Title: Top Hotels in Cape Girardeau County | Expedia.ca [Vacation Rentals in Cape Girardeau County](https://expedia.ca/Destinations-In-Cape-Girardeau-County.d553248635976430467.Vacation-Rental-Destinations)[Cape Girardeau County Car Rentals](https://expedia.ca/Destinations-In-Cape-Girardeau-County.d553248635976430467.Car-Rental-Destinations)[Cape Girardeau County Vacations](https://expedia.ca/Cape-Girardeau-County.d553248635976430467.Destination-Travel-Guides) ![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Alice Burghart ![](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Top Cities in Cape Girardeau County ![Aerial Photo of Cape Girardeau, Missouri, USA](https://images.trvl-media.com/place/820/34f5c59a-7e57-4244-94c6-c657830fc4ab.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Cape Girardeau [](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels) ![Aerial view of Jefferson City, Missouri. Jefferson City is the capital of the U.S. state of Missouri](https://images.trvl-media.com/place/55765/5f6b269f-10cd-40c4-92f0-0144e4b2f10b.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Jackson [](https://expedia.ca/Jackson-Hotels.d55765.Travel-Guide-Hotels) ![The Missouri State Tree - Dogwood](https://images.trvl-media.com/place/553248634983269107/3aabcda1-7e0a-4df4-9788-5f9645899bfb.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Chaffee [](https://expedia.ca/Chaffee-Hotels.d553248634983269107.Travel-Guide-Hotels) ## Check prices for these dates Tonight [Mar 22 - Mar 23](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2026-03-22&endDate=2026-03-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 23 - Mar 24](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Cape Girardeau County hotels ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/db8c9491.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (1,007 reviews) "My favorite place tpstay when in the area." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack CA $137 CA $155 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Jackpot Suite | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (531 reviews) "Room was perfect" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Derrick CA $122 CA $138 total includes taxes & fees Mar 23 - Mar 24 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/ffb58563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/84598bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Cape Girardeau [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (1,006 reviews) "The room was great and the staff was friendly as always. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LuAnne CA $126 CA $142 total includes taxes & fees Apr 12 - Apr 13 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/b5f01af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) Jackson 9.6/10 Exceptional (1,004 reviews) "The staff is so nice here" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura CA $110 CA $116 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8447c54f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/dc7dee1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/23518830.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) Jackson 9.0/10 Wonderful (726 reviews) "Very clean and staff was very nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nastassia CA $122 CA $132 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/f7d52bda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/75079b79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/bf83e8f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Cape Girardeau by IHG [](https://www.expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) Cape Girardeau 8.2/10 Very good (908 reviews) "Great place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chris CA $110 CA $131 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/dba6fd48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/fe0d924e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f71e5ca6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) Cape Girardeau 9.0/10 Wonderful (1,000 reviews) "Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Colleen CA $99 CA $111 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (167 reviews) "Nearby Mexican restaurant, clean room, pleasant staff, good breakfast choices " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Larry CA $127 CA $143 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/dc836bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/44b66206.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/4ac4ba46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cape Girardeau North [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) Cape Girardeau 7.2/10 Good (712 reviews) "Room was clean. Staff was friendly. Hotel itself is due for a renovation. You get what you pay for. 2.5 out of 5 for this place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robin CA $91 CA $103 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Bedroom (Feature)](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/40930878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/64fb9857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (1,000 reviews) "Clean room staff is very nice parking it great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arriel CA $141 CA $159 total includes taxes & fees Apr 5 - Apr 6 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/c7d69739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Cape Girardeau Downtown [](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (497 reviews) "Beautiful property! Quick easy walk to downtown. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelley CA $172 CA $194 total includes taxes & fees Apr 2 - Apr 3 [](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/2f374258.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/0aa802d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/1ca0c293.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/5aa6a52b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau [](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (116 reviews) "Hotel was very clean, quiet and has a great location! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dustin CA $123 CA $140 total includes taxes & fees Apr 7 - Apr 8 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/e6e29f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/b20a49e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/81fbb6f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Cape Girardeau I 55 East [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) Cape Girardeau 9.6/10 Exceptional (797 reviews) "Great place to stay. Clean and close to restaurants! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diane CA $145 CA $164 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/06dc4487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/eec0e02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/70460e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/0ac4753f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Jackson-Cape Girardeau [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) Jackson 8.2/10 Very good (752 reviews) "Beds felt amazing. My family and I had a great time" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary CA $126 CA $137 total includes taxes & fees Mar 29 - Mar 30 [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/c3f8959c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/2b1b1011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/464a0039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/f2b68c48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn Cape Giradreau [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) Cape Girardeau 6.0/10 (213 reviews) "Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary CA $86 CA $101 total includes taxes & fees Apr 7 - Apr 8 [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) ![Economy Single Room, 1 Queen Bed, Kitchenette | Private kitchen](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/2ba6efa1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/00115e7b_edited_b2b6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Room, 2 Queen Beds, Kitchenette](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/affd3e57.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Single Room, 1 Queen Bed, Kitchenette | Bathroom](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/324e501c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) Jackson 7.6/10 Good (440 reviews) "Everything was excellent and comfortable beds " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wesley [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/5950187f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 2 Bedrooms, Non Smoking, Garden View](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/fd5c34e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/7794c781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/9f324b7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rockwood Inn [](https://www.expedia.ca/Cape-Girardeau-Hotels-Rockwood-Inn.h105486893.Hotel-Information) Cape Girardeau 10/10 Exceptional (20 reviews) "My stay was cozy, warm and inviting, and absolutely wonderful shower. I will definitely be returning! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kim CA $192 CA $217 total includes taxes & fees Mar 30 - Mar 31 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Rockwood-Inn.h105486893.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/3867ac72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Little Blue Cottage on Spanish [](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) Cape Girardeau 8.2/10 Very good (53 reviews) "Cozy and perfect for a couple. Great communication with the host" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beth G. CA $111 CA $148 total includes taxes & fees Mar 23 - Mar 24 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/60c56f2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/860b4de6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0622af9a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming Secluded Getaway Cabin within minutes of amenities [](https://www.expedia.ca/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information) Cape girardeau 10/10 Exceptional (18 reviews) "We had a great time at Blair and her family's property. The cabin was very comfortable and as advertised. I would be happy to recommend it to others " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy M. CA $213 CA $421 total includes taxes & fees Mar 23 - Mar 24 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Charming-Getaway-Cabin.h75891457.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/fa9f5d7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/da9b2a8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/93cee70f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/8f1fe4ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau [](https://www.expedia.ca/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information) Cape Girardeau 10/10 Exceptional (12 reviews) "Conveniently located to college and good restaurants. Is a large home with lots of space for a family. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chad [](https://www.expedia.ca/Cape-Girardeau-Hotels-3-Bedroom-3-Full-Bath-In-Beautiful-Historic-District-Downtown-Cape-Girardeau.h120661701.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-05&endDate=2026-04-06®ionId=553248635976430467&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Great weekend hotel deals in Cape Girardeau County, MO ### Showing deals for:**Apr 3 - Apr 5** ### Image gallery for Charming Secluded Getaway Cabin within minutes of amenities ![Interior](https://images.trvl-media.com/lodging/76000000/75900000/75891500/75891457/0c802aa2.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Charming Secluded Getaway Cabin within minutes of amenities Cape Girardeau **10/10**Exceptional (18 reviews) 5% off CA $202 CA $649 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=75891457&adults=2) ### Image gallery for Little Blue Cottage on Spanish ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Little Blue Cottage on Spanish Cape Girardeau **8.2/10**Very good (53 reviews) 10% off CA $111 CA $269 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=45712431&adults=2) ### Image gallery for Urban 2-bedroom Escape in Downtown Cape Girardeau ![Exterior detail](https://images.trvl-media.com/lodging/110000000/109930000/109929600/109929505/23d7d447.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Urban 2-bedroom Escape in Downtown Cape Girardeau Cape Girardeau **10/10**Exceptional (9 reviews) 10% off CA $216 CA $649 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=109929505&adults=2) ### Image gallery for 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau ![Interior](https://images.trvl-media.com/lodging/121000000/120670000/120661800/120661701/fa9f5d7f.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### 3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau Cape Girardeau **10/10**Exceptional (12 reviews) 10% off CA $149 CA $527 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=120661701&adults=2) ### Image gallery for Rockwood Inn ![Lobby](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/5950187f.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### Rockwood Inn Cape Girardeau **10/10**Exceptional (20 reviews) 16% off CA $230 CA $520 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=105486893&adults=2) ### Image gallery for The Riverview ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### The Riverview Cape Girardeau **9.4/10**Exceptional (531 reviews) 18% off CA $188 CA $425 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=105081384&adults=2) ### Image gallery for La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=600&h=400&p=1&q=high) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson **9.0/10**Wonderful (726 reviews) 15% off CA $153 CA $332 total includes taxes & fees [](https://www.expedia.ca/Hotel-Search?startDate=2026-04-03&endDate=2026-04-05&selected=53348099&adults=2) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations) ## Top Cape Girardeau County Hotel Reviews ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "LOVED EVERYTHING ABOUT THIS PLACE" [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/469821a6_y.jpg) ### Holiday Inn Express & Suites Perryville by IHG 2/10 Terrible "I was told i could check in when im 18 but i got their and they would not let me after already paying the price for it. Rip off. Very disrespectful." [](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "We have never stayed at a Drury hotel before and we were pleasantly surprised by amenities that are different from the usual hotel chains. Such as complimentary supper along with breakfast. Definitely a great deal when traveling with a family! Since we travel through the area often, we’ll definitely make this hotel our usual overnight stop." [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 8/10 Good "Beds were clean and well made however carpet in room was stained. There was a chicken nugget on the floor in the elevator upon arrival and was still there the next morning. Breakfast was good except for preparer wiping her nose with her plastic serving gloves on. Good coffee and easy check in." [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Candlewood Suites Cape Girardeau by IHG](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85_y.jpg) ### Candlewood Suites Cape Girardeau by IHG 6/10 Okay "Yes" [](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Quality Inn Cape Girardeau North](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg) ### Quality Inn Cape Girardeau North 8/10 Good "The office chair did not move up or down. The water in the shower was just lukewarm when it was hot at the sink. The drain mechanism didn't let the water drain out." [](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Town House Inn Cape Giradreau](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/c3f8959c_y.jpg) ### Town House Inn Cape Giradreau 10/10 Excellent "Clean room, good location " [](https://expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "Hotel staff were friendly and helpful. Store and restaurants were a short drive away." [](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![The Riverview](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046_y.jpg) ### The Riverview 10/10 Excellent "Room was nice and roomy. Staff friendly and heat worked well" [](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Cape Girardeau County - [Cape Girardeau Hotels ](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels) - [Jackson Hotels ](https://expedia.ca/Jackson-Hotels.d55765.Travel-Guide-Hotels) - [Oak Ridge Hotels ](https://expedia.ca/Oak-Ridge-Hotels.d553248634983311120.Travel-Guide-Hotels) - [Whitewater Hotels ](https://expedia.ca/Whitewater-Hotels.d553248634983531015.Travel-Guide-Hotels) - [Dutchtown Hotels ](https://expedia.ca/Dutchtown-Hotels.d3000349346.Travel-Guide-Hotels) - [Friedheim Hotels ](https://expedia.ca/Friedheim-Hotels.d3000349372.Travel-Guide-Hotels) - [Allenville Hotels ](https://expedia.ca/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) - [Delta Hotels ](https://expedia.ca/Delta-Hotels.d553248634983422827.Travel-Guide-Hotels) ### Hotels near popular Attractions - 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[RV Parks in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-RV-Parks.d553248635976430467-aaRVParks.Travel-Guide-Accommodation) - [Lodges in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Lodges.d553248635976430467-aaLodges.Travel-Guide-Accommodation) - [Farmstay in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Agritourism.d553248635976430467-aaAgritourism.Travel-Guide-Accommodation) - [B&B in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Bed-And-Breakfast.d553248635976430467-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Motels in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Motels.d553248635976430467-aaMotels.Travel-Guide-Accommodation) - [Aparthotels in Cape Girardeau County ](https://expedia.ca/Cape-Girardeau-County-Apart-Hotels.d553248635976430467-aaApartHotels.Travel-Guide-Accommodation) ### Explore more hotels - [Drury Plaza Hotel Cape Girardeau Conference Center ](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) - [The Riverview ](https://expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) - [Drury Inn & Suites Cape Girardeau ](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) - [La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau ](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) - [Drury Inn & Suites Jackson MO ](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) - [Pear Tree Inn Cape Girardeau West ](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) - [Candlewood Suites Cape Girardeau by IHG ](https://expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) - [Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG ](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) - [Quality Inn Cape Girardeau North ](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) - [Courtyard by Marriott Cape Girardeau Downtown ](https://expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) [See a list of all hotels in Cape Girardeau County](https://expedia.ca/All-Cape-Girardeau-County-Hotels.d553248635976430467.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Cape Girardeau County on Expedia.com ](https://www.expedia.com/Destinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations) ### Expedia's Latest Trends Hotels - [Best Hotels in Wentzville](https://expedia.ca/Wentzville-Hotels.d7679.Travel-Guide-Hotels) - [Crossroads Arts District Pet-friendly Hotels](https://expedia.ca/Crossroads-Arts-District-Kansas-City-Hotels-Pet-Friendly-Hotel.0-n6323149-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [GEHA Field at Arrowhead Stadium hotels](https://expedia.ca/GEHA-Field-At-Arrowhead-Stadium-Hotels.0-l6058069-0.Travel-Guide-Filter-Hotels) - [Hotels in Downtown St. Louis](https://expedia.ca/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels) - 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[St. Louis Zoo](https://expedia.ca/St-Louis-Zoo-St-Louis.d502878.Vacation-Attraction) - [Missouri Botanical Gardens and Arboretum](https://expedia.ca/Missouri-Botanical-Gardens-And-Arboretum-St-Louis.d507258.Vacation-Attraction) - [Starlight Theatre](https://expedia.ca/Starlight-Theatre-South-Kansas-City.d6069373.Vacation-Attraction) - [St. Louis Art Museum](https://expedia.ca/St-Louis-Art-Museum-St-Louis.d502859.Vacation-Attraction) - [Kansas City Zoo](https://expedia.ca/Kansas-City-Zoo-South-Kansas-City.d501349.Vacation-Attraction) General - [Visit Dutchtown](https://expedia.ca/St-Louis-Dutchtown.dx896162373499555840) - [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136) - [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828) - [Visit Parkville](https://expedia.ca/Parkville.dx9973) - [Visit River Market](https://expedia.ca/Kansas-City-River-Market.dx6192918) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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