Beginning of main content

4 stars Hotels in Florida Keys, Florida

Search Flights

Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Florida Keys Hotels

Search Flight + Hotel

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured Florida Keys 4 stars Hotels

See all 390 Hotels in Florida Keys
Tranquility Bay Beachfront Hotel and Resort

Tranquility Bay Beachfront Hotel and Resort

2600 Overseas Hwy, Marathon
4.0 out of 5.0
4.5 out of 5 (462 reviews)
Nice hotel but staff could be a little better. Nice hotel on Route 1 and on the beach. Facilities are well maintained, but desk did not tell us they were putting us in a handicap room (not as nice as standard rooms) when they had standard rooms available. Facilities are nice, and well maintained. The Butterfly room is a very good restaurant, ...
  2 Jul 2017

C$316

C$316
Parrot Key Hotel & Resort

Parrot Key Hotel & Resort

2801 N Roosevelt Blvd, Key West
4.0 out of 5.0
4.2 out of 5 (1,122 reviews)
I would recommend this hotel the location is great and the space of the bedrooms is perfect
  23 Jul 2017

C$207

C$207
Santa Maria Suites

Santa Maria Suites

1401 Simonton St, Key West
4.0 out of 5.0
4.8 out of 5 (365 reviews)
beautiful! Room was like an apartment rather than a hotel. Top notch all the way! I'm spoiled now - won't stay anywhere else.
  10 Jul 2017

C$467

C$467
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (644 reviews)
WeddingWe had our wedding there. Went off without a flaw. Would do the same in a beartbeat. Thank you !
  16 Jul 2017

C$186

C$186
The Gardens Hotel

The Gardens Hotel

526 Angela Street, Key West
4.0 out of 5.0
4.8 out of 5 (115 reviews)
Best breakfast... Great location , friendly staff. Parking was limited
  9 Jul 2017

C$202

C$202
Pier House Resort & Spa

Pier House Resort & Spa

1 Duval St, Key West
4.0 out of 5.0
4.4 out of 5 (631 reviews)
Perfect Location! The hotel is beautiful, and the staff exceeded my expectations! They were friendly and accommodating. They made every effort to make sure we had a fantastic stay. Floating in the water while my cocktails were served to me at the beach made me feel very pampered.
  22 Jul 2017

C$326

C$326
Ocean Key Resort - A Noble House Resort

Ocean Key Resort - A Noble House Resort

Zero Duval St., Key West
4.0 out of 5.0
4.6 out of 5 (717 reviews)
Awesome location We went here for our honeymoon and we had a great time everything was amazing great service
  21 Jul 2017

C$289

C$289
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (674 reviews)
Great hotel with beach access My two sons and I had a great experience from the time we arrived. The beach access was great. It was close to the marina with Mallory Square and Duvall street being just a quick walk.
  22 Jul 2017

C$251

C$251
Little Palm Island Resort & Spa - A Noble House Resort

Little Palm Island Resort & Spa - A Noble House Resort

28500 Overseas Hwy, Little Torch Key
4.5 out of 5.0
4.9 out of 5 (23 reviews)
fabulous accommodation and staff...service is superb
  3 Jul 2017

C$991

C$991
Southernmost Beach Resort

Southernmost Beach Resort

508 South St, Key West
4.0 out of 5.0
4.5 out of 5 (1,415 reviews)
Nice hotel with very helpful staffThe hotel staff was very kind. Our room was well kept. The beach was nice and the drinks by the pool were great!
  24 Jul 2017

C$275

C$275
Map

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 stars hotels in Florida Keys are calling your name. Known for providing first-rate service in amazing locations, each of the Florida Keys 4 stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Florida Keys. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 stars hotel in Florida Keys, Florida, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Florida Keys hotels with 4 stars provide everything you need to unwind in style.

Recently booked Florida Keys hotels

The Gardens Hotel
4.0 out of 5.0
Last booking: 4 hours ago