Panama Vacations & Trips 2025 from $549

Your Panama Vacation

Reserve a vacation package to Panama and make travel planning quick and easy. With the finer details organized before you leave, you can focus on enjoying every moment in this destination. Your trip to Panama wouldn't be complete without exploring some of its best cities, starting with Tocumen. Some of the top attractions here include Metromall Panama and Los Pueblos Commercial Centre. Rio Hato should also be on the itineraries of all Panama travellers. Visitors to this city love Playa Blanca and Santa Clara Beach. When you're ready to stop dreaming and start doing, Expedia will help turn your Panama vacation into reality.

Top Panama Vacation Deals

Price found within the past 48 hours. Click for updated prices.

Central Hotel Panama Casco Viejo

Casco Viejo

Save 100% on your flight

per person

Aug 18 - Aug 25

found 20 hours ago

Roundtrip non-stop flight included

Edmonton (YEG) to Panama City (PTY)

9/10 Wonderful! (925 reviews)

Property was in a great location and the the breakfast was really good.

Reviewed on Jun. 29, 2025

The Sands by Wynwood House

Calidonia

Save 100% on your flight

per person

Sep 26 - Oct 3

found 16 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to Panama City (PTY)

No reviews

The Gray by Wynwood House

Bella Vista

Save 100% on your flight

per person

Sep 6 - Sep 13

found 20 hours ago

Roundtrip non-stop flight included

Toronto (YYZ) to Panama City (PTY)

No reviews

Punta Caracol Acqua Lodge

Punta Caracol

Save 100% on your flight

per person

Sep 12 - Sep 19

found 1 day ago

Roundtrip non-stop flight included

Toronto (YYZ) to Panama City (PTY)

8.8/10 Excellent! (143 reviews)

Good place for relax and enjoy good vacations with the family

Reviewed on Apr. 6, 2025

Coral Bay Bungalows

Save 100% on your flight

per person

Aug 22 - Aug 31

found 1 day ago

Roundtrip flight included

Calgary (YYC) to Panama City (PTY)

No reviews

Panama Vacation

While Panama is perhaps best known for its mighty canal, there’s so much more to this Central American country. Visitors will also be wowed by lush rainforests, idyllic beaches, rich indigenous culture and a unique colonial history.

Panama Hotel + Flights

Expedia has 3,214 hotels available here starting at CA $163 a night. But if you want to save some serious money, combine your hotel and flights into a Panama Vacation Package. You can also add car rental and activities to your booking to create an unforgettable getaway. With the dollars you save, why not book a tour and visit island paradises or taste famous local flavours like ceviche?

Your Panama Vacation Itinerary

Day 1-2: Start your adventure in the national capital, Panama City, and head straight to Casco Viejo (the Old Quarter). Wander narrow cobblestone streets and discover colourful Spanish colonial houses, beautiful churches and an impressive gastronomic scene. Plan a day trip to the Panama Canal to watch mammoth ships slip through the Miraflores Locks.

Day 3-5: Stay on some of the world’s most spectacular islands in San Blas. Owned and operated by the Kuna people, this untouched paradise on the Caribbean side of Panama is the perfect place to live out your Robinson Crusoe fantasies.
Day 6-8: Head back to Panama City and fly to the mountain town of Boquete. A top destination for outdoor lovers, it offers jungle hikes, whitewater rafting, canopy tours, zip lining and more.

Panama Information

Party with the locals at Carnival, Panama’s largest annual celebration. You’ll find the biggest events in Panama City and Las Tablas.
If you’ll be spending most of your time in the nation’s capital, check out ourPanama City Vacation PackagesOpens in a new window.
Want to really experience the carefree vibe of this Latin American gem? Book one of ourPanama All Inclusive Resortsand say adios to vacation planning stress.

Panama Hotel Deals

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella, Panama City, Panama

9/10 Wonderful! (4,055 reviews)

"excelente desayuno"

Reviewed on Jul. 3, 2025

Get rates

The Westin Playa Bonita Panama

Km 6 Road to Veracruz, Veracruz, Panama

Fully refundableReserve now, pay when you stay

CA $202

CA $223 total

Jul 11 - Jul 12

includes taxes & fees

8/10 Very Good! (1,001 reviews)

"Property was clean. Very friendly staff. I wish they had more activities."

Reviewed on Jul. 3, 2025

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz, Corregimineto De Tocumen Hacia El, Tocumen, Panama

Fully refundable

CA $163

CA $180 total

Jul 26 - Jul 27

includes taxes & fees

8.4/10 Very Good! (2,125 reviews)

"Many thanks for the comfortable travel!"

Reviewed on Jul. 4, 2025

See all 3,214 properties in Panama

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Panama vacation package cost?

Custom build your Panama vacation package from a low CA $1,541. Choose from any combination of rental cars, flights and hotels to pull together the trip you've been dreaming about. Remember to add on some activities and experiences!

How do I get a cheap travel package to Panama?

One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Hotels, flights, rental cars and activities --- we've got them all. Select the combination that suits you and watch your savings stack up. Of course, a package deal is never one-size-fits-all. That's why we offer over 550 airlines and 1,000,000 hotels worldwide, which lets you customize your Panama vacation.

Where should I stay in Panama?

Panama City is a great place to visit. It draws in many visitors who come to check out its biggest sights, such as Bridge of the Americas and Miraflores Locks.

What are the top hotels in Panama?

When it comes to hotels in Panama City, Hotel Riu Plaza Panama and Crowne Plaza Panama Airport, an IHG Hotel are two terrific options. If you're also visiting Bocas del Toro, Playa Tortuga Hotel Beach And Resort and Azul Paradise will make you feel at home.

How far in advance should I book my Panama vacation?

It's difficult to pick the ideal time for airfares, but we usually say the earlier, the better. Most international journeys on Expedia become available up to 12 months in advance. If you're booking last minute, fear not. Discounted prices appear from time to time just weeks before departure dates.

What does an Expedia Panama travel package include?

Hotels, rental cars and flights, or any combination of them --- it's up to you! Whether you're venturing to Panama with the kids or traveling solo, there's a package to fit your budget and style. Once you've made your booking, why not add on one or two tours or activities?

What should I know before booking a Panama travel package?

A travel package can be customized for your budget and is a terrific way to make your hard-earned dollars stretch further. How much you include is up to you. Rental cars, hotels and flights --- come up with a combination that suits your plans.

Can I choose my airline with a Panama Expedia vacation package?

Yes --- and it's simple too. Expedia has access to more than 550 partner airlines all over the world. Our packages give you the flexibility to pick from available flights, hotels and activities that fit your needs.

If I'm not able to travel, can I cancel my Panama vacation package?

Because we know life is full of surprises, the answer is yes. For further information, head to our Customer Service Portal. But generally speaking, if you've made your booking in the last 24 hours, you may be able to change or cancel it for free. Your airline, hotel or car rental company may impose a fee if you made your booking a while ago.

Discover the most popular places to visit in Panama

Playa Blanca

4.5/5(9 reviews)

Nothing says vacation like spending a lazy day at Playa Blanca, a popular beach in Rio Hato. Amble around this family-friendly area's seaside or experience its entertainment venues.