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Featured Florida Keys Spa Hotels

See all 394 Hotels in Florida Keys
Cheeca Lodge & Spa

Cheeca Lodge & Spa

81801 Overseas Highway, Mile Marker 82, Islamorada
4.0 out of 5.0
4.4 out of 5 (657 reviews)
Daughter got married here on the beach at sunset. Beautiful hotel and spa facilities. Close enough to Miami in terms of travel, but you feel like you're away in the Caribbean.
  11 Sep 2017
Pier House Resort & Spa

Pier House Resort & Spa

1 Duval St, Key West
4.0 out of 5.0
4.5 out of 5 (655 reviews)
Great location! Was awesome to have a beach and pool!
  20 Oct 2017

C$342

C$342
Hyatt Centric Key West Resort and Spa

Hyatt Centric Key West Resort and Spa

601 Front St, Key West
4.0 out of 5.0
4.5 out of 5 (685 reviews)
Found a winnerVery nice place to stay. Staff was unbelievably friendly, and willing to help in anyway. Food was great, and views of the ocean from the pool were amazing. We did have a bad experience with the elevator, but shouldn’t be held against them. I would definitely go back!
  20 Oct 2017

C$251

C$251
The Cabana Inn Key West

The Cabana Inn Key West

413 Applerouth Lane, Key West
3.0 out of 5.0
4.5 out of 5 (274 reviews)
Close to Duvall stClean, comfortable we really enjoyed our stay nice breakfast, wine and cheese at night, will definitely come back
  10 Oct 2017

C$175

C$175
Heron House Court - Adult Only

Heron House Court - Adult Only

412 Frances St, Key West
3.0 out of 5.0
4.3 out of 5 (563 reviews)
Highly Recommend!!Roman made our stay top notch! Great service, great room, great experience!! Thank you!
  19 Oct 2017

C$216

C$216
Southernmost Beach Resort

Southernmost Beach Resort

1319 Duval Street, Key West
4.0 out of 5.0
4.5 out of 5 (1,495 reviews)
Wonderful resort within walking distance of little shops and other nice places to eat. Plenty of other activities available for booking at the tour desk on the island. Would definitely come back.
  20 Oct 2017

C$302

C$302
Seascape Inn

Seascape Inn

420 Olivia Street, Key West
3.0 out of 5.0
4.4 out of 5 (67 reviews)
Nice hotel, great location.We have stayed at the Seascape 4 times. The rooms are nice, they have a continental breakfast, and you can't beat the location. Just steps away from Duval Street.
  11 Aug 2017

C$348

C$348
La Concha Hotel & Spa

La Concha Hotel & Spa

430 Duval St, Key West
4.0 out of 5.0
4.0 out of 5 (608 reviews)
Great hotel in the center of town near shops and rThe room was lovely and clean. The bed was very comfortable The View out the window is lovely. The staff was very polite. And the pool on the second floor was great
  16 Oct 2017

C$246

C$246
Lime Tree Bay Resort

Lime Tree Bay Resort

68500 Overseas Hwy, Long Key
3.5 out of 5.0
4.1 out of 5 (188 reviews)
Very nice. We'll go back. They've done a great job cleaning up after the hurricane.
  15 Oct 2017

C$166

C$166
Hawks Cay Resort

Hawks Cay Resort

61 Hawks Cay Blvd, Duck Key
4.0 out of 5.0
4.1 out of 5 (1,140 reviews)
Nice resort with its own beach and 2 pools We love staying at Hawk's Cay. I love that they have heir own little private beach/lagoon area. Main pool is beautiful, but when you want to get away from other people's kids, there is an adult pool as well. It's a little older but still really nice. My only complaint is that is that the menus have ...
  17 Sep 2017
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Spa Hotel Guide in Florida Keys

When it comes to relaxation, there’s nothing like Florida Keys spa hotels. Unwind with a rejuvenating facial. Treat yourself to a Swedish massage. Melt stress away in the steamy sauna, or settle in for a sampling of the most high-tech treatments. Whether you’re looking for a quiet retreat or prefer to indulge in the most cutting-edge spa hotel near Florida Keys, the choices here are unbelievably tranquil.

It all starts with the personal check-in service, continues with the soothing rooms and gets even better with the dazzling array of made-for-you amenities. What’s more, many of the 394 spa hotels are situated near the best experiences and attractions, so you can uncover the area’s can’t-miss sights after a day of body scrubs, pedicures and facial masks.

Browse Expedia’s selection to find options that are close to your personal style, and then get ready to spend a long weekend — or an entire week — getting massaged, manicured and pampered beyond compare.