Comfort Inn & Suites Sikeston I-55

Property class: 2.5

Choose dates to view prices

You can look forward to laundry facilities, a gym, and a business center at Comfort Inn & Suites Sikeston I-55. Stay connected with free in-room WiFi.

Reviews

8.4 out of 10
Very good

Popular amenities

  • Pool
  • Pet friendly
  • Parking included
  • Free WiFi
  • Air conditioning
  • Gym

Room options

Available filters for rooms
Showing 5 of 5 rooms

View all photos for Standard Room, 2 Queen Beds, Non Smoking

A hotel room with two beds, a desk, a chair, a lamp, and a window with curtains.

Standard Room, 2 Queen Beds, Non Smoking

8.0 out of 10
Very good
(15 reviews)
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Suite, 1 King Bed with Sofa bed, Non Smoking

A hotel room with a blue sofa, a bed, a nightstand, and a lamp. There are three framed pictures on the wall.

Suite, 1 King Bed with Sofa bed, Non Smoking

  • 1 bedroom
  • Sleeps 4
  • 1 King Bed and 1 Double Sofa Bed

View all photos for Room, 1 King Bed, Accessible, Non Smoking

A hotel room with a large bed, a desk, a chair, and a small ottoman.

Room, 1 King Bed, Accessible, Non Smoking

8.6 out of 10
Excellent
(4 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

View all photos for Room, 2 Queen Beds, Accessible, Non Smoking

A hotel room with two beds, a microwave, a mini-fridge, a coffee maker, and a window with curtains.

Room, 2 Queen Beds, Accessible, Non Smoking

10.0 out of 10
Exceptional
(4 reviews)
  • 1 bedroom
  • Sleeps 4
  • 2 Queen Beds

View all photos for Standard Room, 1 King Bed, Non Smoking

A hotel room with a large bed, two bedside tables with lamps, a window with curtains, and a wall-mounted heater.

Standard Room, 1 King Bed, Non Smoking

8.0 out of 10
Very good
(15 reviews)
  • 1 bedroom
  • Sleeps 2
  • 1 King Bed

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A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

Best Western Plus Sikeston I-55

Sikeston
  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
8.4 out of 10, Very good, 1,003 reviews
The price is CA $112
CA $127 total
includes taxes & fees
Nov 8 - Nov 9
Best Western Plus Sikeston I-55
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About the area

Sikeston is home to Comfort Inn & Suites Sikeston I-55. The area's natural beauty can be seen at Mississippi River and Central Park, while Sikeston Depot Museum and Front Street Studio & Art Gallery are cultural highlights. Visit our Sikeston travel guide
Map
109 Matthews Ln, Sikeston, MO, 63801

What's nearby

  • A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.
    Southeast Missouri State University
    31 min drive - 60.8 km
  • City of Miner Convention Center
    5 min walk - 0.4 km
  • Sikeston Depot Museum
    5 min drive - 5.9 km
  • Riverfront Park
    29 min drive - 59.8 km
  • Century Casino & Hotel Cape Girardeau
    31 min drive - 61.5 km

Getting around

  • Cape Girardeau, MO (CGI-Cape Girardeau Municipal)
    29 min drive

Restaurants

  • Lambert's Cafe
    17 min walk
  • Buffalo Wild Wings
    5 min drive
  • The 110 Grill
    2 min drive
  • Pizza Inn
    2 min drive
  • Starbucks
    6 min drive

About this property

Comfort Inn & Suites Sikeston I-55

  • Property highlights
  • Take advantage of laundry facilities, a gym, and a business center at Comfort Inn & Suites Sikeston I-55. Stay connected with free in-room WiFi.
  • Other perks include:
    • An indoor pool
    • Free self parking
    • A 24-hour front desk, a front-desk safe, and laundry services
    • An elevator
    • Guest reviews give top marks for the helpful staff
  • Room features
  • All 64 rooms feature comforts such as air conditioning, in addition to amenities like free WiFi.
  • Other amenities include:
    • Bathrooms with tubs or showers
    • Cable channels, coffee/tea makers, and desks

Similar properties

A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
Best Western Plus Sikeston I-55
Sikeston
  • Pool
  • Breakfast included
  • Pet friendly
  • Parking included
8.4 out of 10, Very good, 1,003 reviews
The price is CA $112
CA $127 total
includes taxes & fees
Nov 8 - Nov 9
Best Western Plus Sikeston I-55
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Frequently asked questions

Does Comfort Inn & Suites Sikeston I-55 have a pool?

Yes, this property has an indoor pool.

How much does it cost to stay at Comfort Inn & Suites Sikeston I-55?

As of Oct 24, 2026, prices found for a 1-night stay for 2 adults at Comfort Inn & Suites Sikeston I-55 on Nov 15, 2026 start from CA $122, excluding taxes and fees. This price is based on the lowest nightly price found in the last 24 hours for stays in the next 30 days. Prices are subject to change. Choose your dates for more accurate prices.

Is Comfort Inn & Suites Sikeston I-55 pet-friendly?

Yes, Comfort Inn & Suites Sikeston I-55 allows cats and dogs (limit 2 total) with a maximum weight of up to 20 lbs per pet. There's a fee of USD 20 per pet, per night. Service animals are exempt from fees.

How much is parking?

Self parking is free at this property.

What time is check-in at Comfort Inn & Suites Sikeston I-55?

Check-in start time: 2:00 PM; Check-in end time: anytime.

What time is check-out at Comfort Inn & Suites Sikeston I-55?

Check-out is at 11:00 AM.

Where is Comfort Inn & Suites Sikeston I-55 located?

Situated in Sikeston, this hotel is 0.4 mi (0.6 km) from City of Miner Convention Center and within 6 mi (10 km) of Sikeston Depot Museum and Central Park. Front Street Studio & Art Gallery is 9 mi (14.5 km) away.

Can I cancel my reservation for free and receive a full refund?

Yes, this property offers free cancellation on select room rates, because flexibility matters! Please refer to the property cancellation policy on our site for more details about any exclusions or requirements.

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Reviews

Comfort Inn & Suites Sikeston I-55 Reviews

8.4

Very good

8.4

Cleanliness

8.6

Location

8.8

Staff & service

8.2

Property conditions & facilities
Rating 10 - Excellent. 151 out of 318 reviews
Rating 8 - Good. 102 out of 318 reviews
Rating 6 - Okay. 31 out of 318 reviews
Rating 4 - Poor. 21 out of 318 reviews
Rating 2 - Terrible. 13 out of 318 reviews

Reviews

Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Our room was very clean and comfy. The bathroom was clean but could use an update. The bathroom tissue and face tissues are on the thin side. Breafast bar was excellent. The staff was very nice and helpful.
Stayed 1 night in Oct 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Hotel was nice an clean. Friendly staff. Clean hotel rooms and free breakfast every morning.
Stayed 3 nights in Apr 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
The hotel was very clean, beds were comfortable, and staff was friendly and helpful.
Stayed 1 night in Dec 2025
Verified review

10/10 Excellent

Liked: Cleanliness, property conditions & facilities
Room was clean, breakfast was very good.
Stayed 1 night in Nov 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities
Very nice staff & clean room
Stayed 1 night in Dec 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
nice room, clean. breakfast was great and lady keeping it full, hot, and clean!
Stayed 1 night in Mar 2026
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
It was a very nice stay. The pool was clean and enjoying!
Stayed 1 night in Jul 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Very clean, nice staff and good breakfast
Stayed 1 night in Aug 2023
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice hotel with great staff. Room was fine, breakfast could be better but overall a good stay for this area.
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We were in town for a pit-stop to sleep and the staff was very nice. Comfy beds and nice location
Stayed 1 night in Mar 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Great for overnights, staff friendly and attentive
Stayed 1 night in Apr 2024
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Right off the main drag, huge complimentary breakfast area
Stayed 1 night in May 2024
Verified review

8/10 Good

hotel was fine clean and convient
Stayed 1 night in Feb 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
The facility was very nice.
Stayed 2 nights in May 2025
Verified review

8/10 Good

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Good stay

It was decent…slept well The room was clean
Stayed 1 night in May 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Conveniant to I55, clean, and comfortable,
Stayed 1 night in Dec 2024
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Perfect Pit Stop

Check in was easy with friendly staff. Hotel had everything you would need, plus walking distance to dining.
Stayed 1 night in Sep 2024
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Nice spacious rooms. Beds were very comfortable. Quiet place.
Stayed 1 night in Jan 2025
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Room carpet could use changing, but otherwise clean, quiet, feiendly staff, and a great morning breakfast.
Stayed 1 night in Sep 2024
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, property conditions & facilities
Check in was quick and easy. Very courteous and professional staff.
Stayed 1 night in Mar 2024
Verified review

8/10 Good

Liked: Property conditions & facilities
Seems like clean well kept property!
Stayed 1 night in May 2024
Verified review

8/10 Good

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very good customer service. Rooms were worth the price.
Stayed 2 nights in May 2024
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
This was very easy to get to and easy on the highway. Clean. Check in was awesome. I would definitely stay here again.
Stayed 1 night in Sep 2023
Verified review

10/10 Excellent

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
our room was clean and well kept.
Stayed 1 night in May 2024
Verified review

8/10 Good

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Just one night

We were in town for a funeral and to visit family. We were only at the hotel for a place to sleep. It was comfortable, quiet, and clean. Plus, it was very affordable.
Stayed 1 night in Nov 2024