Most Popular Florida Keys Hotels

See all 200 Hotels in Florida Keys
The Inn at Key West
The Inn at Key West

3420 N Roosevelt Blvd, Key West 33040

3.5 out of 5.0
4.1 out of 5 (4,190 reviews)

Located within minutes of Old Town, the Ernest Hemingway Home & Museum, Mallory Square, Duval Street shops, restaurants, an …

CA$186
Casa Marina Resort - A Waldorf Astoria Resort
Casa Marina Resort - A Waldorf Astoria Resort

1500 Reynolds Street, Key West 33040

4.0 out of 5.0
4.2 out of 5 (2,121 reviews)

Looking out over the Straits of Florida towards Cuba, this upscale resort places guests a 3-minute drive from downtown Key …

CA$293
Tranquility Bay Beachfront Hotel and Resort
Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon 33050

4.0 out of 5.0
4.5 out of 5 (802 reviews)

Located on a private beach in Marathon, Tranquility Bay Beachfront Hotel and Resort is a 5-minute walk from the turtle …

CA$190
Silver Palms Inn
Silver Palms Inn

830 Truman Ave, Key West 33040

3.5 out of 5.0
4.4 out of 5 (2,033 reviews)

Silver Palms Inn is a half-mile from the Ernest Hemingway House and Museum and Key West Lighthouse, and 3 blocks from Duval …

CA$174
The Reach, A Waldorf Astoria Resort
The Reach, A Waldorf Astoria Resort

1435 Simonton Street, Key West 33040

4.0 out of 5.0
4.1 out of 5 (1,879 reviews)

This attractive resort is set among the quaint buildings of Key West's Old Town and features a large private beach. The resor …

CA$320
Kingsail Resort
Kingsail Resort

7050 Overseas Highway, Marathon 33050

2.0 out of 5.0
3.4 out of 5 (1,412 reviews)

Located in the heart of Marathon, this motel is within 1 mi (2 km) of Crane Point Museum and Nature Center and Sombrero Beach …

CA$110
Tavernier Inn & Hotel
Tavernier Inn & Hotel

91865 Overseas Hwy, Tavernier 33070

2.0 out of 5.0
2.8 out of 5 (605 reviews)

Situated in the historical district, this hotel is within 3 mi (5 km) of Florida Keys Wild Bird Center, Florida Keys Wild Bir …

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Amy Slate's Amoray Dive Resort
Amy Slate's Amoray Dive Resort

104250 Overseas Hwy, Key Largo 33037

2.0 out of 5.0
3.9 out of 5 (697 reviews)

Situated on the waterfront, this hotel is within 3 mi (5 km) of MarineLab Undersea Laboratory, Christ of the Deep, and …

CA$93
Bayside Inn Key Largo
Bayside Inn Key Largo

99490 Overseas Hwy, Key Largo 33037

2.5 out of 5.0
3.1 out of 5 (1,660 reviews)

This beachfront Florida Bay hotel is in the center of Key Largo, within walking distance to numerous restaurants and coffee …

CA$84
Floating Sea Cove Resort & Marina
Floating Sea Cove Resort & Marina

12685 Overseas Highway, Marathon 33050

2.0 out of 5.0
2.6 out of 5 (600 reviews)

Nestled on the beach, this Marathon resort is within 3 mi (5 km) of Captain Hooks Marina and Dive Center, Curry Hammock State …

CA$94

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Florida Keys Hotel Guide

When it comes to American beach destinations, no place beats the Florida Keys. Situated just southwest of the state, this archipelago is like a different world: Tropical flora dots the landscape, aquamarine waters surround the towns, and the pristine beaches gleam in the sun. If you need to escape the everyday hustle and bustle, this is the place to go.

Florida Keys Hotels and Things to Do

The best hotels in Florida Keys are situated on several islands — each within driving distance of each other — so your first order of business should be to choose where you’d like to base your trip. If you’re interested in iconic Florida Keys vacations, focus your search on the hotels in Key Largo. This breathtaking area is home to John Pennekamp Coral Reef State Park, and it features cheap deals and luxury hotels alike.

The hotels Islamorada offers are equally stunning, and these spots come with an extra perk: They’re just a stone’s throw from Bahia Honda State Park, one of America’s most renowned beach areas. This is the ideal place to soak up the sun, snorkel through the reefs, or kayak along the water. Plus, the hotels on the beach in Islamorada are beautiful enough to grace a magazine cover.

Of course, that only scratches the surface of the hotels Florida Keys boasts. Big Pine Key is perfect for adventurers, Key West is a culture buff’s dream, and Duck Key offers a more remote sort of paradise. You might even find a discount Florida Keys hotel in the chilled-out town of Marathon. The possibilities here are endless.

Flights to Florida Keys, Car Rentals, and More

When you’re all set to book your trip, don’t forget to use the travel tools at Expedia to track down flights, search for car rentals, and compare prices on the most popular hotels in the Florida Keys. Whether you’re planning a Key West jaunt or want to get away from it all on Islamorada, we have the deals and packages every traveller needs.