expedia.ca/Depew.dx6338362)[Hotels in Depew](https://expedia.ca/Depew-Hotels.d6338362.Travel-Guide-Hotels)[Vacation Rentals in Depew](https://expedia.ca/Depew-Vacation-Rentals.d6338362.Travel-Guide-VacationRentals)[Flights to Depew](https://expedia.ca/Cheap-Flights-To-Depew.d6338362.Travel-Guide-Flights)[Things to do in Depew](https://expedia.ca/Things-To-Do-In-Depew.d6338362.Travel-Guide-Activities)[Depew Car Rentals](https://expedia.ca/Car-Rentals-In-Depew.d6338362.Car-Rental-Guide)[Depew Vacation Packages](https://expedia.ca/Depew.d6338362.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Depew, Buffalo from CA $168 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Depew 5 Star Hotels Tonight [Oct 26 - Oct 27](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-26&endDate=2025-10-27&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 27 - Oct 28](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-27&endDate=2025-10-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-10-31&endDate=2025-11-02&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6338362&startDate=2025-11-07&endDate=2025-11-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Depew 5 Star Hotels ![2 bars/lounges](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/1b8dbb7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/727bae68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/bde93c89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hot springs](https://images.trvl-media.com/lodging/18000000/17040000/17038300/17038248/65405b68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Curtiss Hotel, an Ascend Collection Hotel Downtown Buffalo 9.2/10 Wonderful (1002) "Nice hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $276 CA $322 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Buffalo-Hotels-Curtiss-Hotel.h17038248.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Depew-Hotels.s50-0-d6338362.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Depew-Hotels.s50-0-d6338362.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Depew. ![The Mansion On Delaware Ave](https://images.trvl-media.com/lodging/1000000/700000/692700/692610/1225a495_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Mansion On Delaware Ave 414 Delaware Ave, Buffalo, NY CA $218 CA $251 total Nov 26 - Nov 27 includes taxes & fees 9.2/10 Wonderful! (1,015 reviews) [](https://expedia.ca/Buffalo-Hotels-The-Mansion-On-Delaware-Ave.h692610.Hotel-Information) ![The Delavan Hotel & Spa](https://images.trvl-media.com/lodging/16000000/15040000/15031200/15031117/c468db44_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### The Delavan Hotel & Spa 6461 Transit Road, Bowmansville, NY CA $175 CA $199 total Nov 10 - Nov 11 includes taxes & fees 8.8/10 Excellent! (1,003 reviews) [](https://expedia.ca/Buffalo-Hotels-The-Delavan-Hotel-Spa.h15031117.Hotel-Information) ![DoubleTree by Hilton Hotel Buffalo - Amherst](https://images.trvl-media.com/lodging/1000000/10000/3000/2914/e3e45ea5_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton Hotel Buffalo - Amherst 10 Flint Rd, Buffalo, NY CA $148 CA $168 total Nov 10 - Nov 11 includes taxes & fees 7.8/10 Good! (1,002 reviews) [](https://expedia.ca/Buffalo-Hotels-DoubleTree-By-Hilton-Hotel-Buffalo-Amherst.h2914.Hotel-Information) Still don't see what you're looking for? [See all properties in Depew.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=27%2F10%2F2025&endDate=28%2F10%2F2025®ionId=6338362&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=27%2F10%2F2025&endDate=28%2F10%2F2025®ionId=6338362&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=27%2F10%2F2025&endDate=28%2F10%2F2025®ionId=6338362&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=27%2F10%2F2025&endDate=28%2F10%2F2025®ionId=6338362&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=27%2F10%2F2025&endDate=28%2F10%2F2025®ionId=6338362&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=27%2F10%2F2025&endDate=28%2F10%2F2025®ionId=6338362&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Depew Hotel Reviews ## Find out more about Depew ## Five Star Hotels in Depew There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Depew so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Depew and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Depew Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Depew The results are in, and Depew 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Depew! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Depew today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### What are the best 5-star hotels in Depew? > If you're looking for a 5-star experience, [Curtiss Hotel, Ascend Hotel Collection](https://www.expedia.ca/Buffalo-Hotels-Curtiss-Hotel.h17038248.Hotel-Information) offers one of the best of them based on Expedia customer reviews. Stay at this Depew escape and you'll get first-rate service, upscale furnishings and superior facilities. ### How much does it cost to stay in a 5-star hotel in Depew? > You'll find a range of pricing options for a 5-star hotel in Depew on Expedia. The amount you pay will depend on your vacation dates, length of your trip and other factors. Compare all of the available properties for your chosen dates and make use of our pricing and other filters to discover the perfect luxury stay. > > > > - Search for the lowest price per night from CA $168 ### What makes a hotel 5 stars in Depew? > In Depew, a hotel is required to offer a specific level of high-end amenities to be designated 5 stars. These may include on-site gyms, spas and saunas, gourmet restaurants, luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their extraordinary standard of service. You can expect things like in-room massages, concierge services and nightly turn-down services. 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