Title: Book The Best Hotels in East Prairie, MO for 2026 from CA $88 - Fully Refundable Options - Expedia.ca

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![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Go beyond your typical stay in East Prairie

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&travelerType=family_friendly)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=POOL)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2026-04-07&d1=2026-04-07&endDate=2026-04-09&d2=2026-04-09&amenities=PETS)

## Check prices for these dates

Tonight

[Mar 24 - Mar 25](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-03-24&endDate=2026-03-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Mar 25 - Mar 26](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-03-25&endDate=2026-03-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for East Prairie hotels

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/978331d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/95135562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

Sikeston

9.4/10

Exceptional

(1,005 reviews)

"Very nice for overnight stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

CA $129

CA $148 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/cbe2898d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/432f7137.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

Sikeston

9.0/10

Wonderful

(513 reviews)

"Great stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

grant

CA $133

CA $150 total

includes taxes & fees

Apr 12 - Apr 13

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Room, 1 Queen Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/5b4d84d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/0acd5e5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/e6403655.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d06bc03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 By Wyndham Marston

[](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

Marston

8.2/10

Very good

(53 reviews)

"Room was clean and fairly priced. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mickey

CA $89

CA $102 total

includes taxes & fees

Apr 3 - Apr 4

[](https://www.expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/e959f8b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/c790aa73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

Sikeston

9.4/10

Exceptional

(64 reviews)

"Nice quiet hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Steven

CA $139

CA $157 total

includes taxes & fees

Apr 2 - Apr 3

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/42667f54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/327b8d22.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave (with Sofabed)](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/b775798e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston I-55

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

Sikeston

8.4/10

Very good

(1,001 reviews)

"nice and covenant have stay here a few times, staff always has a smile. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roger

CA $127

CA $145 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/a42cb957.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/08c2ace2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/15abbdc3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d0a59214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Riverstone Hotel Charleston-Sikeston

[](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

Charleston

6.8/10

(409 reviews)

"Clean "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Chris

CA $79

CA $88 total

includes taxes & fees

Mar 31 - Apr 1

[](https://www.expedia.ca/Charleston-Hotels-The-Riverstone-Hotel.h20594.Hotel-Information)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hypo-allergenic bedding, down comforters, desk, iron/ironing board](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/4b95ba78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

Sikeston

8.6/10

Excellent

(450 reviews)

"Stay was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kourtney

CA $128

CA $145 total

includes taxes & fees

Apr 12 - Apr 13

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7bc13d14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7397c7ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/3fa32ded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/d5184d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Hearth Inn & Suites Union City

[](https://www.expedia.ca/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information)

Union City

8.6/10

Excellent

(556 reviews)

"Very clean nice staff and well run "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

zach

CA $86

CA $103 total

includes taxes & fees

Mar 25 - Mar 26

[](https://www.expedia.ca/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information)

![Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

Charleston

6.8/10

(626 reviews)

"Affordable for a quick one night stay. Restaurant and gas station next to hotel."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Annette

CA $85

CA $95 total

includes taxes & fees

Mar 26 - Mar 27

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/55808580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/54eabc09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/e89ec295.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sleep Inn at Discovery Park of America

[](https://www.expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

Union City

9.2/10

Wonderful

(368 reviews)

"Great stay. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

CA $104

CA $123 total

includes taxes & fees

Apr 5 - Apr 6

[](https://www.expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Individually decorated, individually furnished, desk, blackout drapes](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/594efec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Interior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/bf40a512.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

Sikeston

8.4/10

Very good

(753 reviews)

"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

CA $90

CA $102 total

includes taxes & fees

Mar 31 - Apr 1

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/45782657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Handicap Room](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/6128b6d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/e0fa396b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Reelfoot Lake Inn

[](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

Tiptonville

7.2/10

Good

(475 reviews)

"Everything great "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jayla

CA $94

CA $108 total

includes taxes & fees

Mar 25 - Mar 26

[](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

![Premier Room, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/a77daa89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### New Orleans Inn Portageville 

[](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

Portageville

8.0/10

Very good

(753 reviews)

"The staff was great very helpful and friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Javier

[](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/717baff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn and Suites by Wyndham Sikeston

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

Sikeston

7.4/10

Good

(1,003 reviews)

"Business friendly, clean room staff very friendly, accommodating."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Janice

CA $93

CA $106 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/74187a0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Double Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/96f1c1e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Cairo

6.6/10

(282 reviews)

"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maurice

CA $99

CA $110 total

includes taxes & fees

Mar 31 - Apr 1

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f7d6d20c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/2c1de1a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/8df1e765.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible (Hearing)](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f54017fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Union City

[](https://www.expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

Union City

9.6/10

Exceptional

(175 reviews)

"Spotless , friendly staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gail

CA $170

CA $202 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/c1609da5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/bfe56101.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/97ce04e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/ba65d6e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Union City US 51

[](https://www.expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

Union City

8.4/10

Very good

(500 reviews)

"All was pretty good except for the breakfast."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jeffrey

CA $93

CA $111 total

includes taxes & fees

Apr 19 - Apr 20

[](https://www.expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/c970f53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, individually decorated, individually furnished, desk](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/832ea567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/aadd65c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/6140f4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Union City by IHG

[](https://www.expedia.ca/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information)

Union City

9.4/10

Exceptional

(316 reviews)

"The room was spacious & clean. The complimentary breakfast was nice. Very quiet place and next to a unique tourist attraction."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Angela

CA $148

CA $176 total

includes taxes & fees

Apr 5 - Apr 6

[](https://www.expedia.ca/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information)

![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/97dfc357.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/715f35ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/55187aa2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Sikeston/Miner Area

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information)

Sikeston

6.8/10

(603 reviews)

"Great place"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Misty

CA $84

CA $96 total

includes taxes & fees

Mar 29 - Mar 30

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Studio, 1 King Bed with Sofa bed](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-c8905780.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/de7767c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Sikeston

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

Sikeston

9.2/10

Wonderful

(15 reviews)

"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jason

CA $162

CA $183 total

includes taxes & fees

Apr 2 - Apr 3

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08&regionId=3000349349&adults=2&sort=RECOMMENDED&openPlayBack=true)

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## Stay near popular East Prairie attractions

### Big Oak Tree State Park

3.8/5 (8 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks. 

[See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655754)

## Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

[See all hotels in East Prairie](https://www.expedia.ca/Hotel-Search?startDate=2026-04-07&endDate=2026-04-08&adults=2&regionId=3000349349)

![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=395&h=400&p=1&q=high)

## Top East Prairie Hotel Reviews

## Recent Reviews in East Prairie

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Always a good value. Nice and quiet. Comfortable beds. "

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

10/10 Excellent

"Clean rooms, friendly staff and convenient location."

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg)

### Best Western Plus Sikeston I-55

10/10 Excellent

"Breakfast selection was fresh but not overwhelming in quality."

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Staff was amazing so friendly and welcoming. Room was very clean! "

[](https://expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Very nice and helpful staff "

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231_y.jpg)

### Reelfoot Lake Inn

6/10 Okay

"No stores close by . the room had a musty smell. In need of upgrade. "

[](https://expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information)

![Country Yard Inn and Suite](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/fa4ef12a_y.jpg)

### Country Yard Inn and Suite

10/10 Excellent

"Very good location and very good price besides the staff was very friendly "

[](https://expedia.ca/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information)

![Duck Hunting, Fishing or Relaxing Family Vacation](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/d93cc56b_y.jpg)

### Duck Hunting, Fishing or Relaxing Family Vacation

10/10 Excellent

"The best stocked house we’ve ever stayed at while fishing Reelfoot!!! Highly recommend and will certainly book again!!!"

[](https://expedia.ca/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information)

## More cheap stays in East Prairie

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

CA $90

CA $102 total

Mar 31 - Apr 1

includes taxes & fees

8.4/10 Very Good! (753 reviews)

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $93

CA $106 total

Mar 29 - Mar 30

includes taxes & fees

7.4/10 Good! (1,003 reviews)

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

CA $104

CA $123 total

Apr 5 - Apr 6

includes taxes & fees

9.2/10 Wonderful! (368 reviews)

[](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Holiday Inn Express & Suites Sikeston Southwest by IHG](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO

CA $128

CA $145 total

Apr 12 - Apr 13

includes taxes & fees

8.6/10 Excellent! (450 reviews)

[](https://expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

CA $127

CA $145 total

Mar 29 - Mar 30

includes taxes & fees

8.4/10 Very Good! (1,001 reviews)

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

CA $133

CA $150 total

Apr 12 - Apr 13

includes taxes & fees

9/10 Wonderful! (513 reviews)

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

## Hotels in East Prairie with star rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

5 properties

[](https://expedia.ca/3Star-East-Prairie-Hotels.s30-0-d3000349349.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

28 properties

[](https://expedia.ca/2Star-East-Prairie-Hotels.s20-0-d3000349349.Travel-Guide-Filter-Hotels)

## Frequently asked questions

### What is the best area to stay in East Prairie?

> This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.
> 
>   
> For travellers looking for a straightforward and practical base, staying near Main Street is ideal.

### When is the best time to go to East Prairie?

> These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.
> 
>   
> For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.

### Can I cancel my hotel reservation on Expedia?

### How can I save on a East Prairie hotel booking with Expedia?

### How much is the nightly rate at a East Prairie hotel?

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