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Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22
In one month
Dec 4 - Dec 6
In two months
Jan 1 - Jan 3
No exact matches found, but these alternatives could be just right

Recommended hotels in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,003 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is CA $140
CA $158 total
includes taxes & fees
Nov 15 - Nov 16
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

2. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is CA $134
CA $153 total
includes taxes & fees
Dec 6 - Dec 7
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.

3. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Clean, spacious suite, enjoyable kick back and breakfast!"
United States
Mary
The price is CA $127
CA $143 total
includes taxes & fees
Nov 12 - Nov 13
Drury Inn & Suites Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

4. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (702 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is CA $153
CA $173 total
includes taxes & fees
Nov 10 - Nov 11
The Riverview
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

5. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is CA $102
CA $115 total
includes taxes & fees
Nov 15 - Nov 16
Pear Tree Inn Cape Girardeau West
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.

6. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (858 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is CA $138
CA $156 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Cape Girardeau I 55 East
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (240 reviews)
"Great hotel…!!"
United States
Carlos
The price is CA $143
CA $161 total
includes taxes & fees
Nov 12 - Nov 13
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with marble flooring, elegant seating, and a grand staircase.

8. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (557 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is CA $164
CA $186 total
includes taxes & fees
Nov 19 - Nov 20
Courtyard by Marriott Cape Girardeau Downtown
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

9. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,000 reviews)
"Nice clean room"
United States
James
The price is CA $100
CA $121 total
includes taxes & fees
Nov 22 - Nov 23
Candlewood Suites Cape Girardeau by IHG
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

10. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (200 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is CA $120
CA $137 total
includes taxes & fees
Nov 15 - Nov 16
Tru By Hilton Cape Girardeau
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.

11. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
2.5 star property
Cape Girardeau
7.0 out of 10, Good, (819 reviews)
"Clean rooms, nice staff"
United States
Dayanita
The price is CA $84
CA $95 total
includes taxes & fees
Nov 15 - Nov 16
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.

12. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
2.5 star property
Cape Girardeau
6.2 out of 10, (243 reviews)
"Room was clean, bed was comfortable, staff was friendly, parking was easy. It was an older hotel and could use some renovation but would definitely stay again."
United States
Jaime
The price is CA $99
CA $116 total
includes taxes & fees
Nov 8 - Nov 9
Town House Inn Cape Giradreau
A living room with a TV, a fireplace, a sofa, and wall art.

13. Little Blue Cottage on Spanish

Little Blue Cottage on Spanish
Cape Girardeau
8.4 out of 10, Very good, (59 reviews)
"Great cute place. "
United States
Jeremy W.
The price is CA $114
CA $141 total
includes taxes & fees
Nov 8 - Nov 9
Little Blue Cottage on Spanish
A modern living room with a black sofa, wooden coffee table, and a kitchen in the background.

14. The Cottage, Rusted Route Farms

The Cottage, Rusted Route Farms
Jackson
10.0 out of 10, Exceptional, (3 reviews)
"This Cottage was very nice and clean and well maintained. The meat tray that we ordered and the breakfast tray was beyond Fabulous!!! My husband is still talking about it. . .Rick & Renee Christman"
United States
Renee C.
The price is CA $177
CA $257 total
includes taxes & fees
Nov 15 - Nov 16
The Cottage, Rusted Route Farms
A kitchen with grey cabinets, a stainless steel dishwasher, a microwave, and an oven.

15. Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals

Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Cape Girardeau
The price is CA $151
CA $250 total
includes taxes & fees
Dec 1 - Dec 2
Cozy 2-bedroom house in tranquil Cape Girardeau, close to Semo & Hospitals
Exterior

16. Purple Tiny House with Fire pit & Nature

Purple Tiny House with Fire pit & Nature
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"First time staying in the purple house, second time staying at the property. 10/10 recommend"
United States
Shawn A.
The price is CA $195
CA $277 total
includes taxes & fees
Nov 8 - Nov 9
Purple Tiny House with Fire pit & Nature
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

17. The Little Château | Woodland Escape

The Little Château | Woodland Escape
Cape Girardeau
The price is CA $219
CA $305 total
includes taxes & fees
Nov 8 - Nov 9
The Little Château | Woodland Escape
A row of colorful houses with a clear sky and trees in the background.

18. Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly

Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (1 review)
"Very cute, especially because it's pet friendly! Currently building additional structures on site but appears almost complete and still a beautiful setting and property."
United States
Elizabeth K.
The price is CA $234
CA $324 total
includes taxes & fees
Nov 18 - Nov 19
Enchanted Mermaid A-Frame | Creek + Fire pit | Pet Friendly
A modern living room with a wooden ceiling, a stone fireplace, a TV mounted on the wall, and a bar area with stools.

19. The Twisted Sassafras Treehouse

The Twisted Sassafras Treehouse
Cape Girardeau
10.0 out of 10, Exceptional, (41 reviews)
"The hosts were excellent."
United States
Jason L.
The price is CA $317
CA $484 total
includes taxes & fees
Nov 11 - Nov 12
The Twisted Sassafras Treehouse
An outdoor seating area with Adirondack chairs and a wooden pergola, surrounded by trees and string lights.

20. Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly

Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Cape Girardeau
10.0 out of 10, Exceptional, (3 reviews)
"The house was very clean and Will kept and the whole property was well maintained. It was very comfortable and nicely decorated. The host was very responsive and helpful! Would definitely stay again and recommend."
United States
Sara C.
The price is CA $219
CA $305 total
includes taxes & fees
Nov 8 - Nov 9
Romantic Creekside Retreat | Fireplace | Deck | Pet Friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Learn more about Cape Girardeau

Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets.

See all hotels in Cape Girardeau
A nighttime view of a bridge with its cables illuminated against a starry sky.

Top reviews in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau

10/10 Excellent

Friendly staff, clean room. Great food. Highly recommend this hotel.
Canada
Sareh
Reviewed August 9, 2026
Drury Plaza Hotel Cape Girardeau Conference Center

Frequently Asked Questions

What can I look forward to during my Cape Girardeau aparthotel stay?

You’ll likely stay more centrally in Cape Girardeau by choosing an aparthotel. Why not visit the shops and take time to enjoy the riverfront while you're in this family-friendly area? People who come here also speak highly of the restaurants.

What are the favorite aparthotels in Cape Girardeau?

Located 21.3 mi (34.3 km) from Cape Girardeau, King Suite, Hot Tubs, Cobden is a favorite aparthotel and the apartment features a private patio and a Smart TV along with hotel amenities like a hot tub.

How many aparthotels are available in Cape Girardeau?

Though you won't find many aparthotels that are bookable on Expedia and located in Cape Girardeau, you'll find plenty of choices with 69 lodging options. We can help you locate similar options to aparthotels such as apartments or condos.

What should I see and do in Cape Girardeau?

Family-friendly attractions include Cape Splash Family Aquatic Center and Cape Girardeau Conservation Nature Center, whereas Shawnee National Forest and Mississippi River are a couple of great spots to enjoy the outdoors. Century Casino & Hotel Cape Girardeau and Show Me Center are other places to visit while you're in town.

What is an aparthotel?

An aparthotel is part hotel and part apartment, with amenities you might expect at a traditional hotel, and the privacy and space of an apartment. These accommodations will usually be located centrally in Cape Girardeau, where you can meet the locals. Enjoy cooking in the private kitchen and having the space to spread out while you're in town.

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