
Cairo Vacation Packages
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Your Cairo Vacation
The exciting city of Cairo is calling. Discover its hot spots and hidden treasures with a Cairo vacation package that's custom made for you. Need some ideas on what to do or see first during your trip to Cairo? Head straight for famous attractions like Fort Defiance State Park. No matter your travel plans or the size of your budget, putting together a tailored Cairo vacation is simple with Expedia.
Cairo Hotel Deals

Quality Inn Cairo I-57
13201 Kessler Road, Cairo, IL
Fully refundableReserve now, pay when you stay
The price is CA $100 per night from Aug 10 to Aug 11
CA $100
CA $111 total
Aug 10 - Aug 11
includes taxes & fees
6.4/10 (263 reviews)
"It was ok. We were just passing by"
Reviewed on Jun. 10, 2025

Super 8 by Wyndham Charleston/Sikeston East MO
310 S Story St, Charleston, MO
Fully refundableReserve now, pay when you stay
The price is CA $83 per night from Aug 3 to Aug 4
CA $83
CA $92 total
Aug 3 - Aug 4
includes taxes & fees
6.6/10 (576 reviews)
"Located very close to the expanse of corn fields, quiet, clean rooms, everything is neat, the bathroom is also very clean. Friendly receptionist."
Reviewed on Aug. 1, 2025

Quality Inn Charleston - Sikeston
102 Drake St, I-57 Exit 10, Charleston, MO
Fully refundableReserve now, pay when you stay
The price is CA $94 per night from Aug 13 to Aug 14
CA $94
CA $104 total
Aug 13 - Aug 14
includes taxes & fees
6.8/10 (396 reviews)
"I consistently choose to stay there due to positive past encounters."
Reviewed on Jul. 30, 2025
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.