Cairo Ohio River Bridge traversing over the Ohio River at sunset

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Our top choices for Cairo hotels

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (596 reviews)
"Always a great place to stay in downtown Cape. Easy access to the local hangouts like Speck Pizza on Broadway."
United States
John
The price is CA $168
CA $190 total
includes taxes & fees
Jun 14 - Jun 15
The Riverview

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination
3.5 star property
Metropolis
8.2 out of 10, Very good, (1,003 reviews)
"Very enjoyable stay and even won some money!"
United States
Larry
The price is CA $135
CA $172 total
includes taxes & fees
Jul 14 - Jul 15
Harrah's Metropolis Hotel & Casino - A Caesars Rewards Destination

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,011 reviews)
"Breakfast was good,pool hot tub excellent "
United States
Janica
The price is CA $155
CA $178 total
includes taxes & fees
Jun 28 - Jun 29
Drury Inn & Suites Sikeston, MO

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (518 reviews)
"Great stay!!"
United States
Taylor
The price is CA $188
CA $213 total
includes taxes & fees
Jun 24 - Jun 25
Courtyard by Marriott Cape Girardeau Downtown

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,014 reviews)
"Wonderful room and food offerings were extra thoughtful."
United States
Jonna
The price is CA $154
CA $174 total
includes taxes & fees
Jun 21 - Jun 22
Drury Plaza Hotel Cape Girardeau Conference Center

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (961 reviews)
"It was a great place to stay. Convenient to go any where y"
United States
Marilyn
The price is CA $120
CA $143 total
includes taxes & fees
Jul 2 - Jul 3
Candlewood Suites Cape Girardeau by IHG

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,012 reviews)
"I will definitely be staying here next time I visit SEMO."
United States
Lee
The price is CA $145
CA $164 total
includes taxes & fees
Jun 21 - Jun 22
Drury Inn & Suites Cape Girardeau

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"The room was very spacious and great water pressure. Staff very kind to us, the breakfast was great as well"
United States
Theresa
The price is CA $159
CA $180 total
includes taxes & fees
Jun 21 - Jun 22
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (822 reviews)
"A nice stay"
United States
DAVID
The price is CA $148
CA $167 total
includes taxes & fees
Jul 12 - Jul 13
Hampton Inn Cape Girardeau I 55 East

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (197 reviews)
"The room was clean, the staff was extremely helpful with our check in!"
United States
Travis
The price is CA $130
CA $146 total
includes taxes & fees
Jun 25 - Jun 26
Fairfield Inn & Suites by Marriott Cape Girardeau

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (287 reviews)
"Television in my room did not get any signal for being able to view any channels. Shower was horrible. Towel rack was broken with a handwritten sign to “Do Not Use”. Lobby was dead bolted in the morning so I couldn’t get any complimentary breakfast or coffee that was supposed to be included in the room rate. Will avoid this place in the future."
United States
Matthew
The price is CA $101
CA $112 total
includes taxes & fees
Jul 11 - Jul 12
Quality Inn Cairo I-57

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1,013 reviews)
"Great hotel"
United States
mason
The price is CA $101
CA $114 total
includes taxes & fees
Jul 12 - Jul 13
Pear Tree Inn Cape Girardeau West

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,008 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is CA $98
CA $111 total
includes taxes & fees
Jun 17 - Jun 18
Days Inn and Suites by Wyndham Sikeston

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (295 reviews)
"My main issue was the tub ot had"
United States
Donimique
The price is CA $136
CA $155 total
includes taxes & fees
Jul 6 - Jul 7
Comfort Inn & Suites Sikeston I-55

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (576 reviews)
"Very clean hotel with comfortable bedding. Front desk staff was very nice and accommodating as we were traveling with a small dog."
United States
Connie
The price is CA $148
CA $168 total
includes taxes & fees
Jun 28 - Jun 29
Hampton Inn Sikeston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is CA $100
CA $111 total
includes taxes & fees
Jun 14 - Jun 15
Eagle Inn Charleston

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
The price is CA $178
CA $201 total
includes taxes & fees
Jun 25 - Jun 26
TownePlace Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (84 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is CA $154
CA $174 total
includes taxes & fees
Jun 25 - Jun 26
Fairfield Inn & Suites by Marriott Sikeston
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Stay near popular Cairo attractions

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

More cheap stays in Cairo

Hotels in Cairo with star rating

Frequently asked questions

What is the best area to stay in Cairo?
The best area to stay in Cairo, Illinois, is near the downtown historic district, particularly around Commercial Avenue.

This area, though small, represents the heart of Cairo's history and offers the most convenient access to its remaining landmarks. Commercial Avenue was once the main commercial thoroughfare, and while many buildings are now vacant, it provides a glimpse into the town's past. Travellers will find the most accessible options for overnight stays here.

For history enthusiasts, staying in this central area is ideal. You're within walking distance of historic buildings and the confluence of the Ohio and Mississippi Rivers, a significant geographical point.
What are the best hotels in Cairo that travellers recommend?
For a recommended hotel in Cairo, Illinois, consider the Quality Inn Cairo I-57.

The Quality Inn Cairo I-57 offers a comfortable stay with amenities such as air conditioning, free breakfast including a full breakfast, and a kitchen in the rooms. Guests appreciate the nice, clean rooms and the quite good breakfast. The staff also receives positive comments for being nice. For convenience, the hotel provides free self-parking, accessible van parking, and parking for RVs, buses, and trucks.
What are the best family hotels in Cairo?
For a family-friendly hotel in Cairo, the Quality Inn Cairo I-57 is a highly suitable option.

This hotel offers a range of complimentary amenities that are ideal for families. Guests can enjoy free WiFi, free toiletries, and free self-parking. Furthermore, the hotel provides a complimentary full breakfast, and cribs are available for free, which is very convenient for those travelling with young children. Guests have consistently praised the nice, clean rooms, the quite good breakfast, and the nice staff, all contributing to a pleasant stay. Find more child-friendly accommodations in Cairo
What hotels in Cairo offer free breakfast?
For hotels in Cairo that offer complimentary breakfast, the Quality Inn Cairo I-57 is a superb option.

The Quality Inn Cairo I-57 provides guests with a free full breakfast, ensuring a great start to the day. This hotel also offers free WiFi and complimentary self-parking, adding to the convenience. Guests have frequently commented on the nice, clean rooms and the quite good breakfast. The staff are also regularly mentioned for being nice. This hotel is located within easy reach of the Mississippi River and the Ohio River. Find more hotels with free breakfast in Cairo
What are the top pet-friendly hotels in Cairo?
For pet-friendly accommodation in Cairo, the Quality Inn Cairo I-57 is a highly recommended option.

The Quality Inn Cairo I-57 permits pets, with a cleaning amount applicable for their stay. It also offers a complimentary full breakfast, which many guests describe as quite good. Reviewers often mention the nice and clean rooms, and the staff are frequently praised for being friendly. This hotel is also conveniently located near the Mississippi River and the Ohio River. See more pet-friendly hotels in Cairo
What are the best budget hotels in Cairo?
For a much-loved budget hotel in Cairo, the Quality Inn Cairo I-57 is an excellent option.

This hotel offers convenient amenities such as complimentary WiFi, free toiletries, and free self-parking. Guests particularly appreciate the complimentary full breakfast provided. Reviews frequently mention the nice, clean rooms, the quite good breakfast, and the nice staff. View all budget hotels in Cairo
What are the best hotels in Cairo near Mississippi River?
For a hotel near the Mississippi River in Cairo, consider the Quality Inn Cairo I-57.

This hotel offers convenient amenities for families, including free cots and complimentary full breakfast. Guests frequently praise the nice, clean rooms and the quite good breakfast. The staff also receive positive comments for their helpfulness. You will also benefit from free WiFi, complimentary toiletries, and free self-parking.
When is the best time to go to Cairo?
The best time to visit Cairo, Illinois is during the late spring (April to May) and early autumn (September to October) months.

These periods offer the most pleasant weather for exploring the area. During late spring, temperatures are mild, typically ranging from 15°C to 25°C, and the natural scenery along the rivers is lush. Early autumn brings similar comfortable temperatures, often between 18°C and 28°C, with the added beauty of changing leaves.

For couples looking for a relaxed getaway, these shoulder seasons are ideal. The weather is great for walking along the riverfront, visiting historic sites like the Custom House Museum, or enjoying the quiet charm of the town without the extreme heat of summer. It's a great time for photography as well, capturing the blend of history and nature.

Solo travellers will also appreciate the comfortable conditions for exploring the area's historical significance, particularly its role in the Civil War.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Cairo.
How can I save on a Cairo hotel booking with Expedia?
Members always get our best prices. Find our best Cairo hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Cairo hotel?
Prices for hotels in Cairo often vary, but you can find a great deal from CA $88 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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