Find Spa Hotels in Florida Keys from CA $194

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Check prices for these dates

Tonight
Nov 7 - Nov 8
Tomorrow
Nov 8 - Nov 9
Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22

Our top choices for Florida Keys hotels with a spa

A conference room with a large painting of a blue ocean, two Laptops, and wicker chairs.

1. Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,509 reviews)
  • cleanliness
    Luxury spa sanctuary with 7 treatment rooms offers beachside massages and tranquil gardens for ultimate rejuvenation.
The price is CA $254
CA $388 total
includes taxes & fees
Nov 19 - Nov 20
Cheeca Lodge & Spa
A modern interior with a round wooden table, two glass-top side tables, and a textured wall.

2. Faro Blanco Resort Marathon Florida Keys, Curio by Hilton

Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
4.0 star property
Marathon
8.6 out of 10, Excellent, (1,134 reviews)
  • cleanliness
    Rejuvenate at this waterfront resort's luxurious Ocean Spa with specialized massages in serene rooms.
The price is CA $194
CA $271 total
includes taxes & fees
Nov 29 - Nov 30
Faro Blanco Resort Marathon Florida Keys, Curio by Hilton
A hotel room with a bed, a dresser, a mirror, and a nightstand.

3. Reefhouse Resort & Marina

Reefhouse Resort & Marina
4.5 star property
Key Largo
9.2 out of 10, Wonderful, (1,565 reviews)
  • cleanliness
    Discover tranquil bliss at this waterfront haven with three spa rooms, private beach, and hot stone massages.
The price is CA $307
CA $401 total
includes taxes & fees
Nov 29 - Nov 30
Reefhouse Resort & Marina
A room with a bed, a ceiling fan, and a view of the ocean.

4. Southernmost Beach Resort and Guesthouses

Southernmost Beach Resort and Guesthouses
4.0 star property
Old Town Key West
8.6 out of 10, Excellent, (3,651 reviews)
  • cleanliness
    Serene beachside spa oasis offers tropical relaxation with ocean views and couples treatments.
The price is CA $283
CA $426 total
includes taxes & fees
Nov 30 - Dec 1
Southernmost Beach Resort and Guesthouses
A reception area with a wooden reception desk, a tiled wall, and a hanging light fixture.

5. Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort
4.0 star property
Key West Historic District
9.2 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Waterfront resort spa with exotic massage options and ocean views offers full-service relaxation by the Key West sunset.
The price is CA $356
CA $514 total
includes taxes & fees
Nov 22 - Nov 23
Ocean Key Resort - A Noble House Resort
Lobby

6. Opal Key Resort & Marina, Key West

Opal Key Resort & Marina, Key West
5.0 star property
Old Town Key West
9.2 out of 10, Wonderful, (1,222 reviews)
  • cleanliness
    Indulge in oceanfront spa retreats with sunset views at this tropical Key West haven just steps from Duval Street.
The price is CA $366
CA $467 total
includes taxes & fees
Nov 29 - Nov 30
Opal Key Resort & Marina, Key West
A modern hotel room with a circular white bed, a bathroom with a mirror and toiletries, and a shelf with OSEA products.

7. Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa
4.0 star property
Key West Historic District
9.2 out of 10, Wonderful, (1,002 reviews)
  • cleanliness
    Luxurious oceanfront escape with 3 spa treatment rooms offers deep-tissue massages, facials, and holistic therapies for pure rejuvenation.
The price is CA $357
CA $505 total
includes taxes & fees
Dec 1 - Dec 2
Hyatt Centric Key West Resort and Spa
A beachside spa with two massage tables under a canopy, overlooking the sea and a pier.

8. Casa Marina Key West, Curio Collection by Hilton

Casa Marina Key West, Curio Collection by Hilton
4.0 star property
Old Town Key West
8.4 out of 10, Very good, (1,009 reviews)
  • cleanliness
    Beach resort with spa offering aromatherapy, Ayurvedic treatments, and beachside massages for ultimate relaxation.
The price is CA $316
CA $451 total
includes taxes & fees
Nov 8 - Nov 9
Casa Marina Key West, Curio Collection by Hilton
A massage therapy session in a room with a city view.

9. The Reach Key West, Curio Collection by Hilton

The Reach Key West, Curio Collection by Hilton
4.0 star property
Old Town Key West
8.6 out of 10, Excellent, (1,064 reviews)
  • cleanliness
    Luxurious beachfront spa retreat offers deep-tissue massages and serene outdoor treatments in Key West.
The price is CA $311
CA $445 total
includes taxes & fees
Nov 30 - Dec 1
The Reach Key West, Curio Collection by Hilton
A swimming pool surrounded by palm trees and lounge chairs.

10. Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort
4.0 star property
Marathon
8.8 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Rejuvenate your spirit at this waterfront sanctuary where serene spa treatments complement 3 sparkling pools.
The price is CA $290
CA $417 total
includes taxes & fees
Dec 2 - Dec 3
Tranquility Bay Beachfront Hotel and Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Florida Keys

Pool
Breakfast included

Top Florida Keys Hotel Reviews

A beach with palm trees, a thatched-roof structure, and kayaks.
Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only

Kona Kai Resort and Gallery - Adults Only
Rock Harbor

10/10 Excellent

We had a great stay. Nice, cosy, and clean. Very quiet, which we loved. Great views from the dock. We will be back!
Canada
Daniel
Reviewed November 4, 2026
Kona Kai Resort and Gallery - Adults Only

Find out more about Florida Keys

Top Florida Keys attractions for a relaxing vacation

In the beautiful Florida Keys, travellers can immerse themselves in a range of activities that perfectly complement a stay at a spa hotel. Begin your day with a serene kayak tour through the mangroves, where you can paddle alongside breathtaking landscapes and observe the rich marine life in its natural habitat. After a morning of adventure, indulge in a luxurious spa treatment featuring local ingredients like coconut and sea salt, designed to rejuvenate your senses. For those seeking a taste of culture, exploring the vibrant art scene in charming local galleries offers a delightful way to spend an afternoon. As the sun sets, enjoy a sunset cruise that provides stunning views of the horizon while sipping on a refreshing cocktail. Finally, don't miss the chance to experience the unique culinary flavors of the Keys at local eateries that highlight fresh seafood and tropical fruits. With a perfect blend of relaxation and adventure, the Florida Keys set the stage for an unforgettable getaway, especially for those seeking a pampered experience.

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