Title: Top Hotels in Cape Girardeau County | Expedia.ca [Vacation Rentals in Cape Girardeau County](https://expedia.ca/Destinations-In-Cape-Girardeau-County.d553248635976430467.Vacation-Rental-Destinations)[Cape Girardeau County Car Rentals](https://expedia.ca/Destinations-In-Cape-Girardeau-County.d553248635976430467.Car-Rental-Destinations)[Cape Girardeau County Vacations](https://expedia.ca/Cape-Girardeau-County.d553248635976430467.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/5b27a574bbd8c4a139204e48a625a1c7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Skyy # Search Cape Girardeau County Hotels ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Cape Girardeau County Family friendly [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&travelerType=family_friendly) Cabin [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&lodging=CABIN) Pool [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&amenities=POOL) Farm [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&lodging=AGRITOURISM) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&amenities=HOT_TUB) Apart­ment [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&lodging=APARTMENT) Cottage [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&lodging=COTTAGE) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&amenities=PETS) Waterpark [](https://www.expedia.ca/Hotel-Search?destination=Cape+Girardeau+County%2C+Missouri%2C+United+States+of+America®ionId=553248635976430467&latLong=37.382832%2C-89.668449&adults=2&startDate=2025-11-11&d1=2025-11-11&endDate=2025-11-13&d2=2025-11-13&amenities=WATER_PARK) ## Check prices for these dates Tonight [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2025-10-28&endDate=2025-10-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 29 - Oct 30](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2025-10-29&endDate=2025-10-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=553248635976430467&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Hotels in Cape Girardeau County ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c279dc08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Cape Girardeau Conference Center Cape Girardeau 9.6/10 Exceptional (1005) "Very nice stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charity CA $131 CA $148 total includes taxes & fees Nov 14 - Nov 15 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/363ef183.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview Cape Girardeau 9.4/10 Exceptional (441) "Location was perfect for family weekend!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $153 CA $173 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/47fa1edf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Single Room, 1 King Bed, Non Smoking (Mobility, Bathtub w/Grab Bars)](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/67f5d6f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/8571b84d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau Jackson 8.8/10 Excellent (642) "Stayed on our way south for vacation. It was a clean nice place to stay. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joel CA $118 CA $127 total includes taxes & fees Oct 30 - Oct 31 [](https://www.expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/032aa313.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/284f2de7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/a085469e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau West Cape Girardeau 9.0/10 Wonderful (1005) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heather CA $98 CA $110 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/7a520031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/da4fe5e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/4ea3df4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/40200/40113/2df4267b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pear Tree Inn Cape Girardeau Near the Medical Center Cape Girardeau 9.0/10 Wonderful (1004) "Always enjoy our stay. Staff is very friendly, especially at breakfast! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $98 CA $110 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-Near-The-Medical-Center.h40113.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/fbb12bb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/66c21f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/d0828685.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Jackson MO Jackson 9.6/10 Exceptional (1005) "This was a wonderful stay. We will definitely stay again when we are in town!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Trista CA $126 CA $133 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/c56432e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/05f90b2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Cape Girardeau Cape Girardeau 9.4/10 Exceptional (1003) "Everything nice clean and friendly" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Megan CA $126 CA $142 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/627d4131.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/633eb669.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/c1fba8f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Cape Girardeau Cape Girardeau 9.6/10 Exceptional (82) "The staff was very kind and welcoming!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Natalie CA $125 CA $142 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, pillowtop beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/eb2507f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Cape Girardeau 9.4/10 Exceptional (1001) "It was right off the interstate with lots of restaurant options " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kelly CA $138 CA $156 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily English breakfast](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/e034ecf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/dc836bc2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down comforters](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/c5d3f974.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cape Girardeau 7.2/10 Good (661) "Great place with great employees" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jessica CA $84 CA $95 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/4de18ac4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, stovetop, dishwasher](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/e322869e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/cc0ef67f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Candlewood Suites Cape Girardeau by IHG Cape Girardeau 8.2/10 Very good (860) "Great staff and convenient location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Greg CA $106 CA $128 total includes taxes & fees Nov 14 - Nov 15 [](https://www.expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/ac6f4af6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Cape Girardeau Cape Girardeau 9.4/10 Exceptional (132) "Excellent hotel…" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danny CA $130 CA $147 total includes taxes & fees Nov 6 - Nov 7 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/20bc712d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Cape Girardeau Downtown Cape Girardeau 9.6/10 Exceptional (457) "The Staff was friendly The restaurant was good" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sirron CA $162 CA $184 total includes taxes & fees Nov 23 - Nov 24 [](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ![Courtyard](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/0578314a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/acc0b9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/4c2e6495.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Cape Girardeau I 55 East Cape Girardeau 9.6/10 Exceptional (763) "The property staff were lovely and the hotel was clean and renovated!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary CA $148 CA $167 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) ![Economy Single Room, 1 Queen Bed, Kitchenette](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5eb3395a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Single Room, 1 Queen Bed, Kitchenette](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5dd1852e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/1aa84b52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/6f6795dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn Jackson 7.6/10 Good (419) "Room was clean and had a refrigerator and microwave for use if needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry CA $97 CA $106 total includes taxes & fees Nov 11 - Nov 12 [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/70460e25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/a758bb0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/eec0e02a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/06dc4487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Jackson-Cape Girardeau Jackson 8.2/10 Very good (737) "Great area, fast check in, quiet, very spacious" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeanne CA $124 CA $135 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/7adb4452.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking (NRF)](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/1f46462a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/c3f8959c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free self parking](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/5d555857.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn Cape Giradreau Cape Girardeau 6.0/10 (200) "Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary CA $91 CA $106 total includes taxes & fees Oct 29 - Oct 30 [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) ![Standard Room, 1 Queen Bed, Non Smoking, Garden View](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/fc499141.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/dbe031d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Suite, 2 Bedrooms, Non Smoking, Garden View](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/eaa414ac.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/106000000/105490000/105486900/105486893/000a3467.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rockwood Inn Cape Girardeau 10/10 Exceptional (16) "We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vanessa CA $195 CA $221 total includes taxes & fees Nov 9 - Nov 10 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Rockwood-Inn.h105486893.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/9ff1a808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/ad11073b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/143b0eab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, WiFi](https://images.trvl-media.com/lodging/46000000/45720000/45712500/45712431/1e8bea93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Little Blue Cottage on Spanish Cape Girardeau 8.6/10 Excellent (45) "Some issues with check-in. Very nice area. Lot of history." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey M. CA $113 CA $141 total includes taxes & fees Nov 7 - Nov 8 [](https://www.expedia.ca/Cape-Girardeau-Hotels-Little-Blue-Cottage-On-Spanish.h45712431.Hotel-Information) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103750000/103741400/103741323/503e8265.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/104000000/103750000/103741400/103741323/d9b977d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103750000/103741400/103741323/fef2c0f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103750000/103741400/103741323/87761e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Jackson/cape Girardeau Jackson 9.4/10 Exceptional (3) "Nice place " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jermaine [](https://www.expedia.ca/Jackson-Hotels-Best-Western-Plus-Jackson-Cape-Girardeau.h103741323.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-11&endDate=2025-11-12®ionId=553248635976430467&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations) ## Top Cape Girardeau County Hotel Reviews ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Cape Girardeau County - [Cape Girardeau Hotels](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels) - [Jackson Hotels](https://expedia.ca/Jackson-Hotels.d55765.Travel-Guide-Hotels) - [Oak Ridge Hotels](https://expedia.ca/Oak-Ridge-Hotels.d553248634983311120.Travel-Guide-Hotels) - [Dutchtown Hotels](https://expedia.ca/Dutchtown-Hotels.d3000349346.Travel-Guide-Hotels) - [Whitewater Hotels](https://expedia.ca/Whitewater-Hotels.d553248634983531015.Travel-Guide-Hotels) - [Delta Hotels](https://expedia.ca/Delta-Hotels.d553248634983422827.Travel-Guide-Hotels) - [Friedheim Hotels](https://expedia.ca/Friedheim-Hotels.d3000349372.Travel-Guide-Hotels) - [Allenville Hotels](https://expedia.ca/Allenville-Hotels.d553248634983340903.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near Southeast Missouri State University](https://expedia.ca/Southeast-Missouri-State-University-Hotels.0-l553248621554122994-0.Travel-Guide-Filter-Hotels) - [Hotels near Isle Casino Cape Girardeau](https://expedia.ca/Isle-Casino-Cape-Girardeau-Hotels.0-l553248621532655780-0.Travel-Guide-Filter-Hotels) - [Hotels near Riverfront Bridge Park](https://expedia.ca/Riverfront-Bridge-Park-Hotels.0-l553248621532655774-0.Travel-Guide-Filter-Hotels) - [Hotels near Trail of Tears State Park](https://expedia.ca/Trail-Of-Tears-State-Park-Hotels.0-l553248621532655784-0.Travel-Guide-Filter-Hotels) - [Hotels near Riverfront Park](https://expedia.ca/Riverfront-Park-Hotels.0-l740677735274594304-0.Travel-Guide-Filter-Hotels) - [Hotels near Cape Rock Park](https://expedia.ca/Cape-Rock-Park-Hotels.0-l553248621532655781-0.Travel-Guide-Filter-Hotels) - [Hotels near Cape Splash Family Aquatic Center](https://expedia.ca/Cape-Splash-Family-Aquatic-Center-Hotels.0-l553248621532655772-0.Travel-Guide-Filter-Hotels) - [Hotels near Hunter Valley Winery](https://expedia.ca/Hunter-Valley-Winery-Hotels.0-l553248621532655783-0.Travel-Guide-Filter-Hotels) - [Hotels near eDen Spa & Salon](https://expedia.ca/EDen-Spa-Salon-Hotels.0-l553248621532655776-0.Travel-Guide-Filter-Hotels) - [Hotels near Cape Girardeau Conservation Nature Center](https://expedia.ca/Cape-Girardeau-Conservation-Nature-Center-Hotels.0-l553248621532655773-0.Travel-Guide-Filter-Hotels) ### More ways to book - [Book Hotels in Cape Girardeau County on Expedia.com](https://www.expedia.com/Destinations-In-Cape-Girardeau-County.d553248635976430467.Hotel-Destinations) ### Expedia's Latest Trends Hotels - [Golf Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Golf-Hotel.0-0-d178304-tGolfHotel.Hotel-Filter-Destinations) - [Oceanfront Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Oceanfront-Hotels.0-0-d178304-tOceanfrontHotels.Hotel-Filter-Destinations) - [Hotels near GEHA Field at Arrowhead Stadium](https://expedia.ca/GEHA-Field-At-Arrowhead-Stadium-Hotels.0-l6058069-0.Travel-Guide-Filter-Hotels) - [Hotels in Orange County](https://expedia.ca/Destinations-In-Orange-County.d603224.Hotel-Destinations) - [All Inclusive Resorts and Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-All-Inclusive-Hotel.0-0-d178304-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Hotels in Downtown St. Louis](https://expedia.ca/Downtown-St-Louis-St-Louis-Hotels.0-n800136-0.Travel-Guide-Filter-Hotels) - [Luxury Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Luxury-Hotel.0-0-d178304-tLuxuryHotel.Hotel-Filter-Destinations) - [Mountain Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Mountain-Hotels.0-0-d178304-tMountainHotels.Hotel-Filter-Destinations) - [Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Hotel-Destinations) - [Family Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Family-Hotel.0-0-d178304-tFamilyHotel.Hotel-Filter-Destinations) - [Hotels near Women's and Children's Hospital](https://expedia.ca/Womens-And-Childrens-Hospital-Hotels.0-l553248635974865886-0.Travel-Guide-Filter-Hotels) - [Cheap Hotels in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Cheap-Hotels.0-0-d178304-tCheapHotels.Hotel-Filter-Destinations) - [Hotels in Power and Light District](https://expedia.ca/Power-And-Light-District-Kansas-City-Hotels.0-n6162504-0.Travel-Guide-Filter-Hotels) - [Hotels in Downtown Kansas City](https://expedia.ca/Downtown-Kansas-City-Kansas-City-Hotels.0-n6058828-0.Travel-Guide-Filter-Hotels) - [Beach Hotel in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County-Beach-Hotel.0-0-d178304-tBeachHotel.Hotel-Filter-Destinations) Flights - [Flights to Orange County](https://expedia.ca/Destinations-In-Orange-County.d603224.Flight-Destinations) - [Flights to San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Flight-Destinations) Cars - [Car rentals in San Diego County](https://expedia.ca/Destinations-In-San-Diego-County.d178304.Car-Rental-Destinations) - [Car rental Kansas City Airport (MCI)](https://expedia.ca/Car-Rentals-In-Kansas-City-Intl.d4801357.Car-Rental-Guide) Cruises - [Cruises from San Diego County](https://expedia.ca/Cruises-from-San-Diego-County.d178304.Cruise-Departure-Port) Activities - [Things to do in Baldwin County](https://expedia.ca/Things-To-Do-In-Baldwin-County.d553248635976432245.Travel-Guide-Activities) - [Things to do in San Diego County](https://expedia.ca/Things-To-Do-In-San-Diego-County.d178304.Travel-Guide-Activities) - [Things to do in High Ridge](https://expedia.ca/Things-To-Do-In-High-Ridge.d553248634983579370.Travel-Guide-Activities) - [Things to do in Orange County](https://expedia.ca/Things-To-Do-In-Orange-County.d603224.Travel-Guide-Activities) - [Things to do in Levy County](https://expedia.ca/Things-To-Do-In-Levy-County.d553248635976432502.Travel-Guide-Activities) Packages - [San Diego County Vacations](https://expedia.ca/San-Diego-County.d178304.Destination-Travel-Guides) General - [Visit Downtown St. Louis](https://expedia.ca/St-Louis-Downtown-St-Louis.dx800136) - [Visit Downtown Kansas City](https://expedia.ca/Kansas-City-Downtown-Kansas-City.dx6058828) - [Visit Parkville](https://expedia.ca/Parkville.dx9973) - [Visit Orange County](https://expedia.ca/Orange-County.dx603224) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)