Title: The 10 Best Hotels Near Fort Defiance State Park, Cairo | Expedia.ca [Vacation Rentals in Cairo](https://expedia.ca/Cairo-Vacation-Rentals.d6626.Travel-Guide-VacationRentals)[Flights to Cairo](https://expedia.ca/Cheap-Flights-To-Cairo.d6626.Travel-Guide-Flights)[Fort Defiance State Park Car Rentals](https://expedia.ca/Car-Rentals-In-Fort-Defiance-State-Park.d6091411.Car-Rental-Guide)[Fort Defiance State Park Vacations](https://expedia.ca/Fort-Defiance-State-Park-Cairo.d6091411.Vacation-Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find hotels near Fort Defiance State Park, Cairo ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 27 - Oct 28](https://www.expedia.ca/Hotel-Search?regionId=6091411&startDate=2025-10-27&endDate=2025-10-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 28 - Oct 29](https://www.expedia.ca/Hotel-Search?regionId=6091411&startDate=2025-10-28&endDate=2025-10-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6091411&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=6091411&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Star rating ## Top Hotels Close to Fort Defiance State Park ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/0feda7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 7.8 km from Fort Defiance State Park 6.6/10 (271) "Break fast was excellent " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Uma CA $93 CA $103 total includes taxes & fees Nov 7 - Nov 8 [](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO 17.5 km from Fort Defiance State Park 6.6/10 (599) "Tracey Allen checked me in. She was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $76 CA $84 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hair dryer, towels](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/2b61a8ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/d436dcb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eagle Inn Charleston 16.2 km from Fort Defiance State Park 6.8/10 (102) "Comfortable bed, easy access to room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kathy CA $92 CA $102 total includes taxes & fees Oct 28 - Oct 29 [](https://www.expedia.ca/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Desk, laptop workspace, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/94d9e92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/074a1dfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/cde4423c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Charleston - Sikeston 20.2 km from Fort Defiance State Park 6.8/10 (405) "I consistently choose to stay there due to positive past encounters." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) IMTIAZ CA $92 CA $102 total includes taxes & fees Nov 2 - Nov 3 [](https://www.expedia.ca/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-10&endDate=2025-11-11®ionId=6091411&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Fort Defiance State Park Hotel Reviews ![Drury Inn Paducah](//images.trvl-media.com/lodging/1000000/50000/42500/42447/2d58db7a_y.jpg) ### Drury Inn Paducah 10/10 Excellent "NIce place" [](https://expedia.ca/Paducah-Hotels-Drury-Inn-Paducah.h42447.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "There was no milk at breakfast. When the staff said they have none available " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Paducah](//images.trvl-media.com/lodging/8000000/7780000/7772100/7772019/a5e9bdd3_y.jpg) ### La Quinta Inn & Suites by Wyndham Paducah 10/10 Excellent "Excellent well run and clean hotel" [](https://expedia.ca/Paducah-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Paducah.h7772019.Hotel-Information) ![Pear Tree Inn Sikeston](//images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg) ### Pear Tree Inn Sikeston 10/10 Excellent "Check in was very efficient, with friendly and helpful staff." [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286](//images.trvl-media.com/lodging/54000000/53860000/53856300/53856204/f8ac9a8a_y.jpg) ### Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286 10/10 Excellent "Charming home in the country! Our friends enjoyed their stay. Would definitely return!" [](https://expedia.ca/Quiet-Home-On-Horse-Farm.h53856204.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](//images.trvl-media.com/lodging/1000000/40000/34800/34745/c7be0f94_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 10/10 Excellent "Always have a great stay when I stay here, thank you. " [](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Comfort Suites](//images.trvl-media.com/lodging/78000000/77980000/77979800/77979726/771d9df8_y.jpg) ### Comfort Suites 10/10 Excellent "Enjoy our stay, thanks to the wonderful staff." [](https://expedia.ca/Paducah-Hotels-Comfort-Suites.h77979726.Hotel-Information) ![Best Western Plus Sikeston](//images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Clean and roomy room. Friendly and helpful staff. Great breakfast." [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](//images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg) ### Super 8 by Wyndham Charleston/Sikeston East MO 10/10 Excellent "Tracey Allen checked me in. She was great!" [](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ## Hotels near other Fort Defiance State Park attractions [](https://www.expedia.ca/Columbus-Belmont-State-Park-Hotels.0-l6091579-0.Travel-Guide-Filter-Hotels) ### Columbus-Belmont State Park 3.7/5 (18 reviews) You can learn about the history of Columbus with a stop at Columbus-Belmont State Park. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6091579) [](https://www.expedia.ca/Ullin-City-Hall-Hotels.0-l6187204-0.Travel-Guide-Filter-Hotels) ### Ullin City Hall After visiting Ullin City Hall, make a plan to see the other sights and activities in Ullin. Amble around the area's parks or experience its museums. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6187204) [](https://www.expedia.ca/Limekin-Springs-Trail-Trailhead-Hotels.0-l641530566247731200-0.Travel-Guide-Filter-Hotels) ### Limekin Springs Trail Trailhead You can take time to visit Limekin Springs Trail Trailhead during your travels to Ullin. Make some time to visit the shops while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=641530566247731200) [](https://www.expedia.ca/Front-Street-Studio-Art-Gallery-Hotels.0-l553248621532655753-0.Travel-Guide-Filter-Hotels) ### Front Street Studio & Art Gallery 4.2/5 (9 reviews) You can spend time browsing the exhibits at Front Street Studio & Art Gallery during your travels in Blodgett. While in this relaxing area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655753) [](https://www.expedia.ca/Lower-Cache-River-Access-Area-Hotels.0-l877134620821561344-0.Travel-Guide-Filter-Hotels) ### Lower Cache River Access Area You can take time to visit Lower Cache River Access Area during your travels to Cypress. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=877134620821561344) [](https://www.expedia.ca/City-Of-Miner-Convention-Center-Hotels.0-l818566100963352576-0.Travel-Guide-Filter-Hotels) ### City of Miner Convention Center Learn about the events happening at City of Miner Convention Center during your trip to Miner. While in this relaxing area, you can savor the top-notch restaurants. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=818566100963352576) [](https://www.expedia.ca/Henry-N-Barkhausen-Cache-River-Wetlands-Center-Hotels.0-l553248621532655797-0.Travel-Guide-Filter-Hotels) ### Henry N Barkhausen Cache River Wetlands Center You can spend time studying the exhibits at Henry N Barkhausen Cache River Wetlands Center during your travels in Cypress. Amble around the area's parks or experience its museums. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532655797) ## Frequently asked questions ### What's the area like around Fort Defiance State Park? > Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area. ### What's the best place to stay close to Fort Defiance State Park? > [Quality Inn Cairo I-57](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include [Super 8 by Wyndham Charleston/Sikeston East MO](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) and [La Center Motel](https://www.expedia.ca/La-Center-Hotels-La-Center-Motel.h99665264.Hotel-Information). ### If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund? > Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. 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