Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the best price available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 stars Hotels

See all 511 Hotels in Florida Keys
Casa Marina, A Waldorf Astoria Resort

Casa Marina, A Waldorf Astoria Resort

1500 Reynolds Street, Key West
4.0 out of 5.0
4.2 out of 5 (2,362 reviews)
Nice hotel. Nice breakfast. Poor beach. Rooms good but need bathroom remodelation. Excellent worker.
  6 Sep 2017

C$291

C$291
24 North Hotel Key West

24 North Hotel Key West

3820 North Roosevelt Boulevard, Key West
4.0 out of 5.0
4.1 out of 5 (1,041 reviews)
Hotel has a great shuttle to Mallory Square! The hotel was nice. The shuttle was fantastic because we did not have to use our rental car the whole time we were there. The only complaint I have is it is very noisy in the mornings on the Gulf side. Next time I will get a room on the pool side.
  9 Nov 2017

C$164

C$164
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.0 out of 5.0
4.1 out of 5 (1,862 reviews)
Amazing Location Our stay was very pleasant. We got there super early around 12:00 pm and they were able to provide us a room right away instead of us having to wait until 3pm. The location is awesome, right on Duval St near many restaurants, and convenient stores. Also, right next to the hotel there is a Starbucks ...
  21 Nov 2017

C$239

C$239
The Gates Hotel Key West

The Gates Hotel Key West

3824 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.3 out of 5 (1,063 reviews)
great experience...loved the complimentary rum punch 😁
  21 Nov 2017

C$171

C$171
Margaritaville Key West Resort & Marina

Margaritaville Key West Resort & Marina

245 Front Street, Key West
4.0 out of 5.0
4.3 out of 5 (150 reviews)
Great location Beautiful hotel Many things to do Tours Restaurants Convenient
  21 Nov 2017

C$257

C$257
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (1,288 reviews)
Overall, great property.Treated ourselves to a nice hotel for a last minute trip to Key West. The property was beautiful, room was very nice and even though we didn’t pay for a water front room, we still had a partial view from our balcony. The only complaint I have is that multiple staff members had us a on a search for ...
  10 Nov 2017

C$280

C$280
Pier House Resort & Spa

Pier House Resort & Spa

1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (1,422 reviews)
Nice Key West spotThis was a very nice hotel and friendly hotel staff. The ‘beach’ is very small, but nice, and excellent music in the bar/restaurant next to it close to Duvall street stuff and Mallory square.
  20 Nov 2017

C$344

C$344
Oceans Edge Key West Resort, Hotel & Marina

Oceans Edge Key West Resort, Hotel & Marina

5950 Peninsular Avenue, Key West
4.0 out of 5.0
4.5 out of 5 (295 reviews)
Good overall. A place with beautiful pools, boats.
  22 Nov 2017

C$193

C$193
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (3,089 reviews)
Great HotelGreat Hotel! Has a lot of options for everyone. 2 Beach options, 3 pools, restaurant on/near site and right on Duval street. The rooms had character and were some of the nicest we've been in. Staff was friendly and helpful. Our only negative was the extra fees not included in room rate - (parking, ...
  20 Nov 2017

C$224

C$224
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (1,033 reviews)
Nice room close to waterVery nice! Happy about the hotel. Plan to stay next time with friends. Hope can get a good deal, so we can stay a little longer. Thanks. Nice seafood restaurant close by. Hope we can get more fish tomorrow.
  19 Nov 2017

C$228

C$228
Map

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 stars hotels in Florida Keys are calling your name. Known for providing first-rate service in amazing locations, each of the Florida Keys 4 stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Florida Keys. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 stars hotel in Florida Keys, Florida, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Florida Keys hotels with 4 stars provide everything you need to unwind in style.

Recently booked Florida Keys hotels

The Gates Hotel Key West
4.0 out of 5.0
Last booking: 2 hours ago