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Check prices for these dates

Next weekend
Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29
In one month
Dec 11 - Dec 13
In two months
Jan 8 - Jan 10
No exact matches found, but these alternatives could be just right

Recommended hotels in East Prairie

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

1. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,009 reviews)
"Clean rooms, great parking, very nice staff"
United States
Shelley
The price is CA $103
CA $117 total
includes taxes & fees
Dec 7 - Dec 8
Best Western Plus Sikeston I-55
A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

2. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (830 reviews)
"Very clean property and the staff were very accommodating."
United States
Craig
The price is CA $93
CA $106 total
includes taxes & fees
Nov 11 - Nov 12
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A building with a fountain and flower beds in front.

3. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (443 reviews)
"Everything was great clean helpful Everything friendly."
United States
Kathleen
The price is CA $94
CA $105 total
includes taxes & fees
Nov 12 - Nov 13
The Riverstone Hotel Charleston-Sikeston
A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.

4. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place to stay!"
United States
Tiffany
The price is CA $133
CA $153 total
includes taxes & fees
Nov 15 - Nov 16
Drury Inn & Suites Sikeston, MO
A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.

5. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,001 reviews)
"It was clean, the room was nice and roomy, bed was very comfortable. Some things were in need of minor repairs, but nothing major."
United States
Earl
The price is CA $94
CA $107 total
includes taxes & fees
Nov 12 - Nov 13
Days Inn and Suites by Wyndham Sikeston
A motel with a covered entrance, multiple rooms, and a parking lot.

6. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (696 reviews)
"It is a clean place, and we enjoyed our stay"
United States
Laura
The price is CA $82
CA $93 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Sikeston/Miner Area
A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

7. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.8 out of 10, Excellent, (522 reviews)
"I have always have a great stay each time I’ve been here. Beds comfortable and rooms very clean."
United States
Melissa
The price is CA $143
CA $162 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites Sikeston Southwest by IHG
A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

8. Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (164 reviews)
"It was an ok room for the price paid."
United States
Marianne
The price is CA $76
CA $90 total
includes taxes & fees
Nov 11 - Nov 12
Country Yard Inn and Suite
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

9. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (654 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is CA $142
CA $161 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn Sikeston
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

10. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is CA $155
CA $177 total
includes taxes & fees
Nov 19 - Nov 20
Fairfield Inn & Suites by Marriott Sikeston
A modern building with a flat roof and large windows.

11. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (322 reviews)
"The room was nice"
United States
Fred
The price is CA $123
CA $140 total
includes taxes & fees
Nov 30 - Dec 1
Comfort Inn & Suites Sikeston I-55
A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

12. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is CA $93
CA $104 total
includes taxes & fees
Nov 11 - Nov 12
Eagle Inn Charleston
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

13. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (31 reviews)
"I liked the lobby, bar and breakfast areas. The full breakfast buffet was awesome. Super nice room with kitchenette. Staff were great."
United States
Mark
The price is CA $154
CA $175 total
includes taxes & fees
Nov 19 - Nov 20
TownePlace Suites by Marriott Sikeston
A hotel with a central entrance, multiple parking spaces, and a well-lit facade.

14. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (82 reviews)
"Got there late and staff was very helpful. Room was clean and comfortable"
United States
Wendy
The price is CA $81
CA $93 total
includes taxes & fees
Nov 12 - Nov 13
Super 8 By Wyndham Marston
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.

15. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (297 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is CA $99
CA $110 total
includes taxes & fees
Dec 4 - Dec 5
Quality Inn Cairo I-57
A hotel with a covered entrance, a sign for the brand, and a parking lot with cars.

16. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (685 reviews)
"Breakfast was light but good"
United States
zandra
The price is CA $83
CA $93 total
includes taxes & fees
Dec 1 - Dec 2
Super 8 by Wyndham Charleston/Sikeston East MO
A modern building with a covered entrance, a nameplate, and a landscaped area with shrubs and a street lamp.

17. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (451 reviews)
"Clean room, excellent staff, wonderful breakfast"
United States
Ben
The price is CA $100
CA $119 total
includes taxes & fees
Dec 6 - Dec 7
Sleep Inn at Discovery Park of America
A building with a flat roof, a brick entrance, and a sign that reads 'Travel Inn.'

18. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (130 reviews)
"Quiet safe area."
United States
Frank
The price is CA $57
CA $71 total
includes taxes & fees
Dec 7 - Dec 8
Travel Inn Marston I-55 by Hotel O
A hotel entrance with a covered driveway, a clear sky, and well-maintained landscaping.

19. Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (559 reviews)
"Awesome"
United States
Logan
The price is CA $95
CA $113 total
includes taxes & fees
Dec 6 - Dec 7
Quality Inn Union City US 51
A building with a sign reading "Hospitality House" and decorative pineapple motifs on the facade.

20. Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (413 reviews)
"Nasty rooms, no smoke alarms in rooms, guests yelling all night, peeling tires in the parking lot, running back and forth all night, people throwing stuff off the 2nd floor to the ground. I'll never recommend this place to anyone."
United States
Thomas
The price is CA $81
CA $96 total
includes taxes & fees
Nov 11 - Nov 12
Hospitality House Union City I 69 / US 51
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top reviews in East Prairie

A Drury Inn & Suites building with a covered entrance, multiple windows, and a parking lot.
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston

10/10 Excellent

Manager’s reception is a hit!
Canada
Thomas R
Reviewed April 29, 2026
Drury Inn & Suites Sikeston, MO

Frequently Asked Questions

What are some top RV sites near East Prairie?

Based on our travel knowledge, Solar Eclipse Festival at our Campground at Benton Speedway. April 6-8th 2024. is a top choice for your East Prairie adventure.

What makes RV parks in East Prairie stand out?

If you're planning an RV adventure to East Prairie, booking a spot in an RV park is an excellent way to get to know the area. After you've settled in at the RV park in East Prairie, get out into nature and make it a memorable trip.

What should I see in East Prairie?

If you want to find some ways to explore East Prairie while taking advantage of your travel budget, this destination has a lot to offer. Spots where you'll find the natural beauty on display include Big Oak Tree State Park and Mississippi River.

What's it like to stay in an RV park in East Prairie?

Booking a spot in an RV park is a budget-friendly option if you're traveling to East Prairie. This kind of accommodation provides you with a roomy space to park your trailer and stay overnight where you're often surrounded by nature. Lots of RV parks are close to lakes and hiking spots, which makes it easy to enjoy outdoor activities.

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