Photo by Catherine Edejer-McCormick

Find Boutique Hotels in Downtown South San Francisco, CA

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Downtown South San Francisco Boutique Hotels

Top Downtown South San Francisco Boutique Hotels

Top Downtown South San Francisco Hotel Reviews

Frequently asked questions

What's there to see and do in Downtown South San Francisco?
After you've decided where to stay, figure out some fun things to do on your trip. Top activities and sights around Downtown South San Francisco include Pier 39, San Francisco Bay, and Chase Center. You might also want to see places such as Oracle Park, Coyote Point Park, and California Academy of Sciences during your trip.
#### When Should I Plan a Trip to Downtown South San Francisco?\n
If you're curious about the local weather, use this info to plan your escape to Downtown South San Francisco: