A steel bridge with a sunset in the background.

Find Family Hotels in Cairo, IL from CA $95

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Check availability on Cairo Family Hotels

Tonight
Oct 12 - Oct 13
Tomorrow
Oct 13 - Oct 14
This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Our top choices for Cairo family-friendly hotels

A hotel lobby with a reception desk, seating area, and a large window.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.
A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

1. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
  • Quiet family comfort with free breakfast and modern amenities along the Mississippi River makes this hotel perfect for stress-free trips.
CA $98
CA $109 total
includes taxes & fees
Nov 2 - Nov 3
Quality Inn Cairo I-57
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
  • Unleash family fun in Charleston with premium TV channels, pay movies, and free cribs, all while friendly staff elevate your stay.
CA $85
CA $95 total
includes taxes & fees
Oct 13 - Oct 14
Super 8 by Wyndham Charleston/Sikeston East MO
A building with a fountain and flower beds in front.
A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.
A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
  • Kids stay active and happy with free activities, family-friendly rooms, and morning meals at this welcoming Charleston hotel.
CA $95
CA $106 total
includes taxes & fees
Oct 14 - Oct 15
The Riverstone Hotel Charleston-Sikeston
A loft-style room with a wooden interior, a sofa, a table with a pumpkin decoration, and a staircase leading to an upper level.
A wooden cabin in a forest with a gravel path leading to it.
A cabin interior with a wooden interior, a staircase, a bed, a sofa, and a dining area.
A loft-style bedroom with a wooden ladder leading to a lofted sleeping area, a bed with black bedding, and a small kitchenette with a microwave and sink.

4. Peaceful secluded cabin located near Horseshoe Lake

Peaceful secluded cabin located near Horseshoe Lake
Miller City
CA $180
CA $287 total
includes taxes & fees
Oct 13 - Oct 14
Peaceful secluded cabin located near Horseshoe Lake
A room with a pool table, a sofa, and a dining table with chairs.
A ping pong table in a room with wooden walls and large windows.
A spacious room with a large wooden dining table, several chairs, a ceiling fan, and a television.
A cozy living room with a fireplace, wooden walls, and comfortable seating.

5. Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge

Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
Villa Ridge
CA $257
CA $379 total
includes taxes & fees
Oct 13 - Oct 14
Peaceful 2-bedroom cabin with AC in welcoming Villa Ridge
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.
A living room with a gray sofa, a patterned rug, wooden flooring, a ceiling fan, a wall-mounted lamp, and a framed picture.
A small, single-story house with a front porch and a gravel driveway.
A kitchen with white cabinets, a stainless steel refrigerator, a coffee maker, and a trash can.

6. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
CA $212
CA $414 total
includes taxes & fees
Oct 13 - Oct 14
Quiet Country Stay: Modern Home Near Paducah
A modern kitchen with white cabinetry, stainless steel appliances, and a window with a view of greenery.
A living room with a gray sofa, a patterned rug, wooden flooring, a ceiling fan, a wall-mounted lamp, and a framed picture.
A bedroom with a wooden bed, a bedside table with a lamp, a window with curtains, and a view of the outdoors.
A kitchen with white cabinets, a stainless steel refrigerator, a coffee maker, and a trash can.

7. Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
Cunningham
CA $155
CA $424 total
includes taxes & fees
Oct 13 - Oct 14
Quiet Country Stay: Modern Home Near Paducah
A modern kitchen with a built-in microwave, stainless steel appliances, and a sink.
A dining area with a coffee bar sign, a sign reading "Home Sweet Home", and a table with snacks, wine, and coffee equipment.
A house with a porch, a blue Adirondack chair, and a black door.
A kitchen with a stove, a spice rack, and a 'Welcome' sign.

8. Charming Home just minutes from Interstate and Mall

Charming Home just minutes from Interstate and Mall
Kevil
CA $157
CA $296 total
includes taxes & fees
Oct 13 - Oct 14
Charming Home just minutes from Interstate and Mall
View all properties

Choose what matters most at family-friendly hotels in Cairo

Breakfast included
Pool
All-inclusive
4 stars
5 stars

Top Cairo Hotel Reviews

Quality Inn Cairo I-57

Quality Inn Cairo I-57

8/10 Good
"Good service,nice stuff and no complaints"
Santiago 1-night trip
Posted 1 month ago
Quality Inn Cairo I-57

Frequently asked questions

What's Cairo like for family-friendly vacations?
You might want to consider the historic destination of Cairo if you've been thinking about a trip for the whole family. The entertainment, restaurants, and libraries are just a few things that make this an attractive spot for a family vacation. Arrange a flight into Cairo, IL (CIR-Cairo Regional), which is the closest airport, or Paducah, KY (PAH-Barkley Regional), which is located 22.9 mi (36.8 km) from the city center.
What's the best hotel for a family vacation to Cairo?
Quality Inn Cairo I-57 is a hotel with free parking and free breakfast, and it's a top choice on Expedia for families.
When's the best time to book a family-friendly vacation in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.
What's there to see and do with your family in Cairo?
While you and the family are vacationing in Cairo, you might want to get outside and enjoy the great outdoors at spots such as Mississippi River, Ohio River Valley, and Shawnee National Forest. Make sure you have time to check out activities like Ohio River and Fort Defiance State Park.

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