Book The Best Hotels in Charleston, MO for 2026 from CA $93 - Fully Refundable Options

A sunset over a calm lake with tall trees reflected in the water.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Charleston

Cabin

Family friendly

Apartment

Pet friendly

Pool

Waterpark

Condo

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Charleston hotels

A building with a fountain and flower beds in front.

A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.

A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

A reception area with a stone wall, wooden cabinets, and a sign for The Riverstone Hotel.

1. The Riverstone Hotel Charleston-Sikeston

Charleston

Kathleen

CA $95

CA $105 total

includes taxes & fees

Oct 9 - Oct 10

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

A reception area with a counter, a flat-screen TV, and a window with blinds.

A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.

2. Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

William

CA $85

CA $95 total

includes taxes & fees

Oct 7 - Oct 8

A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.

A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

A hotel room with two beds, a nightstand, a lamp, and a window with curtains.

A motel with a sign reading "Eagle Inn" and a parking lot with several cars.

3. Eagle Inn Charleston

Charleston

Jackson

CA $94

CA $104 total

includes taxes & fees

Oct 11 - Oct 12

An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.

An outdoor seating area with sofas and planters, surrounded by a building with large windows and a brick wall.

A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.

4. Drury Inn & Suites Sikeston, MO

Sikeston

Scott

CA $134

CA $154 total

includes taxes & fees

Oct 11 - Oct 12

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.

5. Best Western Plus Sikeston I-55

Sikeston

Shelley

CA $120

CA $137 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.

A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.

A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.

A living room with a sofa, two chairs, a coffee table, a television, and a window with blinds.

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

Craig

CA $88

CA $100 total

includes taxes & fees

Oct 26 - Oct 27

A hotel with a large parking lot and a well-lit entrance.

A hotel lobby with a reception desk, seating area, and a large window.

A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

A hotel room with two beds, a desk with a computer, a television, and a window with curtains.

7. Quality Inn Cairo I-57

Cairo

Santiago

CA $97

CA $108 total

includes taxes & fees

Oct 30 - Oct 31

An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".

A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

An outdoor bar area with a modern design, featuring a counter, seating, and a view of the interior.

8. Fairfield Inn & Suites by Marriott Sikeston

Sikeston

Allen

CA $144

CA $164 total

includes taxes & fees

Oct 15 - Oct 16

A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

A spacious lobby with a central atrium, a piano, and a reception desk.

9. Days Inn and Suites by Wyndham Sikeston

Sikeston

David

CA $95

CA $108 total

includes taxes & fees

Oct 8 - Oct 9

A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.

A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.

10. Hampton Inn Sikeston

Sikeston

Carolyn

CA $150

CA $171 total

includes taxes & fees

Oct 18 - Oct 19

A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

A hotel kitchen with a long counter, various appliances, and a tiled backsplash.

A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.

A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.

11. Super 8 by Wyndham Sikeston/Miner Area

Sikeston

William

CA $81

CA $93 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.

A buffet with various food items, including omelets and baked goods, served in metal containers.

A reception area with a reception desk, a large wall-mounted sign, and a potted plant.

A kitchenette with a coffee machine, a kettle, and storage shelves.

12. Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

Melissa

CA $144

CA $164 total

includes taxes & fees

Oct 25 - Oct 26

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a painting on the wall.

A compact room with a television on a cabinet, a microwave, a small refrigerator, a table, and a chair.

A reception desk with a computer, a framed picture on the wall, and a vase with flowers.

A motel with a red roof and beige walls, a parking lot, and a signboard.

13. La Center Motel

La Center

Carrie

CA $69

CA $82 total

includes taxes & fees

Oct 7 - Oct 8

An outdoor bar area with a modern design, featuring a counter, bar stools, and a seating area with chairs.

A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.

14. TownePlace Suites by Marriott Sikeston

Sikeston

Stacy

CA $150

CA $170 total

includes taxes & fees

Oct 18 - Oct 19

A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.

A hot tub area with a tiled floor, a wooden deck surrounding the tub, and a view of the sky through large windows.

A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.

A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.

15. Comfort Inn & Suites Sikeston I-55

Sikeston

Starlette

CA $119

CA $135 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with two beds, a desk, a chair, a TV, and a mirror.

A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.

A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

A reception area with a counter, a coffee machine, and seating.

16. Country Yard Inn and Suite

Sikeston

William

CA $80

CA $95 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.

A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

17. Drury Plaza Hotel Cape Girardeau Conference Center

Cape Girardeau

Sandra

CA $143

CA $161 total

includes taxes & fees

Nov 1 - Nov 2

A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

A hotel room with a large bed, two bedside tables, a desk with a chair, and two lamps.

A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

18. Drury Inn & Suites Cape Girardeau

Cape Girardeau

Teresa

CA $131

CA $148 total

includes taxes & fees

Oct 11 - Oct 12

A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.

19. Pear Tree Inn Cape Girardeau West

Cape Girardeau

Elizabeth

CA $103

CA $116 total

includes taxes & fees

Oct 26 - Oct 27

A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.

A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.

A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

20. The Riverview

Cape Girardeau

Alyssa

CA $148

CA $167 total

includes taxes & fees

Oct 26 - Oct 27

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Learn more about Charleston

Quaint Charleston is calling! Discover its opera, entertainment, cathedral, and more.

See all hotels in Charleston

Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent

"Wonderful. Very clean, spacious and lovely staff. Breakfast was delicious also."

Days Inn and Suites by Wyndham Sikeston

8/10 Good

"Everything was good about the room except the bathroom. The stopper on the sink did not work and there was a dent in the wall. The face/wash towels need to be changed out. They are no longer white. They are dull in color. The couch needs to be cleaned and freshen. The staff was excellent and everything else is good. I just wish that breakfast offered hot eggs and meat vs. only waffles. Otherwise the room was good."

Hampton Inn Sikeston

10/10 Excellent

"Clean, safe, quiet and a very good breakfast."

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

10/10 Excellent

"Perfect location, beds were awesome & staff were friendly & accommodating!"

Drury Inn & Suites Cape Girardeau

10/10 Excellent

"No exhaust fan in the bathroom. Other than that very clean comfortable hotel"

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent

"Great place"

Candlewood Suites Cape Girardeau by IHG

8/10 Good

"I usually stay here if I need to because I travel back and forth from northern IL and I usually have a lot of food to take home to southern MS. The full size fridge and freezer is very nice to have available and you don’t have to book a super fancy room to get one. Housekeeping can be hard work, but missing a rather large blood stain on the wall behind the door is disturbing. Thankfully I always travel with Lysol wipes and cleaned it up."

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good

"NA NA NA NA NA NA NA NA NA NA NA NA NA"

Hampton Inn Cape Girardeau I 55 East

8/10 Good

"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."

More cheap stays in Charleston

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO

CA $81

CA $93 total

Oct 22 - Oct 23

includes taxes & fees

7/10 Good! (682 reviews)

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

CA $95

CA $108 total

Oct 8 - Oct 9

includes taxes & fees

7.2/10 Good! (1,001 reviews)

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

CA $103

CA $116 total

Oct 26 - Oct 27

includes taxes & fees

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO

CA $120

CA $137 total

Oct 11 - Oct 12

includes taxes & fees

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO

CA $121

CA $145 total

Oct 11 - Oct 12

includes taxes & fees

8/10 Very good! (1,001 reviews)

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO

CA $144

CA $164 total

Nov 1 - Nov 2

includes taxes & fees

9.4/10 Exceptional! (1,004 reviews)

Hotels in Charleston with star rating

Frequently asked questions

What is the best area to stay in Charleston?

The best area to stay in Charleston, Missouri, is near the intersection of Main Street and US-60, as this is the primary commercial hub.This area offers the most convenience for travellers, with several hotels, local eateries, and essential services clustered together. You'll find most of the town's amenities within a short drive or walk from here, making it an excellent base for exploring the surrounding region.For those travelling for business or looking for easy access to regional transport routes, this central location is ideal.

What are the best hotels in Charleston that travellers recommend?

Two of the best hotels in Charleston that receive consistently high recommendations from travellers are the Super 8 by Wyndham Charleston/Sikeston East MO and the Quality Inn Charleston - Sikeston.The Super 8 by Wyndham Charleston/Sikeston East MO provides air-conditioned rooms, with guests often commenting on how big the rooms are and how helpful the staff are. A free breakfast, including a to-go option, is available.Another highly recommended option is the Quality Inn Charleston - Sikeston. Guests often mention the good rooms, nice beds, and nice showers. This hotel offers a free buffet breakfast and free self-parking, including space for RVs, buses, and trucks. Fitness facilities are available at a nearby location at no extra charge.

What are the best family hotels in Charleston?

For family-friendly hotels in Charleston, consider the Super 8 by Wyndham Charleston/Sikeston East MO, the Quality Inn Charleston - Sikeston, or the Eagle Inn Charleston.The Super 8 by Wyndham Charleston/Sikeston East MO offers free breakfast and complimentary to-go breakfast options, which are very convenient for families on the go. Guests have noted that the staff are helpful and the rooms are big, providing ample space for families. Cribs are also available free of charge.The Quality Inn Charleston - Sikeston provides free buffet breakfast, free self-parking, and free WiFi, which are all excellent amenities for families. Many guests appreciate the comfortable beds, good rooms, and nice showers. Sofa beds are also available.Another good choice is the Eagle Inn Charleston. This hotel offers free WiFi and free parking for RVs, buses, and trucks, which can be useful for families traveling with larger vehicles. Rollaway and extra beds are available free of charge, adding flexibility for sleeping arrangements. Find more child-friendly accommodations in Charleston

What hotels in Charleston offer free breakfast?

For hotels in Charleston that offer a complimentary breakfast, consider the Quality Inn Charleston - Sikeston and the Super 8 by Wyndham Charleston/Sikeston East MO.The Quality Inn Charleston - Sikeston provides guests with a free buffet breakfast daily, and it also includes free self-parking and free WiFi. Guests have noted that the beds are nice and the rooms and showers are good.Another excellent option is the Super 8 by Wyndham Charleston/Sikeston East MO, which offers a free breakfast, including a convenient To Go breakfast option. This hotel also provides free self-parking and free WiFi. Guests frequently comment on the helpful and great staff, and the big rooms. Find more hotels with free breakfast in Charleston

What are the top pet-friendly hotels in Charleston?

For pet-friendly accommodation in Charleston, the Quality Inn Charleston - Sikeston, the Eagle Inn Charleston, and the Super 8 by Wyndham Charleston/Sikeston East MO are all excellent choices.The Quality Inn Charleston - Sikeston allows pets and provides complimentary buffet breakfast and free breakfast. Guests have frequently commented on the nice beds, good rooms, and nice showers.Another great option is the Eagle Inn Charleston, which also permits pets. This hotel offers free WiFi, along with complimentary RV, bus, and truck parking, as well as free self-parking.The Super 8 by Wyndham Charleston/Sikeston East MO welcomes pets and provides early check-in options, along with free breakfast and free to-go breakfast. Guests often praise the helpful and great staff, as well as the big rooms. See more pet-friendly hotels in Charleston

What are the best budget hotels in Charleston?

For budget hotels in Charleston, consider the Quality Inn Charleston - Sikeston, Super 8 by Wyndham Charleston/Sikeston East MO, or the Eagle Inn Charleston.The Quality Inn Charleston - Sikeston offers complimentary self-parking and free buffet breakfast, along with free WiFi. Guests have commented on the nice beds, good rooms, and nice shower facilities.Another good option is the Super 8 by Wyndham Charleston/Sikeston East MO. This hotel provides free to-go breakfast, free self-parking, and free WiFi. Guests often mention the helpful and great staff, as well as the big rooms.The Eagle Inn Charleston provides free WiFi, free RV, bus, or truck parking, and free self-parking. It also features a health club for guests. View all budget hotels in Charleston

When is the best time to go to Charleston?

The best time to visit Charleston, Missouri, is during the spring (April to May) and autumn (September to October) months.These periods offer pleasant weather, with moderate temperatures and less humidity, making it ideal for exploring the town and its surroundings comfortably. Spring brings blooming dogwood trees, while autumn showcases lovely fall foliage, particularly around the Mississippi River.For those interested in local events, the Dogwood-Azalea Festival in April is a highlight, featuring parades, home tours, and craft fairs. It's a popular time, so booking accommodation in advance is a good idea.

Can I cancel my hotel reservation on Expedia?

You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Charleston.

How much is the nightly rate at a Charleston hotel?

Prices for hotels in Charleston often vary, but you can find a great deal from CA $93 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia

Book Hotels in Charleston on Expedia.com

Find hotels in Charleston, MO from CA $93

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Charleston

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Charleston hotels

1. The Riverstone Hotel Charleston-Sikeston

2. Super 8 by Wyndham Charleston/Sikeston East MO

3. Eagle Inn Charleston

4. Drury Inn & Suites Sikeston, MO

5. Best Western Plus Sikeston I-55

6. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

7. Quality Inn Cairo I-57

8. Fairfield Inn & Suites by Marriott Sikeston

9. Days Inn and Suites by Wyndham Sikeston

10. Hampton Inn Sikeston

11. Super 8 by Wyndham Sikeston/Miner Area

12. Holiday Inn Express & Suites Sikeston Southwest by IHG

13. La Center Motel

14. TownePlace Suites by Marriott Sikeston

15. Comfort Inn & Suites Sikeston I-55

16. Country Yard Inn and Suite

17. Drury Plaza Hotel Cape Girardeau Conference Center

18. Drury Inn & Suites Cape Girardeau

19. Pear Tree Inn Cape Girardeau West

20. The Riverview

Learn more about Charleston

Top Charleston Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Days Inn and Suites by Wyndham Sikeston

Hampton Inn Sikeston

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Drury Inn & Suites Cape Girardeau

Super 8 by Wyndham Sikeston/Miner Area

Candlewood Suites Cape Girardeau by IHG

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Hampton Inn Cape Girardeau I 55 East

More cheap stays in Charleston

Super 8 by Wyndham Sikeston/Miner Area

Days Inn and Suites by Wyndham Sikeston

Pear Tree Inn Cape Girardeau West

Best Western Plus Sikeston I-55

Candlewood Suites Cape Girardeau by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hotels in Charleston with star rating

Frequently asked questions

Explore a world of travel with Expedia

Go further with the Expedia app