Title: Hotels by Independent in East Prairie | Expedia.ca [East Prairie Travel Guide](https://expedia.ca/East-Prairie.dx3000349349)[Hotels in East Prairie](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Vacation Rentals in East Prairie](https://expedia.ca/East-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[Flights to East Prairie](https://expedia.ca/Cheap-Flights-To-East-Prairie.d3000349349.Travel-Guide-Flights)[East Prairie Car Rentals](https://expedia.ca/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.ca/East-Prairie.d3000349349.Destination-Travel-Guides) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Apr 7 - Apr 8](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-04-07&endDate=2026-04-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Apr 8 - Apr 9](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Apr 10 - Apr 12](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Apr 17 - Apr 19](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels-Independent.0-0-d3000349349--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels-Independent.0-0-d3000349349--bIndependent.Travel-Guide-Filter-Hotels) ## Top East Prairie Hotel Reviews ![3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters](https://images.trvl-media.com/lodging/124000000/123260000/123259200/123259172/5c6ff00e_y.jpg) ### 3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters 10/10 Excellent "Everything was perfect, very clean well maintained property. Communication was great. Our family had a wonderful stay. Would definitely recommend!!! 5 stars across the board!!" [](https://expedia.ca/Hornbeak-Hotels-3-Bedroom-House-On-Reelfoot-Lake.h123259172.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/85184a8e_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Clean, friendly staff, comfortable!" [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/be0d2e33_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "Very clean and friendly service " [](https://expedia.ca/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Quality Inn Union City US 51](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/c1609da5_y.jpg) ### Quality Inn Union City US 51 6/10 Okay "Room was ok,exterior very dirty and not in good condition. Toilet kept running " [](https://expedia.ca/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information) ![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/543bd231_y.jpg) ### Reelfoot Lake Inn 10/10 Excellent "Was a nice stay " [](https://expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/77525d07_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Was very clean & pet-friendly. Great place to stop on toad" [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54_y.jpg) ### Fairfield Inn & Suites by Marriott Sikeston 10/10 Excellent "Quick and friendly check where they offered us bottles of water. They added a lounge/bar that is very convenient. The outside lounge are is very nice as well. Room is clean with a comfortable bed and 2 different styles of pillows. Which is nice considering most hotels give you one kind of pillow and it is not great. " [](https://expedia.ca/Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/47690ac7_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 8/10 Good "Yes" [](https://expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![New Orleans Inn Portageville ](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg) ### New Orleans Inn Portageville 4/10 Poor "The room was dusty, but other than that, it felt clean. There were 20 or so cats in the parking lot, and this is definitely a hotel people live in. There's too much to mention regarding that... Would I stay there again, probably not, but it was fine for me & my husband when we were too tired to keep driving." 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