Title: Cape Girardeau County Vacation Rentals from CA $138: Short-Term Rentals for 2026 | Expedia.ca

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![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Alice Burghart

![](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Top Cities in Cape Girardeau County

![Mississippi River at Cape Girardeau Missouri. Fall 2020.](https://images.trvl-media.com/place/820/188c8ac6-bb89-4be5-8175-3a09d6a30041.jpg?impolicy=fcrop&w=384&h=216&q=medium)

#### Cape Girardeau

[](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)

## Our top choices for Cape Girardeau County vacation rentals

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/1c1368ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor spa tub](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/b8327ae6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/f4fbd89f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/96000000/95880000/95879200/95879160/c5155680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Twisted Sassafras Treehouse 

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(30 reviews)

"This is the perfect private romantic getaway! We had such a blast here. Definitely recommend!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric S.

CA $293

CA $430 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Twisted-Sassafras-Treehouse.h95879160.Hotel-Information)

![Dining](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/f432dafb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, DVD player, books](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/6d0c8b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/0e13dd89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/39000000/38950000/38940200/38940154/a340bc3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Serenity South -- Gardens, River-Views, and Refreshing Space

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

Cape Girardeau

10/10

Exceptional

(150 reviews)

"Such a great place and location"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tracy H.

CA $205

CA $333 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Sikeston-Hotels-Serenity-Gardens.h38940154.Hotel-Information)

![Pool](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/w1440h810x0y3-bf19009e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/62582c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, video games, foosball](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/a7fa16a5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111980000/111971500/111971489/d2b33581.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

[](https://www.expedia.ca/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(8 reviews)

"Nice place, great times"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jace W.

CA $367

CA $594 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/Cape-Girardeau-Hotels-4-Bedroom-Home-2-King-Beds.h111971489.Hotel-Information)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/2c8cc497.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/bb974ed1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior detail](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/673b3050.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868642/3619a392.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Gorgeous 1856 Log Cabin, Completely Renovated

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

Jackson

10/10

Exceptional

(3 reviews)

"incredible place. I was there for work, but it was a really nice relaxing area to retreat too, and also get some work done in a serene environment. It would be an incredible place for an entire family. And, a good place for friends to get together."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chandler G.

CA $273

CA $427 total

includes taxes & fees

Feb 11 - Feb 12

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Gorgeous-1856-Log-Cabin.h112868642.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/469a5901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/d33a9d5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/a97a55c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace](https://images.trvl-media.com/lodging/72000000/71750000/71745700/71745619/6a739ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

Cape Girardeau

8.8/10

Excellent

(38 reviews)

"Very nice house. The pool and hot tub were perfect for a short getaway. Tons of activities and games to keep the fanily entertained. Will definitely come back! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Emily D.

CA $184

CA $297 total

includes taxes & fees

Feb 15 - Feb 16

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Colorful-Oasis-5mins-To-DownTown-Lush-Yard-W-Summer-PoolVENUE-Now-Open.h71745619.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/927199d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Little Blue Cottage on Spanish

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

Cape Girardeau

8.4/10

Very good

(50 reviews)

"Cozy and perfect for a couple. Great communication with the host"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Beth G.

CA $111

CA $138 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information)

![1 bedroom, desk, iron/ironing board, WiFi](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/add99418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/1862bab6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/94d9c4c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace](https://images.trvl-media.com/lodging/113000000/112870000/112868700/112868647/b0435fb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Cottage, Rusted Route Farms

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

Jackson

10/10

Exceptional

(2 reviews)

"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Renee C.

CA $171

CA $270 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Cottage.h112868647.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0622af9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/60c56f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming Secluded Getaway Cabin within minutes of amenities 

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

Cape girardeau

10/10

Exceptional

(18 reviews)

"We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammy M.

CA $211

CA $396 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/4b65f0bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Microwave, oven, stovetop](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/1ad7ce87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/099c1c0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels, soap, toilet paper](https://images.trvl-media.com/lodging/126000000/125640000/125633400/125633310/4caaeda1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pleasant 2-bedroom mobile home with AC /heat in Friedheim 2 Queen beds 1 Bath.

[](https://www.expedia.ca/Friedheim-Hotels-Pleasant-2-Bedroom-Mobile-Home-With-AC-Heat-In-Friedheim-2-Queen-Beds-1-Bath.h125633310.Hotel-Information)

Friedheim

CA $171

CA $277 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/Friedheim-Hotels-Pleasant-2-Bedroom-Mobile-Home-With-AC-Heat-In-Friedheim-2-Queen-Beds-1-Bath.h125633310.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w691h683x160y0-35462827.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Shower, hair dryer, towels, soap](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-bccaa29a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w693h683x174y0-32d2f409.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/81000000/80800000/80794200/80794106/w675h683x175y0-e472cb80.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Relax in the country at Countryside Villas! - Villa A

[](https://www.expedia.ca/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

Jackson

10/10

Exceptional

(33 reviews)

"Great place to stay, felt like home away from home. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Brittany

CA $205

CA $249 total

includes taxes & fees

Feb 17 - Feb 18

[](https://www.expedia.ca/Jackson-Hotels-Relax-In-The-Country-At-Countryside-Villas.h80794106.Hotel-Information)

![Living area](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/599e7a95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Private kitchen](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/02b08ccf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/a7405e78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Living area](https://images.trvl-media.com/lodging/113000000/112630000/112624300/112624271/403251a8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Cozy upstairs unit in Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Cozy-Upstairs-Unit-In-Cape-Girardeau.h112624271.Hotel-Information)

Cape Girardeau

CA $147

CA $175 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Cozy-Upstairs-Unit-In-Cape-Girardeau.h112624271.Hotel-Information)

![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/84406cc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/0b4f194a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![55-inch Smart TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/586044dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Point of interest](https://images.trvl-media.com/lodging/77000000/76390000/76388000/76388000/2ec33dcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Lofts

[](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

Perryville

9.2/10

Wonderful

(17 reviews)

"Great place to stay! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

[](https://www.expedia.ca/Perryville-Hotels-Urban-Lofts.h76388000.Hotel-Information)

![Interior](https://images.trvl-media.com/lodging/91000000/90680000/90678400/90678327/9875051b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/91000000/90680000/90678400/90678327/7a3a8bf8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/91000000/90680000/90678400/90678327/6d03f6b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/91000000/90680000/90678400/90678327/df31bdf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Urban Loft #1 RED · Urban Loft Downtown above BrewCo & Restaurant

[](https://www.expedia.ca/Perryville-Hotels-Urban-Loft-1-RED-Urban-Loft-Downtown-Above-BrewCo-Restaurant.h90678327.Hotel-Information)

Perryville

10/10

Exceptional

(1 review)

"Everything was perfect!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thor L.

CA $266

CA $435 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Perryville-Hotels-Urban-Loft-1-RED-Urban-Loft-Downtown-Above-BrewCo-Restaurant.h90678327.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/f8286145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/8a8ad86a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/249ed696.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/89000000/88930000/88928400/88928399/63184534.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Winetrail Cabin - SIU, Giant City SP, Shawnee Forest, & Cedar Lake minutes away!

[](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

Makanda

9.6/10

Exceptional

(41 reviews)

"Everything was very nice. We enjoyed our stay! The cabin had everything we needed."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Cheri U.

CA $149

CA $288 total

includes taxes & fees

Feb 9 - Feb 10

[](https://www.expedia.ca/Makanda-Hotels-Winetrail-Cabin-SIU.h88928399.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/103000000/102150000/102145500/102145423/c876875b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV, fireplace, DVD player](https://images.trvl-media.com/lodging/103000000/102150000/102145500/102145423/4151b7f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/103000000/102150000/102145500/102145423/2e055f98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/103000000/102150000/102145500/102145423/5bb5b204.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hot Tub Cabin- In the Heart of Shawnee Wine Trail

[](https://www.expedia.ca/Carbondale-Hotels-Hot-Tub-Cabin-In-The-Heart-Of-Shawnee-Wine-Trail.h102145423.Hotel-Information)

Carbondale

9.6/10

Exceptional

(4 reviews)

"Very nice cabin in a great location. So peaceful. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pam F.

CA $286

CA $413 total

includes taxes & fees

Feb 22 - Feb 23

[](https://www.expedia.ca/Carbondale-Hotels-Hot-Tub-Cabin-In-The-Heart-Of-Shawnee-Wine-Trail.h102145423.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/a1f76995.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/39bdfc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/24e6e51c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor dining](https://images.trvl-media.com/lodging/117000000/116290000/116288600/116288506/14363a53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Magical Victorian near hiking / wine trail

[](https://www.expedia.ca/Anna-Hotels-Magical-Victorian-Near-Hiking-Wine-Trail.h116288506.Hotel-Information)

Anna

10/10

Exceptional

(5 reviews)

"The house was beautiful! We were in awe of the decor and layout. This is a must-stay if you are in southern Illinois!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lori C.

CA $321

CA $574 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Anna-Hotels-Magical-Victorian-Near-Hiking-Wine-Trail.h116288506.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/05ba3853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/d3b8d0f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Dining](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/05da8d7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/28000000/27150000/27145300/27145221/95950b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Contemporary Glamping with Native American Appeal

[](https://www.expedia.ca/Anna-Hotels-Contemporary-Glamping-With-Native-American-Appeal.h27145221.Hotel-Information)

Anna

9.8/10

Exceptional

(157 reviews)

"Every Th I was perfect close to the shopping we wanted to and such quiet area "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Christina S.

CA $244

CA $452 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Anna-Hotels-Contemporary-Glamping-With-Native-American-Appeal.h27145221.Hotel-Information)

![Property grounds](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Smart TV, DVD player](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/3f7db1ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/30627e31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming cottage overlooking Lake Acre

[](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

Dongola

10/10

Exceptional

(102 reviews)

"Great place so peaceful and relaxing "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul D.

CA $184

CA $387 total

includes taxes & fees

Feb 6 - Feb 7

[](https://www.expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Smart TV, fireplace, table tennis](https://images.trvl-media.com/lodging/101000000/100660000/100650100/100650066/ac80d43e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/101000000/100660000/100650100/100650066/58ded3c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/101000000/100660000/100650100/100650066/e455bd73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100660000/100650100/100650066/bea39731.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### 3BR Home w/ Hot Tub & Sunset Views Near SIUC

[](https://www.expedia.ca/Carbondale-Hotels-Hot-Tub-Overlooking-Sunset-Ridge-Sleeps-6.h100650066.Hotel-Information)

Carbondale

9.4/10

Exceptional

(26 reviews)

"Thx great place!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lauren B.

CA $428

CA $533 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Carbondale-Hotels-Hot-Tub-Overlooking-Sunset-Ridge-Sleeps-6.h100650066.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/d22aee4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/2c1a0ed0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, WiFi, bed sheets](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/12dcf221.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/32000000/31190000/31190000/31189922/b0f0a7b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Rest, Relax and Renew. Our log cabin experience awaits your arrival. 

[](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information)

Anna

10/10

Exceptional

(405 reviews)

"Nice cabin and beautiful scenery! We enjoyed our stay."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Hannah G.

CA $160

CA $273 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Anna-Hotels-Rest.h31189922.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-19&endDate=2026-02-20&regionId=553248635976430467&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Aparthotels

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-05-05&d1=2026-05-05&endDate=2026-05-08&d2=2026-05-08&lodging=APART_HOTEL)

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-05-05&d1=2026-05-05&endDate=2026-05-08&d2=2026-05-08&lodging=CABIN)

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-05-05&d1=2026-05-05&endDate=2026-05-08&d2=2026-05-08&lodging=APARTMENT)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-05-05&d1=2026-05-05&endDate=2026-05-08&d2=2026-05-08&lodging=VACATION_HOME)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2026-05-05&d1=2026-05-05&endDate=2026-05-08&d2=2026-05-08&lodging=COTTAGE)

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## Top Cape Girardeau County Hotel Reviews

![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg)

### Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"We were in Cape Girardeau for our daughters, gymnastics meet at SEMO. On arrival we were greeted by the friendly staff. Check-in was easy. The room was very clean and warm being 15° outside as we are from Arizona and welcomed the warm building. Great showers very clean rooms. Everything was new. The breakfast was buffet style and everything was fresh, scrambled eggs, sausage, biscuits and gravy, pancakes. Can choose from oatmeal make your own waffles, yogurt all different kinds of toast, fresh fruit as well and other things. They also have their happy hour which we didn’t partake in only because we were busy for the three night stay. I wish I could have used my two drink coupon and mingle with the people because it was busy. Next time we’re going back we’re definitely staying here. Thank you for a great stay."

[](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg)

### Drury Inn & Suites Jackson MO

10/10 Excellent

"Room was very clean. Staff was very knowledgeable and courteous. Excellent staff in every department. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information)

![Hampton Inn Cape Girardeau I 55 East](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d_y.jpg)

### Hampton Inn Cape Girardeau I 55 East

10/10 Excellent

"Nice staff. Clean room. Good cookies. And breakfast adequate. "

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg)

### Drury Inn & Suites Cape Girardeau

10/10 Excellent

"The room was lage and clean. We really enjoyed the free food and drinks provided."

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Quality Inn](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg)

### Quality Inn

10/10 Excellent

"The lady at the front desk was an amazing person and treated me with the upmost respect "

[](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information)

![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg)

### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent

"Yes everything was great"

[](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information)

![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg)

### Pear Tree Inn Cape Girardeau West

10/10 Excellent

"Comfortable beds and pillows Good breakfast "

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![Town House Inn](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5eb3395a_y.jpg)

### Town House Inn

10/10 Excellent

"Yes"

[](https://expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information)

![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg)

### Tru By Hilton Cape Girardeau

10/10 Excellent

"Very nice room!"

[](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information)

## Find out more about Cape Girardeau County

**Everything you need to know about** **Cape Girardeau County** **vacation rentals**

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Cape Girardeau County vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Cape Girardeau County vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

**Cape Girardeau County vacation rentals: An excellent choice for every season**

Whenever you want to travel, a warm welcome awaits you in Cape Girardeau County. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Cape Girardeau County vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in. The selection of Cape Girardeau County vacation rentals we have selected for you start as low as CA $138 per night. Entering your travel dates in the search wizard you might find even better deals!

**How to find incredible deals on Cape Girardeau County rentals**

At Expedia, we put the best Cape Girardeau County vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top Cape Girardeau County rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Cape Girardeau County vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Cape Girardeau County. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

## Explore a world of travel with Expedia

- Popular Cape Girardeau County Cities
- All accommodation types in Cape Girardeau County

- [Cape Girardeau Vacation Rentals ](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)

- [Vacation Homes in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Private-Vacation-Homes.d553248635976430467-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Cabins.d553248635976430467-aaCabins.Travel-Guide-Accommodation)
- [Apartments in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Apartments.d553248635976430467-aaApartments.Travel-Guide-Accommodation)
- [Cottages in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Cottages.d553248635976430467-aaCottages.Travel-Guide-Accommodation)
- [Lodges in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Lodges.d553248635976430467-aaLodges.Travel-Guide-Accommodation)
- [RV Parks in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-RV-Parks.d553248635976430467-aaRVParks.Travel-Guide-Accommodation)
- [Farmstay in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Agritourism.d553248635976430467-aaAgritourism.Travel-Guide-Accommodation)
- [B&B in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Bed-And-Breakfast.d553248635976430467-aaBedAndBreakfast.Travel-Guide-Accommodation)
- [Motels in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Motels.d553248635976430467-aaMotels.Travel-Guide-Accommodation)
- [Aparthotels in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Apart-Hotels.d553248635976430467-aaApartHotels.Travel-Guide-Accommodation)

### Expedia's Latest Trends

Hotels

- [Hotels in Wentzville](https://expedia.ca/Wentzville-Hotels.d7679.Travel-Guide-Hotels)
- [Hotels near GEHA Field at Arrowhead Stadium](https://expedia.ca/GEHA-Field-At-Arrowhead-Stadium-Hotels.0-l6058069-0.Travel-Guide-Filter-Hotels)
- [Downtown St. Louis hotels](https://expedia.ca/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels)
- [Ski Hotels in Maryland Heights](https://expedia.ca/Maryland-Heights-Hotels-Ski-Hotel.0-0-d7347-tSkiHotel.Travel-Guide-Filter-Hotels)
- [Pet-friendly Hotels in St. Louis County](https://expedia.ca/Destinations-In-St-Louis-County-Pet-Friendly-Hotel.0-0-d553248635083900521-tPetfriendlyHotel.Hotel-Filter-Destinations)
- [Hotels with a Pool in Wentzville](https://expedia.ca/Wentzville-Hotels-Hotel-With-Pool.0-0-d7679-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Hotels in Jadwin](https://expedia.ca/Jadwin-Hotels.d553248635975869184.Travel-Guide-Hotels)
- [Hotels near Thunder Ridge Nature Arena](https://expedia.ca/Thunder-Ridge-Nature-Arena-Hotels.0-l898516100141289472-0.Travel-Guide-Filter-Hotels)
- [Texas County hotel](https://expedia.ca/Destinations-In-Texas-County.d553248635976433684.Hotel-Destinations)
- [Hotels with a Pool in St. George](https://expedia.ca/St-George-Hotels-Hotel-With-Pool.0-0-d553248634983119717-tHotelwithPool.Travel-Guide-Filter-Hotels)
- [Hotels near Women's and Children's Hospital](https://expedia.ca/Womens-And-Childrens-Hospital-Hotels.0-l553248635974865886-0.Travel-Guide-Filter-Hotels)
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- [Downtown Kansas City hotels](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels)
- [Hotels near Crowder College](https://expedia.ca/Crowder-College-Hotels.0-l553248621568464514-0.Travel-Guide-Filter-Hotels)

Flights

- [Cheap Flights to Earth City](https://expedia.ca/Cheap-Flights-To-Earth-City.d181528.Travel-Guide-Flights)
- [Cheap Flights from Adair County](https://expedia.ca/lp/flights/553248635976433873/flights-from-adair-county)

Cars

- [Car rental St. Louis Airport (STL)](https://expedia.ca/Car-Rentals-In-Lambert-St-Louis-Intl.d5002323.Car-Rental-Guide)
- [Car rental Columbia Airport (COU)](https://expedia.ca/Car-Rentals-In-Columbia-Regional.d5590851.Car-Rental-Guide)
- [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide)

Activities

- [Things to do in Maryland Heights](https://expedia.ca/Things-To-Do-In-Maryland-Heights.d7347.Travel-Guide-Activities)

Packages

- [St. Louis Zoo](https://expedia.ca/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction)
- [Missouri Botanical Gardens and Arboretum](https://expedia.ca/Missouri-Botanical-Gardens-And-Arboretum-St-Louis.d507258.Vacation-Attraction)
- [Kansas City Zoo](https://expedia.ca/Kansas-City-Zoo-Kansas-City.d501349.Vacation-Attraction)
- [St. Louis Art Museum](https://expedia.ca/St-Louis-Art-Museum-St-Louis.d502859.Vacation-Attraction)
- [Starlight Theatre](https://expedia.ca/Starlight-Theatre-Kansas-City.d6069373.Vacation-Attraction)

General

- [Visit Dutchtown](https://expedia.ca/St-Louis-Dutchtown.dx896162373499555840)
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- [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828)
- [Visit Parkville](https://expedia.ca/Parkville.dx9973)
- [Visit River Market](https://expedia.ca/Kansas-City-River-Market.dx6192918)