Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 stars Hotels

See all 368 Hotels in Florida Keys
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.0 out of 5.0
3.9 out of 5 (345 reviews)
nice but didnt get to staywell really didnt get to stay. had to evacuate due to the hurricane
  20 Sep 2017

C$133

C$133
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (1,491 reviews)
Hurricane IrmaUnfortunatly, our 5 day stay turned into one and a half days due to hurricane Irma. However the staff remained extremely calm and professional.The rooms and property were beautiful. The food was excellent and the staff even more so. We got out two days before evacuation. Our only hope is the entire ...
  14 Sep 2017

C$289

C$289
Parrot Key Hotel & Resort

Parrot Key Hotel & Resort

2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,154 reviews)
Nice hotel. Close to the water. Nice staff.Pro: Room is large and comfortable. Location is convenient. Staff are nice. It also has complementary shuttle service to downtown if you need transportation. Con: This property seems to be relatively old and is NOT sound-proof. If you're a light sleeper, or you really care about noise level - or ...
  14 Sep 2017

C$162

C$162
Casa Marina, A Waldorf Astoria Resort

Casa Marina, A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.1 out of 5 (986 reviews)
Nice hotel. Nice breakfast. Poor beach. Rooms good but need bathroom remodelation. Excellent worker.
  6 Sep 2017

C$293

C$293
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.0 out of 5.0
4.0 out of 5 (45 reviews)
Enjoyed it!Great place - great location. The staff was friendly and helpful. The resort fee was higher than it should be for what you get but tolerable. Would stay here again......
  2 Sep 2017

C$284

C$284
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (315 reviews)
Hurricane Irmaour stay was less than 24 hours instead of 6 nights due to being evacuated because of hurricane Irma. The staff was helpful on getting us out before the hurricane hit.
  11 Sep 2017

C$158

C$158
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.0 out of 5.0
4.4 out of 5 (100 reviews)
HoneymoonThe hotel and staff that we encountered were wonderful. We unfortunately arrived Monday the 4th and found out Tuesday that we needed to evacuate due to hurricane Irma. We loved everything about the hotel and will definitely be planning a return trip. The staff was very helpful when we found out that ...
  9 Sep 2017

C$164

C$164
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Duck Key
4.0 out of 5.0
4.1 out of 5 (1,140 reviews)
Nice resort with its own beach and 2 pools We love staying at Hawk's Cay. I love that they have heir own little private beach/lagoon area. Main pool is beautiful, but when you want to get away from other people's kids, there is an adult pool as well. It's a little older but still really nice. My only complaint is that is that the menus have ...
  17 Sep 2017

C$243

C$243
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (683 reviews)
Great location near Duval Street. The hotel has beautiful rooms with great views. The staff could not have been any nicer. The service was great. The swimming pool is nice size with comfortable chairs and umbrellas. The Shor Restaurant at the hotel has an amazing breakfast.
  7 Sep 2017

C$316

C$316
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (657 reviews)
Daughter got married here on the beach at sunset. Beautiful hotel and spa facilities. Close enough to Miami in terms of travel, but you feel like you're away in the Caribbean.
  11 Sep 2017

C$179

C$179
Map

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 stars hotels in Florida Keys are calling your name. Known for providing first-rate service in amazing locations, each of the Florida Keys 4 stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Florida Keys. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 stars hotel in Florida Keys, Florida, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Florida Keys hotels with 4 stars provide everything you need to unwind in style.

Recently booked Florida Keys hotels

Hyatt Centric Key West Resort and Spa
4.0 out of 5.0
Last booking: 13 hours ago