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Sikeston Vacation Rentals

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Our top choices for Sikeston vacation homes

1. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $114
CA $141 total
includes taxes & fees
Nov 11 - Nov 12
Little Blue Cottage on Spanish

2. The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO
Dexter
10.0 out of 10, Exceptional, (4 reviews)
"Perfect place for our stay on the way to North Carolina! Clean, cozy and convenient!"
United States
Robert G.
The price is CA $198
CA $232 total
includes taxes & fees
Nov 16 - Nov 17
The Cutie Patootie on Helen- Cute, Cozy, Comfortable - 3 BR Home in Dexter, MO

3. Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy
Dexter
8.0 out of 10, Very good, (40 reviews)
"Overall, it was a good experience. I would stay again."
United States
Tammy G.
The price is CA $151
CA $291 total
includes taxes & fees
Nov 11 - Nov 12
Dexter Victorian Homestead- Brand NEW Remodel April 2026. VERY Clean & Cozy

4. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is CA $219
CA $305 total
includes taxes & fees
Nov 11 - Nov 12
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

5. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is CA $219
CA $305 total
includes taxes & fees
Nov 11 - Nov 12
The Little Château | Woodland Escape

6. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is CA $147
CA $246 total
includes taxes & fees
Nov 16 - Nov 17
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

7. The Little Cape Lofted Cottage | Creek & Nature

The Little Cape Lofted Cottage | Creek & Nature
Cape Girardeau
9.0 out of 10, Wonderful, (2 reviews)
"It was very clean and had a good feel. It was well stocked. I appreciated the cute little ice tray in the freezer that was full. I also appreciated 4 waters in the fridge. The bed on the loft upstairs was atrocious. You can feel the springs through the mattress. The downstairs bed was good. The pillows were fantastic! I’m a pillow snob. We needed a quick place to land for a church function so I can’t say much about the outside amenities as we weren’t there much. But it was a beautifully tucked...
United States
Trisha S.
The price is CA $227
CA $314 total
includes taxes & fees
Nov 11 - Nov 12
The Little Cape Lofted Cottage | Creek & Nature

8. 3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool
Cape Girardeau
8.8 out of 10, Excellent, (46 reviews)
"Will definitely book again! Great location, comfortable stay."
United States
Pynktoria !.
The price is CA $253
CA $427 total
includes taxes & fees
Nov 11 - Nov 12
3+ acre Home: Pool Table, Putt-Putt, 4 miles to Downtown and SEMO, Summer Pool

9. Beautifully Renovated Farmhouse in Jackson, MO

Beautifully Renovated Farmhouse in Jackson, MO
Jackson
9.4 out of 10, Exceptional, (3 reviews)
" great stay,property landscape nicely manicured, quiet and relaxing inside and outside of the the dwelling."
United States
Sandy S.
The price is CA $282
CA $422 total
includes taxes & fees
Nov 11 - Nov 12
Beautifully Renovated Farmhouse in Jackson, MO

10. 4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More
Cape Girardeau
9.8 out of 10, Exceptional, (11 reviews)
"Nice place, great times"
United States
Jace W.
The price is CA $507
CA $782 total
includes taxes & fees
Nov 11 - Nov 12
4-Bedroom Home - 2 King Beds, Summer Pool, Pool Table, Air Hockey + More

11. Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid
10.0 out of 10, Exceptional, (1 review)
"The host was very quick to respond and so great to work with for on our stay. "
United States
Jessica S.
The price is CA $282
CA $499 total
includes taxes & fees
Nov 11 - Nov 12
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

12. Peach Tree Inn, downtown Cobden

Peach Tree Inn, downtown Cobden
Cobden
10.0 out of 10, Exceptional, (3 reviews)
"Amazing place to stay. Excellent location, beautiful rooms and accommodation and the host was so responsive. We will definitely be back!"
United States
Rebecca L.
The price is CA $262
CA $313 total
includes taxes & fees
Nov 17 - Nov 18
Peach Tree Inn, downtown Cobden

13. Hunting / Fishing Cabin at Lake Wappapello

Hunting / Fishing Cabin at Lake Wappapello
Williamsville
8.0 out of 10, Very good, (1 review)
"The coffee pot looked like it hadn't been used for a while. Bathrooms and beds were very nice."
United States
Donna M.
The price is CA $186
CA $337 total
includes taxes & fees
Nov 11 - Nov 12
Hunting / Fishing Cabin at Lake Wappapello

14. Stunning 2 bedroom in town, close to Shawnee National Forest

Stunning 2 bedroom in town, close to Shawnee National Forest
Jonesboro
10.0 out of 10, Exceptional, (15 reviews)
"The place was nice and clean and the hosts were great. Would definitely stay there again!"
United States
Katlynn R.
The price is CA $194
CA $387 total
includes taxes & fees
Nov 11 - Nov 12
Stunning 2 bedroom in town, close to Shawnee National Forest

15. Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass
Alto Pass
10.0 out of 10, Exceptional, (5 reviews)
"The house was very welcoming and clean. Very inviting for our short stay. "
United States
brian O.
The price is CA $247
CA $354 total
includes taxes & fees
Nov 24 - Nov 25
Walk to Weddings-Wineries-Trails, Family Friendly Home in Downtown Alto Pass

16. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (30 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is CA $141
CA $227 total
includes taxes & fees
Nov 16 - Nov 17
Cozy and Updated Farmhouse with King Suite

17. The Weber Farm - Enjoy a beautiful 100 acre farm!

The Weber Farm - Enjoy a beautiful 100 acre farm!
Frohna
10.0 out of 10, Exceptional, (34 reviews)
"Wonderful time! "
United States
Alison C.
The price is CA $184
CA $285 total
includes taxes & fees
Dec 1 - Dec 2
The Weber Farm - Enjoy a beautiful 100 acre farm!

18. Magical Victorian near hiking / wine trail

Magical Victorian near hiking / wine trail
Anna
10.0 out of 10, Exceptional, (21 reviews)
"Everything was beautiful, and although we weren’t there for a long time, enjoyed an Incredible sleep in the most comfortable beds!"
United States
Rachel H.
The price is CA $251
CA $471 total
includes taxes & fees
Nov 15 - Nov 16
Magical Victorian near hiking / wine trail

19. Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda

Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda
Makanda
10.0 out of 10, Exceptional, (3 reviews)
"Easy check-in process and super convenient location to SIU, Carbondale, and the wine trail. Ample space and 2-car garage made it perfect for a group.Only room for improvement would be having central air or cooling options in the bedrooms.Overall great stay"
United States
Adam D.
The price is CA $152
CA $180 total
includes taxes & fees
Nov 16 - Nov 17
Convenient, Cozy and Pet Friendly 2-bedroom home in Beautiful Makanda

20. The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit

The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit
Murphysboro
8.0 out of 10, Very good, (1 review)
"Place overall was decent, it was clean enough. The hot tub and fire pit were a nice touch. The house is very close to the road and there is constant traffic noise even late at night. It is also advertised as more upscale than it was. We noticed several areas of the house that looked like the landlord special took place in getting it ready. Some of the doors didn’t close properly or were only on a single set of hinges instead of multiple. The dining chairs too were not in great shape, they had...
United States
Calista
The price is CA $138
CA $321 total
includes taxes & fees
Dec 1 - Dec 2
The Lux Collective- Private Hot Tub, Dry Bar, 1-Acre Yard & Fire Pit
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Sikeston Hotel Reviews

Find out more about Sikeston

Sikeston Vacation Homes information

Number of reviews
261
Accommodation
101 Vacation Homes
Lowest Price
CA $141
Highest Price
CA $782

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