Title: Visit East Prairie: Best of East Prairie Tourism | Expedia Travel Guide - Expedia.ca [Hotels in East Prairie](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Vacation Rentals in East Prairie](https://expedia.ca/East-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[East Prairie Car Rentals](https://expedia.ca/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.ca/East-Prairie.d3000349349.Destination-Travel-Guides) # East Prairie ## Travel Guide ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit East Prairie Things to do - East Prairie Hotel Deals - Vacation Rentals in East Prairie ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO CA $153 CA $176 total Apr 5 - Apr 6 includes taxes & fees Book a stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ... 9.6/10 Exceptional! (1,006 reviews) We decided we will stay here next year on our trip home from Texas. Reviewed on Apr 3, 2026 [](https://expedia.ca/Hotel-Search?startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=3000349349) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO CA $148 CA $168 total Apr 12 - Apr 13 includes taxes & fees Stay at this hotel in Sikeston. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. Popular attractions Central ... 9/10 Wonderful! (526 reviews) Yes, breakfast was fresh. Room temperature was comfortable. Overall stay was good. Would stay there again Reviewed on Mar 31, 2026 [](https://expedia.ca/Hotel-Search?startDate=12%2F04%2F2026&endDate=13%2F04%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=3000349349) ![Best Western Plus Sikeston I-55](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Sikeston I-55 120 S Interstate Drive Sikeston MO CA $120 CA $136 total Apr 5 - Apr 6 includes taxes & fees Stay at this hotel in Sikeston. Enjoy free breakfast, free parking, and a fitness center. Our guests praise the breakfast and the helpful staff in our reviews. ... 8.4/10 Very Good! (1,002 reviews) The bed and chair was hard. Will not go back Reviewed on Mar 30, 2026 [](https://expedia.ca/Hotel-Search?startDate=05%2F04%2F2026&endDate=06%2F04%2F2026&selected=8420572&PinnedHotelID=8420572&HadPinnedHotel=true®ionId=3000349349) [See all 87 properties in East Prairie](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=04%2F04%2F2026&endDate=05%2F04%2F2026®ionId=3000349349) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Duck Hunting, Fishing or Relaxing Family Vacation](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/d93cc56b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Duck Hunting, Fishing or Relaxing Family Vacation Hornbeak TN Stay at this vacation home in Hornbeak. Enjoy a garden, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located ... 10/10 Exceptional! (227 reviews) Yes, it was very nice. Will be back for sure. View was awesome. The house was very nice and fully stocked. Reviewed on Mar 27, 2026 [](https://expedia.ca/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information) ![Come and relax at the Refuge at beautiful Reelfoot Lake!](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/0a58d14b_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Come and relax at the Refuge at beautiful Reelfoot Lake! Hornbeak TN Enjoy free WiFi, laundry facilities, and patios. Popular attractions Willow Towhead and Rat Island are located nearby. 9.4/10 Exceptional! (27 reviews) We loved The Refuge. We just came down for a weekend fishing trip with our boys, But it would be so perfect for someone who wants to come down with a group of friends, as there's plenty of twin beds. We loved it and would definitely stay again. Reviewed on Mar 23, 2026 [](https://expedia.ca/Hornbeak-Hotels-Enjoy-Beautiful-Sunsets-At-The-HUT-2-At-Beautiful-Reelfoot-Lake.h83571978.Hotel-Information) ![Beautiful Reelfoot Lake](https://images.trvl-media.com/lodging/76000000/75270000/75267600/75267595/4d50be35_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Beautiful Reelfoot Lake Tiptonville TN Stay at this vacation home in Tiptonville. Enjoy free WiFi, a garden, and laundry facilities. Popular attractions Campbell's Point and Reelfoot Lake State Park ... 10/10 Exceptional! (99 reviews) Amazing home. Clean, updated, great value for your money. Dock was incredible. There’s really no point to look anywhere else!! Reviewed on Mar 29, 2026 [](https://expedia.ca/Tiptonville-Hotels-Beautiful-Reelfoot-Lake.h75267595.Hotel-Information) [See all properties in East Prairie](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000349349&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check East Prairie hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-04-03&endDate=2026-04-04)[Apr 3 - Apr 4](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-04-03&endDate=2026-04-04) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-04-04&endDate=2026-04-05)[Apr 4 - Apr 5](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-04-04&endDate=2026-04-05) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026)[Apr 3 - Apr 5](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=03%2F04%2F2026&endDate=05%2F04%2F2026) ### Popular places to visit #### Big Oak Tree State Park You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks. [](https://expedia.ca/Big-Oak-Tree-State-Park-Missouri.d553248621532655754.Vacation-Attraction) - Cities near East Prairie - Places of interest - [Mississippi River ](https://expedia.ca/Mississippi-River-United-States-of-America.d6209928.Vacation-Attraction) - [Reelfoot Lake State Park ](https://expedia.ca/Reelfoot-Lake-State-Park-Tiptonville.d553248621532655205.Vacation-Attraction) - [Ohio River Valley ](https://expedia.ca/Ohio-River-Valley-United-States-of-America.d6233674.Vacation-Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app