Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Downtown San Diego Apartment Hotel

See all 152 Hotels in Downtown San Diego
Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

Residence Inn by Marriott San Diego Downtown/Gaslamp Quarter

356 6th Avenue, San Diego
3.0 out of 5.0
4.5 out of 5 (320 reviews)
Great Location and in the middle of gaslampThe Check-IN is really easy and fast, which is great after a two hour drive from LA. The hotel is also really close to everything and is walking distance from our room which made it really easy. I also liked the location because it is really close to the night life. i would recommend this hotel to ...
  16 Oct 2017

C$186

C$186
Inn at the Park

Inn at the Park

525 Spruce St, San Diego
3.0 out of 5.0
4.3 out of 5 (386 reviews)
Close to everything San Diego! Close to everything; quiet, clean, always friendly. Valet parking excellent but plenty of street parking available in 1-3 blocks if you don’t mind walking. Beverages complimentary and kitchen appliances and amenities more than adequate. Rooftop lounge and outdoor space a haven and the wine and cheese ...
  7 Oct 2017

C$186

C$186
Residence Inn by Marriott San Diego Downtown

Residence Inn by Marriott San Diego Downtown

1747 Pacific Hwy, San Diego
3.0 out of 5.0
4.2 out of 5 (99 reviews)
Nice close to great food and drink choices Very nice staff I would definitely stay here when we visit San Diego again, close to everything.
  7 Oct 2017

C$174

C$174
Parc Suites

Parc Suites

506 22nd Street, San Diego
3.0 out of 5.0
4.6 out of 5 (22 reviews)
Apartments are the way forward!!You just turn up having foretold the owner and that's it - you're up and away!!! You feel like it's your place not just a room. Adequate space and good TV, kitchen facilities. Very comfy bed. Will aim for an apartment again!!
  25 May 2017
2BR Craftsman Home in South Park by RedAwning

2BR Craftsman Home in South Park by RedAwning

2128 Fern St, San Diego
3.0 out of 5.0
4BR House with Rooftop Views by RedAwning

4BR House with Rooftop Views by RedAwning

613 W Maple St, San Diego
3.5 out of 5.0
A King's View in Mission Hills by RedAwning

A King's View in Mission Hills by RedAwning

1019 W Palm St, San Diego
4.0 out of 5.0
City and Bay Views in Banker Hill by RedAwning

City and Bay Views in Banker Hill by RedAwning

448 1 2 W Kalmia St, San Diego
3.5 out of 5.0
Close to Gaslamp and Convention Center

Close to Gaslamp and Convention Center

1670 Kettner Blvd, San Diego
3.5 out of 5.0
3.0 out of 5 (1 reviews)
Eco Studio

Eco Studio

3270 Cedar Street, San Diego
3.0 out of 5.0
Map

Recently booked Downtown San Diego hotels

The Horton Grand Hotel
3.5 out of 5.0
Last booking: 1 minute ago
Pendry San Diego
5.0 out of 5.0
Last booking: 3 minutes ago
The Westin San Diego Gaslamp Quarter
4.0 out of 5.0
Last booking: 17 minutes ago
Andaz San Diego
4.0 out of 5.0
Last booking: 22 minutes ago
The Westin San Diego
4.0 out of 5.0
Last booking: 23 minutes ago
Hard Rock Hotel San Diego
4.0 out of 5.0
Last booking: 25 minutes ago
Comfort Inn Gaslamp Convention Center
2.5 out of 5.0
Last booking: 25 minutes ago
Embassy Suites by Hilton San Diego Bay Downtown
4.0 out of 5.0
Last booking: 26 minutes ago
Residence Inn by Marriott San Diego Downtown/Bayfront
3.0 out of 5.0
Last booking: 51 minutes ago

Pocket Guide: Apartment Hotel in Downtown San Diego

Search for hotels in Downtown San Diego on Expedia. You can easily find your hotels in Downtown San Diego using one of the methods below:

  • View our selection of featured hotels in Downtown San Diego
  • Use the map to find hotels in the Downtown San Diego neighborhood you prefer
  • Use the filters to see hotels in a specific area of Downtown San Diego, select a specific theme, brand, or hotel class from basic (1 Star) to luxury hotels (5 Stars) in Downtown San Diego
  • Enter your travel dates to view the best deals on hotels in Downtown San Diego - while they last