Title: Book The Best Hotels in Cairo, IL for 2026 from CA $92 - Fully Refundable Options - Expedia.ca [Vacation Rentals in Cairo](https://expedia.ca/Cairo-Vacation-Rentals.d6626.Travel-Guide-VacationRentals)[Flights to Cairo](https://expedia.ca/Cheap-Flights-To-Cairo.d6626.Travel-Guide-Flights)[Cairo Car Rentals](https://expedia.ca/Car-Rentals-In-Cairo.d6626.Car-Rental-Guide)[Cairo Vacation Packages](https://expedia.ca/Cairo.d6626.Destination-Travel-Guides) ![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels in Cairo, IL from CA $92 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in Cairo Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=Cairo%2C+Illinois%2C+United+States+of+America®ionId=6626&latLong=37.005329%2C-89.176461&adults=2&startDate=2025-12-27&d1=2025-12-27&endDate=2025-12-29&d2=2025-12-29&amenities=PETS) ## Check prices for these dates Tonight [Dec 13 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-13&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 14 - Dec 15](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-14&endDate=2025-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6626&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Cairo hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/0feda7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/c71a6d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 [](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) Cairo 6.6/10 (273) "Break fast was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Uma CA $101 CA $112 total includes taxes & fees Jan 10 - Jan 11, 2026 [](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) Charleston 6.6/10 (612) "Staff was great! Room was nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lana CA $86 CA $95 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/94d9e92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/fa992d12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/074a1dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Charleston - Sikeston [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information) Charleston 6.8/10 (406) "The staff was very friendly and accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arturo CA $90 CA $100 total includes taxes & fees Dec 21 - Dec 22 [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information) ![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/e769dedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/2b61a8ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eagle Inn Charleston [](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) Charleston 6.8/10 (103) "Middle of nowhere hotel was ok" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $83 CA $92 total includes taxes & fees Dec 14 - Dec 15 [](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Basic Double Room](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/6218157c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/520db902.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Double Room | Living area](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/dc7ca140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Double Room](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/1016c5b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Center Motel [](https://www.expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information) La Center 7.8/10 Good (16) "The place was very clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Victoria [](https://www.expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/9b8cfc2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/a98ba719.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/3a420a79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![House (2 Bedrooms) | Interior](https://images.trvl-media.com/lodging/123000000/122900000/122892200/122892138/13eae39f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quiet Country Stay: Modern Home Near Paducah [](https://www.expedia.ca/Quiet-Country-Stay-Modern-Home-Near-Paducah.h122892138.Hotel-Information) Cunningham CA $167 CA $399 total includes taxes & fees Dec 19 - Dec 20 [](https://www.expedia.ca/Quiet-Country-Stay-Modern-Home-Near-Paducah.h122892138.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-27&endDate=2025-12-28®ionId=6626&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCairo-Hotels.d6626.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCairo-Hotels.d6626.Travel-Guide-Hotels) ## Learn more about Cairo At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town. [See all hotels in Cairo](https://www.expedia.ca/Hotel-Search?startDate=2025-12-27&endDate=2025-12-28&adults=2®ionId=6626) ![Cairo Ohio River Bridge traversing over the Ohio River at sunset](https://images.trvl-media.com/place/6626/5a2a2e7f-cbef-414c-a9c1-20af7a0fca3a.jpg?impolicy=fcrop&w=899&h=599&p=1&q=high) ### Stay near popular Cairo attractions [](https://expedia.ca/Fort-Defiance-State-Park-Hotels.0-l6091411-0.Travel-Guide-Filter-Hotels) #### Fort Defiance State Park You can take time to visit Fort Defiance State Park during your travels to Cairo. Stroll along the riverfront or visit the churches while you're in the area. [See properties](https://expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091411) ## More cheap stays in Cairo ![Eagle Inn Charleston](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Eagle Inn Charleston 2811 East Marshall Street Charleston MO CA $83 CA $92 total Dec 14 - Dec 15 includes taxes & fees 6.6/10 (103 reviews) [](https://expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Super 8 by Wyndham Charleston/Sikeston East MO 310 S Story St Charleston MO CA $86 CA $95 total Dec 14 - Dec 15 includes taxes & fees 6.6/10 (611 reviews) [](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Quality Inn Charleston - Sikeston](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Charleston - Sikeston 102 Drake St Charleston MO CA $90 CA $100 total Dec 21 - Dec 22 includes taxes & fees 6.8/10 (406 reviews) [](https://expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information) ![Quality Inn Cairo I-57](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Quality Inn Cairo I-57 13201 Kessler Road Cairo IL CA $101 CA $112 total Jan 10 - Jan 11, 2026 includes taxes & fees 6.4/10 (273 reviews) [](https://expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout.](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/bd476bf3_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout. Tamms IL [Get rates](https://expedia.ca/Hotel-Search?startDate=27%2F12%2F2025&endDate=28%2F12%2F2025&selected=109109006&PinnedHotelID=109109006&HadPinnedHotel=true®ionId=6626) 9.8/10 Exceptional! (23 reviews) [](https://expedia.ca/Tamms-Hotels-Attention-Hunters-Deer-Camp.h109109006.Hotel-Information) ![La Center Motel](https://images.trvl-media.com/lodging/100000000/99670000/99665300/99665264/6218157c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### La Center Motel 474 W Kentucky Dr La Center KY [Get rates](https://expedia.ca/Hotel-Search?startDate=27%2F12%2F2025&endDate=28%2F12%2F2025&selected=99665264&PinnedHotelID=99665264&HadPinnedHotel=true®ionId=6626) 7.8/10 Good! (16 reviews) [](https://expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information) ## Hotels in Cairo with star-rating ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 1 properties [](https://expedia.ca/3Star-Cairo-Hotels.s30-0-d6626.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 6 properties [](https://expedia.ca/2Star-Cairo-Hotels.s20-0-d6626.Travel-Guide-Filter-Hotels) ## Recent reviews of Cairo hotels ![Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286](https://images.trvl-media.com/lodging/54000000/53860000/53856300/53856204/f8ac9a8a_y.jpg) ### Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286 5/5 Excellent "We loved our stay in this country location. It was quiet and peaceful yet close enough to Paducah for shopping and restaurants. The home was spotless, and every amenity was available - basic kitchen supplies (mixer, oil, sugar, spices, and much more), lots of towels and blankets and pillows, wifi and TV, washer and dryer, and more I'm probably not thinking of.It was very cold and snowy during our visit, so we made the home a cozy place to watch movies and relax. We even had our three small dogs with us, and there was lots of yard space to walk them.If you visit here, don't miss the National Quilt Museum. It's not your grandmother's quilt - it's amazing fabric art! Oh, and we found a vegan restaurant we liked: Branch Out.Definitely recommend staying here!!!" A verified traveller from Godfrey, IL, USA stayed at Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286 Posted 6 days ago [](https://expedia.ca/Quiet-Home-On-Horse-Farm.h53856204.Hotel-Information) ![Charming cottage overlooking Lake Acre](https://images.trvl-media.com/lodging/40000000/39680000/39671200/39671140/7bfe8087_y.jpg) ### Charming cottage overlooking Lake Acre 5/5 Excellent "Enjoyed our stay great hospitality, everything we needed was addressed. We would highly recommend staying there. Great location " A verified traveller stayed at Charming cottage overlooking Lake Acre Posted 8 days ago [](https://expedia.ca/Charming-Cabin-Overlooking-5-Acre-Lake.h39671140.Hotel-Information) ![Cozy cabins on beautiful Horseshoe Lake](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388_y.jpg) ### Cozy cabins on beautiful Horseshoe Lake 5/5 Excellent "The cabin was great" A verified traveller stayed at Cozy cabins on beautiful Horseshoe Lake Posted 12 days ago [](https://expedia.ca/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information) ![Charming 3-bedroom house near ball park in quiet neighborhood](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/8a1aff87_y.jpg) ### Charming 3-bedroom house near ball park in quiet neighborhood 5/5 Excellent "Host was fantastic. Property was amazing. House was cozy, spacious and very clean. It had everything we needed. Will definitely be booking again. " A verified traveller stayed at Charming 3-bedroom house near ball park in quiet neighborhood Posted 1 month ago [](https://expedia.ca/Bardwell-Hotels-Charming-3-Bedroom-House-Near-Ball-Park-In-Quiet-Neighborhood.h106623184.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg) ### Super 8 by Wyndham Charleston/Sikeston East MO 5/5 Excellent "Thank you " A verified traveller stayed at Super 8 by Wyndham Charleston/Sikeston East MO Posted 1 month ago [](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout.](https://images.trvl-media.com/lodging/110000000/109110000/109109100/109109006/bd476bf3_y.jpg) ### Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout. 5/5 Excellent "Very nice property. Loved the outdoor space and we would love to stay again! The owners are chef kiss. " A verified traveller stayed at Beer and s'mores anyone? We've got you! Hunting cabin meets weekend hideout. Posted 2 months ago [](https://expedia.ca/Tamms-Hotels-Attention-Hunters-Deer-Camp.h109109006.Hotel-Information) ![The Rested Duck Mallard Room](https://images.trvl-media.com/lodging/91000000/90340000/90331100/90331048/29d5afe7_y.jpg) ### The Rested Duck Mallard Room 5/5 Excellent "It was fine. It was fairly clean and the bed was comfortable. No where to put anything down in the bathroom. " A verified traveller stayed at The Rested Duck Mallard Room Posted 2 months ago [](https://expedia.ca/The-Rested-Duck-Mallard-Room.h90331048.Hotel-Information) ![Peaceful secluded cabin located near Horseshoe Lake ](https://images.trvl-media.com/lodging/110000000/109740000/109730100/109730068/b6736ddb_y.jpg) ### Peaceful secluded cabin located near Horseshoe Lake 5/5 Excellent "The cabin is perfect for a quiet getaway. Location is great close to Dollar General, gas station and restaurants" A verified traveller stayed at Peaceful secluded cabin located near Horseshoe Lake Posted 2 months ago [](https://expedia.ca/Peaceful-Secluded-Cabin-Located-Near-Horseshoe-Lake.h109730068.Hotel-Information) ![Quality Inn Cairo I-57](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d_y.jpg) ### Quality Inn Cairo I-57 5/5 Excellent "Break fast was excellent " A verified traveller stayed at Quality Inn Cairo I-57 Posted 3 months ago [](https://expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ## Frequently asked questions ### What are the best budget hotels in Cairo? ### When is the best time to go to Cairo? > As you venture into the peak season from March to May, you'll find an increase in tourist activity, with visitors flocking to iconic landmarks such as the Pyramids of Giza and the Egyptian Museum. The warm weather and clear skies provide an excellent backdrop for sightseeing, ensuring that you can fully appreciate the rich history and stunning architecture that Cairo has to offer. > > > For those who appreciate a more tranquil atmosphere while still enjoying the city's attractions, consider planning your visit in November. During this time, you may find fewer crowds, allowing for a more intimate experience as you explore Cairo's treasures at a leisurely pace. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Cairo hotel booking with Expedia? ### How much is the nightly rate at a Cairo hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [3 Star Hotels in West Vienna ](https://www.expedia.ca/3Star-West-Vienna-Hotels.s30-0-d553248635975864465.Travel-Guide-Filter-Hotels) - [Alto Pass Hotels ](https://www.expedia.ca/Alto-Pass-Hotels.d73449.Travel-Guide-Hotels) - [Farmstay in Anna ](https://www.expedia.ca/Anna-Agritourism.d6406-aaAgritourism.Travel-Guide-Accommodation) - [B&B in Anna ](https://www.expedia.ca/Anna-Bed-And-Breakfast.d6406-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Chalets in Anna ](https://www.expedia.ca/Anna-Chalets.d6406-aaChalets.Travel-Guide-Accommodation) - [Guest Houses in Anna ](https://www.expedia.ca/Anna-Guest-Houses.d6406-aaGuestHouses.Travel-Guide-Accommodation) - 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