5 Stars Hotels in Florida Keys, United States of America from CA $514

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Check availability on Florida Keys 5 Star Hotels

Our top choices for Florida Keys 5-star hotels

Balcony

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,311 reviews)
"Place was great!"
United States
Greg
The price is CA $377
CA $525 total
includes taxes & fees
May 10 - May 11
Cheeca Lodge & Spa
On the beach, sun loungers, beach umbrellas, beach towels

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa
5.0 star property
Marathon
9.2 out of 10, Wonderful, (1,110 reviews)
"All rooms have an ocean view-beautiful for sure!"
United States
Wanda
The price is CA $380
CA $514 total
includes taxes & fees
May 3 - May 4
Isla Bella Beach Resort & Spa
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Florida Keys.
Reefhouse Resort & Marina

Reefhouse Resort & Marina

103800 Overseas Hwy Key Largo FL
The price is CA $414 per night from Apr 19 to Apr 20
CA $414
CA $521 total
Apr 19 - Apr 20
includes taxes & fees
9.4/10 Exceptional! (1,405 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Florida Keys

Snorkel crystal-clear waters teeming with colourful fish, then feast on fresh-caught lobster at a laid-back waterfront shack. Drive the scenic Overseas Highway, stopping at Key West's Ernest Hemingway Home and Dry Tortugas National Park for island adventures.

See all hotels in Florida Keys

Top Florida Keys Hotel Reviews

Isla Bella Beach Resort & Spa

Isla Bella Beach Resort & Spa

10/10 Excellent
"Perfect. An amazing place to relax and watch the sun set. "
Richard 8-night trip
Posted 2 days ago
Isla Bella Beach Resort & Spa
Cheeca Lodge & Spa

Cheeca Lodge & Spa

10/10 Excellent
"Amazing! Loved everything can’t wait to go back!!"
Rachel 3-night trip
Posted 4 days ago
Cheeca Lodge & Spa

Find out more about Florida Keys

Five Star Hotels in Florida Keys

There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Florida Keys so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Florida Keys and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Florida Keys

Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places.

Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town.

Make Your Escape to Florida Keys

The results are in, and Florida Keys 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Florida Keys! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Florida Keys today and settle down in the lap of luxury tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Florida Keys?
The amount you pay for a 5-star hotel in Florida Keys can vary depending on when you decide to travel and how long you plan to stay, among a number of factors. Use our price per night filter and other search tools to find the best rate on a luxurious stay.

  • Search for the lowest price per night from CA $521

What makes a hotel 5 stars in Florida Keys?
In Florida Keys, a hotel is required to offer a specific number of upscale features to earn a 5-star rating. These can include gourmet restaurants, on-site gyms, saunas and spas, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their guest-centric standard of service. You'll enjoy things like nightly turn-down services, concierge services and in-room massages. Some may also offer special touches like welcome gifts.
Are there any 5-star all-inclusive resorts in Florida Keys?
Use Expedia's filter tool to find an upscale retreat in Florida Keys where everything you need is included in the price. Next, narrow down your results for properties that have a 5-star rating and are listed as "All inclusive." The first thing on the itinerary at these stays? Relaxation and enjoyment.