Title: Hotels by Independent in Cape Girardeau from CA $87 | Expedia.ca [Cape Girardeau Travel Guide](https://expedia.ca/Cape-Girardeau.dx820)[Hotels in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Hotels.d820.Travel-Guide-Hotels)[Vacation Rentals in Cape Girardeau](https://expedia.ca/Cape-Girardeau-Vacation-Rentals.d820.Travel-Guide-VacationRentals)[Flights to Cape Girardeau](https://expedia.ca/Cheap-Flights-To-Cape-Girardeau.d820.Travel-Guide-Flights)[Cape Girardeau Car Rentals](https://expedia.ca/Car-Rentals-In-Cape-Girardeau.d820.Car-Rental-Guide)[Cape Girardeau Vacation Packages](https://expedia.ca/Cape-Girardeau.d820.Destination-Travel-Guides) ![Beautiful city by the Mississippi River](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Alice Burghart ![](https://images.trvl-media.com/place/820/c000ed90-c592-47c7-a850-3eeb29bbc936.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Feb 2 - Feb 3](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-02&endDate=2026-02-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 3 - Feb 4](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=820&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Cape Girardeau Independent ![Lobby sitting area](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/d68c9046.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Grand Riverview Two Queen Room](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/8ba17328.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/f27091ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, lunch, dinner served; American cuisine](https://images.trvl-media.com/lodging/106000000/105090000/105081400/105081384/53cb7546.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Riverview [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) Cape Girardeau 9.4/10 Exceptional (496 reviews) "The room was clean and I was able to check in a bit early." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara CA $128 CA $145 total includes taxes & fees Feb 9 - Feb 10 [](https://www.expedia.ca/Cape-Girardeau-Hotels-The-Riverview.h105081384.Hotel-Information) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/9000000/8300000/8295800/8295732/3bfecde9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Family Room, Multiple Beds](https://images.trvl-media.com/lodging/9000000/8300000/8295800/8295732/c3d8fe66.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast](https://images.trvl-media.com/lodging/9000000/8300000/8295800/8295732/8928d3dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/9000000/8300000/8295800/8295732/e7ab16b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel 7 Inn Anna [](https://www.expedia.ca/Anna-Hotels-Hotel-7-Inn-Anna.h8295732.Hotel-Information) Anna 6.6/10 (218 reviews) "Room needs updates. Staff was great. Breakfast wasn't worth noting. Could use better breakfast options. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jody CA $119 CA $139 total includes taxes & fees Feb 3 - Feb 4 [](https://www.expedia.ca/Anna-Hotels-Hotel-7-Inn-Anna.h8295732.Hotel-Information) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/c3f8959c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/464a0039.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/2b1b1011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking (NRF)](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/1f46462a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn Cape Giradreau [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) Cape Girardeau 6.2/10 (210 reviews) "Along a main street but not a lot of noise, especially in the rooms. Rooms exit to the outdoors." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gary CA $75 CA $87 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) ![Economy Single Room, 1 Queen Bed, Kitchenette](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/5eb3395a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/ef0f7e68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/2abc797b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Economy Single Room, 1 Queen Bed, Kitchenette | Private kitchen](https://images.trvl-media.com/lodging/12000000/11620000/11613500/11613476/2ba6efa1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town House Inn [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) Jackson 7.6/10 Good (432 reviews) "The staff member Tim was very friendly and nice. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie CA $91 CA $99 total includes taxes & fees Mar 5 - Mar 6 [](https://www.expedia.ca/Sikeston-Hotels-Town-House-Inn.h11613476.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/0eaa42e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/db7eaad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/66621448.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89650000/89641100/89641032/5b6de44e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Exquisite views of Shawnee National Forest seen from a private, covered hot tub. [](https://www.expedia.ca/Cobden-Hotels-Exquisite-Views-Of-Shawnee-National-Forest-Seen-From-A-Private.h89641032.Hotel-Information) Cobden 9.8/10 Exceptional (43 reviews) "Cozy! Great views. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Holly M. [](https://www.expedia.ca/Cobden-Hotels-Exquisite-Views-Of-Shawnee-National-Forest-Seen-From-A-Private.h89641032.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/a0829ae4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/145de6a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Double Room](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/f646a9e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/75000000/74670000/74660800/74660768/ac6df1a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EC Reed's Mercantile and Hotel [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) Marble Hill 9.6/10 Exceptional (84 reviews) "Cute room, great food, fun soda fountain and friendly owners! Will return! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie [](https://www.expedia.ca/Marble-Hill-Hotels-EC-Reeds-Mercantile-And-Hotel.h74660768.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/38000000/37860000/37859700/37859643/70c5320a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV, fireplace, DVD player](https://images.trvl-media.com/lodging/38000000/37860000/37859700/37859643/139e144e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/38000000/37860000/37859700/37859643/ee8685a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/38000000/37860000/37859700/37859643/76cc4810.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### On the Shawnee Wine Trail [](https://www.expedia.ca/On-The-Shawnee-Wine-Trail.h37859643.Hotel-Information) Carbondale 10/10 Exceptional (234 reviews) "Great place to stay clean and private" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Beth H. [](https://www.expedia.ca/On-The-Shawnee-Wine-Trail.h37859643.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19670000/19663200/19663190/610174de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/20000000/19670000/19663200/19663190/2175d0c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/20000000/19670000/19663200/19663190/aa5bc9d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/20000000/19670000/19663200/19663190/41b86fdc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower [](https://www.expedia.ca/Carbondale-Hotels-Walk-To-Wineries-Quaint-Village-Grill-Patio-Wifi-Amazing-Shower.h19663190.Hotel-Information) Alto Pass 9.8/10 Exceptional (179 reviews) "The host was very accommodating, fit us in last minute which gave us more time to see the sites. The beds were so comfy and the bathroom was a dream for a rental. Lots of room to spread out. The proximity to the Wine trail was a big plus after hiking all day we could visit close to our stay! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Debbie B. [](https://www.expedia.ca/Carbondale-Hotels-Walk-To-Wineries-Quaint-Village-Grill-Patio-Wifi-Amazing-Shower.h19663190.Hotel-Information) ![TV](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/826a8705.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/241f90a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![TV](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/4456c8fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/70000000/69800000/69799800/69799724/ebb83244.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### \* On the Wine Trail \* Hot Tub \* Wi-Fi \* [](https://www.expedia.ca/Carbondale-Hotels-On-The-Wine-Trail-Hot-Tub-Wi-Fi.h69799724.Hotel-Information) Alto Pass 9.8/10 Exceptional (242 reviews) "Very nice and comfortable place to stay. The basket of snacks and coffee packets was a nice touch! Good location to hit several wineries and a quick walk to the bourbon bar!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mary H. [](https://www.expedia.ca/Carbondale-Hotels-On-The-Wine-Trail-Hot-Tub-Wi-Fi.h69799724.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/cb67aaf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, fireplace, books](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/42428d17.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/5387ea90.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/35000000/34340000/34332000/34331993/aa1de11c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cabin in Southern Illinois - Hot Tub - Romantic Getaway -Shawnee National Forest [](https://www.expedia.ca/Jonesboro-Hotels-Cabin-In-Southern-Illinois-Hot-Tub-Romantic-Getaway-Shawnee-National-Forest.h34331993.Hotel-Information) Jonesboro 10/10 Exceptional (271 reviews) "Great little cabin! Perfect for a couples get away along the wine trails of sourthern IL! Hot tub was fantastic, the property was very clean! The cabin had everything we needed! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kayla G. [](https://www.expedia.ca/Jonesboro-Hotels-Cabin-In-Southern-Illinois-Hot-Tub-Romantic-Getaway-Shawnee-National-Forest.h34331993.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-16&endDate=2026-02-17®ionId=820&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FCape-Girardeau-Hotels-Independent.0-0-d820--bIndependent.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FCape-Girardeau-Hotels-Independent.0-0-d820--bIndependent.Travel-Guide-Filter-Hotels) ## Top Cape Girardeau Hotel Reviews ![Hampton Inn Cape Girardeau I 55 East](https://images.trvl-media.com/lodging/13000000/12790000/12786700/12786627/540ce58d_y.jpg) ### Hampton Inn Cape Girardeau I 55 East 10/10 Excellent "Nice staff. Clean room. Good cookies. And breakfast adequate. " [](https://expedia.ca/Sikeston-Hotels-Hampton-Inn-Cape-Girardeau-I-55-East.h12786627.Hotel-Information) ![Drury Inn & Suites Cape Girardeau](https://images.trvl-media.com/lodging/1000000/50000/40900/40831/4b521966_y.jpg) ### Drury Inn & Suites Cape Girardeau 10/10 Excellent "The room was lage and clean. We really enjoyed the free food and drinks provided." [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Cape-Girardeau.h40831.Hotel-Information) ![Quality Inn](https://images.trvl-media.com/lodging/1000000/860000/856000/855988/d2a0e781_y.jpg) ### Quality Inn 10/10 Excellent "The lady at the front desk was an amazing person and treated me with the upmost respect " [](https://expedia.ca/Sikeston-Hotels-Quality-Inn.h855988.Hotel-Information) ![Pear Tree Inn Cape Girardeau West](https://images.trvl-media.com/lodging/1000000/30000/21500/21410/3a7dec89_y.jpg) ### Pear Tree Inn Cape Girardeau West 10/10 Excellent "Comfortable beds and pillows Good breakfast " [](https://expedia.ca/Sikeston-Hotels-Pear-Tree-Inn-Cape-Girardeau-West.h21410.Hotel-Information) ![Drury Plaza Hotel Cape Girardeau Conference Center](https://images.trvl-media.com/lodging/18000000/17270000/17270000/17269948/742aaf1e_y.jpg) ### Drury Plaza Hotel Cape Girardeau Conference Center 10/10 Excellent "This place feels like customer service from 1950\. The service was outstanding " [](https://expedia.ca/Sikeston-Hotels-Drury-Plaza-Hotel-Cape-Girardeau-Conference-Center.h17269948.Hotel-Information) ![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg) ### Tru By Hilton Cape Girardeau 10/10 Excellent "Very nice room!" [](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Fairfield Inn & Suites by Marriott Cape Girardeau](https://images.trvl-media.com/lodging/100000000/99980000/99972100/99972043/347bcd98_y.jpg) ### Fairfield Inn & Suites by Marriott Cape Girardeau 10/10 Excellent "Clean rooms and friendly staff" [](https://expedia.ca/Cape-Girardeau-Hotels-Fairfield-Inn-Suites-By-Marriott-Cape-Girardeau.h99972043.Hotel-Information) ![Town House Inn Cape Giradreau](https://images.trvl-media.com/lodging/12000000/11620000/11613900/11613884/7adb4452_y.jpg) ### Town House Inn Cape Giradreau 10/10 Excellent "spotless smelled good as well " [](https://expedia.ca/Sikeston-Hotels-Town-House-Inn-Cape-Giradreau.h11613884.Hotel-Information) ![Courtyard by Marriott Cape Girardeau Downtown](https://images.trvl-media.com/lodging/25000000/24330000/24322100/24322039/ae49c8da_y.jpg) ### Courtyard by Marriott Cape Girardeau Downtown 10/10 Excellent "Room was spotless, comfy bed, friendly staff" [](https://expedia.ca/Sikeston-Hotels-Courtyard-By-Marriott-Cape-Girardeau-Downtown.h24322039.Hotel-Information) ## Explore a world of travel with Expedia - 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