Title: Book The Best Hotels in East Prairie, MO for 2026 from CA $90 - Fully Refundable Options - Expedia.ca

 

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# Find hotels in East Prairie, MO from CA $90

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## Go beyond your typical stay in East Prairie

Family friendly

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2025-12-15&d1=2025-12-15&endDate=2025-12-17&d2=2025-12-17&travelerType=family_friendly)

Pool

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2025-12-15&d1=2025-12-15&endDate=2025-12-17&d2=2025-12-17&amenities=POOL)

Pet friendly

[](https://www.expedia.ca/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2025-12-15&d1=2025-12-15&endDate=2025-12-17&d2=2025-12-17&amenities=PETS)

## Check prices for these dates

Tonight

[Dec 1 - Dec 2](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-12-01&endDate=2025-12-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Dec 2 - Dec 3](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-12-02&endDate=2025-12-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Dec 5 - Dec 7](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Dec 12 - Dec 14](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Compare 84 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

![1 bedroom, desk, laptop workspace, blackout drapes](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/7335ffbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/5e8a3e29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn and Suites by Wyndham Sikeston

Sikeston

7.2/10

Good

(1009)

"A great stay in every aspect. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gertrude

CA $88

CA $100 total

includes taxes & fees

Dec 2 - Dec 3

[](https://www.expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/686f0126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

Sikeston

9.0/10

Wonderful

(436)

"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Doncheial

CA $133

CA $151 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/1fd79e2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, sun loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

8.6/10

Excellent

(442)

"Clean and nice facilities. All the staff we met were friendly and helpful. Breakfast was great."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristen

CA $133

CA $151 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Free daily full breakfast](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/b92f19d3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/8874e729.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston

Sikeston

8.4/10

Very good

(1006)

"Very convenient and great breakfast "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Duwaine

CA $112

CA $127 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/67794888.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/57e73ffd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/6532f5b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sleep Inn at Discovery Park of America

Union City

9.2/10

Wonderful

(310)

"Awesome room wonderful breakfast great staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thomas

CA $113

CA $134 total

includes taxes & fees

Dec 28 - Dec 29

[](https://www.expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/4329af11.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/e7b8b662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

8.4/10

Very good

(715)

"Stayed one night. Good rate for the Hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

CA $91

CA $104 total

includes taxes & fees

Dec 3 - Dec 4

[](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/be665de4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/cc9ac69a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/715f35ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Sikeston/Miner Area

Sikeston

6.6/10

(561)

"The room was good a/c kept it cold "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mary

CA $81

CA $92 total

includes taxes & fees

Dec 2 - Dec 3

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8fe6deab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout drapes, iron/ironing board, free cribs/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/e3fbcab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily breakfast](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8df39481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Sikeston

Sikeston

9.4/10

Exceptional

(1006)

"Everything was clean, staff was friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew

CA $108

CA $124 total

includes taxes & fees

Dec 6 - Dec 7

[](https://www.expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

6.6/10

(611)

"Staff was great! Room was nice. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lana

CA $82

CA $91 total

includes taxes & fees

Dec 2 - Dec 3

[](https://www.expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/w1290h938x0y0-9734f59a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Banquet hall](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/3817bb3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, 1 King Bed, Non Smoking, Microwave](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/73298be5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, 1 King Bed, Non Smoking, Microwave](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/c064d51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hospitality House Union City I 69 / US 51

Union City

6.8/10

(363)

"Easy to check in.. Clean Room..Lots of food options near by.. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pooran

CA $76

CA $90 total

includes taxes & fees

Dec 30 - Dec 31

[](https://www.expedia.ca/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/6afdbde2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast area](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/5641af73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/5be64f6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/664c9838.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Sikeston I-55

Sikeston

8.4/10

Very good

(280)

"Room was clean, breakfast was very good. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Connie

CA $118

CA $134 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/7736e60a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/00c11afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free cribs/infant beds, rollaway beds, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/8d3af018.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/0cb56003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Union City US 51

Union City

8.4/10

Very good

(483)

"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Walter

CA $94

CA $111 total

includes taxes & fees

Dec 28 - Dec 29

[](https://www.expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub)](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/08371d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

Sikeston

9.4/10

Exceptional

(1010)

"Clean room, great location and friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

CA $126

CA $145 total

includes taxes & fees

Dec 5 - Dec 6

[](https://www.expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/39cbec08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

Sikeston

9.2/10

Wonderful

(37)

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

AHMAD

CA $153

CA $174 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/d5184d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property grounds](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7397c7ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/3fa32ded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7bc13d14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Hearth Inn & Suites Union City

Union City

8.6/10

Excellent

(547)

"Clean rooms, helpful and polite staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

CA $101

CA $119 total

includes taxes & fees

Dec 2 - Dec 3

[](https://www.expedia.ca/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f7d6d20c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/3f790516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing)](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/78e85b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/6c3de37b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Union City

Union City

9.6/10

Exceptional

(162)

"Staff was very friendly, room was quiet, easy to get to. Room was clean and comfortable❤️"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diana

CA $122

CA $145 total

includes taxes & fees

Dec 26 - Dec 27

[](https://www.expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/0e9a77e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 Bedroom](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/917691e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Sikeston

Sikeston

9.0/10

Wonderful

(8)

"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

CA $159

CA $180 total

includes taxes & fees

Dec 7 - Dec 8

[](https://www.expedia.ca/Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

![Free daily buffet breakfast](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/c9703c12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/2feca880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/6140f4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 1 King Bed](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/dc6c1a0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Union City by IHG

Union City

9.2/10

Wonderful

(307)

"It was a great hotel! No complaints. Loved the front staff!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Felicia

CA $133

CA $158 total

includes taxes & fees

Dec 19 - Dec 20

[](https://www.expedia.ca/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/0feda7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property - evening/night](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/c71a6d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

Cairo

6.6/10

(272)

"Break fast was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Uma

CA $101

CA $112 total

includes taxes & fees

Dec 12 - Dec 13

[](https://www.expedia.ca/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Gazebo](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/501c540f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/825a993b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from room](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/6099e00f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/a3f1cfc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn

Marston

6.0/10

(116)

"Had a great time loved it "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shyianne

[](https://www.expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-12-15&endDate=2025-12-16&regionId=3000349349&adults=2&sort=RECOMMENDED&openPlayBack=true)

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Save an average of 15% on thousands of hotels when you're signed in

[Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)

![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_CA_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

Black Friday Sale

Limited-time deals: save up to 50% on select hotels

[Book now](https://expedia.ca/deals?rfrr=HTG_BF_PROMO_3000349349)

## Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

[See all hotels in East Prairie](https://www.expedia.ca/Hotel-Search?startDate=2025-12-15&endDate=2025-12-16&adults=2&regionId=3000349349)

![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=900&h=292&p=1&q=high)

## More cheap stays in East Prairie

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $88

CA $100 total

Dec 2 - Dec 3

includes taxes & fees

7.2/10 Good! (1,005 reviews)

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

CA $133

CA $151 total

Dec 7 - Dec 8

includes taxes & fees

8.8/10 Excellent! (432 reviews)

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

CA $113

CA $134 total

Dec 28 - Dec 29

includes taxes & fees

9/10 Wonderful! (306 reviews)

[](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

CA $91

CA $104 total

Dec 3 - Dec 4

includes taxes & fees

8.4/10 Very Good! (713 reviews)

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

CA $112

CA $127 total

Dec 7 - Dec 8

includes taxes & fees

8.2/10 Very Good! (1,003 reviews)

[](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

CA $108

CA $124 total

Dec 6 - Dec 7

includes taxes & fees

9.2/10 Wonderful! (1,004 reviews)

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

## Hotels in East Prairie with star-rating

![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg)

3 Star Hotels

5 properties

[](https://expedia.ca/3Star-East-Prairie-Hotels.s30-0-d3000349349.Travel-Guide-Filter-Hotels)

![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg)

2 Star Hotels

28 properties

[](https://expedia.ca/2Star-East-Prairie-Hotels.s20-0-d3000349349.Travel-Guide-Filter-Hotels)

## Recent reviews of East Prairie hotels

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg)

### Hampton Inn Sikeston

5/5 Excellent

"Clean room chuck was very helpful with checking in ect..."

A verified traveller from Tatum stayed at Hampton Inn Sikeston

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

5/5 Excellent

"Everything was clean and comfortable. "

A verified traveller stayed at Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Posted 4 days ago

[](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Super 8 By Wyndham Marston](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d663210_y.jpg)

### Super 8 By Wyndham Marston

5/5 Excellent

"Great staff "

A verified traveller stayed at Super 8 By Wyndham Marston

Posted 4 days ago

[](https://expedia.ca/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

5/5 Excellent

"Friendly staff, clean room, comfortable beds and great breakfast"

A verified traveller stayed at Drury Inn & Suites Sikeston, MO

Posted 5 days ago

[](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Hampton Inn Union City](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f7d6d20c_y.jpg)

### Hampton Inn Union City

5/5 Excellent

"Spotless with courteous staff"

A verified traveller stayed at Hampton Inn Union City

Posted 6 days ago

[](https://expedia.ca/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg)

### Pear Tree Inn Sikeston

5/5 Excellent

"Check-in took only a few minutes and staff was courteous and efficient. All was explained clearly and efficiently. Room was clean and well maintained. I did not take part in the 5:30 pm event or attend breakfact, so I cannot comment on these amenities. Everything else was wonderful."

A verified traveller stayed at Pear Tree Inn Sikeston

Posted 6 days ago

[](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

5/5 Excellent

"Comfortable bed. Remodeled. Clean. Good breakfast & friendly staff."

A verified traveller stayed at Days Inn and Suites by Wyndham Sikeston

Posted 6 days ago

[](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg)

### Sleep Inn at Discovery Park of America

5/5 Excellent

"Love this hotel! Staff are great! Great location next to Discovery Pak!"

A verified traveller stayed at Sleep Inn at Discovery Park of America

Posted 7 days ago

[](https://expedia.ca/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Hospitality House Union City I 69 / US 51](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/w1290h938x0y0-9734f59a_y.jpg)

### Hospitality House Union City I 69 / US 51

5/5 Excellent

"Yes, that was very nice andStaff friendly"

A verified traveller stayed at Hospitality House Union City I 69 / US 51

Posted 8 days ago

[](https://expedia.ca/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information)

## Frequently asked questions

### When is the best time to go to East Prairie?

> The most popular time to visit East Prairie is June. As the summer begins, the weather is typically warm, with temperatures ranging from 22 to 28 Celsius, superb for enjoying the great outdoors and taking part in local events.
> 
>   
> 
> From June through August, East Prairie experiences its peak season, drawing in visitors eager to explore the area's natural beauty and vibrant community. This is an ideal time for those who love outdoor activities, as the lush landscapes and scenic parks offer ample opportunities for hiking, biking, and picnicking. The comfortable warmth encourages leisurely strolls through the town and along the lakes, making it a delightful time for sightseeing.
> 
>   
> 
> If you're considering a trip with family or friends, June is particularly lively, with various festivals and events taking place, allowing you to immerse yourself in the local culture and traditions. The friendly atmosphere and the chance to connect with residents can enhance your experience, making your adventure even more memorable.
> 
>   
> 
> For travellers seeking a more budget-friendly option, November presents a great opportunity to explore East Prairie at slightly lower prices. While the weather may be cooler, you can still enjoy the charm of the town and its surroundings, perhaps even embracing the quieter pace of life during this season.

### Can I cancel my hotel reservation on Expedia?

> You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.

### How can I save on a East Prairie hotel booking with Expedia?

> Before booking your East Prairie hotel, remember to join Expedia's free travel rewards program. Just sign up and sign in to access our lowest Member Prices as well as members-only perks. You could also enjoy savings by bundling together your hotel and flights on Expedia.

### How much is the nightly rate at a East Prairie hotel?

> Prices for hotels in East Prairie often vary, but you can find a great deal from CA $90 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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