Find hotels near Fort Defiance State Park, Cairo from CA $65

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Nov 8 - Nov 9
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Nov 9 - Nov 10
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Nov 13 - Nov 15
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Our top choices for Fort Defiance State Park hotels

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

1. La Center Motel

La Center Motel
2.0 star property
17.5 km from Fort Defiance State Park
8.0 out of 10, Very good, (25 reviews)
"Property is located just outside of town, so very convenient yet slightly off the beaten path."
United States
Carrie
The price is CA $66
CA $78 total
includes taxes & fees
Dec 8 - Dec 9
La Center Motel
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
17.5 km from Fort Defiance State Park
6.8 out of 10, (685 reviews)
"Breakfast was light but good"
United States
zandra
The price is CA $83
CA $93 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
20.2 km from Fort Defiance State Park
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is CA $94
CA $105 total
includes taxes & fees
Nov 10 - Nov 11
The Riverstone Hotel Charleston-Sikeston
A hotel lobby with a reception desk, seating area, and a large window.

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
7.8 km from Fort Defiance State Park
6.4 out of 10, (296 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is CA $97
CA $108 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cairo I-57
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

5. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
16.2 km from Fort Defiance State Park
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is CA $93
CA $104 total
includes taxes & fees
Nov 9 - Nov 10
Eagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Compare popular hotels close to Fort Defiance State Park

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.
La Center Motel
2.0 star property
8.0
Very good
25 reviews
View
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
6.8
685 reviews
View
A building with a fountain and flower beds in front.
The Riverstone Hotel Charleston-Sikeston
2.5 star property
6.8
443 reviews
View
A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57
2.5 star property
6.4
296 reviews
View
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
Eagle Inn Charleston
2.0 star property
6.6
107 reviews
View

Other attractions near Fort Defiance State Park

Columbus-Belmont State Park

7.4/10 (23 reviews)
You can learn about the history of Columbus with a stop at Columbus-Belmont State Park.
See properties

Top Fort Defiance State Park Hotel Reviews

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston

10/10 Excellent

Manager’s reception is a hit!
Canada
Thomas R
Reviewed April 29, 2026
Drury Inn & Suites Sikeston, MO

Frequently Asked Questions

What's the area like around Fort Defiance State Park?

Fort Defiance State Park is located in Cairo. When you want to settle in and find a place to stay, check out some of the hotels and other accommodations that Expedia offers in the area.

What's the best place to stay close to Fort Defiance State Park?

Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.8 mi (7.8 km) from Fort Defiance State Park. Other good choices around the area include Super 8 by Wyndham Charleston/Sikeston East MO and The Riverstone Hotel Charleston-Sikeston.

If I need to cancel the hotel reservation for my stay near Fort Defiance State Park, will I receive a refund?

Yes! The majority of hotel reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If your reservation is non-refundable, you may still be able to cancel and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then filter by "fully refundable" to review the best options available near Fort Defiance State Park.

Where can I learn more about changing or cancelling my trip in the area near Fort Defiance State Park?

For more information about updating your stay near Fort Defiance State Park or cancelling it, head over to our customer service page.

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