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Check prices for these dates

Tonight
May 8 - May 9
Tomorrow
May 9 - May 10
This weekend
May 8 - May 10
Next weekend
May 15 - May 17

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,010 reviews)
"Nice place to stay"
United States
Lance
The price is CA $151
CA $174 total
includes taxes & fees
May 31 - Jun 1
Drury Inn & Suites Sikeston, MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (556 reviews)
"Perfect nights stay!! "
United States
Amanda
The price is CA $144
CA $163 total
includes taxes & fees
May 24 - May 25
Hampton Inn Sikeston
Premier Room, 1 Bedroom, Non Smoking

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (763 reviews)
"The staff was great very helpful and friendly "
United States
Javier
The price is CA $71
CA $77 total
includes taxes & fees
Jun 7 - Jun 8
New Orleans Inn Portageville
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (570 reviews)
"Very clean nice staff and well run "
United States
zach
The price is CA $82
CA $97 total
includes taxes & fees
May 9 - May 10
Country Hearth Inn & Suites Union City
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"All very just okay "
United States
Sherry
The price is CA $102
CA $113 total
includes taxes & fees
May 17 - May 18
The Riverstone Hotel Charleston-Sikeston
Individually decorated, individually furnished, desk, blackout drapes

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (772 reviews)
"Breakfast was adequate room was clean."
United States
Daniel
The price is CA $75
CA $86 total
includes taxes & fees
May 11 - May 12
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (631 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is CA $84
CA $93 total
includes taxes & fees
Jun 1 - Jun 2
Super 8 by Wyndham Charleston/Sikeston East MO
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,002 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is CA $123
CA $141 total
includes taxes & fees
Jun 4 - Jun 5
Best Western Plus Sikeston I-55
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (462 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is CA $138
CA $156 total
includes taxes & fees
Jun 7 - Jun 8
Holiday Inn Express & Suites Sikeston Southwest by IHG
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (74 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
The price is CA $150
CA $170 total
includes taxes & fees
May 21 - May 22
Fairfield Inn & Suites by Marriott Sikeston
Room, 1 Queen Bed, Non Smoking

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (62 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is CA $98
CA $112 total
includes taxes & fees
May 28 - May 29
Super 8 By Wyndham Marston
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (385 reviews)
"Great stay. "
United States
Paul
The price is CA $116
CA $137 total
includes taxes & fees
May 24 - May 25
Sleep Inn at Discovery Park of America
1 bedroom, desk, laptop workspace, blackout drapes

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,002 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is CA $89
CA $101 total
includes taxes & fees
May 10 - May 11
Days Inn and Suites by Wyndham Sikeston
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (391 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is CA $78
CA $92 total
includes taxes & fees
May 10 - May 11
Hospitality House Union City I 69 / US 51
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (509 reviews)
"Bathroom walls were dirty and bathroom ceiling had mold on it"
United States
Emily
The price is CA $92
CA $109 total
includes taxes & fees
May 28 - May 29
Quality Inn Union City US 51
Room, 1 King Bed, Non Smoking | View from room

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (106 reviews)
"Great"
United States
Jackson
The price is CA $95
CA $105 total
includes taxes & fees
May 9 - May 10
Eagle Inn Charleston
Room, 1 King Bed, Accessible, Non Smoking

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (622 reviews)
"Cheap room not bad for the price. Would stay again if I was in the area. "
United States
Jenny
The price is CA $86
CA $98 total
includes taxes & fees
May 9 - May 10
Super 8 by Wyndham Sikeston/Miner Area
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (182 reviews)
"Spotless , friendly staff."
United States
Gail
The price is CA $151
CA $179 total
includes taxes & fees
May 24 - May 25
Hampton Inn Union City
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (325 reviews)
"Great hotel. Well worth it"
United States
Shannon
The price is CA $157
CA $187 total
includes taxes & fees
May 17 - May 18
Holiday Inn Express & Suites Union City by IHG
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (285 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is CA $97
CA $108 total
includes taxes & fees
Jun 5 - Jun 6
Quality Inn Cairo I-57
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Recent Reviews in East Prairie

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Everything was excellent"
Eugene 1-night trip
Posted 3 hours ago
Drury Inn & Suites Sikeston, MO

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is CA $75 per night from May 11 to May 12
CA $75
CA $86 total
May 11 - May 12
includes taxes & fees
8.4/10 Very Good! (772 reviews)

Hotels in East Prairie with star rating

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
Members always get our best prices. Find our best East Prairie hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from CA $77 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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