Cape Girardeau County Vacation Rentals

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Top cities in Cape Girardeau County

A nighttime view of a bridge with its cables illuminated against a starry sky.
Vacation Rentals

Cape Girardeau

Cape Girardeau

Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Cape Girardeau County vacation rentals

A living room with a TV, a fireplace, a sofa, and wall art.

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $114
CA $141 total
includes taxes & fees
Nov 10 - Nov 11
Little Blue Cottage on Spanish
A modern living room with a black sofa, wooden coffee table, and a kitchen in the background.

2. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $177
CA $257 total
includes taxes & fees
Nov 15 - Nov 16
The Cottage, Rusted Route Farms
A kitchen with grey cabinets, a stainless steel dishwasher, a microwave, and an oven.

3. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is CA $151
CA $260 total
includes taxes & fees
Dec 1 - Dec 2
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
A row of colorful houses with a clear sky and trees in the background.

4. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"Very cute, especially because it's pet friendly! Currently building additional structures on site but appears almost complete and still a beautiful setting and property."
United States
Elizabeth K.
The price is CA $236
CA $327 total
includes taxes & fees
Nov 13 - Nov 14
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
A modern living room with a wooden ceiling, a stone fireplace, a TV mounted on the wall, and a bar area with stools.

5. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (41 reviews)
"The hosts were excellent."
United States
Jason L.
The price is CA $317
CA $484 total
includes taxes & fees
Nov 11 - Nov 12
The Twisted Sassafras Treehouse
Exterior

6. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
The price is CA $195
CA $278 total
includes taxes & fees
Nov 10 - Nov 11
Purple Tiny House with Fire pit & Nature
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

7. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is CA $219
CA $307 total
includes taxes & fees
Nov 10 - Nov 11
The Little Château | Woodland Escape
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

8. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is CA $219
CA $307 total
includes taxes & fees
Nov 10 - Nov 11
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
A compact kitchen with wooden cabinets and a dining area with a table and chairs.

9. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
9.8 out of 10, Exceptional, (16 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
The price is CA $212
CA $241 total
includes taxes & fees
Nov 10 - Nov 11
Villa B offers peace and quiet with beautiful views of the countryside.
A log cabin interior with a stone fireplace, leather sofa, and a mounted deer head.

10. Gorgeous 1856 Log Cabin, Completely Renovated

Gorgeous 1856 Log Cabin, Completely Renovated
Jackson
10.0 out of 10, Exceptional, (6 reviews)
"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."
United States
Chandler G.
The price is CA $283
CA $422 total
includes taxes & fees
Nov 10 - Nov 11
Gorgeous 1856 Log Cabin, Completely Renovated
Our sign and entryway.

11. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is CA $227
CA $315 total
includes taxes & fees
Nov 10 - Nov 11
The Little Cape Lofted Cottage | Creek & Nature
A room with a dark wooden floor, a green artificial turf area, and a window with blinds.

12. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $253
CA $427 total
includes taxes & fees
Nov 10 - Nov 11
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
A modern kitchen with a large island, white cabinetry, and a brick accent wall.

13. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is CA $283
CA $422 total
includes taxes & fees
Nov 10 - Nov 11
Beautifully Renovated Farmhouse in Jackson, MO
A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

14. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (39 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is CA $212
CA $241 total
includes taxes & fees
Nov 10 - Nov 11
Relax in the country at Countryside Villas! - Villa A
A house with a backyard swimming pool, outdoor furniture, and a barbecue area.

15. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $507
CA $782 total
includes taxes & fees
Nov 10 - Nov 11
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

16. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.4 out of 10, Exceptional, (12 reviews)
"What an amazing little suite wrapped in a very thought-filled overall venue. Very unique room with a so many details. The overall building with fire pit, game rooms, and local vendor items…all was quite amazing. Every element is thought out very well. It is very convenient and overall comfortable. It was a great getaway."
United States
Brian
The price is CA $125
CA $143 total
includes taxes & fees
Nov 10 - Nov 11
The Atrium - A Boutique Hotel
A large outdoor area with a pond, several wooden cabins, and a road.

17. Pet Friendly! Couples Retreat in Southern Illinois

Pet Friendly! Couples Retreat in Southern Illinois
3.0 star property
Murphysboro
The price is CA $170
CA $332 total
includes taxes & fees
Nov 15 - Nov 16
Pet Friendly! Couples Retreat in Southern Illinois
A cozy room with a wooden table and chairs, a large window, and a door with a sign.

18. Cozy cabins on beautiful Horseshoe Lake

Cozy cabins on beautiful Horseshoe Lake
Olive Branch
9.8 out of 10, Exceptional, (44 reviews)
"Super communication! . Accommodating. Nice people"
United States
JASEN
The price is CA $159
CA $186 total
includes taxes & fees
Nov 10 - Nov 11
Cozy cabins on beautiful Horseshoe Lake
A small, single-story building with a wooden exterior and large windows.

19. The Rested Duck Mallard Room

The Rested Duck Mallard Room
Olive Branch
9.4 out of 10, Exceptional, (32 reviews)
"This is an excellent place to stay. With a nice lake right across the street. If i. In the are i will stay again for sure"
United States
mike b.
The price is CA $159
CA $186 total
includes taxes & fees
Nov 10 - Nov 11
The Rested Duck Mallard Room
A rural landscape with a red barn, a small white shed, and a dirt road leading to the barn.

20. The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!
Frohna
10.0 out of 10, Exceptional, (34 reviews)
"Wonderful time! "
United States
Alison C.
The price is CA $184
CA $273 total
includes taxes & fees
Dec 1 - Dec 2
The Weber Farm - Enjoy a beautiful 100 acre farm!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Find vacation rentals that suit your style

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Top Cape Girardeau County Hotel Reviews

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau

10/10 Excellent

Friendly staff, clean room. Great food. Highly recommend this hotel.
Canada
Sareh
Reviewed August 9, 2026
Drury Plaza Hotel Cape Girardeau Conference Center

Find out more about Cape Girardeau County

Everything you need to know about Cape Girardeau County vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau County vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Cape Girardeau County vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau County. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cape Girardeau County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Cape Girardeau County vacation rentals we have selected for you start as low as CA $114 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Cape Girardeau County rentals

At Expedia, we put the best Cape Girardeau County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Cape Girardeau County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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