Santa Ana Vacation Packages

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Your Santa Ana Vacation

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana vacation package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're traveling with and whatever you want to spend, your dream Santa Ana vacation is just clicks away with Expedia.

Top Holiday Package Deals in Santa Ana

Price found within the past 48 hours. Click for updated prices.
Villa Botero By Casa Mojito B&B

Villa Botero By Casa Mojito B&B

3 out of 5
per person
Oct 10 - Oct 15
found 8 hours ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
9.8/10 Exceptional! (60 reviews)
Host was excellent. Great communication and very helpful. The rooms were nice and great value.

Reviewed on Apr. 18, 2025

Casa Fofo Family House

Casa Fofo Family House

3 out of 5
per person
Oct 10 - Oct 15
found 8 hours ago
Roundtrip flight included
Toronto (YYZ) to Panama City (PTY)
No reviews
Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
per person
Oct 11 - Oct 18
found 1 day ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
No reviews
NAYARA Bocas del Toro

NAYARA Bocas del Toro

4 out of 5
per person
Oct 11 - Oct 18
found 1 day ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
10/10 Exceptional! (52 reviews)
Very quiet and isolated, Far from the maddening crowd. Fantastic service, great food.

Reviewed on Mar. 5, 2025

La Coralina Island House

La Coralina Island House

3.5 out of 5
per person
Sep 21 - Sep 28
found 4 hours ago
Roundtrip flight included
Montreal (YUL) to Panama City (PTY)
9.4/10 Exceptional! (82 reviews)
Wow! This resort is absolutely amazing! Bekar went above and beyond for us! He even brought in a TV to the lobby so we could watch the NHL playoff game! Food is 10/10 as well. We will definitely go back!

Reviewed on May 18, 2025

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
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Casco Viejo

4/5(32 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Santa Ana Hotel Deals

Casco View Apartments

Casco View Apartments

3 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
9.2/10 Wonderful! (41 reviews)
"Very helpful and offered great suggestions. Cant wait to return!"

Reviewed on Jul. 12, 2025

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Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is CA $153 per night from Aug 27 to Aug 28
CA $153
CA $169 total
Aug 27 - Aug 28
includes taxes & fees
9/10 Wonderful! (4,140 reviews)
"Enjoyed our stay. The place is very clean and staff was very helpful. Its very to close to everything. We will be back for sure."

Reviewed on Jul. 28, 2025

Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
The price is CA $271 per night from Aug 27 to Aug 28
CA $271
CA $271 total
Aug 27 - Aug 28
includes taxes & fees
7.2/10 Good! (1,023 reviews)
"Beautiful resort ."

Reviewed on Jul. 25, 2025

Dreams Playa Bonita Panama - All Inclusive
See all 1,492 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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All Inclusive Vacations
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Frequently asked questions

How much does a Santa Ana vacation package cost?
From as little as CA $1,117. Yes, you read that correctly. Our Santa Ana vacation packages are an easy way to stretch your budget further. Combine your favorite hotels, flights and rental car and explore this destination your way.
How do I get a cheap travel package to Santa Ana?
One of the easiest ways to save cash (and time) is to combine your bookings with Expedia. Flights, hotels, activities and rental cars — we've got it all. Pick and choose the combination that best fits you and see your savings grow. We know a package deal is never a one-size-fits-all. That's why Expedia offers over 550 air carriers and 1,000,000 hotels throughout the world, which lets you customize your Santa Ana vacation.
Where should I stay in Santa Ana?
Most who travel to Santa Ana include both Miraflores Locks and Metropolitan Cathedral of Panama on their bucket lists. Why not go for a hotel right near these great attractions?
What are the top hotels in Santa Ana?
If it's your first time in Santa Ana, make a reservation at Hotel Riazor or Hotel Doral. Both hotels will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Santa Ana vacation?
While prices change from time to time, we generally suggest booking your seats as soon as possible. Most international airfares are available on Expedia up to a year in advance. If circumstances have left you booking late, you might still be in luck. Low prices to Santa Ana sometimes occur only weeks before departure.
What does an Expedia Santa Ana travel package include?
That mostly depends on you. You can select from a range of Santa Ana packages, such as a rental car, flight and hotel. You can also book a hotel and a flight, or a rental car and a flight. Once you've made your booking, you can add on the fun stuff like tours and activities. Whatever your perfect Santa Ana break looks like, get set to save!
What should I know before booking a Santa Ana travel package?
Discover deals to suit your budget with an Expedia package. Hotels, airfares, rental cars — we've got everything you need to plan your getaway. You'll save big dollars just for bundling your bookings. Whether you're taking off on a ski trip or getting some sun on a warm beach, your ideal getaway is only clicks away.
Can I choose my airline with a Santa Ana Expedia vacation package?
Definitely. Expedia has more than 550 airline partners to pick from globally. With all that choice at your fingertips, finding the right carrier to get you to Santa Ana shouldn't be hard.
If I'm not able to travel, can I cancel my Santa Ana vacation package?
We totally get it — life can throw you the odd curveball. If you've booked a Santa Ana vacation package and have to amend or cancel it, we're here to help. It's always worth visiting our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary at no cost. If it's been longer than 24 hours, your hotel, airline or car rental company may charge a fee.

Discover the most popular places to visit in Santa Ana

Multiplaza Pacific Mall

Multiplaza Pacific Mall

During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.

Multiplaza Pacific Mall
Cinta Costera

Cinta Costera

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Avenida Balboa

Avenida Balboa

You can find the perfect gifts to bring home at Avenida Balboa during your trip to Panama City. While you're in the area, wander around the natural setting.

Avenida Balboa

Things to do

Panama City: Poin Glass Observation Deck Ticket with VR Tour

Panama City: Poin Glass Observation Deck Ticket with VR Tour

CA $44
per adult
100% of travellers recommend
Panama City: Poin Glass Observation Deck Ticket with VR Tour
Guided Jungle Adventure with Gatun Lake Cruise

Guided Jungle Adventure with Gatun Lake Cruise

CA $122
per adult
90% of travellers recommend
Guided Jungle Adventure with Gatun Lake Cruise
Panama Canal Tour

Panama Canal Tour

CA $62
per adult
Panama Canal Tour
See all activities in Panama City
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.