Title: Book the Best Florida Keys SPA Resorts - Spa Hotels in Florida Keys | Expedia.ca [Florida Keys Travel Guide](https://expedia.ca/Florida-Keys.dx6023765)[Hotels in Florida Keys](https://expedia.ca/Florida-Keys-Hotels.d6023765.Travel-Guide-Hotels)[Vacation Rentals in Florida Keys](https://expedia.ca/Florida-Keys-Vacation-Rentals.d6023765.Travel-Guide-VacationRentals)[Flights to Florida Keys](https://expedia.ca/Cheap-Flights-To-Florida-Keys.d6023765.Travel-Guide-Flights)[Things to do in Florida Keys](https://expedia.ca/Things-To-Do-In-Florida-Keys.d6023765.Travel-Guide-Activities)[Florida Keys Car Rentals](https://expedia.ca/Car-Rentals-In-Florida-Keys.d6023765.Car-Rental-Guide)[Florida Keys Vacation Packages](https://expedia.ca/Florida-Keys.d6023765.Destination-Travel-Guides) ![Dry Tortugas National Park which includes general coastal views and heritage architecture](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/175000/175790-South-Florida.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Florida Keys ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Florida Keys Spa Hotels Tonight [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2025-10-18&endDate=2025-10-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 19 - Oct 20](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2025-10-19&endDate=2025-10-20&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2025-10-24&endDate=2025-10-26&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6023765&startDate=2025-10-31&endDate=2025-11-02&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Florida Keys Spa Hotels ![Couples treatment rooms, sauna, steam room, body treatments](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/e77d9aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/79d31a44.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private beach, sun loungers, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/617c0723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/10000/5800/5780/981feca1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cheeca Lodge & Spa Matecumbe 9.2/10 Wonderful (1234) "This resort was amazing!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $195 CA $314 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Islamorada-Hotels-Cheeca-Lodge-Spa.h5780.Hotel-Information) ![Body treatments, aromatherapy, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/1000000/20000/16700/16682/7a4ee33e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/20000/16700/16682/08834b0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor wedding area](https://images.trvl-media.com/lodging/1000000/20000/16700/16682/50962e29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/20000/16700/16682/a299c4a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ocean Key Resort - A Noble House Resort Key West Historic District 9.2/10 Wonderful (1007) "Great stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sarit CA $239 CA $372 total includes taxes & fees Nov 4 - Nov 5 [](https://www.expedia.ca/Key-West-Hotels-Ocean-Key-Resort-A-Noble-House-Resort.h16682.Hotel-Information) ![Sports facility](https://images.trvl-media.com/lodging/2000000/1170000/1169600/1169583/9a1dea7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; Caribbean cuisine](https://images.trvl-media.com/lodging/2000000/1170000/1169600/1169583/eb6dc866.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 outdoor pools, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/2000000/1170000/1169600/1169583/16bbce87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 restaurants, breakfast, lunch, dinner served; Caribbean cuisine](https://images.trvl-media.com/lodging/2000000/1170000/1169600/1169583/w3836h2560x4y0-ddd4202c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Faro Blanco Resort & Yacht Club Marathon, Curio by Hilton Marathon 8.8/10 Excellent (1271) "My second time staying here. Great spot for food, wine and a marina out back for your boat. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael CA $201 CA $282 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Marathon-Hotels-Faro-Blanco-Resort-Yacht-Club.h1169583.Hotel-Information) ![Steam room, body treatments, aromatherapy, hot stone massages](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/aa92b0ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/b0c6ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/acafccbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges, poolside bar](https://images.trvl-media.com/lodging/11000000/10560000/10554600/10554536/fe602972.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Faro Blanco Resort Marathon 9.0/10 Wonderful (1001) "great staff and clean facility" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tom CA $212 CA $293 total includes taxes & fees Oct 22 - Oct 23 [](https://www.expedia.ca/Marathon-Hotels-Courtyard-By-Marriott-Marathon-Florida-Keys.h10554536.Hotel-Information) ![Body treatments, aromatherapy, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/c2842ab0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/af093823.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/b2a768a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fireplace](https://images.trvl-media.com/lodging/1000000/10000/3500/3427/f2f49899.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reefhouse Resort & Marina Key Largo 9.2/10 Wonderful (1317) "Great resort and great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William CA $307 CA $402 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Key-Largo-Hotels-Reefhouse-Resort-Marina.h3427.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/fcd75612.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite | Living area](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/4ae3e8fd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/396da292.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed | Terrace/patio](https://images.trvl-media.com/lodging/75000000/74510000/74501700/74501641/bf338fd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kona Kai Resort and Gallery - Adults Only Key Largo 9.8/10 Exceptional (267) "Property was very clean including beach, pool, and grounds." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Drew CA $163 CA $223 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Key-Largo-Hotels-Kona-Kai-Resort-And-Gallery.h74501641.Hotel-Information) ![Couples treatment rooms, body treatments, aromatherapy](https://images.trvl-media.com/lodging/1000000/10000/1000/901/c73d9fc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1000/901/0b72a249.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, ocean views ](https://images.trvl-media.com/lodging/1000000/10000/1000/901/ea2f021f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/1000/901/399f6b5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Centric Key West Resort and Spa Key West Historic District 9.0/10 Wonderful (1011) "Location location location is why u stay here. Walking distance to everything, 40 spot for parking is a bit steep but had a great stay. We would stay there again. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eric CA $258 CA $382 total includes taxes & fees Oct 27 - Oct 28 [](https://www.expedia.ca/Key-West-Hotels-Hyatt-Centric-Key-West-Resort-And-Spa.h901.Hotel-Information) ![Outdoor treatment areas, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/460000/457900/457821/6f2bdc21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/460000/457900/457821/b515d08c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/460000/457900/457821/eb7f9b00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/460000/457900/457821/02b8eaa6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Reach Key West, Curio Collection by Hilton Old Town Key West 8.4/10 Very good (1012) "Great staff, view and food!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gregory CA $263 CA $380 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Key-West-Hotels-The-Reach-Key-West.h457821.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/00c7105d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dock](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/d5633e15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/1b2ea44f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/25000000/24110000/24101800/24101706/e1765627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Isla Bella Beach Resort & Spa Marathon 9.2/10 Wonderful (1060) "Extremely clean; nice surroundings; great pool choices; restaurant was good." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lana CA $339 CA $462 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Marathon-Hotels-Isla-Bella-Beach-Resort-Spa.h24101706.Hotel-Information) ![Body treatments, aromatherapy, deep-tissue massages, Swedish massages](https://images.trvl-media.com/lodging/1000000/120000/117100/117099/3ac23f21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, sun loungers](https://images.trvl-media.com/lodging/1000000/120000/117100/117099/a50ca43c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Villa, 2 Bedrooms, Beachfront | Living area](https://images.trvl-media.com/lodging/1000000/120000/117100/117099/8c99c2b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/120000/117100/117099/2097bc20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tranquility Bay Beachfront Hotel and Resort Marathon 8.8/10 Excellent (1002) "Clean, large rooms with a comfortable bed and nice balcony. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kippi CA $335 CA $468 total includes taxes & fees Nov 18 - Nov 19 [](https://www.expedia.ca/Marathon-Hotels-Tranquility-Bay-Beachfront-Hotel-And-Resort.h117099.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-01&endDate=2025-11-02®ionId=6023765&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Florida Keys ### Top Florida Keys attractions for a relaxing vacation The Florida Keys offer a luxurious escape for those seeking spa hotels amidst stunning natural beauty and vibrant culture. Begin your journey in Key West, where you can unwind at the famous Southernmost Point Buoy and indulge in a sunset sailing excursion, complete with gourmet hors d'oeuvres and the soothing sounds of the sea. A visit to the tranquil Dry Tortugas National Park is a must; explore its pristine beaches and historic Fort Jefferson before returning to your spa hotel for a relaxing massage or rejuvenating facial. For a unique experience, head to Islamorada and enjoy a guided eco-tour of the mangroves, followed by a soak in a hot tub overlooking the ocean. The nearby Florida Keys Brewing Company offers tastings of local craft beers, providing a delightful contrast to your day of pampering. Finally, don’t miss the opportunity to snorkel or dive in the vibrant coral reefs of John Pennekamp Coral Reef State Park, where the underwater world will leave you in awe. Consider staying in a spa hotel in Key Largo for easy access to both relaxation and adventure, enjoying amenities such as oceanfront pools, wellness classes, and on-site restaurants that celebrate fresh local seafood. ## Top Florida Keys Hotel Reviews ## Explore a world of travel with Expedia - Lodging - Packages - More ways to book - [Hotels near Christ of the Abyss](https://www.expedia.ca/Christ-Of-The-Abyss-Hotels.0-l6069273-0.Travel-Guide-Filter-Hotels) - [Hotels near John Pennekamp Coral Reef State Park](https://www.expedia.ca/John-Pennekamp-Coral-Reef-State-Park-Hotels.0-l6068611-0.Travel-Guide-Filter-Hotels) - [John Pennekamp Coral Reef State Park](https://www.expedia.ca/John-Pennekamp-Coral-Reef-State-Park-United-States-of-America.d6068611.Vacation-Attraction) - [Book Spa Hotels in Florida Keys on Expedia.com](https://www.expedia.com/Florida-Keys-Hotels-Spa-Hotel.0-0-d6023765-tSpaHotel.Travel-Guide-Filter-Hotels)