Title: 5 Stars Hotels in Sikeston, Missouri - Find Cheap Sikeston Hotels With 5 Stars | Expedia.ca [Sikeston Travel Guide](https://expedia.ca/Sikeston.dx6058766)[Hotels in Sikeston](https://expedia.ca/Sikeston-Hotels.d6058766.Travel-Guide-Hotels)[Vacation Rentals in Sikeston](https://expedia.ca/Sikeston-Vacation-Rentals.d6058766.Travel-Guide-VacationRentals)[Flights to Sikeston](https://expedia.ca/Cheap-Flights-To-Sikeston.d6058766.Travel-Guide-Flights)[Sikeston Car Rentals](https://expedia.ca/Car-Rentals-In-Sikeston.d6058766.Car-Rental-Guide)[Sikeston Vacation Packages](https://expedia.ca/Sikeston.d6058766.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/2/798fcf2b70d51325aa2ef18edc87befc.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Coleman # 5 Stars Hotels in Sikeston, Missouri ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sikeston 5 Star Hotels Tonight [Oct 9 - Oct 10](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-09&endDate=2025-10-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-10&endDate=2025-10-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-10&endDate=2025-10-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6058766&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sikeston 5 Star Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Sikeston-Hotels.s50-0-d6058766.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Sikeston-Hotels.s50-0-d6058766.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Sikeston. ![Davie School Inn](https://images.trvl-media.com/lodging/34000000/33420000/33418200/33418130/3020a524_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Davie School Inn 300 Freeman St, Anna, IL [Get rates](https://expedia.ca/Hotel-Search?startDate=23%2F10%2F2025&endDate=24%2F10%2F2025&selected=33418130&PinnedHotelID=33418130&HadPinnedHotel=true®ionId=6058766) 10/10 Exceptional! (51 reviews) [](https://expedia.ca/Anna-Hotels-Davie-School-Inn.h33418130.Hotel-Information) ![Urban Lofts](https://images.trvl-media.com/lodging/40000000/39930000/39926100/39926011/1b66adae_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Urban Lofts 104 North Jackson Street, Perryville, MO [Get rates](https://expedia.ca/Hotel-Search?startDate=23%2F10%2F2025&endDate=24%2F10%2F2025&selected=39926011&PinnedHotelID=39926011&HadPinnedHotel=true®ionId=6058766) [](https://expedia.ca/Perryville-Hotels-Urban-Lofts.h39926011.Hotel-Information) Still don't see what you're looking for? [See all properties in Sikeston.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6058766&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6058766&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6058766&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6058766&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6058766&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F10%2F2025&endDate=11%2F10%2F2025®ionId=6058766&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Sikeston and related destinations - Sikeston - Florence - Los Banos - Lima Explore Sikeston: its food, riverfront, university life, and more! [See all hotels in Sikeston](https://www.expedia.ca/Hotel-Search?startDate=2025-10-23&endDate=2025-10-24&adults=2®ionId=6058766) ![](https://mediaim.expedia.com/destination/2/798fcf2b70d51325aa2ef18edc87befc.jpg?impolicy=fcrop&w=655&h=655&p=1&q=high) Photo by Ryan Coleman ## Top Sikeston Hotel Reviews ## Find out more about Sikeston ## Five Star Hotels in Sikeston There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Sikeston so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Sikeston and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Sikeston Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Sikeston The results are in, and Sikeston 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Sikeston! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Sikeston today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Sikeston? > The amount you pay for a 5-star hotel in Sikeston depends on factors such as when you plan to go and the length of your getaway. Our insider tip for scoring the best deal? Use our pricing filters to check out the available accommodations for your selected dates. > > > > - Search for the lowest price per night ### What makes a hotel 5 stars in Sikeston? > From fine dining venues and fitness centres to pools and the finest bedding, the 5-star experience in Sikeston is all about indulgence and comfort. But it takes more than just upscale conveniences to get a 5-star rating. Accommodations must also provide exceptional guest-focused services like beauty treatments, on-site laundry and dry cleaning and 24-hour room service. ### Are there any 5-star all-inclusive resorts in Sikeston? > Expedia's filter tool is the easiest way to search for exactly what you're looking for. Select "5-star" and "All inclusive" to see the most upscale hotels in Sikeston where your lodging, meals, entertainment and activities are included in the upfront price. 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