A calm body of water, a sandy beach, and a forested area in the distance.

Find Hotels by Independent in Cape Girardeau

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Sep 15 - Sep 16
Tomorrow
Sep 16 - Sep 17
This weekend
Sep 18 - Sep 20
Next weekend
Sep 25 - Sep 27
Save an average of 15% on thousands of hotels when you're signed in

Top Cape Girardeau Hotel Reviews

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

10/10 Excellent
"Clean room, nice comfortable beds. It was very quiet and we felt very safe. The only drawback was the toilet was too low."
Judy 1-night trip
Posted 19 hours ago
Pear Tree Inn Cape Girardeau West
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau

10/10 Excellent
"Had A Wonderful Weekend on this property. Very home feeling! The Moore family gives some really nice gifts for you, which is a very nice jester."
April P. 3-night trip
Posted 21 hours ago
3 Bed 3 Bath Beautiful Historic District Within Walking Downtown Cape Girardeau
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

10/10 Excellent
"Excellent hotel!! Great water pressure in showers!"
Stacey 2-night trip
Posted 2 days ago
Tru By Hilton Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Great experience- food, cleanliness, friendly staff"
Patti 1-night trip
Posted 2 days ago
Drury Plaza Hotel Cape Girardeau Conference Center
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent
"Excellent breakfast,friendly staff and clean rooms"
Serapia 1-night trip
Posted 3 days ago
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau

10/10 Excellent
"The receptionist was very courteous. Helped answer all my questions. We loved the room. And we had a great breakfast before we left."
David 1-night trip
Posted 7 days ago
Fairfield Inn & Suites by Marriott Cape Girardeau
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

8/10 Good
"The outside needed cleaning, but the room was very clean and well maintained."
Michael p 1-night trip
Posted 11 days ago
Town House Inn Cape Giradreau
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

10/10 Excellent
"Beautiful house. Polite and accommodating owner. Wonderful stay"
Ted P. 2-night trip
Posted 3 weeks ago
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

10/10 Excellent
"I cannot say enough about the hosts. I messed up my dates. They immediately found me a place to cover the night. I had expected to have to find a hotel but they smoothly moved us into a nearby property. It was such a relief. Both houses are perfect for our needs. Small but they had everything we needed. The Eden house was a lovely old carriage house. Beautifully done. Very comfortable. The little blue house is also small but again perfect. Both are less than a block from our new favorite Tapas bar. The location was perfect. We could get everywhere we needed to go off one of the two cross streets. The house could use some updates, but it seems like they are doing that. Everything worked. The AC did an amazing job keeping up with the extreme heat. The bed was extremely comfortable for both of us, which doesn't usually happen. One cautionary note, the extremely comfortable bed was extremely high. It took me a few tries to figure out how to get into it. If you have mobility issues you may want to ask for the other house.These hosts made our stay in Cape a lovely one. And I cannot thank them enough for going out of their way to solve a problem I created. They were wonderful and I will stay with them again anytime the need arises."
Charlene W. 3-night trip
Posted 1 month ago
Little Blue Cottage on Spanish

Explore a world of travel with Expedia