Photo by Ryan Coleman

Find hotels in Sikeston, MO from CA $73

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check Sikeston hotel prices

Tomorrow night
This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Top 10 Sikeston hotels and places to stay

Days Inn and Suites by Wyndham Sikeston
2.0 star property
7.0 out of 10, Good, (1001)
"Clean, large room"
The price is CA $95
CA $107 total
includes taxes & fees
Oct 3 - Oct 4
Days Inn and Suites by Wyndham Sikeston
Pear Tree Inn Sikeston
2.5 star property
9.4 out of 10, Exceptional, (1002)
"I recommend Pear Tree Inn, it is reasonably priced, the room was comfortable, the staff was friendly and helpful. It is located with easy access to the interstate. "
The price is CA $109
CA $124 total
includes taxes & fees
Oct 8 - Oct 9
Pear Tree Inn Sikeston
Drury Inn & Suites Sikeston, MO
3.0 star property
9.4 out of 10, Exceptional, (1001)
"Great stay"
The price is CA $133
CA $151 total
includes taxes & fees
Oct 20 - Oct 21
Drury Inn & Suites Sikeston, MO
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
8.4 out of 10, Very good, (585)
"Decent place for a one-night stay."
The price is CA $85
CA $96 total
includes taxes & fees
Oct 9 - Oct 10
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Best Western Plus Sikeston
2.5 star property
8.4 out of 10, Very good, (1002)
"Check in was very pleasant. The woman at the front desk was very nice. Arrived to our room and it was warm and stuffy. Dropped our bags, turned temperature down and went to eat. Came back and all was cool. As far as the room being clean- there was a piece of tile by the tub floor off the wall laying there and the carpet was questionable. Indoor pool was heated and clean. (No towels). No hot tub. 😢. Breakfast was awesome with a nice variety. All said and done. If in the area I...
The price is CA $115
CA $130 total
includes taxes & fees
Oct 3 - Oct 4
Best Western Plus Sikeston
Country Yard Inn and Suite
2.0 star property
7.2 out of 10, Good, (49)
"I would definitely stay here again!!! Thank you "
The price is CA $78
CA $92 total
includes taxes & fees
Oct 3 - Oct 4
Country Yard Inn and Suite
Dexter Inn
2.5 star property
7.0 out of 10, Good, (264)
"Clean and good parking"
The price is CA $73
CA $83 total
includes taxes & fees
Oct 16 - Oct 17
Dexter Inn
Hampton Inn Sikeston
2.5 star property
8.8 out of 10, Excellent, (291)
"Excellent location "
The price is CA $156
CA $177 total
includes taxes & fees
Oct 20 - Oct 21
Hampton Inn Sikeston
Hickory House Inn
2.5 star property
5.4 out of 10, (104)
"Nice place for the price."
The price is CA $74
CA $83 total
includes taxes & fees
Oct 4 - Oct 5
Hickory House Inn
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
2.5 star property
8.6 out of 10, Excellent, (369)
"The continental breakfast "
The price is CA $165
CA $186 total
includes taxes & fees
Oct 3 - Oct 4
Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel
Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
6.6 out of 10, (496)
"Good "
The price is CA $81
CA $92 total
includes taxes & fees
Oct 3 - Oct 4
Super 8 by Wyndham Sikeston/Miner Area
Comfort Inn & Suites Sikeston I-55
2.5 star property
8.2 out of 10, Very good, (220)
"Check in was easy with friendly staff. Hotel had everything you would need, plus walking distance to dining. "
The price is CA $118
CA $134 total
includes taxes & fees
Oct 16 - Oct 17
Comfort Inn & Suites Sikeston I-55
Econo Lodge Dexter
2.0 star property
6.8 out of 10, (204)
"Typical hotel stay, some dingy lights and older carpet that smelled but it was clean and quiet. "
The price is CA $83
CA $93 total
includes taxes & fees
Oct 4 - Oct 5
Econo Lodge Dexter
Travelodge by Wyndham Dexter
2.0 star property
7.4 out of 10, Good, (343)
"Bathtub drain in 111 didn’t plug completely "
The price is CA $122
CA $138 total
includes taxes & fees
Oct 10 - Oct 11
Travelodge by Wyndham Dexter
The Blue Door
10.0 out of 10, Exceptional, (1)
The price is CA $111
CA $138 total
includes taxes & fees
Oct 2 - Oct 3
The Blue Door
Dexter Homestead. VERY Cozy & Clean 7 Bed home.
8.6 out of 10, Excellent, (17)
"Plenty of room to move about. Quiet neighborhood. Host took care of all our needs."
The price is CA $119
CA $261 total
includes taxes & fees
Oct 2 - Oct 3
Dexter Homestead. VERY Cozy & Clean 7 Bed home.
Modern and Cozy Apartment with large windows and sunlight.
Modern and Cozy Apartment with large windows and sunlight.
Don't see what you're looking for?
See all available properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Frequently asked questions

Where is the best place to stay in Sikeston?

Drury Inn & Suites Sikeston, MO is ranked highly by Expedia customers. This hotel offers free breakfast and an outdoor pool. Other top choices based on reviews include Pear Tree Inn Sikeston and Hampton Inn Sikeston. See all available top hotels, or vacation rentals in Sikeston.

What are some of the best vacation rentals in Sikeston?

Notting Hill Cottage: This vacation home rental outside of Sikeston offers a patio, a private yard, and a barbecue grill to help you feel perfectly comfortable in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. You and your friends and family can relax into your vacation with amenities like a spa tub. See all vacation rentals in Sikeston.

If I need to cancel my hotel reservation in Sikeston, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, it might still be possible to cancel it and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Sikeston.

Where can I learn more about changing or cancelling my trip to Sikeston?

For more details about changing or cancelling your trip to Sikeston, head over to our customer service page.

What's the best budget-friendly hotel in Sikeston?

Based on reviews, Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) is a popular hotel for our travelers who want a more economical choice, and features free breakfast and free WiFi. View all budget hotels in Sikeston.

What's the best hotel for a family vacation in Sikeston?

Drury Inn & Suites Sikeston, MO is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Pear Tree Inn Sikeston is another good choice for your stay with the kids. Kids of all ages will also enjoy a visit to The Book Bug. Find more child-friendly accommodations in Sikeston.

What is the top LGBTQ-friendly hotel in Sikeston?

Drury Inn & Suites Sikeston, MO is a top LGBTQ-friendly hotel, and features free breakfast and free WiFi. Pear Tree Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options for your vacation. See all available hotels listed as LGBTQ-friendly in Sikeston.

What's the best pet-friendly accommodation in Sikeston?

Drury Inn & Suites Sikeston, MO is a top hotel for people traveling with their pets, and offers an indoor pool and free WiFi for its human guests. Other good options for you and your pet's trip include Pear Tree Inn Sikeston and Days Inn and Suites by Wyndham Sikeston. See more pet-friendly hotel accommodations in Sikeston.

Where is the best hotel to stay close to Central Park?

Hampton Inn Sikeston is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located just a short 1 mi (1.6 km) from Central Park. Another good option is Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel, located just 0.9 mi (1.5 km) away.

What about the best place to stay close to Sikeston Depot Museum?

One of the top choices for your stay is Pear Tree Inn Sikeston, located 3.1 mi (5 km) from Sikeston Depot Museum, and this hotel offers free breakfast and an outdoor pool. Hampton Inn Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel are two other good options within a few miles.

What's the best hotel for a golf vacation in Sikeston?

Travel Inn & Suites is a hotel featuring free breakfast and free WiFi, and it's a top choice for playing a round of golf. You can tee off at Boot Heel Golf Club during your trip. See more golf hotels in Sikeston.

What are some accommodations with pools in Sikeston?

Drury Inn & Suites Sikeston, MO is a top hotel with an indoor pool, an outdoor pool, and free buffet breakfast. Other choices with an onsite pool include Best Western Plus Sikeston and Holiday Inn Express & Suites Sikeston Southwest, an IHG Hotel. View all hotels with pools in Sikeston.

What is the best spa hotel in Sikeston?

Drury Inn & Suites Sikeston, MO is a top spa hotel featuring a pool and a fitness center. See all spa hotels in Sikeston.

What's the best place to stay near Barkley Regional Airport (PAH)?

Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.

What is staying in Sikeston like?

Families will find kid-friendly activities in Sikeston, and visitors give high marks for the top-notch restaurants and shopping. This welcoming city also attracts tourists with its riverfront and university setting. In Sikeston, there are 13 hotels and other accommodations to choose from. Find out more about Sikeston.

What are the top places to visit in Sikeston?

Favorite places to visit include The Book Bug, Sikeston Depot Museum, and Boot Heel Golf Club. Additionally, you might want to add Central Park to your itinerary. Check out what more to see and do in Expedia's Sikeston guide.

What's the seasonal weather like in Sikeston?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Sikeston is 60 inches.