Title: Book The Best Hotels in Cairo, IL for 2026 from CA $95 - Fully Refundable Options - Expedia.ca

[Vacation Rentals in Cairo](https://expedia.ca/Cairo-Vacation-Rentals.d6626.Travel-Guide-VacationRentals)[Flights to Cairo](https://expedia.ca/Cheap-Flights-To-Cairo.d6626.Travel-Guide-Flights)[Cairo Car Rentals](https://expedia.ca/Car-Rentals-In-Cairo.d6626.Car-Rental-Guide)[Cairo Vacation Packages](https://expedia.ca/Cairo.d6626.Destination-Travel-Guides)

![Cairo Ohio River Bridge traversing over the Ohio River at sunset](https://images.trvl-media.com/place/6626/5a2a2e7f-cbef-414c-a9c1-20af7a0fca3a.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6626/5a2a2e7f-cbef-414c-a9c1-20af7a0fca3a.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in Cairo

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=Cairo%2C+Illinois%2C+United+States+of+America&regionId=6626&latLong=37.005329%2C-89.176461&adults=2&startDate=2026-03-28&d1=2026-03-28&endDate=2026-03-30&d2=2026-03-30&amenities=PETS)

Cabin

[](https://www.expedia.ca/Hotel-Search?destination=Cairo%2C+Illinois%2C+United+States+of+America&regionId=6626&latLong=37.005329%2C-89.176461&adults=2&startDate=2026-03-28&d1=2026-03-28&endDate=2026-03-30&d2=2026-03-30&lodging=CABIN)

## Check prices for these dates

Tonight

[Mar 14 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2026-03-14&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 15 - Mar 16](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2026-03-15&endDate=2026-03-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Cairo hotels

![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Jackpot Suite | Living area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/e87009c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverview

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(526 reviews)

"Room was perfect"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Derrick

CA $124

CA $140 total

includes taxes & fees

Mar 18 - Mar 19

[](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598928/27748d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Casino](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598928/ada044bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 restaurants, lunch, dinner, brunch served; American cuisine](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598928/5da35cce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/2000000/1600000/1599000/1598928/d9e945cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

[](https://www.expedia.ca/Metropolis-Hotels-Harrahs-Metropolis-Hotel-Casino.h1598928.Hotel-Information)

Metropolis

8.2/10

Very good

(1,000 reviews)

"Great staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Eric

[](https://www.expedia.ca/Metropolis-Hotels-Harrahs-Metropolis-Hotel-Casino.h1598928.Hotel-Information)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,004 reviews)

"Very nice for overnight stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

CA $129

CA $148 total

includes taxes & fees

Mar 19 - Mar 20

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/927db718.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/c7d69739.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/18325925.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/20bc712d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott Cape Girardeau Downtown

[](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(495 reviews)

"Very nice hotel!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angie

CA $171

CA $194 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/5929e46c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/16f1820b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/6f9bce18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/c65fb6ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Plaza Hotel Cape Girardeau Conference Center

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(1,003 reviews)

"My favorite place tpstay when in the area."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jack

CA $137

CA $155 total

includes taxes & fees

Mar 19 - Mar 20

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/6afa6c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, soundproofing](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/75079b79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/c3df8884.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/4000000/3540000/3530400/3530303/f7d52bda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Candlewood Suites Cape Girardeau by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

Cape Girardeau

8.2/10

Very good

(903 reviews)

"Nice room and easy access to bathroom "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maureen

CA $96

CA $116 total

includes taxes & fees

Mar 16 - Mar 17

[](https://www.expedia.ca/Sikeston-Hotels-Candlewood-Suites-Cape-Girardeau.h3530303.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/6966efed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/5b2269be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed with Sofa bed, Accessible (Sofa Sleeper, Tub, 2 Rooms)](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/0f190cb0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/84598bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Cape Girardeau

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(1,000 reviews)

"Great stop. Great facility and food. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Randy

CA $123

CA $139 total

includes taxes & fees

Mar 22 - Mar 23

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/182edc95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free breakfast](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom (Feature)](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/40930878.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(1,003 reviews)

"Clean room staff is very nice parking it great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Arriel

CA $136

CA $153 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/e6e29f10.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/b20a49e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Non Smoking, Refrigerator & Microwave](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/051de21c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/81fbb6f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Cape Girardeau I 55 East

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

Cape Girardeau

9.6/10

Exceptional

(795 reviews)

"Great place to stay. Clean and close to restaurants! "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diane

CA $145

CA $164 total

includes taxes & fees

Mar 22 - Mar 23

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/8bb15ffe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/6cd5cd8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/51a3fe78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/266a85bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Cape Girardeau

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

Cape Girardeau

9.4/10

Exceptional

(166 reviews)

"Staff was wonderful"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Victoria

CA $139

CA $157 total

includes taxes & fees

Mar 19 - Mar 20

[](https://www.expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/74187a0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Cairo

6.6/10

(282 reviews)

"The room was somewhat clean, but that’s the best I can say. The door from outside to the hallway didn’t lock or even close all the way. No staff and the office closed 11pm-5am. Sketchy part of town. No eateries close by. I would not recommend. Didn’t feel safe but we were exhausted so we stayed."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Tammie

CA $94

CA $104 total

includes taxes & fees

Mar 21 - Mar 22

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Desk, laptop workspace, blackout drapes, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/71011e95.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/f71e5ca6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible (Tub)](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/86c003aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/fe0d924e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Cape Girardeau West

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

Cape Girardeau

9.0/10

Wonderful

(1,001 reviews)

"Very clean and updated bathroom, clean room; outstanding hot breakfast and friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Colleen

CA $99

CA $111 total

includes taxes & fees

Mar 19 - Mar 20

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information)

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/3d86dbb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn and Suites by Wyndham Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

Sikeston

7.2/10

Good

(1,003 reviews)

"Rooms were clean. Close to our event."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michelle

CA $93

CA $106 total

includes taxes & fees

Mar 17 - Mar 18

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/4da73ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7a78d337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/07d69819.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/7657c6fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Sikeston I-55

[](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

Sikeston

8.4/10

Very good

(288 reviews)

"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

aileen

CA $127

CA $145 total

includes taxes & fees

Mar 19 - Mar 20

[](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

![Fitness studio](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/b3776435.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,001 reviews)

"Rooms were very clean and comfortable "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lydia

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(499 reviews)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

grant

CA $126

CA $143 total

includes taxes & fees

Apr 12 - Apr 13

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 1 King Bed, Non Smoking | Bathroom](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/352edf3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eagle Inn Charleston

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

Charleston

6.6/10

(105 reviews)

"Convenient "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Marcelle

CA $88

CA $97 total

includes taxes & fees

Mar 16 - Mar 17

[](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/fcfb42b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-c8905780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Sikeston

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

Sikeston

9.4/10

Exceptional

(13 reviews)

"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jason

CA $162

CA $183 total

includes taxes & fees

Mar 22 - Mar 23

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

Sikeston

9.4/10

Exceptional

(63 reviews)

"Nice quiet hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

CA $139

CA $157 total

includes taxes & fees

Mar 22 - Mar 23

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## 

The Annual Vacation Sale 

Members save up to 40% on hotels and homes. Plan this year’s big trip and save. 

[Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_6626)

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## Stay near popular Cairo attractions

### Fort Defiance State Park

You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=6091411)

## Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

[See all hotels in Cairo](https://www.expedia.ca/Hotel-Search?startDate=2026-03-29&endDate=2026-03-30&adults=2&regionId=6626)

![Cairo Ohio River Bridge traversing over the Ohio River at sunset](https://images.trvl-media.com/place/6626/5a2a2e7f-cbef-414c-a9c1-20af7a0fca3a.jpg?impolicy=fcrop&w=899&h=599&p=1&q=high)

## Top Cairo Hotel Reviews

## Recent Reviews in Cairo

![Ducks and geese are here! Booking for turkey season too. We're ready for you!](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/bd476bf3_y.jpg)

### Ducks and geese are here! Booking for turkey season too. We're ready for you!

10/10 Excellent

"Everything was great. Had plenty of space for the 5 of us and hunting gear.comfortable beds and nice amenities.Did not take advantage of the outdoor patio or grill or other amenities but all seemed ready to go with firewood for the firepit. Host was fantastic. sent pictures of the area, restaurant ideas and stayed in touch our entire trip"

[](https://expedia.ca/Tamms-Hotels-Attention-Hunters-Deer-Camp.h109109006.Hotel-Information)

![Cozy cabins on beautiful Horseshoe Lake](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388_y.jpg)

### Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent

"The cabin was extremely clean and nice. Amenities were perfect. Right by the lake. Would highly recommend."

[](https://expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6_y.jpg)

### Super 8 by Wyndham Charleston/Sikeston East MO

6/10 Okay

"The room needed updated"

[](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Quality Inn Cairo I-57](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457_y.jpg)

### Quality Inn Cairo I-57

6/10 Okay

"the hotel needs updateing poor brekfesr"

[](https://expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Charming Home just minutes from Interstate and Mall](https://images.trvl-media.com/lodging/91000000/90930000/90923000/90922960/46c181aa_y.jpg)

### Charming Home just minutes from Interstate and Mall

10/10 Excellent

"Comfortable couch and recliner, abundant space, great shower head, hosts were phenomenal! It was perfect for our needs. "

[](https://expedia.ca/Paducah-Hotels-Charming-Home.h90922960.Hotel-Information)

![Peaceful secluded cabin located near Horseshoe Lake ](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/1be40475_y.jpg)

### Peaceful secluded cabin located near Horseshoe Lake 

10/10 Excellent

"The place was quiet, clean and secluded. Exactly what my wife and I were looking for. Thanks for having us!"

[](https://expedia.ca/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information)

![Charming cottage overlooking Lake Acre](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/09707f79_y.jpg)

### Charming cottage overlooking Lake Acre

10/10 Excellent

"beautiful solid cabin. Great books on the history of the area. Truly enjoyed are restful stay! I just wish it was warmer, so we could have enjoyed the amazing stars at night and just the beauty of the area. We would rent again."

[](https://expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information)

![Quiet Country Stay: Modern Home Near Paducah](https://images.trvl-media.com/lodging/123000000/122890000/122882400/122882332/c1fa9596_y.jpg)

### Quiet Country Stay: Modern Home Near Paducah

10/10 Excellent

"Very clean very fun stat. Great host great ammenities!"

[](https://expedia.ca/Quiet-Country-Stay-Modern-Home-Near-Paducah.h122882332.Hotel-Information)

![Eagle Inn Charleston](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9_y.jpg)

### Eagle Inn Charleston

2/10 Terrible

"The hotel needs a renovation. For the price I didn’t expect much, but it feels neglected."

[](https://expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

## More cheap stays in Cairo

![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO

CA $85

CA $95 total

Mar 16 - Mar 17

includes taxes & fees

6.8/10 (625 reviews)

[](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Eagle Inn Charleston](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Eagle Inn Charleston

2811 East Marshall Street Charleston MO

CA $88

CA $97 total

Mar 16 - Mar 17

includes taxes & fees

6.6/10 (105 reviews)

[](https://expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Quality Inn Cairo I-57](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Quality Inn Cairo I-57

13201 Kessler Road Cairo IL

CA $94

CA $104 total

Mar 21 - Mar 22

includes taxes & fees

6.6/10 (282 reviews)

[](https://expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![The Riverstone Hotel Charleston-Sikeston](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/08c2ace2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### The Riverstone Hotel Charleston-Sikeston

102 Drake St Charleston MO

CA $96

CA $107 total

Mar 16 - Mar 17

includes taxes & fees

[](https://expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

![La Center Motel](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/e95f9062_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### La Center Motel

474 W Kentucky Dr La Center KY

[Get rates](https://expedia.ca/Hotel-Search?startDate=29%2F03%2F2026&endDate=30%2F03%2F2026&selected=99665264&PinnedHotelID=99665264&HadPinnedHotel=true&regionId=6626)

[](https://expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information)

## Hotels in Cairo with star rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

1 properties

[](https://expedia.ca/3Star-Cairo-Hotels.s30-0-d6626.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

6 properties

[](https://expedia.ca/2Star-Cairo-Hotels.s20-0-d6626.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### What is the best area to stay in Cairo?

> This area, though small, represents the heart of Cairo's history and offers the most convenient access to its remaining landmarks. Commercial Avenue was once the main commercial thoroughfare, and while many buildings are now vacant, it provides a glimpse into the town's past. Travellers will find the most accessible options for overnight stays here.
> 
>   
> For history enthusiasts, staying in this central area is ideal. You're within walking distance of historic buildings and the confluence of the Ohio and Mississippi Rivers, a significant geographical point.

### What are the best hotels in Cairo that travellers recommend?

> The Quality Inn Cairo I-57 offers a comfortable stay with amenities such as air conditioning, free breakfast including a full breakfast, and a kitchen in the rooms. Guests appreciate the nice, clean rooms and the quite good breakfast. The staff also receives positive comments for being nice. For convenience, the hotel provides free self-parking, accessible van parking, and parking for RVs, buses, and trucks.

### What are the best family hotels in Cairo?

> This hotel offers a range of complimentary amenities that are ideal for families. Guests can enjoy free WiFi, free toiletries, and free self-parking. Furthermore, the hotel provides a complimentary full breakfast, and cribs are available for free, which is very convenient for those travelling with young children. Guests have consistently praised the nice, clean rooms, the quite good breakfast, and the nice staff, all contributing to a pleasant stay. Find more [child-friendly accommodations in Cairo](https://www.expedia.ca/Cairo-Hotels-Family-Hotel.0-0-d6626-tFamilyHotel.Travel-Guide-Filter-Hotels)

### What hotels in Cairo offer free breakfast?

> The Quality Inn Cairo I-57 provides guests with a free full breakfast, ensuring a great start to the day. This hotel also offers free WiFi and complimentary self-parking, adding to the convenience. Guests have frequently commented on the nice, clean rooms and the quite good breakfast. The staff are also regularly mentioned for being nice. This hotel is located within easy reach of the Mississippi River and the Ohio River. Find more [hotels with free breakfast in Cairo](https://www.expedia.ca/Cairo-Hotels-Hotels-With-Free-Breakfast.0-0-d6626-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels)

### What are the top pet-friendly hotels in Cairo?

> The Quality Inn Cairo I-57 permits pets, with a cleaning amount applicable for their stay. It also offers a complimentary full breakfast, which many guests describe as quite good. Reviewers often mention the nice and clean rooms, and the staff are frequently praised for being friendly. This hotel is also conveniently located near the Mississippi River and the Ohio River. See more [pet-friendly hotels in Cairo](https://www.expedia.ca/Cairo-Hotels-Pet-Friendly-Hotel.0-0-d6626-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)

### What are the best budget hotels in Cairo?

> This hotel offers convenient amenities such as complimentary WiFi, free toiletries, and free self-parking. Guests particularly appreciate the complimentary full breakfast provided. Reviews frequently mention the nice, clean rooms, the quite good breakfast, and the nice staff. View all [budget hotels in Cairo](https://www.expedia.ca/Cairo-Hotels-Cheap-Hotels.0-0-d6626-tCheapHotels.Travel-Guide-Filter-Hotels)

### What are the best hotels in Cairo near Mississippi River?

> This hotel offers convenient amenities for families, including free cots and complimentary full breakfast. Guests frequently praise the nice, clean rooms and the quite good breakfast. The staff also receive positive comments for their helpfulness. You will also benefit from free WiFi, complimentary toiletries, and free self-parking.

### When is the best time to go to Cairo?

> These periods offer the most pleasant weather for exploring the area. During late spring, temperatures are mild, typically ranging from 15°C to 25°C, and the natural scenery along the rivers is lush. Early autumn brings similar comfortable temperatures, often between 18°C and 28°C, with the added beauty of changing leaves.
> 
>   
> For couples looking for a relaxed getaway, these shoulder seasons are ideal. The weather is great for walking along the riverfront, visiting historic sites like the Custom House Museum, or enjoying the quiet charm of the town without the extreme heat of summer. It's a great time for photography as well, capturing the blend of history and nature.
> 
>   
> Solo travellers will also appreciate the comfortable conditions for exploring the area's historical significance, particularly its role in the Civil War.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a Cairo hotel booking with Expedia?

### How much is the nightly rate at a Cairo hotel?

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- [Flights to Metropolis ](https://www.expedia.ca/Cheap-Flights-To-Metropolis.d8831.Travel-Guide-Flights)
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- [Shawnee Community College ](https://www.expedia.ca/Shawnee-Community-College-Anna.d6183446.Vacation-Attraction)
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- [Visit Vienna ](https://www.expedia.ca/Vienna.dx56022)

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