Title: Hotels by Independent in East Prairie from CA $76 | Expedia.ca [East Prairie Travel Guide](https://expedia.ca/East-Prairie.dx3000349349)[Hotels in East Prairie](https://expedia.ca/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Vacation Rentals in East Prairie](https://expedia.ca/East-Prairie-Vacation-Rentals.d3000349349.Travel-Guide-VacationRentals)[Flights to East Prairie](https://expedia.ca/Cheap-Flights-To-East-Prairie.d3000349349.Travel-Guide-Flights)[East Prairie Car Rentals](https://expedia.ca/Car-Rentals-In-East-Prairie.d3000349349.Car-Rental-Guide)[East Prairie Vacation Packages](https://expedia.ca/East-Prairie.d3000349349.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Independent in East Prairie from CA $76 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 17 - Oct 18](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-10-17&endDate=2025-10-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 18 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-10-18&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=3000349349&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top East Prairie Independent Hotels ![Hallway](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/c7be0f94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking | Living area](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/a63c84b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/3727e01c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/2dc19e85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) Sikeston 8.4/10 Very good (695) "Stayed one night. Good rate for the Hotel " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Paul CA $76 CA $87 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/w1290h938x0y0-9734f59a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/8c5087c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite, 1 King Bed, Non Smoking, Microwave](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/c064d51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/3817bb3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hospitality House Union City I 69 / US 51 Union City 6.8/10 (341) "Great staff wonderful and professional demeanor. Will definitely stay again " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Julius CA $76 CA $91 total includes taxes & fees Nov 15 - Nov 16 [](https://www.expedia.ca/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information) ![Premier Room, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premier Room, 1 Bedroom, Non Smoking](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/06367e7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/91bb8871.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### New Orleans Inn Portageville Portageville 8.0/10 Very good (708) "This is a hidden gem of a place. It is so peaceful and serene. Large clean rooms, hot showers, restaurant next door, cant ask for much more in life. All the staff were excellent as well. " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Quincy CA $71 CA $76 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Handicap Room](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/755237c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/60633b31.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/45782657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Handicap Room](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/6128b6d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Reelfoot Lake Inn Tiptonville 7.2/10 Good (453) "The room was filthy and smelled so bad we could not stay and lost a whole weeks rent. I cleaned when we went in but nothing could be done about the smell and spiders. " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Sherry CA $86 CA $98 total includes taxes & fees Oct 18 - Oct 19 [](https://www.expedia.ca/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Gazebo](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/501c540f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Soundproofing, free WiFi, bed sheets](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/a3f1cfc5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/6099e00f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/17000000/16090000/16087600/16087543/825a993b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travel Inn Marston 5.8/10 (112) "Great place" ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian CA $69 CA $79 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Hayti-Hotels-Travel-Inn.h16087543.Hotel-Information) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/b7b36182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/980dd49e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/131ce4dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/91000000/90830000/90821500/90821467/392abeff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Yard Inn and Suite Sikeston 6.8/10 (111) "Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew CA $76 CA $91 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Sikeston-Hotels-Country-Yard-Inn-And-Suite.h90821467.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/09116238.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/af4dad21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/b7a606eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/ff6f2d55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Duck Hunting, Fishing or Relaxing Family Vacation Hornbeak 10/10 Exceptional (210) "Our favorite place to stay! Always super clean! " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda F. [](https://www.expedia.ca/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/84000000/83510000/83500500/83500478/dbfefe0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, in-room safe, free WiFi, bed sheets](https://images.trvl-media.com/lodging/84000000/83510000/83500500/83500478/de4a4d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/84000000/83510000/83500500/83500478/d82952b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/84000000/83510000/83500500/83500478/687381a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Premier lodging at Reelfoot lake , First class upgrade! Hornbeak 9.8/10 Exceptional (50) "Great place close to everything " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) William U. [](https://www.expedia.ca/Hornbeak-Hotels-Premier-Lodging-At-Reelfoot-Lake.h83500478.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/67000000/66870000/66860500/66860462/2de61914.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace](https://images.trvl-media.com/lodging/67000000/66870000/66860500/66860462/8ce0c3f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/67000000/66870000/66860500/66860462/e53ab62e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/67000000/66870000/66860500/66860462/bde518a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dancing Diamonds Waterfront Retreat Tiptonville 10/10 Exceptional (95) "Fantastic location on the water. Great neighborhood. Really enjoyed my stay." ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Anonymous traveller [](https://www.expedia.ca/Tiptonville-Hotels-Vrbo-Property.h66860462.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/76000000/75270000/75267600/75267595/5199219e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/76000000/75270000/75267600/75267595/ecbaa404.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/76000000/75270000/75267600/75267595/3e1d9990.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 bedrooms, free WiFi](https://images.trvl-media.com/lodging/76000000/75270000/75267600/75267595/db8cf56a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful Reelfoot Lake Tiptonville 10/10 Exceptional (84) "Plenty of room for our family and is located in a quiet neighborhood. Always super clean as well! " ![](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda F. [](https://www.expedia.ca/Tiptonville-Hotels-Beautiful-Reelfoot-Lake.h75267595.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-31&endDate=2025-11-01®ionId=3000349349&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels-Independent.0-0-d3000349349--bIndependent.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels-Independent.0-0-d3000349349--bIndependent.Travel-Guide-Filter-Hotels) ## Top East Prairie Hotel Reviews ![Hospitality House Union City I 69 / US 51](//images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/w1290h938x0y0-9734f59a_y.jpg) ### Hospitality House Union City I 69 / US 51 10/10 Excellent "Amazing.. Clean Rooms.. Comfortable Beds.. Reasonable Price " [](https://expedia.ca/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information) ![Drury Inn & Suites Sikeston, MO](//images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "Clean. Happy hour at 530, decent breakfast options " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Best Western Plus Sikeston](//images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg) ### Best Western Plus Sikeston 10/10 Excellent "Clean and roomy room. Friendly and helpful staff. Great breakfast." [](https://expedia.ca/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information) ![New Orleans Inn Portageville ](//images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936_y.jpg) ### New Orleans Inn Portageville 10/10 Excellent "This is a hidden gem of a place. It is so peaceful and serene. Large clean rooms, hot showers, restaurant next door, cant ask for much more in life. All the staff were excellent as well. " [](https://expedia.ca/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](//images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg) ### Super 8 by Wyndham Charleston/Sikeston East MO 10/10 Excellent "Tracey Allen checked me in. She was great!" [](https://expedia.ca/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Hampton Inn Sikeston](//images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "Very good " [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Pear Tree Inn Sikeston](//images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg) ### Pear Tree Inn Sikeston 10/10 Excellent "The Pear Tree was clean, comfortable, and the staff were extremely friendly!" [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](//images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "The staff was very professional, kind and accommodating. 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