Sikeston

Travel Guide

A tree with sunlight filtering through its leaves, creating a warm glow.
A person walking through a cornfield.
A building with three tall chimneys, surrounded by blooming trees with pink and white flowers.
A sign for Lambert's, a place of worship.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
The price is CA $134 per night from Nov 22 to Nov 23
CA $134
CA $154 total
Nov 22 - Nov 23
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
Drury Inn & Suites Sikeston, MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
The price is CA $95 per night from Nov 18 to Nov 19
CA $95
CA $108 total
Nov 18 - Nov 19
includes taxes & fees
Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff and the clean ...
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston

Hampton Inn Sikeston

2.5 out of 5
1240 Commerce Drive Sikeston MO
The price is CA $143 per night from Nov 22 to Nov 23
CA $143
CA $163 total
Nov 22 - Nov 23
includes taxes & fees
Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ...
9/10 Wonderful! (661 reviews)
"Everything was great. Room was clean. Fitness center was nice"

Reviewed on Nov 15, 2026

Hampton Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Rest, Relax and Renew. Our log cabin experience awaits your arrival.

Anna IL
Stay at this cabin in Anna. Enjoy a garden, patios, and cable/satellite TV service. Our guests praise the helpful staff and the property condition in our reviews. ...
10/10 Exceptional! (432 reviews)
"The room was very clean, the host was accommodating and responded very quickly. It's very peaceful and quiet and would definitely recommend if you are looking to unwind and relax. If you are looking for things to do in the area there was a book with all kinds of places to go explore or eat and the ..."

Reviewed on Oct 25, 2026

Rest, Relax and Renew. Our log cabin experience awaits your arrival.
3  Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

Makanda IL
Book a stay at this golf cabin in Makanda. Enjoy free WiFi, a garden, and patios. Popular attractions Stone Creek Golf Club and Resort and Makanda Boardwalk ...
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

Cape Girardeau MO
Stay at this vacation home in Cape Girardeau. Enjoy free WiFi, laundry facilities, and an in-room coffeemaker. Popular attractions Show Me Center and Century ...
9.8/10 Exceptional! (40 reviews)
"Perfect location to stay whilst visiting our daughter at SEMO. Katrina was super helpful and she even had the house decorated for Halloween."

Reviewed on Nov 10, 2026

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions