A tree-lined landscape with a river and fields.

East Prairie Vacation Rentals

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Check prices for these dates

In two weeks
Oct 30 - Nov 1
In two months
Dec 11 - Dec 13
In three months
Jan 8 - Jan 10
In four months
Feb 5 - Feb 7

Our top choices for East Prairie vacation rentals

A single-story house with a gabled roof, a front porch with two chairs, and a front door with a decorative glass panel.

1. Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!

Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
New Madrid
10.0 out of 10, Exceptional, (1 review)
"The host was very quick to respond and so great to work with for on our stay. "
United States
Jessica S.
The price is CA $284
CA $527 total
includes taxes & fees
Oct 17 - Oct 18
Spacious 3-bedroom 2 story house in New Madrid near boat ramp with a toy room!
A covered outdoor seating area with stone flooring and chairs, a stone pathway, and a wooden structure.

2. Vacation rental attached to our house out in the country.

Vacation rental attached to our house out in the country.
Union City
10.0 out of 10, Exceptional, (7 reviews)
"The home was spotless, very comfortable and a great location for what we needed."
United States
Sherrie S.
The price is CA $142
CA $231 total
includes taxes & fees
Oct 16 - Oct 17
Vacation rental attached to our house out in the country.
A wooden interior with a herringbone floor, a sliding barn door, a wooden door with a glass panel, and a window with blinds.

3. Tiny house on the lake with tv free internet walk shower

Tiny house on the lake with tv free internet walk shower
Tiptonville
10.0 out of 10, Exceptional, (1 review)
"Dave was very accommodating and the home was clean."
United States
Katherine P.
The price is CA $256
CA $441 total
includes taxes & fees
Oct 21 - Oct 22
Tiny house on the lake with tv free internet walk shower
A kitchen with wooden cabinets, a stainless steel refrigerator, a built-in oven, and a large window.

4. 3-bedroom house in charming Tiptonville with cool AC and washer and dryer

3-bedroom house in charming Tiptonville with cool AC and washer and dryer
Tiptonville
10.0 out of 10, Exceptional, (1 review)
"Easy to get along with and great communication. "
United States
Shane W.
The price is CA $192
CA $335 total
includes taxes & fees
Oct 20 - Oct 21
3-bedroom house in charming Tiptonville with cool AC and washer and dryer
A modern kitchen with wooden cabinetry, a marble countertop, and a central island with bar stools.

5. Cozy rustic studio near Reelfoot Lake

Cozy rustic studio near Reelfoot Lake
Troy
The price is CA $166
CA $218 total
includes taxes & fees
Oct 19 - Oct 20
Cozy rustic studio near Reelfoot Lake
A covered outdoor area with a grill, chairs, and a table.

6. Come and relax at the Refuge at beautiful Reelfoot Lake!

Come and relax at the Refuge at beautiful Reelfoot Lake!
Hornbeak
9.4 out of 10, Exceptional, (37 reviews)
"Location was great. We were down for a few days fishing."
United States
Andrew
The price is CA $186
CA $348 total
includes taxes & fees
Oct 23 - Oct 24
Come and relax at the Refuge at beautiful Reelfoot Lake!
A small, single-story mobile home with a covered porch and a sign that reads "THE HUT".

7. The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed

The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed
Hornbeak
9.8 out of 10, Exceptional, (60 reviews)
"Great place to stay! Clean and convenient location what more can you ask for! "
United States
Austin E.
The price is CA $178
CA $346 total
includes taxes & fees
Oct 25 - Oct 26
The Hut. Cozy 2-bedroom mobile home on peaceful Reelfoot Lake with boat shed
A kitchen with a stainless steel stove, a range hood, wooden cabinets, and a herringbone wood backsplash.

8. Charming 3-bedroom house with free wifi and coffee it is close to the lake

Charming 3-bedroom house with free wifi and coffee it is close to the lake
Hornbeak
10.0 out of 10, Exceptional, (11 reviews)
"This place was great! It has everything you need and the neighborhood was quiet. The beautiful view of the lake makes it very peaceful! "
United States
Jamie M.
The price is CA $224
CA $396 total
includes taxes & fees
Oct 16 - Oct 17
Charming 3-bedroom house with free wifi and coffee it is close to the lake
A covered patio with a white bench, a glass table, and a fan.

9. Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR

Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR
Hornbeak
9.8 out of 10, Exceptional, (63 reviews)
"Very clean and very helpful host"
United States
Whitney C.
The price is CA $237
CA $413 total
includes taxes & fees
Oct 21 - Oct 22
Fish cleaning station, screened porch, covered front porch, fire pit, 3 BR
A wooden interior with a dining table, chairs, a sofa, and a fireplace.

10. 3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters

3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters
Hornbeak
10.0 out of 10, Exceptional, (15 reviews)
"As long time visitors to Reelfoot this is hands down the best place we have ever stayed! We rented for a family hunting trip and the property is amazing. "
United States
Paul M.
The price is CA $284
CA $546 total
includes taxes & fees
Oct 25 - Oct 26
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters
A bedroom with a bed, a dresser, a television, and a small table with a plant.

11. Sunkist beach house. Lake side house 3 bedroom house

Sunkist beach house. Lake side house 3 bedroom house
Tiptonville
10.0 out of 10, Exceptional, (5 reviews)
"Great experience!! A quality stay with great communication from Host. Will be back! "
United States
Steven L.
The price is CA $320
CA $523 total
includes taxes & fees
Oct 16 - Oct 17
Sunkist beach house. Lake side house 3 bedroom house
A large, single-story building with two open garage-style doors, surrounded by trees with autumn foliage.

12. Guest house and spacious shop located between Discovery Park and Reelfoot Lake

Guest house and spacious shop located between Discovery Park and Reelfoot Lake
Union City
10.0 out of 10, Exceptional, (3 reviews)
"Wonderful place to relax. Home has everything you need. The additional party barn is an added bonus!!"
United States
william P.
The price is CA $358
CA $550 total
includes taxes & fees
Oct 16 - Oct 17
Guest house and spacious shop located between Discovery Park and Reelfoot Lake
A wooden structure with a porch, labeled "1086", and a sign advertising nightly rentals at "The Hut II" with contact information.

13. The Hut II on Reelfoot Lake

The Hut II on Reelfoot Lake
Hornbeak
9.8 out of 10, Exceptional, (11 reviews)
"It’s one of our favorite places to stay. "
United States
Laura W.
The price is CA $215
CA $393 total
includes taxes & fees
Nov 2 - Nov 3
The Hut II on Reelfoot Lake
A hot tub in an outdoor setting with a wooden deck and lounge chairs.

14. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
The price is CA $174
CA $265 total
includes taxes & fees
Oct 17 - Oct 18
Perfect Couples Retreat - firepit
A kitchen with wooden cabinets, a stainless steel stove, and a wall-mounted sign.

15. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
The price is CA $203
CA $296 total
includes taxes & fees
Oct 27 - Oct 28
The Roost | Hot Tub, Ponds & Farm Views
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top East Prairie Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Very friendly & professional staff. Trustworthy room attendants, with attention to details. Beds comfortable. Everyone enjoyed the morning breakfast, with a good menu. Cocktail hour widely attended. Would definitely stay here again!"
Sherri 2-night trip
Posted 3 hours ago
Drury Inn & Suites Sikeston, MO

Find out more about East Prairie

Everything you need to know about East Prairie vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the East Prairie vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect East Prairie vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search. 

East Prairie vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in East Prairie. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in . 

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A East Prairie vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of East Prairie vacation rentals we have selected for you start as low as CA $231 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on East Prairie rentals

At Expedia, we put the best East Prairie vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia. 

To find some top East Prairie rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream East Prairie vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around East Prairie. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence. 

Frequently asked questions

Can I find a vacation rental in East Prairie?

Yes, you can find vacation rentals near the most popular sights in East Prairie, or you can select a more secluded option if you're looking for a relaxing stay.

What's the top vacation rental that East Prairie has to offer?

Duck Hunting, Fishing or Relaxing Family Vacation: This vacation home rental near East Prairie is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family.

What can I see and do in East Prairie?

Big Oak Tree State Park and Mississippi River are a couple of lovely local spots to get outside and enjoy nature. In the larger area, you’ll find Columbus-Belmont State Park and Fort Defiance State Park.

What are vacation rentals like in East Prairie?

Vacation rentals are privately owned accommodations you can reserve for a few days or a quick weekend in East Prairie. Vacation rentals feature extras like kitchens and laundry facilities so you'll feel right at home. If you're concerned about a sanitized environment, vacation rentals can offer a sense of security away from public hotel elevators and lobbies packed with people while still allowing you to travel. You'll also get more space in a vacation rental than in a traditional hotel, which is another reason why a vacation rental is a popular choice for family trips.